2025
Simultaneous Symmetrizing Surgery on the Contralateral Breast in Unilateral Autologous Breast Reconstruction Is Cost-Effective
Zhao K, Kammien A, Graetz E, Moore M, Evans B, Schneider E, Ayyala H. Simultaneous Symmetrizing Surgery on the Contralateral Breast in Unilateral Autologous Breast Reconstruction Is Cost-Effective. Journal Of Reconstructive Microsurgery 2025 PMID: 39821138, DOI: 10.1055/a-2517-0803.Peer-Reviewed Original ResearchFree flap reconstructionSymmetrization surgeryFlap reconstructionBreast reconstructionDelayed reconstructionPatient characteristicsSingle-stage breast reconstructionUnilateral autologous breast reconstructionAutologous breast reconstructionSurgical site infectionThirty-day complicationsContralateral breastUnilateral reconstructionImmediate reconstructionSite infectionWound dehiscenceThirty-dayIncreased complicationsNational administrative dataSurgeryRevision surgeryComplicationsPatientsWilcoxon testChi-squarePreferences for Care Among African American Women Considering Postmastectomy Breast Reconstruction.
Shammas R, Hung A, Ramkalawan J, Mullikin A, Moore A, Greenup R, Hollenbeck S, Phillips B, Matros E, Reed S, Lee C. Preferences for Care Among African American Women Considering Postmastectomy Breast Reconstruction. Plastic & Reconstructive Surgery 2025 PMID: 39903878, DOI: 10.1097/prs.0000000000012003.Peer-Reviewed Original ResearchImplant reconstructionBreast reconstructionPatient valuesReconstructive optionsRisk of complicationsBreast reconstruction optionsPostmastectomy breast reconstructionPost-mastectomy reconstructionNon-white womenAcademic medical centerAfrican American WomenAbdominal morbidityProphylactic mastectomyAA patientsFlap reconstructionSurgical complicationsAA womenComplication riskCommunity partnershipsAcademic centersTreatment preferencesSurgeryComplicationsPatientsMedical CenterThe Use of Acellular Dermal Matrix May Not Increase 30-Day Complications in Direct-to-Implant Breast Reconstruction: A Multi-institutional Analysis of 10,177 Cases.
Knoedler S, Klimitz F, Friedrich S, Schemet L, Broer P, Cherubino M, Könneker S, Kim B, Pomahac B, Kauke-Navarro M. The Use of Acellular Dermal Matrix May Not Increase 30-Day Complications in Direct-to-Implant Breast Reconstruction: A Multi-institutional Analysis of 10,177 Cases. Annals Of Plastic Surgery 2025 PMID: 39874559, DOI: 10.1097/sap.0000000000004234.Peer-Reviewed Original ResearchDirect-to-implant breast reconstructionDirect-to-implantAcellular dermal matrixBreast reconstructionPropensity score matchingHigher risk of short-term complicationsMedical complicationsAmerican College of Surgeons National Surgical Quality Improvement Program databaseSurgeons National Surgical Quality Improvement Program databaseNational Surgical Quality Improvement Program databaseIncreased 30-day complicationsMultivariate analysisRisk of short-term complicationsQuality Improvement Program databaseThirty-day postoperative complicationsSurgical complication rateIncorporation of acellular dermal matrixScore matchingMulti-institutional analysisMulti-institutional databaseShort-term complicationsComplication ratePostoperative complicationsWound dehiscenceNo significant difference
2024
Living Flat: Stories from Women of Color After Mastectomy
Khubchandani J, Suttiratana S, Washington R, White-Bracey D, KC M, Silber A, Fayanju O, Butler P, Menon A, Greenup R. Living Flat: Stories from Women of Color After Mastectomy. Annals Of Surgical Oncology 2024, 32: 104-114. PMID: 39407064, DOI: 10.1245/s10434-024-16337-y.Peer-Reviewed Original ResearchCancer stigmaKnowledge of family historyBreast cancer stigmaPatient-reported outcome measuresBreast cancerCommunity-partnered studyTeam-based approachPatient-reported outcomesWomen of color livingPost-mastectomy breast reconstructionQuality of lifeHealth QuestionnaireEthnic disparitiesInterview guideSemistructured interviewsThemes related to cultureResultsThe final cohortOutcome measuresWhite womenConclusionAmong womenFamily historyBreast reconstructionAdvocacy effortsStigmaFinal cohortA Randomized Trial of Hypofractionated Post-Mastectomy Radiation Therapy (PMRT) in Women with Breast Reconstruction (RT CHARM, Alliance A221505)
