2024
The impact of implementing a non-invasive preimplantation genetic testing for aneuploidies (niPGT-A) embryo culture protocol on embryo viability and clinical outcomes
Sakkas D, Navarro-Sánchez L, Ardestani G, Barroso G, Bisioli C, Boynukalin K, Cimadomo D, Frantz N, Kopcow L, Andrade G, Ozturk B, Rienzi L, Weiser A, Valbuena D, Simón C, Rubio C. The impact of implementing a non-invasive preimplantation genetic testing for aneuploidies (niPGT-A) embryo culture protocol on embryo viability and clinical outcomes. Human Reproduction 2024, 39: 1952-1959. PMID: 39059790, DOI: 10.1093/humrep/deae156.Peer-Reviewed Original ResearchNon-invasive preimplantation genetic testingEmbryo culture protocolsNiPGT-ADay of biopsyPreimplantation genetic testingPGT-APregnancy outcomesPregnancy rateIVF clinicsClinical outcomesControl groupStudy groupGenetic testingReproductive outcomesConcordance rateDay 6Clinical pregnancy rateOverall pregnancy outcomeClinical reproductive outcomesBiopsy stepBlastocyst mediumBlastocyst viabilityBlastocyst developmentCulture protocolMiscarriage rateP-533 Impact on clinical outcomes of day-6 extended culture and reduced culture media volume applied to non-invasive PGT-A
LLuesa C, Navarro-Sánchez L, Ardestani G, Barroso G, Bisioli C, Boynukalin K, Cimadomo D, Andrade G, Valbuena D, Simon-Valles C, Sakkas D. P-533 Impact on clinical outcomes of day-6 extended culture and reduced culture media volume applied to non-invasive PGT-A. Human Reproduction 2024, 39: deae108.873. DOI: 10.1093/humrep/deae108.873.Peer-Reviewed Original ResearchNon-invasive PGT-ACell-free DNAPGT-ASingle embryo transferClinical outcomesDay 5Pregnancy rateStudy groupNiPGT-AConcordance ratePregnancy outcomesDay 6Control groupCell-free DNA resultsDay 5 blastocystsDay 6 blastocystsClinical pregnancy rateDay of biopsyOverall pregnancy outcomeEmbryo culture protocolsBiopsy stepPGT-A.Euploidy rateBlastocyst viabilityBlastocyst qualityCulture time to optimize embryo cell-free DNA analysis for frozen-thawed blastocysts undergoing noninvasive preimplantation genetic testing for aneuploidy
Ardestani G, Banti M, García-Pascual C, Navarro-Sánchez L, Van Zyl E, Castellón J, Simón C, Sakkas D, Rubio C. Culture time to optimize embryo cell-free DNA analysis for frozen-thawed blastocysts undergoing noninvasive preimplantation genetic testing for aneuploidy. Fertility And Sterility 2024, 122: 465-473. PMID: 38718960, DOI: 10.1016/j.fertnstert.2024.04.037.Peer-Reviewed Original ResearchFrozen-thawed blastocystsCell-free DNANon-invasive preimplantation genetic testingPreimplantation genetic testingNiPGT-ADay 5Concordance rateDay 6Genetic testingExpansion gradeBlastocyst expansion gradeNext generation sequencingSpent mediumWhole genome amplificationBlastocyst DNABlastocyst mediumPGT-ANo significant differenceGrade 3BlastocystSignificant differenceGenome amplificationAneuploidyIdeal timeCompare time
2023
Phase II Trial of Reduced-Intensity Fludarabine, Melphalan, and Total Body Irradiation Conditioning Results in Favorable Outcomes with Haploidentical Donor Peripheral Blood Stem Cell Transplant
