2025
Reducing clinical trial eligibility barriers for patients with MDS: an icMDS position statement
Borate U, Pugh K, Waller A, Welkie R, Huang Y, Bewersdorf J, Stahl M, DeZern A, Platzbecker U, Sekeres M, Wei A, Buckstein R, Roboz G, Savona M, Loghavi S, Hasserjian R, Fenaux P, Sallman D, Hourigan C, Della Porta M, Nimer S, Little R, Santini V, Efficace F, Taylor J, Garcia-Manero G, Odenike O, Kim T, Halene S, Komrokji R, Griffiths E, Greenberg P, Xu M, Xie Z, Bejar R, Sanz G, Patnaik M, Figueroa M, Carraway H, Abdel-Wahab O, Starczynowski D, Padron E, Boultwood J, Gore S, Daver N, Churpek J, Majeti R, Bennett J, List A, Brunner A, Zeidan A. Reducing clinical trial eligibility barriers for patients with MDS: an icMDS position statement. Blood 2025, 145: 1369-1381. PMID: 40146152, DOI: 10.1182/blood.2023023717.Peer-Reviewed Original ResearchConceptsBarriers to clinical trial enrollmentPhase 3 trialClinical trial eligibilityClinical trial enrollmentClinical trialsEligibility criteriaTrial eligibilitySafety signalsTrial enrollmentExclusion criteriaEarly-phase trialsReal-world populationPhase of trialPatientsDrug safety signalsPosition statementUnderrepresentation and exclusion of patients with cardiovascular disease in intensive care randomized controlled trials
Ali T, Grimshaw A, Thomas A, Solomon M, Ross J, Miller P. Underrepresentation and exclusion of patients with cardiovascular disease in intensive care randomized controlled trials. European Heart Journal Acute Cardiovascular Care 2025, zuaf023. PMID: 39950988, DOI: 10.1093/ehjacc/zuaf023.Peer-Reviewed Original ResearchContemporary cardiac intensive care unitsRandomized controlled trialsIschemic heart diseaseCardiovascular diseaseHeart failureDisciplines of critical care medicineHistory of heart failureProspective randomized controlled trialsHeart diseaseControlled trialsExclusion criteriaMultivariate logistic regression analysisCardiac intensive care unitProportion of patientsExclusion of patientsComorbid cardiovascular diseaseCardiovascular disease historyIntensive care unitLogistic regression analysisApplication of randomized controlled trialsComplex patient populationGeneral internal medicineCardiovascular disease comorbiditiesMulticenter trialIndependent predictorsThe healthcare burden of isolated aortic valve insufficiency
Sultan I, Ryan M, Gunnarsson C, Heidrich N, Vallabhajosyula P. The healthcare burden of isolated aortic valve insufficiency. Scientific Reports 2025, 15: 4771. PMID: 39922868, PMCID: PMC11807181, DOI: 10.1038/s41598-025-87179-1.Peer-Reviewed Original ResearchConceptsHealthcare utilizationSAI patientsAnnual healthcare utilizationHealth care databasesYears post-diagnosisEstimate healthcare utilizationHome healthBaseline periodCare databaseMonths of continuous enrollmentCox proportional modelsPost-diagnosisAAI patientsMeasured outcomesHealthcareAI claimEstimate mortalityHealthcare burdenContinuous enrollmentExclusion criteriaUS patientsDiagnosis of aortic stenosisAortic valve insufficiencyProportional modelAnnual costExploring Calcium Channels as Potential Therapeutic Targets in Blast Traumatic Brain Injury
Wachtler N, O’Brien R, Ehrlich B, McGuone D. Exploring Calcium Channels as Potential Therapeutic Targets in Blast Traumatic Brain Injury. Pharmaceuticals 2025, 18: 223. PMID: 40006037, PMCID: PMC11859800, DOI: 10.3390/ph18020223.Peer-Reviewed Original ResearchCalcium signalingCalcium channelsTherapeutic strategiesCalcium homeostasisFunction of calcium channelsDysregulated calcium signalingModulation of injuryTraumatic brain injuryBrain injuryLoss of calcium homeostasisBlast-related traumatic brain injuryDevelopment of neuroprotective interventionsIntracellular calcium dynamicsPlasma membrane stabilityExtracellular calciumBlast traumatic brain injuryPreclinical modelsTherapeutic outcomesNeuroprotective interventionsMembrane abnormalitiesPharmacological inhibitorsNeuronal somataExclusion criteriaCalcium dynamicsSecondary injuryIncidence of Surgery for Pediatric Wrist Ganglion Cysts.