Poppe M, Le-Rademacher J, Haffty B, Hansen E, Agarwal J, Wagner J, Kong I, Armer J, Arthur D, Whelan T, Lee M, Kour O, Lustberg M, Partridge A, Carey L, Ruddy K, Gaffney D, Stecklein S, Bernstein M, Khan A. A Randomized Trial of Hypofractionated Post-Mastectomy Radiation Therapy (PMRT) in Women with Breast Reconstruction (RT CHARM, Alliance A221505). International Journal Of Radiation Oncology • Biology • Physics 2024, 120: s11. DOI: 10.1016/j.ijrobp.2024.07.002.Peer-Reviewed Original ResearchPost-mastectomy radiation therapyNeoadjuvant chemotherapyBreast reconstructionComplication rateReconstruction complicationsBreast cancerNon-inferiorityHigh-risk breast cancerBody mass index >Conventionally fractionated radiationGenetic predisposition genesImplant-only reconstructionsMedian follow-upImmediate breast reconstructionOne-sided type I errorNon-inferiority marginStandard of careHypofractionated radiationRegional recurrenceRadiation therapyTumor characteristicsInvasive BCAdjuvant chemotherapyPredisposition genesMedian ageFuture of autologous breast reconstruction: a review of novel technological innovations
Allam O, Foster C, Knoedler L, Knoedler S, Oh S, Pomahac B, Ayyala H. Future of autologous breast reconstruction: a review of novel technological innovations. Plastic And Aesthetic Research 2024, 11: n/a-n/a. DOI: 10.20517/2347-9264.2024.21.Peer-Reviewed Original ResearchImmediate DIEP Breast Reconstruction in a Trans Woman with Breast Cancer
Avery E, Barone N, Haykal S. Immediate DIEP Breast Reconstruction in a Trans Woman with Breast Cancer. Plastic & Reconstructive Surgery Global Open 2024, 12: e5834. PMID: 38798942, PMCID: PMC11124744, DOI: 10.1097/gox.0000000000005834.Peer-Reviewed Original ResearchImmediate breast reconstructionBreast reconstructionBreast cancerEstrogen therapyRisk of breast cancerTrans womenBilateral skin-sparing mastectomyDeep inferior epigastric perforator free flapHistory of estrogen therapySentinel lymph node biopsyManagement of breast cancerDIEP breast reconstructionPostoperative flap complicationsSkin-sparing mastectomyLymph node biopsyLymph node involvementRight breast cancerInvasive mucinous carcinomaBreast cancer diagnosisFree flap reconstructionBreast cancer managementHolistic treatment approachPerforator free flapFinal pathologyNode biopsySmooth versus Textured Tissue Expanders: Comparison of Outcomes and Complications in 536 Implants
Allam O, Dinis J, Almeida M, Junn A, Mozaffari M, Shah R, Chong L, Olawoyin O, Mehta S, Park K, Avraham T, Alperovich M. Smooth versus Textured Tissue Expanders: Comparison of Outcomes and Complications in 536 Implants. Archives Of Plastic Surgery 2024, 51: 042-051. PMID: 38425846, PMCID: PMC10901592, DOI: 10.1055/s-0043-1775592.Peer-Reviewed Original ResearchTextured tissue expandersPain scoresTissue expanderTwo-stage breast reconstructionTextured surface implantsExpander fill volumeStudy evaluated outcomesAssociated with ageComparison of outcomesRegression analysisBilateral reconstructionPrepectoral placementComplication rateTextured implantsNo significant differenceBreast reconstructionPerioperative informationSurface implantsOperative timeTE exchangeComplicationsLinear regression analysisSignificant differencePainChi-square
2023
Patient Preferences for Postmastectomy Breast Reconstruction
