2025
Towards Automating Risk Stratification of Intraductal Papillary Mucinous Neoplasms: Artificial Intelligence Advances Beyond Human Expertise with Confocal Laser Endomicroscopy
Krishna S, Abdelbaki A, Li Z, Culp S, Xiong X, Napoleon B, Mok S, Bertani H, Feng Y, Kongkam P, Luthra A, Machicado J, El-Dika S, Leblanc S, Tan D, Burlen J, Keane M, Keihanian T, Ladd A, Muniraj T, Visrodia K, Chen W, Esnakula A, Hart P, Chao W. Towards Automating Risk Stratification of Intraductal Papillary Mucinous Neoplasms: Artificial Intelligence Advances Beyond Human Expertise with Confocal Laser Endomicroscopy. Pancreatology 2025 PMID: 40447463, DOI: 10.1016/j.pan.2025.05.011.Peer-Reviewed Original ResearchNeedle-based confocal laser endomicroscopyIntraductal papillary mucinous neoplasmBD-IPMNInterobserver agreementArtificial intelligenceConfocal laser endomicroscopyLaser endomicroscopyBranch ductPapillary mucinous neoplasmPerformance of expertsHuman expertiseAI modelsPost hoc analysisMucinous neoplasmsDysplasia gradeEndoscopic ultrasoundClinical criteriaInterobserver variabilityCyst epitheliumSuperior accuracyDysplasiaAUCPost-hocArtificialDiagnostic parametersTOWARDS AUTOMATING RISK STRATIFICATION OF INTRADUCTAL PAPILLARY MUCINOUS NEOPLASMS: ARTIFICIAL INTELLIGENCE ADVANCES BEYOND HUMAN EXPERTISE WITH CONFOCAL LASER ENDOMICROSCOPY
Krishna S, Abdelbaki A, Li Z, Culp S, Xiong X, Napoleon B, Mok S, Bertani H, Feng Y, Kongkam P, Anjuli A, Machicado J, El-Dika S, Tan D, Burlen J, Keane M, Keihanian T, Ladd A, Muniraj T, Visrodia K, Chen W, Esnakula A, Hart P, Chao W. TOWARDS AUTOMATING RISK STRATIFICATION OF INTRADUCTAL PAPILLARY MUCINOUS NEOPLASMS: ARTIFICIAL INTELLIGENCE ADVANCES BEYOND HUMAN EXPERTISE WITH CONFOCAL LASER ENDOMICROSCOPY. Gastrointestinal Endoscopy 2025, 101: s4. DOI: 10.1016/j.gie.2025.03.012.Peer-Reviewed Original Research
2023
Improving Pancreatic Cyst Management: Artificial Intelligence-Powered Prediction of Advanced Neoplasms through Endoscopic Ultrasound-Guided Confocal Endomicroscopy
Jiang J, Chao W, Cao T, Culp S, Napoléon B, El-Dika S, Machicado J, Pannala R, Mok S, Luthra A, Akshintala V, Muniraj T, Krishna S. Improving Pancreatic Cyst Management: Artificial Intelligence-Powered Prediction of Advanced Neoplasms through Endoscopic Ultrasound-Guided Confocal Endomicroscopy. Biomimetics 2023, 8: 496. PMID: 37887627, PMCID: PMC10604893, DOI: 10.3390/biomimetics8060496.Peer-Reviewed Original ResearchSurveillance of Pancreatic Cystic Neoplasms
