Midbrain Activation During Pavlovian Conditioning and Delusional Symptoms in Schizophrenia
Romaniuk L, Honey GD, King JR, Whalley HC, McIntosh AM, Levita L, Hughes M, Johnstone EC, Day M, Lawrie SM, Hall J. Midbrain Activation During Pavlovian Conditioning and Delusional Symptoms in Schizophrenia. JAMA Psychiatry 2010, 67: 1246-1254. PMID: 21135324, DOI: 10.1001/archgenpsychiatry.2010.169.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmygdalaBasal GangliaCase-Control StudiesConditioning, ClassicalCross-Sectional StudiesCuesDelusionsDiagnostic and Statistical Manual of Mental DisordersFemaleHumansMagnetic Resonance ImagingMaleMesencephalonMiddle AgedNeuropsychological TestsPsychotic DisordersSchizophreniaSchizophrenic PsychologySeverity of Illness IndexConceptsHealthy control participantsDelusional symptomsVentral striatumDSM-IV-diagnosed schizophreniaInappropriate activationControl participantsBlood oxygen level-dependent (BOLD) responseAcademic medical centerNegative Syndrome ScaleFunctional magnetic resonance imagingMagnetic resonance imagingRegional brain activationLevel-dependent responsesFunctional magnetic resonanceFunctional neuroimaging studiesPatient groupMedical CenterPavlovian conditioning taskSchizoaffective disorderAbnormal activationSyndrome ScalePatientsResonance imagingMidbrain activationSymptom severity
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