2025
Is There More to POCUS Than the Heart and Lungs in the Parturient-Venous Excess Ultrasound Score?
Munoz-Acuna R, Charchaflieh J, Deshpande R. Is There More to POCUS Than the Heart and Lungs in the Parturient-Venous Excess Ultrasound Score? Obstetric Anesthesia Digest 2025, 45: 19-20. DOI: 10.1097/01.aoa.0001097560.30255.cc.Peer-Reviewed Original ResearchUltrasound scoreVenous excess ultrasound scoreVenous hemodynamic dysfunctionVolume overloadPulmonary edemaCardiac functionHemodynamic dysfunctionEndothelial dysfunctionVenous disordersTailored treatmentCapillary permeabilityMultisystem conditionPreeclampsiaDysfunctionScoresEdemaVExUSPathophysiologyMultisystemAcute Systemic Sclerosis-Associated Cardiomyopathy That Improved With Glucocorticoids and Cyclophosphamide
Gustafson A, Trinh K, Lomasney J, Shah S, Hinchcliff M. Acute Systemic Sclerosis-Associated Cardiomyopathy That Improved With Glucocorticoids and Cyclophosphamide. JACC Case Reports 2025, 30: 102948. PMID: 39972702, PMCID: PMC11862153, DOI: 10.1016/j.jaccas.2024.102948.Peer-Reviewed Original ResearchSystemic sclerosisEndomyocardial biopsyDiffuse cutaneous systemic sclerosisCutaneous systemic sclerosisAssociated with increased mortalityT lymphocyte infiltrationAcute heart failureIntravenous cyclophosphamideDiagnosing myocarditisDiastolic dysfunctionSystolic dysfunctionT lymphocytesHeart failureProlonged recoveryPatientsCardiomyopathy treatmentCyclophosphamideBiopsyCardiomyopathyGlucocorticoidDysfunctionMyopericarditisMyocarditis
2024
Rewiring of the glymphatic landscape in metabolic disorders
Chen B, Meseguer D, Lenck S, Thomas J, Schneeberger M. Rewiring of the glymphatic landscape in metabolic disorders. Trends In Endocrinology And Metabolism 2024 PMID: 39638721, DOI: 10.1016/j.tem.2024.11.005.Peer-Reviewed Original ResearchMetabolic dysfunctionNeurological disordersBlood-brain barrier leakageCerebral blood flow disruptionBlood flow disruptionGlymphatic systemTreatment strategiesCognitive declineRisk factorsMetabolic disordersNeurovascular uncouplingBarrier leakageGlymphatic clearance systemMetabolic diseasesDisordersObesityDysfunctionRegulation of Cardiac Function by the Autonomic Nervous System
Hafez O, Chang R. Regulation of Cardiac Function by the Autonomic Nervous System. Physiology 2024, 40: 000-000. PMID: 39585760, DOI: 10.1152/physiol.00018.2024.Peer-Reviewed Original ResearchAutonomic nervous systemNervous systemNeurocardiac axisIntrinsic cardiac nervous systemRegulation of cardiac functionCardiac nervous systemAutonomic control of the heartRegulating cardiovascular physiologyAutonomic dysfunctionSensory neuronsCardiac functionParasympathetic nervous systemClinical conditionsCardiac reflexesThe heartNeuronal populationsTreatment approachesCardiovascular diseaseCardiovascular physiologyMotor circuitsPhysiological roleAutonomic controlClinical fieldHeartDysfunctionLactate fermentation intoxicates TILs
Hunt B, Kessler E, Joshi N. Lactate fermentation intoxicates TILs. Nature Immunology 2024, 25: 2176-2177. PMID: 39516647, DOI: 10.1038/s41590-024-02020-7.Peer-Reviewed Original ResearchOutcomes Following In-Office Peroneal Needle Tendoscopy: A Retrospective Review
Butler J, Randall G, Wingo T, Gianakos A, Kennedy J. Outcomes Following In-Office Peroneal Needle Tendoscopy: A Retrospective Review. Foot & Ankle Orthopaedics 2024, 9: 2473011424s00398. PMCID: PMC11686665, DOI: 10.1177/2473011424s00398.Peer-Reviewed Original ResearchReturn to sportPre-operative MRIVisual analog scaleFollow-upIn-officeTendon dysfunctionRetrospective reviewAmerican Orthopaedic Foot and Ankle Society (AOFAS) ankle-hindfoot scoreAnkle-hindfoot scorePeroneal tendon disordersPeroneal tearsComplication rateRadiological outcomesPatient demographicsAnalog scaleRetrospective studyEffective modalityPathological characteristicsTreatment characteristicsTendon disordersTEN casesPatientsTendoscopyOperating suiteDysfunctionThe role of parvalbumin interneuron dysfunction across neurodegenerative dementias
