2023
Causal Bayesian machine learning to assess treatment effect heterogeneity by dexamethasone dose for patients with COVID-19 and severe hypoxemia
Blette B, Granholm A, Li F, Shankar-Hari M, Lange T, Munch M, Møller M, Perner A, Harhay M. Causal Bayesian machine learning to assess treatment effect heterogeneity by dexamethasone dose for patients with COVID-19 and severe hypoxemia. Scientific Reports 2023, 13: 6570. PMID: 37085591, PMCID: PMC10120498, DOI: 10.1038/s41598-023-33425-3.Peer-Reviewed Original ResearchConceptsCritical COVID-19Better long-term outcomesCOVID-19Entire trial populationStandardized dosing protocolsMultiple patient characteristicsDose of dexamethasoneLong-term outcomesIL-6 inhibitorsDexamethasone doseSevere hypoxemiaMost patientsPatient characteristicsRespiratory supportDiabetes mellitusClinical outcomesDosing protocolTrial populationTreatment effect heterogeneityPatient featuresPatientsAdditional studiesDexamethasoneDoseMore evidence
2018
Dexamethasone Injected Perineurally is More Effective than Administered Intravenously for Peripheral Nerve Blocks
Zorrilla-Vaca A, Li J. Dexamethasone Injected Perineurally is More Effective than Administered Intravenously for Peripheral Nerve Blocks. The Clinical Journal Of Pain 2018, 34: 276-284. PMID: 28591086, DOI: 10.1097/ajp.0000000000000519.Peer-Reviewed Original ResearchConceptsPeripheral nerve blocksDuration of analgesiaPerineural dexamethasoneOpioid consumptionPain scoresPostoperative nauseaSensory blockNerve blockMotor block durationPain modulation mechanismsPerioperative pain controlPreservative-free dexamethasoneBetter analgesic effectDose of dexamethasoneTerms of prolongationSubgroup of studiesRandom-effects modelIntravenous dexamethasonePain controlAnalgesic effectMotor blockPostoperative outcomesAdministered IntravenouslyIntraoperative eventsSystemic absorption
1982
The Effect of Dexamethasone on Renal Electrolyte Excretion in the Adrenalectomized Rat
BIA M, TYLER K, DEFRONZO R. The Effect of Dexamethasone on Renal Electrolyte Excretion in the Adrenalectomized Rat. Endocrinology 1982, 111: 882-888. PMID: 7106056, DOI: 10.1210/endo-111-3-882.Peer-Reviewed Original ResearchConceptsDose of dexamethasoneHigh dose of dexamethasoneRenal electrolyte excretionSodium excretionAdrenalectomized ratsK excretionElectrolyte excretionHigh dosesLow dosesLow dose of dexamethasoneLow dose of aldosteroneUrinary sodium excretionDose of aldosteroneDecreased sodium excretionLowest effective doseGlomerular filtration rateRenal potassium excretionUrinary K excretionAffecting sodium excretionK concentrationEffect of dexamethasoneAcute administrationUrinary potassiumPlasma K concentrationPotassium excretion
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