Shammas R, Hung A, Mullikin A, Sergesketter A, Lee C, Reed S, Fish L, Greenup R, Hollenbeck S. Patient Preferences for Postmastectomy Breast Reconstruction. JAMA Surgery 2023, 158: 1285-1292. PMID: 37755818, PMCID: PMC10535024, DOI: 10.1001/jamasurg.2023.4432.Peer-Reviewed Original ResearchConceptsRisk of complicationsBreast reconstructionAbdominal morbidityFlap reconstructionBreast cancerGenetic predispositionPatient-physician discussionsImplant-based reconstructionPostmastectomy breast reconstructionCross-sectional studyChance of complicationsPatient-centered careAdditional operationsHigher educational levelMajor complicationsPreoperative counselingPatient preferencesFlap appearanceTreatment preferencesImplant reconstructionMAIN OUTCOMENew diagnosisPatient valuesComplicationsMean increaseThe significance of timing in breast reconstruction after mastectomy: An ACS-NSQIP analysis
Knoedler S, Kauke-Navarro M, Knoedler L, Friedrich S, Ayyala H, Haug V, Didzun O, Hundeshagen G, Bigdeli A, Kneser U, Machens H, Pomahac B, Orgill D, Broer P, Panayi A. The significance of timing in breast reconstruction after mastectomy: An ACS-NSQIP analysis. Journal Of Plastic Reconstructive & Aesthetic Surgery 2023, 89: 40-50. PMID: 38134626, DOI: 10.1016/j.bjps.2023.11.049.Peer-Reviewed Original ResearchImmediate BRTime pointsACS-NSQIP databaseLow complication rateACS-NSQIP AnalysisBreast cancer patientsBreast reconstruction optionsAutologous cohortsComplication rateSignificance of timingFemale patientsMedical complicationsMultivariable analysisMore complicationsPatient eligibilityCancer patientsBreast reconstructionOncological purposesPatientsComplicationsReconstruction optionsPropensity scoreCase workupMastectomyEligibilityPatient-Reported and Toxicity Results from the FABREC Study: A Multicenter Randomized Trial of Hypofractionated vs. Conventionally-Fractionated Postmastectomy Radiation Therapy after Implant-Based Reconstruction
Wong J, Uno H, Tramontano A, Pellegrini C, Bellon J, Cheney M, Hardenbergh P, Ho A, Horst K, Kim J, Leonard K, Moran M, Park C, Recht A, Shiloh R, Taghian A, Warren L, Wright J, Chun Y, Punglia R. Patient-Reported and Toxicity Results from the FABREC Study: A Multicenter Randomized Trial of Hypofractionated vs. Conventionally-Fractionated Postmastectomy Radiation Therapy after Implant-Based Reconstruction. International Journal Of Radiation Oncology • Biology • Physics 2023, 117: e3-e4. DOI: 10.1016/j.ijrobp.2023.08.029.Peer-Reviewed Original ResearchPreoperative endocrine therapyCW toxicityEndocrine therapyQuality-of-lifeLymph nodesHF-PMRTRadiation therapyBreast reconstructionRandomized trialsResults Median follow-upChest wallTissue expanderImplant-based breast reconstructionImmediate prosthetic reconstructionPostmastectomy radiation therapyCompare quality-of-lifeMedian follow-upImplant-based reconstructionPost-operative infectionPlacement of tissue expandersMulticenter randomized trialQuality-of-life scoresSide effects of treatmentStage 0-III breast cancerPhysical well-being scoresSingle Stitch Vicryl Mesh Wrap for Prepectoral Implant Breast Reconstruction
Mookerjee V, Stögner V, Alper D, Evans B, Pomahac B. Single Stitch Vicryl Mesh Wrap for Prepectoral Implant Breast Reconstruction. Plastic & Reconstructive Surgery Global Open 2023, 11: e5058. PMID: 37313479, PMCID: PMC10259646, DOI: 10.1097/gox.0000000000005058.Peer-Reviewed Original ResearchPrepectoral breast reconstructionAcellular dermal matrixBreast reconstructionPrepectoral reconstructionVicryl meshDermal matrixAcellular dermal matrix groupOverall complication rateImplant breast reconstructionConventional reconstructive techniquesComplication ratePatient demographicsRetrospective reviewOperative timeImplant coverageSingle institutionTacking suturesMesh wrapVicryl groupSafe techniqueReconstructive techniquesSeparate cohortPatientsBreastComplicationsPrepectoral versus Submuscular Implant-Based Breast Reconstruction: A Matched-Pair Comparison of Outcomes