Smeralda C, Pandit S, Turrini S, Reilly J, Palmisano A, Sprugnoli G, Hampel H, Benussi A, Borroni B, Press D, Rotenberg A, El Fakhri G, Koch G, Rossi S, Santarnecchi E. The role of parvalbumin interneuron dysfunction across neurodegenerative dementias. Ageing Research Reviews 2024, 101: 102509. PMID: 39306248, DOI: 10.1016/j.arr.2024.102509.Peer-Reviewed Original ResearchInterneuron dysfunctionCortical hyperexcitabilityTherapeutic targetCortical excitation/inhibition balanceRhythm disruptionFast-spikingPV+ cellsBasket neuronsPotential therapeutic targetInhibitory interneuronsExcitation/inhibition balanceOscillatory disruptionsSymptom onsetNovel biomarkersHyperexcitabilityDysfunctionNeuronal deathOscillatory activityDementia with Lewy bodiesPathophysiological frameworkClinical symptom onsetFrontotemporal dementiaPrognosis After Withdrawal of Cardioprotective Therapy in Patients With Improved Cancer Therapeutics–Related Cardiac Dysfunction
Park H, Lee N, Hwang C, Cho S, Choi G, Cho J, Yoon H, Kim K, Ahn Y. Prognosis After Withdrawal of Cardioprotective Therapy in Patients With Improved Cancer Therapeutics–Related Cardiac Dysfunction. JACC CardioOncology 2024, 6: 699-710. PMID: 39479323, PMCID: PMC11522502, DOI: 10.1016/j.jaccao.2024.07.018.Peer-Reviewed Original ResearchCancer therapeutics-related cardiac dysfunctionLeft ventricular ejection fractionBaseline left ventricular ejection fractionCardioprotective therapiesCardiac dysfunctionClinical outcomesSingle-center prospective cohort studyMedian follow-up durationVentricular ejection fractionFollow-up durationLong-term prognosisProspective cohort studyEjection fractionEchocardiographic changesHeart failureRetrospective analysisClinical eventsCohort studyPatientsPrognosisDiagnosisTherapyDysfunctionWithdrawalBaselineMetabolic regulation of the mitochondrial immune checkpoint
Montrose D, Saha S, Galluzzi L. Metabolic regulation of the mitochondrial immune checkpoint. OncoImmunology 2024, 13: 2394247. PMID: 39206097, PMCID: PMC11352702, DOI: 10.1080/2162402x.2024.2394247.Peer-Reviewed Original ResearchConceptsTumor-targeting immune responsesColorectal cancer cellsAnticancer immunityImmune checkpointsActivation of cGASMalignant cellsImmune responseCancer cellsDisrupt mitochondrial functionAccumulation of mitochondrial DNACytosolic accumulationMitochondrial dysfunctionMetabolic regulationMitochondrial DNAMitochondrial functionSerine resultsCellsDysfunctionCannabis Exposure and Adverse Pregnancy Outcomes Related to Placental Function
Metz T, Allshouse A, McMillin G, Greene T, Chung J, Grobman W, Haas D, Mercer B, Parry S, Reddy U, Saade G, Simhan H, Silver R. Cannabis Exposure and Adverse Pregnancy Outcomes Related to Placental Function. Obstetric Anesthesia Digest 2024, 44: 139-140. DOI: 10.1097/01.aoa.0001026572.72882.bd.Peer-Reviewed Original ResearchExposure to cannabisCannabis usePlacental functionPregnancy outcomesPrevalence of cannabis usePoor fetal growthAdverse pregnancy outcomesInfluence pregnancy outcomePlacental dysfunctionCannabis exposureFetal growthPregnant individualsSelf-reported useTobacco useCannabisDrug usePregnancyOutcome relationsPotential legal consequencesOutcomesAssociationExposureUseDysfunctionPublished researchMeningeal lymphatic vessel dysfunction driven by CGRP signaling causes migraine-like pain in mice