Rancu A, Kammien A, Katsnelson B, Diatta F, Lewis K, Grauer J, Colen D. Incidence of Surgery for Pediatric Wrist Ganglion Cysts. Hand 2025, 15589447251314142. PMID: 39891524, PMCID: PMC11787722, DOI: 10.1177/15589447251314142.Peer-Reviewed Original ResearchWrist ganglion cystsGanglion cystYears of follow-upIncidence of surgeryPercentage of patientsNationwide analysisStatistically significant differenceMagnetic resonance imagingNonoperative managementSurgical managementPearlDiver databaseDiagnosis of ganglion cystPediatric populationFollow-upSurgical planningPatient counselingSurgeryPatientsExclusion criteriaResonance imagingFirst diagnosisCystsSignificant differenceDiagnosis codesDiagnosisQuantitative valve motion assessment in adolescents using point-of-care ultrasound: short communication
Riera A, Chen L, Wright D, Leviter J. Quantitative valve motion assessment in adolescents using point-of-care ultrasound: short communication. The Ultrasound Journal 2025, 17: 11. PMID: 39847270, PMCID: PMC11757829, DOI: 10.1186/s13089-025-00402-y.Peer-Reviewed Original ResearchTricuspid annular plane systolic excursionE-point septal separationPoint-of-care ultrasoundAnnular plane systolic excursionRight ventricular systolic functionPediatric emergency departmentAbnormal vital signsCross-sectional studyVentricular systolic functionBody mass indexUnpaired t-testM-mode measurementsEmergency departmentSystolic excursionAnthropometric dataSystolic functionCardiopulmonary complaintsNo significant correlationMass indexPsychiatric illnessMental statusPearson correlationExclusion criteriaSeptal separationMotion assessmentHand therapy utilization following digital flexor tendon repair: Trends, timing, predictive factors, and association with reoperation
Kammien A, Hu K, Yu C, Grauer J, Colen D. Hand therapy utilization following digital flexor tendon repair: Trends, timing, predictive factors, and association with reoperation. Journal Of Hand Therapy 2025 PMID: 39755488, DOI: 10.1016/j.jht.2024.07.002.Peer-Reviewed Original ResearchTherapy utilizationAssociated with several clinical factorsHand therapyMonths of surgeryProportion of patientsPostoperative hand therapyPostoperative week 4Tendon repairFlexor tendon repairConcomitant proceduresPredictive factorsClinical factorsFollow-upZone II flexor tendon repairNonclinical characteristicsPatient factorsWeek 4TherapyNerve repairExclusion criteriaNonclinical factorsClinical practiceLogistic regressionComponent of recoveryDigital flexor tendon repairDeclining postoperative ninety-day opioid prescriptions from 2010 to 2021 following hip arthroscopy for femoroacetabular impingement syndrome
Day W, Halperin S, Surucu S, Jimenez A, Katsnelson B, Zhu J, Grauer J. Declining postoperative ninety-day opioid prescriptions from 2010 to 2021 following hip arthroscopy for femoroacetabular impingement syndrome. Arthroscopy Sports Medicine And Rehabilitation 2025, 101078. DOI: 10.1016/j.asmr.2025.101078.Peer-Reviewed Original ResearchPostoperative opioid prescriptionsFemoroacetabular impingement syndromeOpioid prescriptionsPostoperative mmeElixhauser Comorbidity IndexHip arthroscopyNinety-dayHistory of chronic painImpingement syndromeAmount of narcoticsNational administrative databaseChronic painAdult patientsPatient sexPostoperative recoveryMultivariate linear regressionComorbidity indexMultivariate analysisComorbidity burdenClinical relevancePatientsExclusion criteriaSurgeryPatient variablesAdministrative databases
2024
Greater Detail is Needed When Reporting Schenck KD V Injuries in the Orthopaedic Literature: A Systematic Review
