2025
BCL2 inhibition for multiple myeloma and AL amyloidosis
Cani L, Gupta V, Kaufman J. BCL2 inhibition for multiple myeloma and AL amyloidosis. British Journal Of Haematology 2025 PMID: 40090369, DOI: 10.1111/bjh.20046.Peer-Reviewed Original ResearchMultiple myelomaAL amyloidosisBCL2 inhibitorsLight-chain (ALTreatment landscape of MMPlasma cell disorderMalignant blood disordersDevelopment of novel treatmentsBCL2 inhibitionTreatment landscapeDose optimizationCell disordersPatient selectionClinical studiesBlood disordersNovel treatmentAmyloidosisBCL2Light chainMyelomaToxicity concernsPatientsInhibitorsDrugTreatment
2023
Prevalence and significance of extracardiac uptake on pyrophosphate imaging in the SCAN-MP study: the first 379 cases
Chan N, Einstein A, Griffin J, Rosenblum H, Teruya S, Cuomo M, De Los Santos J, DeLuca A, Johnson L, Kinkhabwala M, Leb J, Mintz A, Fine D, Helmke S, Muralidhar V, Pandey S, Sabogal N, Saith S, Winburn M, Smiley D, Miller E, Ruberg F, Maurer M. Prevalence and significance of extracardiac uptake on pyrophosphate imaging in the SCAN-MP study: the first 379 cases. Journal Of Nuclear Cardiology 2023, 30: 2531-2539. PMID: 37311914, DOI: 10.1007/s12350-023-03310-7.Peer-Reviewed Original ResearchConceptsExtracardiac uptakePYP uptakeCardiac amyloidosisBone uptakeActionable findingsTiming of scansTransthyretin cardiac amyloidosisHeart failureBreast uptakeMean ageBlack raceRenal uptakeHispanic ethnicityThyroid uptakeATTR-CANuclear scintigraphyHispanic participantsTechnetium pyrophosphateNuclear imagingPYP scanPopulation studiesSelf-identified BlackAdditional testingAmyloidosisSubjectsTEMPORALITY OF ISCHEMIC STROKE AND NEW-ONSET ATRIAL FIBRILLATION AND THE UTILITY OF LEFT ATRIAL STRAIN IN PATIENTS WITH CARDIAC AMYLOIDOSIS
Akintoye E, Majid M, Hanna M, Klein A. TEMPORALITY OF ISCHEMIC STROKE AND NEW-ONSET ATRIAL FIBRILLATION AND THE UTILITY OF LEFT ATRIAL STRAIN IN PATIENTS WITH CARDIAC AMYLOIDOSIS. Journal Of The American College Of Cardiology 2023, 81: 340. DOI: 10.1016/s0735-1097(23)00784-2.Peer-Reviewed Original Research
2022
Radiotracers to Address Unmet Clinical Needs in Cardiovascular Imaging, Part 2: Inflammation, Fibrosis, Thrombosis, Calcification, and Amyloidosis Imaging
Stendahl JC, Kwan JM, Pucar D, Sadeghi MM. Radiotracers to Address Unmet Clinical Needs in Cardiovascular Imaging, Part 2: Inflammation, Fibrosis, Thrombosis, Calcification, and Amyloidosis Imaging. Journal Of Nuclear Medicine 2022, 63: 986-994. PMID: 35772956, PMCID: PMC9258561, DOI: 10.2967/jnumed.121.263507.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCardiovascular imagingDevice-related thrombusDetection of thrombusUnmet diagnostic needsFibroblast activation proteinCardiovascular fibrosisCardiovascular inflammationRisk stratificationDiagnostic needsCardiovascular calcificationMyocardial infarctionInflammatory responseUnmet ClinicalNew radiotracersCardiovascular medicinePersonalized therapyFibrosisActivation proteinSPECT imagingAmyloidosisCalcificationThrombosisInflammationRadiotracer developmentThrombus
2021
A Case Report on Papillary Muscle Rupture Following Mitral Valve Replacement in the Setting of Previously Undiagnosed Amyloidosis.