Thomas J, Schindler E, Gottschalk C. Meningeal lymphatic vessel dysfunction driven by CGRP signaling causes migraine-like pain in mice. Journal Of Clinical Investigation 2024, 134: e182556. PMID: 39087472, PMCID: PMC11290958, DOI: 10.1172/jci182556.Peer-Reviewed Original ResearchConceptsBlocking CGRP signalingCGRP receptor componentsMigraine-like painCervical lymph nodesGap junction proteinPrimary headache disordersLymphatic vessel dysfunctionAcute migrainePharmacological blockadeLymph nodesHeadache disordersNeurological symptomsJunction proteinsCGRPLymphatic vesselsMeningeal lymphatic vesselsInducible knockoutVessel dysfunctionMigraineReceptor componentsHeadachePainPathophysiologyDysfunctionMiceA review on polyamines as promising next-generation neuroprotective and anti-aging therapy
Arthur R, Jamwal S, Kumar P. A review on polyamines as promising next-generation neuroprotective and anti-aging therapy. European Journal Of Pharmacology 2024, 978: 176804. PMID: 38950837, DOI: 10.1016/j.ejphar.2024.176804.Peer-Reviewed Original ResearchCognitive dysfunctionNeurodegenerative disordersRegulation of gene expressionProgressive degeneration of neuronsProgrammed cell deathDegeneration of neuronsSymptomatic therapyPharmacological strategiesAnti-oxidative effectsAnti-aging therapyAverage ageProgressive degenerationNeuroprotective effectsLocomotor abnormalitiesIon channelsCell deathBiochemical activityGene expressionPopulation average ageTherapyMolecular mechanismsDisordersPolyamine supplementationDysfunctionAnti-aging effectsErectile Dysfunction in Adolescents and Young Adults
Pantazis A, Franco I, Gitlin J. Erectile Dysfunction in Adolescents and Young Adults. Current Urology Reports 2024, 25: 225-232. PMID: 38922362, DOI: 10.1007/s11934-024-01213-9.Peer-Reviewed Original ResearchConceptsPsychogenic etiologyCognitive behavioral therapyYoung adultsErectile dysfunctionBehavioral therapyPornography consumptionCortisol levelsAdolescent malesNormal testosterone levelsPediatric urology practiceAnxietyDepressionOnline pornography consumptionFindingsThe latest researchAdolescentsPediatric urologistsVascular resistanceUrological practiceTreatment recommendationsTestosterone levelsWork-upReviewThe goalDysfunctionAdultsErectilePersonalized brain circuit scores identify clinically distinct biotypes in depression and anxiety
Tozzi L, Zhang X, Pines A, Olmsted A, Zhai E, Anene E, Chesnut M, Holt-Gosselin B, Chang S, Stetz P, Ramirez C, Hack L, Korgaonkar M, Wintermark M, Gotlib I, Ma J, Williams L. Personalized brain circuit scores identify clinically distinct biotypes in depression and anxiety. Nature Medicine 2024, 30: 2076-2087. PMID: 38886626, PMCID: PMC11271415, DOI: 10.1038/s41591-024-03057-9.Peer-Reviewed Original ResearchBehavioral therapyFunctional magnetic resonance imaging protocolTask-free functional connectivityHeterogeneity of depressionBrain circuit dysfunctionResponse to pharmacotherapyTheoretical taxonomyAttentional circuitsNeurobiological dysfunctionBehavioral performanceCircuit dysfunctionCognitive tasksSubcortical regionsFunctional connectivityTask-freeAnxietyDepressionTheory-drivenPharmacotherapyStratification of patientsMagnetic resonance imaging protocolScoresPsychiatryDysfunctionClinical careUnderstanding Impact of CFTR Dysfunction on Airway Immune Cell Composition in Early Lung Disease Pathogenesis
Kockar Kizilirmak T, Yin H, Garrison A, Bruscia E, Egan M, Britto-Leon C. Understanding Impact of CFTR Dysfunction on Airway Immune Cell Composition in Early Lung Disease Pathogenesis. 2024, a6357-a6357. DOI: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a6357.Peer-Reviewed Original ResearchTaste dysfunction after endoscopic endonasal resection of olfactory groove meningioma: Case series and review of the literature
