Adaptive multi-interventional trial platform to improve patient care for fibrotic interstitial lung diseases
Kawano-Dourado L, Kulkarni T, Ryerson C, Rivera-Ortega P, Baldi B, Chaudhuri N, Funke-Chambour M, Hoffmann-Vold A, Johannson K, Khor Y, Montesi S, Piccari L, Prosch H, Molina-Molina M, Torres J, Bauer-Ventura I, Rajan S, Jacob J, Richards D, Spencer L, Wendelberger B, Jensen T, Quintana M, Kreuter M, Gordon A, Martinez F, Kaminski N, Cornelius V, Lewis R, Adams W, Jenkins G, consortium R, Bravery A, Goodwin A, Etges A, Boshoff A, Günther A, Briggs A, Palmer A, Wilson A, Crawshaw A, Hoffmann-Vold A, Bergeron A, Holland A, Gordon A, Prasse A, Tzouvelekis A, Trachalaki A, Wells A, Nair A, Adegunsoye A, Wendelberger B, Hope-Gill B, Kaul B, Gooptu B, Baldi B, Crestani B, Polanczyk C, Vancheri C, Crobal C, Summers C, Grainge C, Ryerson C, von Garnier C, Huntley C, Ravaglia C, Valenzuela C, Hayton C, McCarthy C, Chambers D, Babalis D, Thicket D, Turner D, Talwar D, Anand D, Dhasmana D, Parek D, Griffiths D, Villegas D, Richards D, Santucci E, Bendstrup E, Balestro E, Tsitoura E, Falaschetti E, Gupta E, Farrand E, Khan F, Martinez F, Bonella F, Lombardi F, Hunninghake G, Saini G, Jenkins G, Gudmundsson G, Collard H, Parfrey H, Prosch H, Fainberg H, Adamali H, Stewart I, Forrest I, Glaspole I, Bauer-Ventura I, Noth I, Cox I, Strambu I, Sellares J, Eaden J, Johnston J, Swigris J, Blaikley J, Kim J, Chung J, Lasky J, Jacob J, Lee J, Behr J, Storrer K, Lewandowska K, Johnson K, Antoniou K, Hostettler K, Johannson K, Hurley K, Hett K, Schwarzkopf L, Fabbri L, Price L, Pearmain L, Kawano-Dourado L, Galvin L, Spencer L, Watson L, Crowley L, Richeldi L, Piccari L, Funke-Chambour M, Molina-Molina M, Jones M, Spears M, Toshner M, Wijsenbeek-Lourens M, Brutsche M, Vasakova M, Quintana M, Gibbons M, Henry M, Keane M, Kreuter M, Man M, Sadatsafavi M, Kaminski N, Chaudhuri N, Weatherley N, Hirani N, Mladinescu O, Spagnolo P, Beirne P, Bryce P, George P, Molyneaux P, Rivera-Ortega P, Crisan-Dabija R, Maida R, Borie R, Takei R, Lewis R, Rolo R, Guler S, Paganoni S, Singh S, Freitas S, Piciucchi S, Malik S, Barratt S, Hart S, Dal Corso S, Fletcher S, Stanel S, Bianchi S, Jones S, Nathan S, Rajan S, Birring S, Montesi S, Reoto T, Corte T, Zaman T, Kulkarni T, Gatheral T, Jensen T, McMillan T, Quinn V, Poletti V, Cornelius V, Cottin V, Adams W, Wuyts W, Kondoh Y, Miyazaki Y, Khor Y, Haider Y. Adaptive multi-interventional trial platform to improve patient care for fibrotic interstitial lung diseases. Thorax 2024, 79: 788-795. PMID: 38448221, PMCID: PMC11287572, DOI: 10.1136/thorax-2023-221148.Peer-Reviewed Original ResearchMeSH KeywordsAdaptive Clinical Trials as TopicDisease ProgressionHumansLung Diseases, InterstitialRandomized Controlled Trials as TopicResearch DesignConceptsFibrotic interstitial lung diseaseInterstitial lung diseaseRandomised controlled trial approachTarget populationCare of peopleImprove patient careLung diseaseDisease associated with significant morbiditySafety of interventionsDissemination of resultsTrial deliveryImprove careProgression of fibrosisPatient careResponse adaptive randomisationPrimary outcomeCareSignificant morbidityAdult patientsApproaches to drug developmentClinical trialsDrug development pipelineTrial approachHeterogeneous groupPatients
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