Marcel A, Levitt S, Green J, Moran J, Jokl P, Schenck R, Wascher D, Alaia M, Medvecky M. Greater Detail is Needed When Reporting Schenck KD V Injuries in the Orthopaedic Literature: A Systematic Review. Arthroscopy Sports Medicine And Rehabilitation 2024, 101046. DOI: 10.1016/j.asmr.2024.101046.Peer-Reviewed Original ResearchV injuriesSystematic reviewOrthopaedic literatureTear patternsKnee dislocationInclusion criteriaClasses I-IVPediatric patientsClassification systemMeta-analysisExclusion criteriaLigament tearsAnimal studiesPeriarticular fracturesFracture patternsI-IVCINAHLReview articleLigamentTechnique papersFractureKneeReviewEarly vigabatrin to augment GABAergic pathways in post-anoxic status epilepticus
Maciel C, Ahmad B, Jose Bruzzone Giraldez M, Eisenschenk S, Ramsay E, Maranchick N, Peloquin C, Hirsch L, Busl K. Early vigabatrin to augment GABAergic pathways in post-anoxic status epilepticus. Epilepsy & Behavior 2024, 160: 110082. PMID: 39393141, DOI: 10.1016/j.yebeh.2024.110082.Peer-Reviewed Original ResearchStatus epilepticusGamma-aminobutyric acidGABAergic pathwayHypoxic-ischemic brain injuryPost-cardiac arrest periodHypoxic-ischemic insultOutcomes of patientsEffective adjunctive therapyInhibition of gamma-aminobutyric acidLondon-Innsbruck ColloquiumAdjunctive therapyAcute seizuresEffective therapyPoor outcomeEpilepticusExclusion criteriaEarly inhibitionSynergistic augmentationGamma-aminobutyric acid catabolismArrest periodTherapeutic nihilismSeizuresClinal trialsAllosteric modulatorsVigabatrinPoster 251: Tibial Tuberosity to Trochlear Groove Distance (TT-TG): A Patellar Instability Gold Standard Prone to Errors?
Sieberer J, Park N, Rancu A, Manafzadeh A, Tommasini S, Wiznia D, Fulkerson J. Poster 251: Tibial Tuberosity to Trochlear Groove Distance (TT-TG): A Patellar Instability Gold Standard Prone to Errors? Orthopaedic Journal Of Sports Medicine 2024, 12: 2325967124s00220. PMCID: PMC11328310, DOI: 10.1177/2325967124s00220.Peer-Reviewed Original ResearchClinical decision-makingAngular malalignmentLongitudinal tibial axisDistal pointTT-TGClinical practiceTrochlear grooveAxial alignmentLateral patellofemoral instabilityPatellar instabilityError prevalenceKnee alignmentPatient careTibial axisDecision-makingKneeMann-Whitney U testRadiological protocolPatient's kneeFemoral posterior condylesInstitutional review boardTT-TG distanceCoronal angleExclusion criteriaControl knees0488 Exploring Study Recruitment Trends in the Acute Post-Stroke Setting
Schwarz J, Masroor K, Radulescu R, Tsang S, Sheth K, Redeker N, Yaggi H, Geer J. 0488 Exploring Study Recruitment Trends in the Acute Post-Stroke Setting. Sleep 2024, 47: a210-a210. DOI: 10.1093/sleep/zsae067.0488.Peer-Reviewed Original ResearchContinuous positive airway pressureObstructive sleep apneaPositive airway pressureAcute ischemic strokeAirway pressureUpper airway closureSleep-disordered breathingYale-New Haven HospitalCerebral blood flowOSA screeningOSA treatmentSleep apneaImpact cerebral blood flowAcademic medical centerSympathetic activityClinical trialsPatient populationHemodynamic changesRisk factorsPatientsFunctional recoveryExclusion criteriaAirway closureCardiovascular diseaseBlood flowExtended Reality and Older Adult Mental Health: A Systematic Review of the Field and Current Applications