Fecker A, Studer M, Manes R, Omay S, Detwiller K, Smith T, Andersen P, Sanusi O, Collins K, Geltzeiler M, Rimmer R. Taste dysfunction after endoscopic endonasal resection of olfactory groove meningioma: Case series and review of the literature. American Journal Of Otolaryngology 2024, 45: 104302. PMID: 38678798, DOI: 10.1016/j.amjoto.2024.104302.Peer-Reviewed Original ResearchResection of olfactory groove meningiomasOlfactory groove meningiomasEndoscopic endonasal resectionMinority of patientsSense of tasteTaste changesSeverity of symptomsOlfactory dysfunctionTaste dysfunctionMedian timeCase seriesClinical characteristicsOlfactory functionPatient counselingPatientsSense of smellAssociated with lateralizationResectionMeningiomasSurgeryDysfunctionRated severityNeoplasmsSurvey responsesAgeusiaParasympathetic neurons derived from human pluripotent stem cells model human diseases and development
Wu H, Saito-Diaz K, Huang C, McAlpine J, Seo D, Magruder D, Ishan M, Bergeron H, Delaney W, Santori F, Krishnaswamy S, Hart G, Chen Y, Hogan R, Liu H, Ivanova N, Zeltner N. Parasympathetic neurons derived from human pluripotent stem cells model human diseases and development. Cell Stem Cell 2024, 31: 734-753.e8. PMID: 38608707, PMCID: PMC11069445, DOI: 10.1016/j.stem.2024.03.011.Peer-Reviewed Original ResearchConceptsAutonomic nervous systemSjogren's syndromeParasympathetic neuronsFamilial dysautonomiaWhite adipocytesAutoimmune disease Sjogren's syndromeHuman pluripotent stem cellsHuman pluripotent stem cell (hPSC)-derived neuronsHuman developmental studiesPluripotent stem cellsSARS-CoV-2 infectionSchwann cell progenitorsAutonomic neuropathyCell progenitorsStem cellsModel systemNervous systemSARS-CoV-2Human diseasesDysfunctionNeuronsDifferentiation paradigmOrgan developmentNeuropathyDrug discovery studiesEssential right heart physiology for the perioperative practitioner POQI IX: current perspectives on the right heart in the perioperative period
McEvoy M, Heerdt P, Morton V, Bartz R, Miller T. Essential right heart physiology for the perioperative practitioner POQI IX: current perspectives on the right heart in the perioperative period. Perioperative Medicine 2024, 13: 27. PMID: 38594738, PMCID: PMC11003027, DOI: 10.1186/s13741-024-00378-8.Peer-Reviewed Original ResearchRight heart physiologyPerioperative Quality InitiativePerioperative periodRight heartRight ventricular (RV) dysfunctionHeart physiologyRight-sided heart functionRight heart anatomyRight heart diseasePrevent subsequent morbidityRV dysfunctionPerioperative morbidityChronic health issuesHeart functionHeart diseasePerioperative careHeart anatomyPerioperative cliniciansMorbidityPatientsHealth issuesDysfunctionQuality InitiativeImagination, Agency, and Predictive Processing
Corlett P. Imagination, Agency, and Predictive Processing. 2024, 60-78. DOI: 10.1093/oso/9780198872221.003.0004.Peer-Reviewed Original ResearchPredictive processing theoryTheories of delusionsPredictive coding theorySensory inputDelusion formationSource monitoringProcess theoryDelusionsMediated learningHallucinationsConscious experienceImaginative processesReality perceptionPrediction processNeurocomputer architectureBeliefsPerceptionDysfunctionDirect Application Therapy for Erectile Dysfunction
Heckscher D, Grinnan J, Bieniek J, Honig S. Direct Application Therapy for Erectile Dysfunction. 2024 DOI: 10.1016/b978-0-443-21477-6.00107-3.Peer-Reviewed Original Research
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