Choudhury N, Munoz Acuna R, Chaudhary O, Chu L, VanderLaan P, Mahmood F, Sharkey A. A Case Report on Papillary Muscle Rupture Following Mitral Valve Replacement in the Setting of Previously Undiagnosed Amyloidosis. A&A Practice 2021, 15: e01415. PMID: 33684090, DOI: 10.1213/xaa.0000000000001415.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseAbsence of CADMitral valve replacement surgeryMitral valve replacementValve replacement surgeryLight chain subtypesCardiac involvementValve replacementArtery diseaseCardiopulmonary bypassAmyloid depositionCase reportReplacement surgeryCardiac amyloidosisSubvalvular apparatusPapillary musclesSubsequent pathologyAmyloidosisPatientsIschemiaSurgeryBypassTherapyMortalitySubtypes
2020
Advances in PET-Based Cardiac Amyloid Radiotracers
Gallegos C, Miller EJ. Advances in PET-Based Cardiac Amyloid Radiotracers. Current Cardiology Reports 2020, 22: 40. PMID: 32430600, DOI: 10.1007/s11886-020-01284-3.Peer-Reviewed Original ResearchConceptsPositron emission tomographyCardiac amyloidosisAmyloid depositionAmyloid radiotracersCardiac amyloid depositionCare of patientsTransthyretin cardiac amyloidosisCardiac imaging techniquesCongo red stainingPurpose of ReviewWeNovel positron emission tomographyEndomyocardial biopsyImaging featuresAmyloid depositsUnmet needInvasive methodEmission tomographyAmyloidosisGold standardAdditive valueRed stainingBiopsyFurther dataDiagnosisRecent studies
2019
SYSTEMIC AMYLOIDOSIS IN A POPULATION OF PRONGHORN ANTELOPE (ANTILOCAPRA AMERICANA)
Martinez ME, Zimmerman D, Seeley KE, Zhang L, Bapodra P, Cianciolo RE. SYSTEMIC AMYLOIDOSIS IN A POPULATION OF PRONGHORN ANTELOPE (ANTILOCAPRA AMERICANA). Journal Of Zoo And Wildlife Medicine 2019, 50: 147-158. PMID: 31120673, DOI: 10.1638/2018-0055.Peer-Reviewed Original ResearchConceptsChronic inflammationClinical historySystemic amyloidosisSerum amyloid ACases of amyloidosisPresence of amyloidosisΓ-globulin levelsNegative energy balanceHistologic evidenceAdrenal glandGlomerular depositsAmyloid ARenal specimensGlobulin levelsAmyloid presentHistologic examinationPostmortem findingsRenal tissueGastrointestinal tractNormal rangeRetrospective investigationThyroid glandSignificant associationAmyloidosisUnderlying causeSURVIVAL FOLLOWING IMPLANTABLE CARDIOVERTER-DEFIBRILLATOR IMPLANTATION IN PATIENTS WITH CARDIAC AMYLOIDOSIS
Higgins A, Annapureddy A, Wang Y, Minges K, Lampert R, Rosenfeld L, Jacoby D, Curtis J, Miller E, Freeman J. SURVIVAL FOLLOWING IMPLANTABLE CARDIOVERTER-DEFIBRILLATOR IMPLANTATION IN PATIENTS WITH CARDIAC AMYLOIDOSIS. Journal Of The American College Of Cardiology 2019, 73: 694. DOI: 10.1016/s0735-1097(19)31302-6.Peer-Reviewed Original Research
2018
Time Course of Common Clinical Manifestations in Patients with Transthyretin Cardiac Amyloidosis: Delay From Symptom Onset to Diagnosis
Papoutsidakis N, Miller EJ, Rodonski A, Jacoby D. Time Course of Common Clinical Manifestations in Patients with Transthyretin Cardiac Amyloidosis: Delay From Symptom Onset to Diagnosis. Journal Of Cardiac Failure 2018, 24: 131-133. PMID: 29305186, DOI: 10.1016/j.cardfail.2017.12.005.Peer-Reviewed Original Research
2017
Severe Orthostatic Hypotension Complicating Multiple Myeloma
Sury K, Mutter M, Moeckel G, Perazella M. Severe Orthostatic Hypotension Complicating Multiple Myeloma. Journal Of Onco-Nephrology 2017, 1: e8-e12. DOI: 10.5301/jo-n.5000029.Peer-Reviewed Original ResearchRenal replacement therapySevere hemodynamic instabilityVascular amyloidosisMultiple myelomaOrthostatic hypotensionHemodynamic instabilityReplacement therapyContinuous veno-venous hemodialysisSevere orthostatic hypotensionAcute kidney injuryMaximal medical therapyFatal cardiac arrestGlomerular amyloidosisKidney injuryUrinary findingsPersistent symptomsKidney biopsyMedical therapyKidney functionCardiac arrestMultiple fallsRenal amyloidosisTreatment challengesClinical aspectsAmyloidosis
2016
National patterns in imaging utilization for diagnosis of cardiac amyloidosis: A focus on Tc99m-pyrophosphate scintigraphy
Harb SC, Haq M, Flood K, Guerrieri A, Passerell W, Jaber WA, Miller EJ. National patterns in imaging utilization for diagnosis of cardiac amyloidosis: A focus on Tc99m-pyrophosphate scintigraphy. Journal Of Nuclear Cardiology 2016, 24: 1094-1097. PMID: 27016106, DOI: 10.1007/s12350-016-0478-3.Peer-Reviewed Original ResearchConceptsCardiac amyloidosisCA diagnosisContralateral lung ratioTransthyretin cardiac amyloidosisLung ratioDiagnostic modalitiesMost centersTest utilizationWeb-based surveyScintigraphyMultiple centersDiagnosisQuantification of uptakeLow penetranceNational surveyAmyloidosisNational patternsCardiologistsDoseAutologous Hematopoietic Cell Transplant (AHCT) Offers Prolonged Progression Free and Overall Survival in Patients with Light Chain Amyloidosis (AL) Compared with Chemotherapy Alone
Ukaegbu O, Sethi T, Goodman S, Rubinstein S, Hung R, Jagasia M, Kassim A, Lacy S, Langone A, Lenihan D, Savani B, Slosky D, Cornell R. Autologous Hematopoietic Cell Transplant (AHCT) Offers Prolonged Progression Free and Overall Survival in Patients with Light Chain Amyloidosis (AL) Compared with Chemotherapy Alone. Transplantation And Cellular Therapy 2016, 22: s233-s234. DOI: 10.1016/j.bbmt.2015.11.642.Peer-Reviewed Original Research
2015
Nodular amyloidosis.