Dickinson R, Fahed M, Sekhon H, Faruque S, Kimball J, Gupta S, Handa I, Alkhatib F, Singh A, Vahia I. Extended Reality and Older Adult Mental Health: A Systematic Review of the Field and Current Applications. American Journal Of Geriatric Psychiatry 2024, 32: s130. DOI: 10.1016/j.jagp.2024.01.219.Peer-Reviewed Original ResearchOlder adult populationOlder adultsFall riskMental healthAdult populationCare of older adultsFall risk assessmentAdult mental healthEvidence-based applicationsPhysical activitySystematic literature searchCommon barriersHealthcare providersHealthy lifestylePhysical healthClinical careLack of knowledgeSystematic reviewSnowball techniqueLiterature searchPhysiotherapyHealthExclusion criteriaAdultsCareGeriatric Vertebral Compression Fracture: A Database Study Characterizing Use and Trends for Prescribed Thoracic/Lumbar Orthoses
Halperin S, Dhodapkar M, Moran J, Jeong S, Grauer J, Varthi A. Geriatric Vertebral Compression Fracture: A Database Study Characterizing Use and Trends for Prescribed Thoracic/Lumbar Orthoses. Global Spine Journal 2024, 15: 1318-1323. PMID: 38546972, PMCID: PMC11572230, DOI: 10.1177/21925682241238672.Peer-Reviewed Original ResearchCompression fracturesFractures associated with osteoporosisVertebral compression fracturesMultivariate logistic regressionIndicator of infectionPearlDiver databaseIndependent predictorsTreatment algorithmInclusion criteriaFemale sexLogistic regressionT5-L5Geographic regionsFracture managementFracture levelNational databasePatientsExclusion criteriaYounger ageBraceNon-clinicalCharacterized useOrthosesDatabaseFractureHealth Care Simulation in Person and at a Distance
Birido N, Brown K, Olmo Ferrer D, Friedland R, Bailey S, Wawersik D, Charnetski M, Nair B, Kutzin J, Gross I, Palaganas J. Health Care Simulation in Person and at a Distance. Simulation In Healthcare The Journal Of The Society For Simulation In Healthcare 2024, 19: s65-s74. PMID: 38240620, DOI: 10.1097/sih.0000000000000763.Peer-Reviewed Original ResearchExploring Facilitators and Barriers to STD/STI/HIV Self-Testing Among College Students in the United States: A Scoping Review
Reeves J, Zigah E, Shamrock O, Khan D, Batten J, Abu-Ba’are G, Nelson L, Djiadeu P. Exploring Facilitators and Barriers to STD/STI/HIV Self-Testing Among College Students in the United States: A Scoping Review. Journal Of Primary Care & Community Health 2024, 15: 21501319241291758. PMID: 39439284, PMCID: PMC11497516, DOI: 10.1177/21501319241291758.Peer-Reviewed Original ResearchConceptsAvailability of healthcareSelf-test kitsRisk of STIsSelf-testingEnglish-language studiesYoung adult college studentsDiminish stigmaScoping reviewHealth policyWeb of Science Core CollectionTesting ratesCollege studentsRemoving duplicatesOvid MEDLINEGeneral populationCochrane CENTRALScience Core CollectionOvid EmbaseAdult college studentsExclusion criteriaSexual practicesU.S. ResultsInclusion requirementsDatabase searchOvid
2023
Lumbar Laminotomy: Variables Affecting 90-day Overall Reimbursement
Halperin S, Dhodapkar M, Gouzoulis M, Laurans M, Varthi A, Grauer J. Lumbar Laminotomy: Variables Affecting 90-day Overall Reimbursement. Journal Of The American Academy Of Orthopaedic Surgeons 2023, 32: 265-270. PMID: 38064482, DOI: 10.5435/jaaos-d-23-00365.Peer-Reviewed Original ResearchPostoperative adverse eventsAdverse eventsInsurance typePostoperative emergency department visitsPostoperative emergency departmentEmergency department visitsElixhauser Comorbidity IndexMultivariable linear regression modelsMultivariable linear regressionHealthcare deliveryIndications of traumaPostoperative readmissionsComorbidity indexInfectious diagnosisConservative treatmentPerioperative dataDepartment visitsEmergency departmentOutpatient surgeryLarge cohortSpinal proceduresExclusion criteriaDiskectomyOverall reimbursementCommon procedureA multi-laboratory preclinical trial in rodents to assess treatment candidates for acute ischemic stroke
