2024
Changes in Red Blood Cell Transfusion Burden with Luspatercept Versus Epoetin Alfa in Patients with Lower-Risk Myelodysplastic Syndromes in the Phase 3, Open-Label, Randomized, Controlled COMMANDS Trial
Garcia-Manero G, Della Porta M, Santini V, Zeidan A, Komrokji R, Fenaux P, Valcárcel D, Shortt J, Glassberg M, Yucel A, Lai Y, Miteva D, Rose S, Hnoosh A, Platzbecker U. Changes in Red Blood Cell Transfusion Burden with Luspatercept Versus Epoetin Alfa in Patients with Lower-Risk Myelodysplastic Syndromes in the Phase 3, Open-Label, Randomized, Controlled COMMANDS Trial. Blood 2024, 144: 1832-1832. DOI: 10.1182/blood-2024-198304.Peer-Reviewed Original ResearchRegular red blood cell transfusionsLower-risk myelodysplastic syndromesErythropoiesis-stimulating agentsTreated with epoetin alfaEpoetin alfaRBC unitsLuspatercept treatmentTransfusion burdenMyelodysplastic syndromeOpen-labelFirst-in-class erythroid maturation agentRed blood cell transfusion burdenEfficacy of erythropoiesis-stimulating agentsRed blood cell transfusionErythroid maturation agentBlood cell transfusionBaseline Hb levelsArm of treatmentRBC-TICell transfusionMedian ageResponse durabilityChronic anemiaHb levelsLuspatercept
2023
Bone marrow sinusoidal endothelial cells are a site of Fgf23 upregulation in a mouse model of iron deficiency anemia
Li X, Lozovatsky L, Tommasini S, Fretz J, Finberg K. Bone marrow sinusoidal endothelial cells are a site of Fgf23 upregulation in a mouse model of iron deficiency anemia. Blood Advances 2023, 7: 5156-5171. PMID: 37417950, PMCID: PMC10480544, DOI: 10.1182/bloodadvances.2022009524.Peer-Reviewed Original ResearchConceptsSinusoidal endothelial cellsEndothelial cellsBone marrowBM sectionsFGF23 upregulationFibroblast growth factor 23Iron deficiencyElevated serum erythropoietinFGF23 promoter activityBM endothelial cellsGrowth factor 23Vitamin D metabolismIron deficiency anemiaSystemic iron deficiencyKnockout mice exhibitBone marrow sinusoidal endothelial cellsNormal iron balanceNonanemic controlsChronic anemiaFactor 23D metabolismEndothelial cell populationErythropoietin treatmentDeficiency anemiaMouse model
2020
Idiopathic pulmonary hemosiderosis - A rare cause of chronic anemia
Butt A, Ahmed R, Sheikh MDA, Khan O, Iqbal N, Rahman AJ, Khan JA. Idiopathic pulmonary hemosiderosis - A rare cause of chronic anemia. Monaldi Archives For Chest Disease 2020, 90 PMID: 32512987, DOI: 10.4081/monaldi.2020.1267.Peer-Reviewed Original ResearchConceptsIdiopathic pulmonary hemosiderosisDiffuse alveolar hemorrhageChronic anemiaPulmonary hemosiderosisLung biopsyCases of IPHCauses of DAHDiagnosis of IPHReversible encephalopathy syndromeAccumulation of hemosiderinAlveolar bleedingEncephalopathy syndromeAlveolar hemorrhageRare causeSevere anemiaPatient's conditionRare diseaseAnemiaPatientsAzathioprinePrednisoloneHemosiderosisGood responseBiopsyFirst case
2018
In utero Partial Exchange Transfusion Combined with in utero Blood Transfusion for Prenatal Management of Twin Anemia-Polycythemia Sequence
Bahtiyar MO, Ekmekci E, Demirel E, Irani RA, Copel JA. In utero Partial Exchange Transfusion Combined with in utero Blood Transfusion for Prenatal Management of Twin Anemia-Polycythemia Sequence. Fetal Diagnosis And Therapy 2018, 45: 28-35. PMID: 29533957, DOI: 10.1159/000486198.Peer-Reviewed Original ResearchConceptsTwin anemia-polycythemia sequencePlacental vascular connectionsBlood transfusionTwin-twin transfusion syndromePartial exchange transfusionMonochorionic twin pregnanciesVascular connectionsFetoscopic laser photocoagulationLimited outcome dataAbsence of polyhydramniosAnemic twinPlacental territoryTAPS casesDonor twinRecipient twinPlacental sharingTransfusion syndromeChronic anemiaTwin pregnanciesDangerous complicationExchange transfusionPlacental vesselsUnique complicationsLaser photocoagulationPrenatal treatment
2016
Parvovirus B19
Landry ML. Parvovirus B19. Microbiology Spectrum 2016, 4: 10.1128/microbiolspec.dmih2-0008-2015. PMID: 27337440, DOI: 10.1128/microbiolspec.dmih2-0008-2015.Peer-Reviewed Original ResearchConceptsParvovirus B19 infectionIntravenous immunoglobulinB19 infectionIgG antibodiesImmune systemActive parvovirus B19 infectionPrimary parvovirus B19 infectionPure red cell aplasiaMaintenance intravenous immunoglobulinRed cell transfusionSufficient immune responsePatient's immune systemRed cell aplasiaReal-time polymerase chain reaction methodRed cell precursorsB19 variantsGiant pronormoblastsRecurrent anemiaB19 IgMChronic anemiaPolymerase chain reaction methodSevere anemiaTherapeutic optionsPrimary infectionParvovirus B19
2008
Parvovirus
Landry M. Parvovirus. 2008, 183-193. DOI: 10.1128/9781555815455.ch9.Peer-Reviewed Original ResearchParvovirus B19 infectionParvovirus B19B19 infectionChronic fatigue syndromeTreatable causeAcute infectionChronic anemiaFatigue syndromeImmunocompetent hostsHuman bocavirusNeurologic syndromeIgG antibodiesCerebrospinal fluidRenal syndromeImmunoglobulin MBone marrowInfectionSyndromeB19Parvoviridae familyParvovirusHuman diseasesMinute virusVasculitisUveitis
2000
Fulminant parvovirus infection following erythropoietin treatment in a patient with acquired immunodeficiency syndrome.
Borkowski J, Amrikachi M, Hudnall S. Fulminant parvovirus infection following erythropoietin treatment in a patient with acquired immunodeficiency syndrome. Archives Of Pathology & Laboratory Medicine 2000, 124: 441-5. PMID: 10705404, DOI: 10.5858/2000-124-0441-fpifet.Peer-Reviewed Original ResearchConceptsAcquired Immunodeficiency SyndromeBone marrow biopsyChronic anemiaImmunodeficiency syndromeMarrow biopsyReticulocyte responseParvovirus infectionErythroid aplasiaSecond bone marrow biopsyHuman parvovirus infectionSevere chronic anemiaIntravenous immunoglobulinErythropoietin treatmentErythroid hyperplasiaErythropoietin administrationRapid correctionHistologic examinationAnemiaInfectious naturePatientsInfectionBiopsyAplasiaSyndromeBlack men
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