Chhoda A, Schmidt J, Farrell J. Surveillance of Pancreatic Cystic Neoplasms. Gastrointestinal Endoscopy Clinics Of North America 2023, 33: 613-640. PMID: 37245939, DOI: 10.1016/j.giec.2023.03.010.Peer-Reviewed Original ResearchConceptsPancreatic cystic neoplasmsAdvanced neoplasiaCystic neoplasmsIntraductal papillary mucinous neoplasmClinical surveillance guidelinesHigh-risk morphologyConsensus clinical guidelinesPapillary mucinous neoplasmAccurate preoperative diagnosisCross-sectional imagingSurgical resectionSurgical indicationsPreoperative diagnosisSurveillance guidelinesSurveillance intervalsMucinous neoplasmsMalignant potentialClinical evaluationClinical guidelinesPancreatic cystsClinical challengeSurveillance strategiesNeoplasmsNeoplasiaCurrent conceptsUtility of promoter hypermethylation in malignant risk stratification of intraductal papillary mucinous neoplasms
Chhoda A, Sharma A, Sailo B, Tang H, Ruzgar N, Tan W, Ying L, Khatri R, Narayanan A, Mane S, De Kumar B, Wood L, Iacobuzio-Donahue C, Wolfgang C, Kunstman J, Salem R, Farrell J, Ahuja N. Utility of promoter hypermethylation in malignant risk stratification of intraductal papillary mucinous neoplasms. Clinical Epigenetics 2023, 15: 28. PMID: 36803844, PMCID: PMC9942382, DOI: 10.1186/s13148-023-01429-5.Peer-Reviewed Original ResearchConceptsPapillary mucinous neoplasmMalignant risk stratificationCACNA1G geneRisk stratificationMucinous neoplasmsBiomarker panelBackgroundIntraductal papillary mucinous neoplasmIntraductal papillary mucinous neoplasmEarly detectionPrevious case-control studyHigh-grade dysplasiaCase-control studyPancreatic cancer precursorsReceiver Operating Characteristic (ROC) curve analysisSignificant diagnostic challengeCross-sectional imagingCharacteristic curve analysisOperating Characteristic curve analysisG geneHigh diagnostic specificityPrior validation studiesSignificant procedural riskIPMN tissuesSurgical resectionAdvanced neoplasia
2022
Benefit of Extended Surveillance of Low-Risk Pancreatic Cysts After 5-Year Stability: A Systematic Review and Meta-Analysis
Chhoda A, Singh S, Sheth AH, Grimshaw AA, Gunderson C, Sharma P, Kunstman JW, Sharma A, Ahuja N, Gonda TA, Farrell JJ. Benefit of Extended Surveillance of Low-Risk Pancreatic Cysts After 5-Year Stability: A Systematic Review and Meta-Analysis. Clinical Gastroenterology And Hepatology 2022, 21: 1430-1446. PMID: 35568304, DOI: 10.1016/j.cgh.2022.04.025.Peer-Reviewed Original ResearchConceptsDisease-specific mortalityAdvanced neoplasiaBD-IPMNsExtended surveillancePooled incidenceWorrisome featuresSystematic reviewIntraductal papillary mucinous neoplasmHigh-grade dysplasiaPapillary mucinous neoplasmHigh-quality studiesRandom-effects modelWarrants further investigationWeb of ScienceNeoplasia incidenceWarrants further explorationSurvival benefitCochrane LibraryMucinous neoplasmsPancreatic cancerPancreatic cystsSurveillance periodEligible studiesOvid MEDLINELower incidenceA Review of Mucinous Cystic and Intraductal Neoplasms of the Pancreatobiliary Tract.
