2023
Convergent evolution and B-cell recirculation in germinal centers in a human lymph node
Pelissier A, Stratigopoulou M, Donner N, Dimitriadis E, Bende R, Guikema J, Martinez M, van Noesel C. Convergent evolution and B-cell recirculation in germinal centers in a human lymph node. Life Science Alliance 2023, 6: e202301959. PMID: 37640448, PMCID: PMC10462906, DOI: 10.26508/lsa.202301959.Peer-Reviewed Original ResearchConceptsGerminal centersLymph nodesHuman lymph nodesGC responseHuman LNImmune responseDevelopment of autoimmune diseasesConvergent evolutionB cell clonesB cell recirculationEffective immune responseExpanded clonesLaser capture microdissectionPhylogenetic tree analysisIndividual germinal centersB cellsAutoimmune diseasesAntigen responseMouse modelModel antigenAntigenClonal diversity
2007
A Network Analysis of the Human T-Cell Activation Gene Network Identifies Jagged1 as a Therapeutic Target for Autoimmune Diseases
Palacios R, Goni J, Martinez-Forero I, Iranzo J, Sepulcre J, Melero I, Villoslada P. A Network Analysis of the Human T-Cell Activation Gene Network Identifies Jagged1 as a Therapeutic Target for Autoimmune Diseases. PLOS ONE 2007, 2: e1222. PMID: 18030350, PMCID: PMC2077806, DOI: 10.1371/journal.pone.0001222.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBayes TheoremCalcium-Binding ProteinsCase-Control StudiesEncephalomyelitis, Autoimmune, ExperimentalEnzyme-Linked Immunosorbent AssayFemaleFlow CytometryHumansImmunotherapyIntercellular Signaling Peptides and ProteinsJagged-1 ProteinLymphocyte ActivationMaleMembrane ProteinsMiceMice, Inbred C57BLMultiple SclerosisReverse Transcriptase Polymerase Chain ReactionSerrate-Jagged ProteinsT-LymphocytesConceptsAutoimmune diseasesMultiple sclerosisTherapeutic targetDevelopment of autoimmune diseasesControlling T cell activationExperimental autoimmune encephalomyelitisT cell proliferationTreatment of miceT cell activationTherapy induced changesLevels similar to controlsIn vitro treatmentGene networksGene interactionsTh1 functionTh2 functionTreg functionImmunomodulatory therapyAutoimmune encephalomyelitisSimilar to controlsIngenuity databaseImmune interventionT cellsDisease courseAgonist peptide
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