Preclinical characterization of [18F]T-008, a novel PET imaging radioligand for cholesterol 24-hydroxylase
Koike T, Constantinescu CC, Ikeda S, Nishi T, Sunahara E, Miyamoto M, Cole P, Barret O, Alagille D, Papin C, Morley T, Fowles K, Seibyl J, Tamagnan G, Kuroita T. Preclinical characterization of [18F]T-008, a novel PET imaging radioligand for cholesterol 24-hydroxylase. European Journal Of Nuclear Medicine And Molecular Imaging 2021, 49: 1148-1156. PMID: 34651220, PMCID: PMC8921165, DOI: 10.1007/s00259-021-05565-z.Peer-Reviewed Original ResearchConceptsBrain sectionsMouse brain sectionsEnzyme occupancyBrain-specific enzymeBrain cholesterol homeostasisTreatment of seizuresWild-type miceAdult rhesus macaquesDose-dependent mannerWarrants further studyLogan graphical analysisEpileptic encephalopathySoticlestatBaseline scanAutoradiography studiesPreclinical characterizationLassen plotPreclinical validationBrain regionsCortical regionsPET studiesRhesus macaquesCholesterol homeostasisPET imagingARG study
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