Ozcan K, Klimstra D. A Review of Mucinous Cystic and Intraductal Neoplasms of the Pancreatobiliary Tract. Archives Of Pathology & Laboratory Medicine 2022, 146: 298-311. PMID: 35192699, DOI: 10.5858/arpa.2021-0399-ra.Peer-Reviewed Original ResearchConceptsMucinous cystic neoplasmsIntraductal neoplasmsPancreatobiliary tractCystic neoplasmsPancreatic neoplasmsIntraductal papillary mucinous neoplasmPancreatic intraductal neoplasmsIntraductal oncocytic papillary neoplasmBile duct neoplasmsPapillary mucinous neoplasmCystic pancreatic neoplasmsMass-forming neoplasmIntraductal tubulopapillary neoplasmIntraductal papillary neoplasmIntraductal papillary neoplasm of bile ductSensitive imaging techniqueMucinous neoplasmsPapillary neoplasmPancreatobiliary neoplasmsPrognostic variationsGenomic alterationsTubulopapillary neoplasmNeoplasmsBile ductPathological features
2021
Sa302 IS MULTIFOCALITY IN INTRADUCTAL PAPILLARY MUCINOUS NEOPLASMS A RISK FACTOR FOR PANCREATIC MALIGNANCY?: A SYSTEMATIC REVIEW AND META-ANALYSIS
Chhoda A, Singh S, Grimshaw A, Sheth A, Sharma A, Kunstman J, Ahuja N, Farrell J. Sa302 IS MULTIFOCALITY IN INTRADUCTAL PAPILLARY MUCINOUS NEOPLASMS A RISK FACTOR FOR PANCREATIC MALIGNANCY?: A SYSTEMATIC REVIEW AND META-ANALYSIS. Gastroenterology 2021, 160: s-477. DOI: 10.1016/s0016-5085(21)01845-x.Peer-Reviewed Original ResearchIntraductal papillary mucinous neoplasmPapillary mucinous neoplasmMucinous neoplasmsPancreatic malignancyRisk factorsSystematic reviewMalignancyNeoplasmsCystic Tumors Other than IPMN
Kunstman J, Farrell J. Cystic Tumors Other than IPMN. 2021, 608-623. DOI: 10.1002/9781119570097.ch74.Peer-Reviewed Original ResearchIntraductal papillary mucinous neoplasmMucinous cystic neoplasmCystic lesionsCystic neoplasmsCystic pancreatic endocrine neoplasmsNeoplastic cystic lesionsPapillary mucinous neoplasmSolid pseudopapillary neoplasmPancreatic endocrine neoplasmsPancreatic specialistsCystic tumorSurgical interventionMucinous neoplasmsCommon lesionsSerous cystadenomaPseudopapillary neoplasmEndocrine neoplasmsNeoplasmsClinical issuesLesionsNatural historyPancreasSuccessful managementLongitudinal seriesCystadenoma
2020
S0106 Imaging Resource Utilization in the Surveillance of Presumed Branched Duct Intraductal Papillary Mucinous Neoplasm (BD-IPMN)
Yousaf M, Zhang Z, Chhoda A, Madhani K, Chaudhary F, Suarez A, Muniraj T, Kunstman J, Jamidar P, Aslanian H, Salem R, Farrell J. S0106 Imaging Resource Utilization in the Surveillance of Presumed Branched Duct Intraductal Papillary Mucinous Neoplasm (BD-IPMN). The American Journal Of Gastroenterology 2020, 115: s51-s51. DOI: 10.14309/01.ajg.0000702472.90174.1c.Peer-Reviewed Original ResearchEndoscopic Ultrasound-Guided Fine Needle Aspiration Cytologic Evaluation of Intraductal Papillary Mucinous Neoplasm and Mucinous Cystic Neoplasms of Pancreas
Gilani SM, Adeniran AJ, Cai G. Endoscopic Ultrasound-Guided Fine Needle Aspiration Cytologic Evaluation of Intraductal Papillary Mucinous Neoplasm and Mucinous Cystic Neoplasms of Pancreas. American Journal Of Clinical Pathology 2020, 154: 559-570. PMID: 32589187, DOI: 10.1093/ajcp/aqaa079.Peer-Reviewed Original ResearchConceptsIntraductal papillary mucinous neoplasmMucinous cystic neoplasmMucinous cystic lesionsHigh-grade dysplasiaPapillary mucinous neoplasmCystic neoplasmsMucinous neoplasmsAncillary