Talwar A, Lanni M, Ryan I, Kodali P, Bernstein E, McAuliffe P, Broach R, Serletti J, Butler P, Fosnot J. Prepectoral versus Submuscular Implant-Based Breast Reconstruction: A Matched-Pair Comparison of Outcomes. Plastic & Reconstructive Surgery 2023, 153: 281e-290e. PMID: 37159266, DOI: 10.1097/prs.0000000000010618.Peer-Reviewed Original ResearchBreast reconstructionPrepectoral ImplantSecondary reconstructionSubmuscular reconstructionClinical outcomesSubmuscular implantsCapsular contracturePrepectoral reconstructionImplant-based breast reconstructionSurgical site infectionLarge academic medical centerSurgical site occurrenceAcademic medical centerMean followDeep infectionSite infectionNegative infectionsPostoperative differencesAntibiotic managementAnimation deformityMedical CenterCohort analysisExplantationInfectionPropensity score
2022
Flap to Mastectomy Mass: Are Higher Ratios Associated with Greater Breast Reconstruction Satisfaction?
Long AS, Ching A, Hauc SC, Mozaffari MA, Junn AH, Rivera JC, Almeida MN, Alper DP, Allam O, Alperovich M. Flap to Mastectomy Mass: Are Higher Ratios Associated with Greater Breast Reconstruction Satisfaction? Journal Of Reconstructive Microsurgery 2022, 39: 209-213. PMID: 35752166, DOI: 10.1055/a-1885-1540.Peer-Reviewed Original ResearchConceptsBREAST-Q surveysAutologous breast reconstructionBody mass indexPatient satisfactionBreast reconstructionHigh patient-reported satisfactionLong-term patient satisfactionPatient underwent radiation therapySuperior patient-reported outcomesDeep inferior epigastric perforator flapPatient-reported satisfactionUnderwent radiation therapyPatient-reported outcomesNumber of surgeriesMost patientsMass indexRetrospective studySurgery failureBreast ScoreRadiation therapySmall breastsPerforator flapProsthetic techniquesBreast sizePatientsRegional block pilot for microvascular free-flap breast reconstruction.
Kim L, Long A, Miller J, Zurich H, Golshan M, Li J. Regional block pilot for microvascular free-flap breast reconstruction. Journal Of Clinical Oncology 2022, 40: e18646-e18646. DOI: 10.1200/jco.2022.40.16_suppl.e18646.Peer-Reviewed Original ResearchAnterior quadratus lumborum blockDeep inferior epigastric perforatorDIEP flap reconstructionERAS pathwayERAS protocolBaseline patientBreast reconstructionFlap reconstructionMicrovascular free flap breast reconstructionPost-anesthesia care unit lengthQuaternary care academic centerFree flap breast reconstructionTransversus abdominus plane blockDaily opioid consumptionPain control modalitiesAverage pain scoreQuadratus lumborum blockMicrosurgical breast reconstructionContinuous quality improvement projectDirect ultrasound guidanceInferior epigastric perforatorQuality improvement projectPilot groupEvidence-based approachOpioid consumptionThe modified 5-item frailty index is a predictor of perioperative risk in breast reconstruction: An analysis of 40,415 cases
Panayi AC, Foroutanjazi S, Parikh N, Haug V, Kauke-Navarro M, Diehm YF, Pomahac B. The modified 5-item frailty index is a predictor of perioperative risk in breast reconstruction: An analysis of 40,415 cases. Journal Of Plastic Reconstructive & Aesthetic Surgery 2022, 75: 2941-2954. PMID: 35599223, DOI: 10.1016/j.bjps.2022.04.035.Peer-Reviewed Original ResearchConceptsImplant-based reconstructionBreast reconstructionMFI-5Unplanned readmissionPostoperative outcomesSurgical complicationsMedical complicationsMFI scoreRisk predictorsSurgeons National Surgical Quality Improvement Program databaseNational Surgical Quality Improvement Program databaseQuality Improvement Program databaseBreast reconstruction patientsFrailty index-5Powerful risk predictorImprovement Program databasePreoperative risk stratificationStrong risk predictorAutologous breast reconstructionAdverse surgical outcomesType of reconstructionHigh rateFrail patientsHospital stayPerioperative riskRacial and Ethnic Disparities in Surgical Outcomes after Postmastectomy Breast Reconstruction.