Lyden P, Diniz M, Bosetti F, Lamb J, Nagarkatti K, Rogatko A, Kim S, Cabeen R, Koenig J, Akhter K, Arbab A, Avery B, Beatty H, Bibic A, Cao S, Simoes Braga Boisserand L, Chamorro A, Chauhan A, Diaz-Perez S, Dhandapani K, Dhanesha N, Goh A, Herman A, Hyder F, Imai T, Johnson C, Khan M, Kamat P, Karuppagounder S, Kumskova M, Mihailovic J, Mandeville J, Morais A, Patel R, Sanganahalli B, Smith C, Shi Y, Sutariya B, Thedens D, Qin T, Velazquez S, Aronowski J, Ayata C, Chauhan A, Leira E, Hess D, Koehler R, McCullough L, Sansing L. A multi-laboratory preclinical trial in rodents to assess treatment candidates for acute ischemic stroke. Science Translational Medicine 2023, 15: eadg8656. PMID: 37729432, DOI: 10.1126/scitranslmed.adg8656.Peer-Reviewed Original ResearchConceptsPreclinical assessmentFocal cerebral ischemic insultAcute ischemic strokeCerebral ischemic insultLarge clinical trialsDiet-induced obesityNew clinical interventionsIntravascular thrombectomyIschemic strokeStroke treatmentHypertensive ratsIschemic insultBlinded assessmentClinical trialsYoung miceTreatment candidatesExclusion criteriaAnimal modelsYoung ratsFutile interventionsPreclinical trialsClinical interventionsFutility boundariesMiceDisease areasStandardizing Randomized Controlled Trials in Celiac Disease: An International Multidisciplinary Appropriateness Study
Lebwohl B, Ma C, Lagana S, Pai R, Baker K, Zayadi A, Hogan M, Bouma G, Cellier C, Goldsmith J, Lundin K, Pinto-Sanchez M, Robert M, Rubio-Tapia A, Sanders D, Schaeffer D, Semrad C, Silvester J, Verdú E, Verma R, Wu T, Feagan B, Crowley E, Jairath V, Murray J. Standardizing Randomized Controlled Trials in Celiac Disease: An International Multidisciplinary Appropriateness Study. Gastroenterology 2023, 166: 88-102. PMID: 37704112, DOI: 10.1053/j.gastro.2023.08.051.Peer-Reviewed Original ResearchConceptsRandomized controlled trialsSecondary patient-reported outcome measuresOutcome measuresRandomized controlled trial designPatient-reported outcome measuresControlled trialsGluten challengeStandard Randomized Controlled TrialPatient-reported outcomesGluten-free dietReversal of histological changesMethods studyCeliac diseaseEligibility criteriaHistological end pointsPrevention of relapseEffective pharmacological optionsAppropriate studiesTrial outcomesExclusion criteriaClinical trial designTrial designTreatment of celiac diseasePediatric patientsPharmacological optionsRepresentativeness of Patients Enrolled in the Lung Cancer Master Protocol (Lung-MAP)
Vaidya R, Unger J, Qian L, Minichiello K, Herbst R, Gandara D, Neal J, Leal T, Patel J, Dragnev K, Waqar S, Edelman M, Sigal E, Adam S, Malik S, Blanke C, LeBlanc M, Kelly K, Gray J, Redman M. Representativeness of Patients Enrolled in the Lung Cancer Master Protocol (Lung-MAP). JCO Precision Oncology 2023, 7: e2300218. PMID: 37677122, PMCID: PMC10581630, DOI: 10.1200/po.23.00218.Peer-Reviewed Original ResearchConceptsCharacteristics of patientsLung-MAPMaster protocolsNSCLC populationCell lung cancer trialsSEER registry dataPatients 65 yearsPrecision medicine clinical trialsPatient exclusion criteriaLung cancer trialsRepresentativeness of patientsMedicine clinical trialsNSCLC trialsOlder patientsMedicaid/More patientsSubgroup analysisCancer trialsClinical trialsVulnerable patientsRegistry dataExclusion criteriaPatientsNSCLC studiesSociodemographic characteristics
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