testingFine-needle aspiration cytologic evaluationUltrasound-guided fine-needle aspiration cytologyEndoscopic ultrasound-guided fine-needle aspiration cytologyFine needle aspiration cytologyRisk of malignancyNeedle aspiration cytologyUse of cytologyPositive cytologic diagnosisCytologic categoriesModerate dysplasiaCystic lesionsCytopathology guidelinesInvasive malignancyMalignancy rateHistologic diagnosisCytologic evaluationEndoscopic ultrasoundSimple mucinous cysts of the pancreas have heterogeneous somatic mutations
Attiyeh M, Zhang L, Iacobuzio-Donahue C, Allen P, Imam R, Basturk O, Klimstra D, Sigel C. Simple mucinous cysts of the pancreas have heterogeneous somatic mutations. Human Pathology 2020, 101: 1-9. PMID: 32380013, PMCID: PMC7321854, DOI: 10.1016/j.humpath.2020.04.006.Peer-Reviewed Original ResearchConceptsIntraductal papillary mucinous neoplasmPapillary mucinous neoplasmMucinous neoplasmsMucinous cystsGenomic alterationsSpectrum of genomic alterationsPancreatic intraepithelial neoplasiaHeterogeneous somatic mutationsSimple mucinous cystTargeted sequencing analysisPancreatic cancer genesIntraepithelial neoplasiaMucinous neoplasiaGNAS mutationsNeoplasmsSomatic mutationsEpithelial liningMutated genesCancer genesPreinvasive neoplasmsCystsPancreasNeoplasiaMutationsAlterations
2019
Pancreatic Intraductal Papillary Mucinous Neoplasm With Elevated Pre-Operative Cystic Carcinoembryonic Antigen Level: A Histopathologic Correlation
Beech C, Freedman-Weiss M, Salem R, Jain D, Zhang X. Pancreatic Intraductal Papillary Mucinous Neoplasm With Elevated Pre-Operative Cystic Carcinoembryonic Antigen Level: A Histopathologic Correlation. Gastroenterology Research 2019, 12: 185-190. PMID: 31523327, PMCID: PMC6731045, DOI: 10.14740/gr1201.Peer-Reviewed Original ResearchCarcinoembryonic antigen levelCEA levelsInvasive carcinomaAntigen levelsCEA stainingIntraductal papillary mucinous neoplasm subtypesPancreatic intraductal papillary mucinous neoplasmsIntraductal papillary mucinous neoplasmPresence of dysplasiaPapillary mucinous neoplasmGrade of dysplasiaRisk of malignancySize of lesionsDuct involvementPathologic variablesCystic lesionsIPMN casesMucinous neoplasmsMucinous secretionHistopathologic correlationNeoplasm subtypesCarcinomaGlycoprotein expressionSignificant correlationDysplasiaAJCC 7th edition staging classification is more applicable than AJCC 8th edition staging classification for invasive IPMN
Fan Z, Cheng H, Jin K, Gong Y, Huang Q, Xu J, Ni Q, Yu X, Liu C, Luo G. AJCC 7th edition staging classification is more applicable than AJCC 8th edition staging classification for invasive IPMN. World Journal Of Surgical Oncology 2019, 17: 137. PMID: 31387646, PMCID: PMC6685146, DOI: 10.1186/s12957-019-1682-9.Peer-Reviewed Original ResearchConceptsInvasive IPMNInvasive intraductal papillary mucinous neoplasmStage IB diseaseStage IIA diseaseHazard ratioEdition classificationIIA diseaseIB diseaseStaging classificationStaging systemEnd Results cancer registryIntraductal papillary mucinous neoplasmEdition staging systemPredictors of survivalAmerican Joint CommitteeCancer (AJCC) staging systemPapillary mucinous neoplasmConclusionsThe AJCCResectable tumorsAJCC stagingStage IIACancer RegistryTumor sizeMucinous neoplasmsResultsIn totalHistomorphology of pancreatic cancer in patients with inherited ATM serine/threonine kinase pathogenic variants