Elmariah H, Kim J, Mishra A, Faramand R, Perez L, Lazaryan A, Khimani F, Liu H, Ochoa-Bayona J, Nieder M, Figura N, Robinson T, Nishihori T, Anasetti C, Pidala J, Bejanyan N. Phase II Trial of Reduced-Intensity Fludarabine, Melphalan, and Total Body Irradiation Conditioning Results in Favorable Outcomes with Haploidentical Donor Peripheral Blood Stem Cell Transplant. Blood 2023, 142: 4900. DOI: 10.1182/blood-2023-187473.Peer-Reviewed Original ResearchDisease-free survivalPost-transplant cyclophosphamideHematopoietic cell transplantNon-relapse mortalityPhase II trialTotal body irradiationAllogeneic hematopoietic cell transplantReduced-intensity conditioningBone marrow graftsPrimary endpointII trialCumulative incidenceGVHD prophylaxisCell transplantHematologic malignanciesCyclophosphamide/total body irradiationGVHD-free relapse-free survivalHematopoietic cell transplant comorbidity indexPeripheral blood stem cell graftsSingle-center phase II trialPeripheral blood stem cell transplantBlood stem cell graftsHigh-risk hematologic malignanciesMonths disease free survivalDay 6
2022
Fertilization and Implantation
Arkfeld C, Taylor H. Fertilization and Implantation. 2022, 79-107. DOI: 10.1007/978-3-030-99596-6_4.ChaptersFollicle-stimulating hormoneRelease of FSHFailure of implantationCalcium-mediated processesFailure of fertilizationAbnormal placentationEndometrial receptivityVaginal vaultNormal implantationEndometrial epitheliumProstatic secretionsSubsequent ovulationPathological basisAntral folliclesDominant follicleSuccessful implantationGenomic unionHealthy oocytesDay 6Leydig cellsTesticular SertoliMajor causeInfertilitySeminiferous tubulesNormal fertilization
2018
Layer I Interneurons Sharpen Sensory Maps during Neonatal Development
Che A, Babij R, Iannone A, Fetcho R, Ferrer M, Liston C, Fishell G, De Marco García N. Layer I Interneurons Sharpen Sensory Maps during Neonatal Development. Neuron 2018, 99: 98-116.e7. PMID: 29937280, PMCID: PMC6152945, DOI: 10.1016/j.neuron.2018.06.002.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornCalciumCell Adhesion Molecules, NeuronalCerebral CortexExtracellular Matrix ProteinsGene Knockdown TechniquesInterneuronsMiceNerve Tissue ProteinsNeural PathwaysOptogeneticsPatch-Clamp TechniquesPhysical StimulationPyramidal CellsReceptors, N-Methyl-D-AspartateReceptors, Serotonin, 5-HT3Reelin ProteinSensory DeprivationSerine EndopeptidasesSomatosensory CortexTouchVibrissaeConceptsNMDA receptorsWhisker-dependent behaviorsSpontaneous calcium transientsDiverse neuronal typesPostnatal day 6Barrel map formationLayer IIntrinsic neuronal activityCalcium transientsSerotonin receptorsBarrel cortexWhisker stimulationInterneuron typesLongitudinal calcium imagingMouse pupsNeonatal developmentSensory mapsWhisker responsesCalcium imagingNeonatal mammalsNeuronal activityInterneuronsNeuron typesThalamic inputDay 6Sphingolipid de novo biosynthesis is essential for intestine cell survival and barrier function
Li Z, Kabir I, Tietelman G, Huan C, Fan J, Worgall T, Jiang XC. Sphingolipid de novo biosynthesis is essential for intestine cell survival and barrier function. Cell Death & Disease 2018, 9: 173. PMID: 29415989, PMCID: PMC5833386, DOI: 10.1038/s41419-017-0214-1.Peer-Reviewed Original ResearchConceptsTamoxifen treatmentBarrier functionInflammatory bowel diseaseGoblet cell numbersCell survivalConcurrent diarrheaSPTLC2 expressionIntestinal cell survivalRectal bleedingBowel diseaseRate-limiting enzymeBody weightColon specimensGoblet cellsSerine palmitoyltransferaseSmall intestineDay 6MiceEarly lifeIntestineReduced lethalitySPT activityCell numberSPTLC2Survival
2017