Sarver MM, Rames JD, Ren Y, Greenup RA, Shammas RL, Hwang ES, Hollenbeck ST, Hyslop T, Butler PD, Fayanju OM. Racial and Ethnic Disparities in Surgical Outcomes after Postmastectomy Breast Reconstruction. Journal Of The American College Of Surgeons 2022, 234: 760-771. PMID: 35426388, PMCID: PMC9347225, DOI: 10.1097/xcs.0000000000000143.Peer-Reviewed Original ResearchConceptsLength of stayLonger LOSPostmastectomy breast reconstructionPostoperative complicationsWhite womenBreast reconstructionBreast cancerNational Inpatient Sample databasePost-mastectomy reconstructionType of reconstructionRace/ethnicityPerioperative comorbiditiesPreoperative comorbiditiesComorbidity scorePerioperative complicationsPerioperative factorsPatient demographicsPerioperative outcomesSurgical complicationsComorbid conditionsSurgical outcomesPostmastectomy reconstructionMicrosurgical complicationsPrimary careAutologous reconstructionEffect of health care disparities on procedure selection of autologous breast reconstruction in Florida.
Huayllani MT, Torres-Guzman RA, Avila FR, Advani PP, Spaulding AC, Cochuyt JJ, Nguyen MT, Lu X, Rinker BD, Forte AJ. Effect of health care disparities on procedure selection of autologous breast reconstruction in Florida. Breast Disease 2022, 41: 75-80. PMID: 34487016, DOI: 10.3233/bd-210004.Peer-Reviewed Original ResearchConceptsAutologous breast reconstructionBreast reconstructionFree flapFlap reconstructionReconstructive surgeryAutologous breast reconstructive surgeryFlorida Inpatient Discharge DatasetPatients 18 yearsBreast reconstructive surgeryMultivariate logistic regressionPedicled flap reconstructionHealth care disparitiesMann-Whitney testHispanic patientsIndependent associationAutologous reconstructionBreast cancerHigher oddsPatientsCare disparitiesPedicled flapsProcedure selectionLogistic regressionPrivate insuranceFlap
2021
The Modified 5-item Frailty Index Is a Risk Predictor in Breast Reconstruction: An Analysis of 40,415 Patients
Panayi A, Foroutanjazi S, Parikh B, Haug V, Kauke-Navarro M, Diehm Y, Pomahac B. The Modified 5-item Frailty Index Is a Risk Predictor in Breast Reconstruction: An Analysis of 40,415 Patients. Journal Of The American College Of Surgeons 2021, 233: s30. DOI: 10.1016/j.jamcollsurg.2021.07.037.Peer-Reviewed Original ResearchComparison of Autologous Breast Reconstruction Complications by Type of Neoadjuvant Chemotherapy Regimen
Olawoyin OM, Mehta S, Chouairi F, Gabrick KS, Avraham T, Pusztai L, Alperovich M. Comparison of Autologous Breast Reconstruction Complications by Type of Neoadjuvant Chemotherapy Regimen. Plastic & Reconstructive Surgery 2021, 148: 1186-1196. PMID: 34644277, DOI: 10.1097/prs.0000000000008505.Peer-Reviewed Original ResearchConceptsNeoadjuvant chemotherapy regimensMicrovascular breast reconstructionNeoadjuvant chemotherapyChemotherapy regimensComplication rateFat necrosisBreast reconstructionImmune cellsCLINICAL QUESTION/LEVELMultivariate binary logistic regressionYale-New Haven HospitalAdministration of taxanesBreast Reconstruction ComplicationsInclusion of anthracyclinesNeoadjuvant chemotherapy regimenDosage of chemotherapyNew Haven HospitalNeoadjuvant chemotherapy completionLogistic regression modelsBinary logistic regressionOncologic historyTaxane administrationChemotherapy regimenChemotherapy completionPathologic response
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