Hutchings D, Jiang Z, Skaro M, Weiss M, Wolfgang C, Makary M, He J, Cameron J, Zheng L, Klimstra D, Brand R, Singhi A, Goggins M, Klein A, Roberts N, Hruban R. Histomorphology of pancreatic cancer in patients with inherited ATM serine/threonine kinase pathogenic variants. Modern Pathology 2019, 32: 1806-1813. PMID: 31285527, PMCID: PMC7403604, DOI: 10.1038/s41379-019-0317-6.Peer-Reviewed Original ResearchConceptsATM pathogenic variantsIntraductal papillary mucinous neoplasmGermline pathogenic variantsPapillary mucinous neoplasmPancreatic cancerPathogenic variantsHistological subtypesMucinous neoplasmsDuctal adenocarcinomaIncreased risk of pancreatic ductal adenocarcinomaIncipient intraductal papillary mucinous neoplasmsRisk of pancreatic ductal adenocarcinomaSporadic pancreatic cancerGermline genetic testingPancreatic intraepithelial neoplasiaPancreatic cancer patientsNon-invasive precursor lesionsPancreatic ductal adenocarcinomaAdenosquamous carcinomaIntraepithelial neoplasiaPrecursor lesionsChemotherapeutic drugsCancer patientsIncreased riskATM serine/threonine kinaseUndifferentiated carcinoma with osteoclast-like giant cells of the pancreas arising from an intraductal papillary mucinous neoplasm
Charifa A, Walther Z, Salem R, Jain D. Undifferentiated carcinoma with osteoclast-like giant cells of the pancreas arising from an intraductal papillary mucinous neoplasm. Human Pathology Reports 2019, 15: 95-98. DOI: 10.1016/j.ehpc.2018.12.007.Peer-Reviewed Case Reports and Technical NotesOsteoclast-like giant cellsUndifferentiated carcinomaInvasive carcinomaGiant cellsMucinous neoplasmsEndoscopic ultrasoundIntraductal papillary mucinous neoplasmIntraductal mucinous neoplasmPapillary mucinous neoplasmRare pancreatic tumorPancreatic ductal carcinomaDuctal lesionsDuctal carcinomaPancreatic tumorsPancreatic adenocarcinomaCarcinoma subtypesHistological examinationPancreatic massCarcinomaEpithelial markersAmpullary massEpithelial originIPMNNeoplastic progressionNeoplasms
2018
Microwave Thermal Ablation in an Unusual Case of Malignant and Locally Advanced Rare Tumor of Pancreas in ASA IV Old Male Patient and Literature Review
D’Amico F, Finotti M, Di Renzo C, Pasquale A, Bertacco A, Caturegli G, Gondolesi GE, Cillo U. Microwave Thermal Ablation in an Unusual Case of Malignant and Locally Advanced Rare Tumor of Pancreas in ASA IV Old Male Patient and Literature Review. Case Reports In Gastrointestinal Medicine 2018, 2018: 6064912. PMID: 29850295, PMCID: PMC5925082, DOI: 10.1155/2018/6064912.Peer-Reviewed Original ResearchIntraductal papillary mucinous neoplasmSystemic disease statusPapillary mucinous neoplasmComputed tomographyPancreatic tumorsPancreatic intraductal papillary mucinous tumorsDisease statusPancreatic intraductal papillary mucinous neoplasmsIntraductal papillary mucinous tumorBiliary tree dilatationWorsening of jaundiceLines of chemotherapyStaging CT scanHead of pancreasRare primary neoplasmOld male patientKinds of tumorsCardiovascular complicationsPalliative surgeryMultimodality treatmentOverall survivalPalliative treatmentComplete responseMale patientsPrimary neoplasmsProgression Patterns in the Remnant Pancreas after Resection of Non-Invasive or Micro-Invasive Intraductal Papillary Mucinous Neoplasms (IPMN)