Fertilization and Implantation
Mutlu L, Taylor H. Fertilization and Implantation. 2017, 65-90. DOI: 10.1007/978-3-319-52210-4_4.Peer-Reviewed Original ResearchFollicle-stimulating hormoneRelease of FSHFailure of implantationCalcium-mediated processesFailure of fertilizationAbnormal placentationEndometrial receptivityVaginal vaultNormal implantationEndometrial epitheliumProstatic secretionsSubsequent ovulationPathological basisAntral folliclesDominant follicleSuccessful implantationGenomic unionHealthy oocytesDay 6Leydig cellsTesticular SertoliMajor causeInfertilitySeminiferous tubulesNormal fertilizationUp-regulation of Intracellular Calcium Handling Underlies the Recovery of Endotoxemic Cardiomyopathy in Mice
Morse JC, Huang J, Khona N, Miller EJ, Siwik DA, Colucci WS, Hobai IA. Up-regulation of Intracellular Calcium Handling Underlies the Recovery of Endotoxemic Cardiomyopathy in Mice. Anesthesiology 2017, 126: 1125-1138. PMID: 28410273, DOI: 10.1097/aln.0000000000001627.Peer-Reviewed Original ResearchConceptsCalcium transientsCardiac recoveryLipopolysaccharide challengeCalcium handlingDay 3Sarcomere shorteningCardiomyocyte calcium handlingSepsis-induced cardiomyopathyVentricular ejection fractionIntracellular calcium handlingSarcoplasmic reticulum calcium loadMale C57BL/6 miceSodium/calcium exchangeMyocardial protein expressionSarcoplasmic reticulum calcium pumpSystemic inflammationEjection fractionEndotoxemic miceC57BL/6 miceMyocardial mechanismsCardiac functionCalcium loadCardiac contractilityBaseline levelsDay 6
2016
Appearance of High-Affinity Antibodies Precedes Clinical Diagnosis of FVIII Inhibitors - Preliminary Analysis from the Hemophilia Inhibitor PUP Study (HIPS)
Reipert B, Gangadharan B, Hofbauer C, Scheiflinger F, Bowen J, Donnachie E, Fijvandraat K, Gruppo R, Klintman J, Male C, McGuinn C, Meeks S, Recht M, Ragni M, Yaish H, Santagostino E, Brown D. Appearance of High-Affinity Antibodies Precedes Clinical Diagnosis of FVIII Inhibitors - Preliminary Analysis from the Hemophilia Inhibitor PUP Study (HIPS). Blood 2016, 128: 328. DOI: 10.1182/blood.v128.22.328.328.Peer-Reviewed Original ResearchFVIII-specific antibodiesFactor VIII inhibitorEntity's Board of DirectorsSevere hemophilia AFactor VIIIHemophilia AHigh-affinity antibodiesFVIII inhibitorsIgG1 antibodiesDay 6Exposure daysInhibitor developmentPUP studiesStudy criteriaClass switchingFactor VIII inhibitor developmentHealthy individualsT cell-dependent antibody responsesFVIII inhibitor developmentTransient FVIII inhibitorsDevelopment of neutralizing antibodiesIdentification of early biomarkersCohort of patientsHemophilia A patientsNon-neutralizing antibodiesReal-time Tumor Oxygenation Changes After Single High-dose Radiation Therapy in Orthotopic and Subcutaneous Lung Cancer in Mice: Clinical Implication for Stereotactic Ablative Radiation Therapy Schedule Optimization
Song C, Hong BJ, Bok S, Lee CJ, Kim YE, Jeon SR, Wu HG, Lee YS, Cheon GJ, Paeng JC, Carlson DJ, Kim HJ, Ahn GO. Real-time Tumor Oxygenation Changes After Single High-dose Radiation Therapy in Orthotopic and Subcutaneous Lung Cancer in Mice: Clinical Implication for Stereotactic Ablative Radiation Therapy Schedule Optimization. International Journal Of Radiation Oncology • Biology • Physics 2016, 95: 1022-1031. PMID: 27130790, DOI: 10.1016/j.ijrobp.2016.01.064.Peer-Reviewed Original ResearchConceptsStereotactic