2025
Evaluation of a Machine Learning-Guided Strategy for Elevated Lipoprotein(a) Screening in Health Systems
Aminorroaya A, Dhingra L, Oikonomou E, Khera R. Evaluation of a Machine Learning-Guided Strategy for Elevated Lipoprotein(a) Screening in Health Systems. Circulation Genomic And Precision Medicine 2025, 18: e004632. PMID: 39846171, PMCID: PMC11835527, DOI: 10.1161/circgen.124.004632.Peer-Reviewed Original ResearchConceptsYale New Haven Health SystemHealth systemVanderbilt University Medical CenterHealth system electronic health recordUniversity Medical CenterCoronary Artery Risk DevelopmentMulti-Ethnic Study of AtherosclerosisElectronic health recordsMedical CenterUS health systemHealth system patientsAssociated with significantly higher oddsMulti-Ethnic StudyUS-based cohortStudy of AtherosclerosisSignificantly higher oddsHealth recordsUK BiobankAtherosclerosis RiskRisk DevelopmentHigher oddsElevated Lp(aUniversal screeningSystem patientsStudy cohort
2024
Development and multinational validation of an algorithmic strategy for high Lp(a) screening
Aminorroaya A, Dhingra L, Oikonomou E, Saadatagah S, Thangaraj P, Vasisht Shankar S, Spatz E, Khera R. Development and multinational validation of an algorithmic strategy for high Lp(a) screening. Nature Cardiovascular Research 2024, 3: 558-566. PMID: 39195936, DOI: 10.1038/s44161-024-00469-1.Peer-Reviewed Original ResearchElectronic health recordsAssociated with premature atherosclerotic cardiovascular diseaseElevated Lp(aHealth recordsUK BiobankPremature atherosclerotic cardiovascular diseaseMachine learning modelsAtherosclerotic cardiovascular diseaseCohort studyReal-world settingsTargeted screeningCardiovascular diseaseLearning modelsNovel targeted therapeuticsAlgorithmic strategiesCohortProbability thresholdScreeningClinical featuresValidation cohortElevated lipoproteinRisk inspectionARICLp(a
2023
Association of Lipoprotein(a) Levels With Myocardial Fibrosis in the Multi-Ethnic Study of Atherosclerosis
Chehab O, Abdollahi A, Whelton S, Wu C, Ambale-Venkatesh B, Post W, Bluemke D, Tsai M, Lima J. Association of Lipoprotein(a) Levels With Myocardial Fibrosis in the Multi-Ethnic Study of Atherosclerosis. Journal Of The American College Of Cardiology 2023, 82: 2280-2291. PMID: 38057070, PMCID: PMC11730445, DOI: 10.1016/j.jacc.2023.10.016.Peer-Reviewed Original ResearchConceptsCardiac magnetic resonanceInterstitial myocardial fibrosisNative T1 timeMyocardial fibrosisCardiac remodelingMulti-Ethnic Study of AtherosclerosisElevated Lp(aMyocardial scarAssociated with greater prevalenceCardiac magnetic resonance measurementsMulti-Ethnic StudyMeasurement of extracellular volumeParameters of cardiac remodelingAssociated with left atrial enlargementStudy of AtherosclerosisLate gadolinium enhancementLeft atrial remodelingCine cardiac magnetic resonanceLeft atrial enlargementAssociation of lipoprotein(aT1 timesAssociation of Lp(aGreater prevalencePrognostic thresholdGadolinium enhancement
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