An In Vivo Model for Elucidating the Role of an Erythroid-Specific Isoform of Nuclear Export Protein Exportin 7 (Xpo7) in Murine Erythropoiesis
Modepalli S, Martinez-Morilla S, Venkatesan S, Fasano J, Paulsen K, Görlich D, Hattangadi S, Kupfer G. An In Vivo Model for Elucidating the Role of an Erythroid-Specific Isoform of Nuclear Export Protein Exportin 7 (Xpo7) in Murine Erythropoiesis. Experimental Hematology 2022, 114: 22-32. PMID: 35973480, PMCID: PMC10165728, DOI: 10.1016/j.exphem.2022.08.001.Peer-Reviewed Original ResearchConceptsErythroid-specific isoformStress erythropoiesisNuclear condensationPenetrant embryonic lethalityStress response factorsGene-targeted mouse modelsEmbryonic lethalityTerminal erythropoiesisDefinitive erythropoiesisExportin-7Cell divisionSteady-state erythropoiesisUbiquitous isoformErythroid isoformComplete knockdownMurine erythropoiesisSpecific isoformsXPO7Response factorIsoformsFunctional differencesExon 4Fetal liverErythropoiesisExpression
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