2025
Liver lipid droplet cholesterol content is a key determinant of metabolic dysfunction–associated steatohepatitis
Sakuma I, Gaspar R, Nasiri A, Dufour S, Kahn M, Zheng J, LaMoia T, Guerra M, Taki Y, Kawashima Y, Yimlamai D, Perelis M, Vatner D, Petersen K, Huttasch M, Knebel B, Kahl S, Roden M, Samuel V, Tanaka T, Shulman G. Liver lipid droplet cholesterol content is a key determinant of metabolic dysfunction–associated steatohepatitis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2502978122. PMID: 40310463, DOI: 10.1073/pnas.2502978122.Peer-Reviewed Original ResearchConceptsCholine-deficient l-amino acid-defined high-fat dietBempedoic acidLiver fibrosisLiver diseaseL-amino acid-defined high-fat dietAdvanced liver diseaseCholesterol contentHSD17B13 variantsHigh-fat dietTotal liver cholesterol contentTreated miceActivate signaling pathwaysVariant rs738409Liver cholesterol contentLiver lipidsFibrotic responsePromote inflammationTherapeutic approachesSteatotic liver diseaseDietary cholesterol supplementationFibrosisHuman liver samplesI148MAntisense oligonucleotidesProgressive form
2024
Comparative analysis of aldosterone and renin assays for primary aldosteronism screening
Taki Y, Kono T, Teruyama K, Ichijo T, Sakuma I, Nagano H, Miyagawa H, Kono S, Fujimoto M, Hashimoto N, Yokoyama M, Kawakami E, Miki T, Tanaka T. Comparative analysis of aldosterone and renin assays for primary aldosteronism screening. Scientific Reports 2024, 14: 26040. PMID: 39472614, PMCID: PMC11522277, DOI: 10.1038/s41598-024-75645-1.Peer-Reviewed Original ResearchConceptsAldosterone-to-renin ratioPlasma aldosterone concentrationWeak mineralocorticoidLC-MS/MSPrimary aldosteronismChemiluminescent enzyme immunoassayAnalysis of aldosteroneLiquid chromatography/mass spectrometry/mass spectrometryPA diagnosisPrimary aldosteronism screeningNon-PA groupPlasma aldosterone concentration valuesReceiver operating characteristic curveRenin samplingRenin valuesAldosterone concentrationRetrospective studyCutoff valuePassing-Bablok regressionPAC samplesRenin assayPAC measurementsRadioimmunoassay methodEnzyme immunoassayRadioimmunoassayPrimary adrenal insufficiency due to lymphomatoid granulomatosis in a 32-year-old man
Sakuma I, Ishibashi R, Matsue K, Vatner D, Nakamura Y, Yokote K, Tanaka T. Primary adrenal insufficiency due to lymphomatoid granulomatosis in a 32-year-old man. The Lancet 2024, 403: e33. PMID: 38823995, DOI: 10.1016/s0140-6736(24)00974-7.Peer-Reviewed Case Reports and Technical Notes
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