ablative radiation therapyTumor/brain ratiosAblative radiation therapyRadiation therapyDay 0Day 6Brain ratioSingle doseVascular collapseHigh-dose irradiationDay 2Single high-dose irradiationHigh-dose radiation therapyTumor hypoxiaSyngeneic Lewis lung carcinomaHoechst 33342 perfusionTumor oxygenation changesRadiation therapy schedulesLewis lung carcinomaOrthotopic lung tumorsOptimal fractionation schedulePositron emission tomography (PET) imagingEmission Tomography ImagingTumor hypoxia levelsFluorescence-activated cell
2014
Pomalidomide Modulates Transcription Networks Regulating Human Erythropoiesis and Globin Switching: Implications for Treatment of Hemoglobinopathies
Dulmovits B, Appiah-Kubi A, Papoin J, Gould M, An X, Mohandas N, Gallagher P, Lipton J, Liu J, Blanc L. Pomalidomide Modulates Transcription Networks Regulating Human Erythropoiesis and Globin Switching: Implications for Treatment of Hemoglobinopathies. Blood 2014, 124: 1375. DOI: 10.1182/blood.v124.21.1375.1375.Peer-Reviewed Original ResearchSickle cell diseaseWestern blot analysisΓ-globin productionSide effectsDay 6Painful vaso-occlusive crisesSecond-generation immunomodulatory drugMay-Grunwald Giemsa stainingVaso-occlusive crisisSignificant side effectsQRT-PCRCurrent treatment approachesHbF productionErythroid differentiationBlot analysisFlow cytometric analysisRed cell sicklingMechanism of actionImmunomodulatory drugsNormal samplesPeripheral bloodPharmacologic interventionsCulture systemCell diseaseSimilar doseGlycemic control after 6 days of insulin pump reservoir use in type 1 diabetes: Results of double‐blind and open‐label cross‐over trials of insulin lispro and insulin aspart 1型糖尿病患者连续使用胰岛素泵6天后的血糖控制情况:赖脯胰岛素与门冬胰岛素的双盲、开放标签、交叉试验
Tamborlane WV, Renard E, Wadwa RP, Blevins T, Jacober SJ, Liu R, D'Souza DN, Rees TM. Glycemic control after 6 days of insulin pump reservoir use in type 1 diabetes: Results of double‐blind and open‐label cross‐over trials of insulin lispro and insulin aspart 1型糖尿病患者连续使用胰岛素泵6天后的血糖控制情况:赖脯胰岛素与门冬胰岛素的双盲、开放标签、交叉试验. Journal Of Diabetes 2014, 7: 270-278. PMID: 24734891, DOI: 10.1111/1753-0407.12162.Peer-Reviewed Original ResearchMeSH KeywordsAdultBlood GlucoseBlood Glucose Self-MonitoringChinaCross-Over StudiesDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2Double-Blind MethodFemaleFollow-Up StudiesHumansHyperglycemiaHypoglycemiaHypoglycemic AgentsInsulin AspartInsulin Infusion SystemsInsulin LisproMalePostprandial PeriodPrognosisRisk FactorsConceptsContinuous subcutaneous insulin infusionSelf-monitoring blood glucoseTreatment periodCross-over designBlood glucoseDay 6Insulin aspartInsulin lisproMean total daily insulin doseTotal daily insulin doseTotal hypoglycemia rateDaily insulin dosePrimary efficacy measureType 1 DMMean blood glucoseSubcutaneous insulin infusionType 1 diabetesHypoglycemia ratesInsulin doseRandomized trialsEfficacy measuresSMBG profilesInsulin infusionDay 1Two-treatment
2013
Fertilization and Implantation
Mutlu L, Macer M, Taylor H. Fertilization and Implantation. 2013, 75-90. DOI: 10.1007/978-1-4614-6837-0_5.ChaptersFollicle-stimulating hormoneRelease of FSHFailure of implantationCalcium-mediated processesFailure of fertilizationAbnormal placentationEndometrial receptivityVaginal vaultNormal implantationEndometrial epitheliumProstatic secretionsPathological basisSubsequent ovulationAntral folliclesDominant follicleSuccessful implantationGenomic unionHealthy oocytesDay 6Leydig cellsTesticular SertoliMajor causeInfertilitySeminiferous tubulesNormal fertilization
