BK channels mediate a presynaptic form of mGluR-LTD in the neonatal hippocampus
Ancatén-González C, Meza R, Gonzalez-Sanabria N, Segura I, Alcaino A, Peña-Pichicoi A, Latorre R, Chiu C, Chávez A. BK channels mediate a presynaptic form of mGluR-LTD in the neonatal hippocampus. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2411506122. PMID: 39773031, PMCID: PMC11745352, DOI: 10.1073/pnas.2411506122.Peer-Reviewed Original ResearchConceptsBK channelsLong-term depressionMGluR-LTDNeonatal hippocampusPostsynaptic metabotropic glutamate receptorsActivation of BK channelsChannel open probabilityCA3-CA1 synapsesMetabotropic glutamate receptorsArachidonic acid metabolitesRegulating synaptic strengthActivity-dependent changesOpen probabilityHippocampal slicesCircuit maturationCA3-CA1Glutamate receptorsElectrophysiological propertiesPresynaptic formP7-P10Synaptic strengthAcid metabolitesCentral synapsesNeuronal functionSynaptic function
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