Al Efishat M, Attiyeh M, Eaton A, Gönen M, Basturk O, Klimstra D, D’Angelica M, DeMatteo R, Kingham T, Balachandran V, Jarnagin W, Allen P. Progression Patterns in the Remnant Pancreas after Resection of Non-Invasive or Micro-Invasive Intraductal Papillary Mucinous Neoplasms (IPMN). Annals Of Surgical Oncology 2018, 25: 1752-1759. PMID: 29589164, PMCID: PMC7461605, DOI: 10.1245/s10434-018-6445-2.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overCarcinomaDisease ProgressionFemaleFollow-Up StudiesHumansMagnetic Resonance ImagingMaleMiddle AgedNeoplasm InvasivenessNeoplasm Recurrence, LocalPancreasPancreatectomyPancreatic Intraductal NeoplasmsProgression-Free SurvivalRetrospective StudiesSurvival RateTomography, X-Ray ComputedTumor BurdenConceptsIntraductal papillary mucinous neoplasmSegmental resectionPancreatic remnantIncreased risk of progressionMultivariate Cox regression modelIPMN progressionMedian follow-upBranch ductRisk of progressionPapillary mucinous neoplasmPredictors of progressionCox regression modelsHigh-risk groupMicroinvasive diseaseDevelopment of cancerInitial resectionIPMN lesionsInvasive cancerMedian ageRemnant pancreasMucinous neoplasmsInvasive diseaseRadiographic surveillanceResectionFollow-up
2017
Pancreatic intraductal tubulopapillary neoplasm is genetically distinct from intraductal papillary mucinous neoplasm and ductal adenocarcinoma
Basturk O, Berger M, Yamaguchi H, Adsay V, Askan G, Bhanot U, Zehir A, Carneiro F, Hong S, Zamboni G, Dikoglu E, Jobanputra V, Wrzeszczynski K, Balci S, Allen P, Ikari N, Takeuchi S, Akagawa H, Kanno A, Shimosegawa T, Morikawa T, Motoi F, Unno M, Higuchi R, Yamamoto M, Shimizu K, Furukawa T, Klimstra D. Pancreatic intraductal tubulopapillary neoplasm is genetically distinct from intraductal papillary mucinous neoplasm and ductal adenocarcinoma. Modern Pathology 2017, 30: 1760-1772. PMID: 28776573, DOI: 10.1038/modpathol.2017.60.Peer-Reviewed Original ResearchConceptsGenetic characteristicsIdentification of sequence mutationsIntraductal papillary mucinous neoplasmWhole-genome sequencingIntraductal tubulopapillary neoplasmPapillary mucinous neoplasmWhole-exome sequencingCopy number alterationsNext-generation sequencingPI3K) pathwayChromatin remodeling genesMAP kinase pathwayPhosphatidylinositol 3-kinaseTargeted next-generation sequencingLoss of CDKN2AGenomic analysisTubulopapillary neoplasmSequence mutationsMucinous neoplasmsTested genesMutated genesGenesGenetic alterationsMAP kinaseRemodeling genesCirculating Epithelial Cells in Intraductal Papillary Mucinous Neoplasms and Cystic Pancreatic Lesions
Poruk KE, Valero V, He J, Ahuja N, Cameron JL, Weiss MJ, Lennon AM, Goggins M, Wood LD, Wolfgang CL. Circulating Epithelial Cells in Intraductal Papillary Mucinous Neoplasms and Cystic Pancreatic Lesions. Pancreas 2017, 46: 943-947. PMID: 28697136, DOI: 10.1097/mpa.0000000000000869.Peer-Reviewed Original ResearchConceptsIntraductal papillary mucinous neoplasmHigh-grade dysplasiaPapillary mucinous neoplasmBlood of patientsEpithelial cellsMucinous neoplasmsPancreatic lesionsAbsence of malignancyBenign pancreatic lesionsCystic pancreatic lesionsNineteen patientsPancreatic resectionPeripheral bloodPancreatic cystsISET methodPatientsPancreas-specific markersResectionMalignancyDysplasiaBloodNeoplasmsPancreatic sourceLow gradeLesions
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