2012
Sleep restriction leads to increased activation of brain regions sensitive to food stimuli
St-Onge MP, McReynolds A, Trivedi ZB, Roberts AL, Sy M, Hirsch J. Sleep restriction leads to increased activation of brain regions sensitive to food stimuli. American Journal Of Clinical Nutrition 2012, 95: 818-824. PMID: 22357722, PMCID: PMC3302360, DOI: 10.3945/ajcn.111.027383.Peer-Reviewed Original ResearchConceptsFood stimuliNeuronal activityHabitual sleepSleep restrictionNormal-weight menOverall neuronal activityAverage sleep durationFunctional magnetic resonance imagingMagnetic resonance imagingPartial sleep restrictionCrossover studyEpidemiologic evidenceClinical studiesNeuronal activationNucleus accumbensSleep durationFasted stateResonance imagingBrain regionsDay 6Prefrontal cortexSleepBrain activityRelative increaseStimuli
2009
Decitabine combined with fractionated gemtuzumab ozogamicin therapy in patients with relapsed or refractory acute myeloid leukemia
Chowdhury S, Seropian S, Marks PW. Decitabine combined with fractionated gemtuzumab ozogamicin therapy in patients with relapsed or refractory acute myeloid leukemia. American Journal Of Hematology 2009, 84: 599-600. PMID: 19650144, DOI: 10.1002/ajh.21478.Peer-Reviewed Original ResearchConceptsAcute myeloid leukemiaRefractory acute myeloid leukemiaGemtuzumab ozogamicinNonhematologic toxicityMyeloid leukemiaHematopoietic stem cell transplantationGemtuzumab ozogamicin therapySignificant nonhematologic toxicityStem cell transplantationLow response ratePrior regimensSalvage chemotherapyComplete remissionComplete responseCell transplantationToxicity profileDay 1PatientsSingle agentDay 6Grade 1DecitabineOzogamicinRegimenLeukemia
2000
Expression of GABAC receptor ρ1 and ρ2 subunits during development of the mouse retina
Greka A, Lipton S, Zhang D. Expression of GABAC receptor ρ1 and ρ2 subunits during development of the mouse retina. European Journal Of Neuroscience 2000, 12: 3575-3582. PMID: 11029627, DOI: 10.1046/j.1460-9568.2000.00247.x.Peer-Reviewed Original ResearchConceptsRetinal developmentGamma-aminobutyric acid type C receptorMouse retinaRho subunitsReceptor-mediated currentsPostnatal day 6Type C receptorsBipolar cell differentiationMouse retinal developmentΡ2 subunitsBipolar cellsC receptorRho2 subunitsRho1 subunitDay 6ReceptorsEye openingSubunit transcriptionSubunit messageAdulthoodRetinaFuture studiesCompetitive PCRCell differentiationP9
1997
Risk of Hemorrhage and Appropriate use of Blood Transfusions in Pediatric Blunt Splenic Injuries
Shafi S, Gilbert J, Carden S, Allen J, Glick P, Caty M, Azizkhan R. Risk of Hemorrhage and Appropriate use of Blood Transfusions in Pediatric Blunt Splenic Injuries. Journal Of Trauma And Acute Care Surgery 1997, 42: 1029-1032.. PMID: 9210536, DOI: 10.1097/00005373-199706000-00007.Peer-Reviewed Original ResearchConceptsBlunt splenic injuryPediatric blunt splenic injurySplenic injuryTransfusion rateBlood transfusionMultiple injuriesDay 6Retrospective case seriesRisk of hemorrhageCase seriesTransfusion practiceHct changesTransfusionDay 7InjuryDay 13Whole groupHctAppropriate useChildrenHoursHemorrhageInitial dropHematocrit
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