White F, Shvartsbeyn M, Meehan SA, Ramachandran S. Nodular amyloidosis. Dermatology Online Journal 2015, 21 PMID: 26990345, DOI: 10.5070/d32112029547.Peer-Reviewed Original ResearchConceptsNodular amyloidosisSkin biopsy specimenAmorphous eosinophilic materialCongo red stainPrimary cutaneous amyloidosisApple-green birefringenceEight-year historyHyperpigmented plaquesPretibial areaSystemic diseaseBiopsy specimenEosinophilic materialCutaneous amyloidosisRare formSystemic amyloidosisAmyloidosisSmall risk
2014
A fatal case of primary cutaneous gamma–delta T‐cell lymphoma complicated by HLH and cardiac amyloidosis
Gibson JF, Kapur L, Sokhn J, Xu M, Foss FM. A fatal case of primary cutaneous gamma–delta T‐cell lymphoma complicated by HLH and cardiac amyloidosis. Clinical Case Reports 2014, 3: 34-38. PMID: 25678971, PMCID: PMC4317209, DOI: 10.1002/ccr3.142.Peer-Reviewed Original ResearchGamma-delta T-cell lymphomaT-cell lymphomaHemophagocytic lymphohistiocytosisCardiac amyloidosisPrimary cutaneous gamma-delta T-cell lymphomaCutaneous gamma-delta T-cell lymphomaSyndrome of feverFatal neoplasmMultiorgan failureFatal casesRapid deathRapid deteriorationLymphomaFirst caseAmyloidosisNovel mechanismCytopeniasLymphohistiocytosisPatientsFeverNeoplasmsSyndrome
2012
Transthyretin Cardiac Amyloidoses in Older North Americans
Dharmarajan K, Maurer MS. Transthyretin Cardiac Amyloidoses in Older North Americans. Journal Of The American Geriatrics Society 2012, 60: 765-774. PMID: 22329529, PMCID: PMC3325376, DOI: 10.1111/j.1532-5415.2011.03868.x.Peer-Reviewed Original ResearchConceptsCardiac amyloidosesCardiac amyloidosisOlder personsSupportive medical careCongestive heart failureDisease-modifying agentsTTR cardiac amyloidosisConduction system diseaseSenile cardiac amyloidosisHeart failureUnderdiagnosed disorderAmyloid depositionRestrictive cardiomyopathyClinical registryDisease progressionCommon causeParkinson's diseaseSystem diseasesElderly adultsAlzheimer's diseaseMedical careExtracellular depositionDiseaseCardiac imagingAmyloidosis
2009
Pulmonary amyloidosis with calcified nodules and masses - a six-year computed tomography follow-up: a case report
Vieira I, Marchiori E, Zanetti G, Cabral R, Takayassu T, Spilberg G, Batista R. Pulmonary amyloidosis with calcified nodules and masses - a six-year computed tomography follow-up: a case report. Cases Journal 2009, 2: 6540. PMID: 19918529, PMCID: PMC2769299, DOI: 10.4076/1757-1626-2-6540.Peer-Reviewed Original ResearchPulmonary amyloidosisPulmonary nodulesOpen lung biopsyMultiple pulmonary nodulesPrimary pulmonary amyloidosisLung biopsyCase presentationWeUncommon diseaseNodular amyloidosisCase reportDifferential diagnosisChest radiographsFibrillary proteinExtracellular depositionAmyloidosisCalcified nodulesSix yearsNodulesTomographyReportDyspneaHemoptysisLong-term observationsCoughPulmonary
2008
The Association of Hashimoto Disease and Congo Red Negative Amyloidosis
Chaiban JT, Kalache SM, Salti I, Abu Alfa A, Shabb N. The Association of Hashimoto Disease and Congo Red Negative Amyloidosis. The American Journal Of The Medical Sciences 2008, 336: 293-296. PMID: 18794630, DOI: 10.1097/maj.0b013e31815b9d51.Peer-Reviewed Original ResearchConceptsCongo red stainHashimoto's thyroiditisPrimary amyloidosisMultiple organ involvementRed stainMonoclonal immunoglobulin light chainsOrgan involvementRenal failureHeart failureHashimoto's diseaseAmyloid depositionEnlarged tongueRare caseImmunoglobulin light chainsSystemic amyloidosisExtracellular depositionImmunofixation studiesAmyloidosisUltrastructural featuresThyroiditisPatientsLight chainStainEarly stagesBiopsy
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