2024
Rare presentations of glioblastoma multiforme in the septum pellucidum: illustrative case
Subah G, Zeller S, Jain A, Gozum N, Smith G, Cooper J, Kleinman G, Gandhi C, Hanft S. Rare presentations of glioblastoma multiforme in the septum pellucidum: illustrative case. Journal Of Neurosurgery Case Lessons 2024, 8: case23770. PMID: 39432918, PMCID: PMC11505928, DOI: 10.3171/case23770.Peer-Reviewed Original ResearchGlioblastoma multiformeSeptum pellucidumInitial head computed tomographyHistory of prostate carcinomaKi-67 labeling indexHigh-grade primary brain tumorsTumor grade 4Head computed tomographyDiverse clinical presentationsPrimary brain tumorGlial fibrillary acidic proteinFibrillary acidic proteinMagnetic resonance imagingProstate carcinomaBiopsy findingsRare presentationIntracranial malignanciesClinical presentationKi-67Mass lesionDiagnostic advancesLabeling indexLateral ventricleNeuro-oncologyInfiltrative growth
2018
A common classification framework for neuroendocrine neoplasms: an International Agency for Research on Cancer (IARC) and World Health Organization (WHO) expert consensus proposal
Rindi G, Klimstra D, Abedi-Ardekani B, L. S, Bosman F, Brambilla E, Busam K, de Krijger R, Dietel M, El-Naggar A, Fernandez-Cuesta L, Klöppel G, McCluggage W, Moch H, Ohgaki H, Rakha E, Reed N, Rous B, Sasano H, Scarpa A, Scoazec J, Travis W, Tallini G, Trouillas J, van Krieken J, Cree I. A common classification framework for neuroendocrine neoplasms: an International Agency for Research on Cancer (IARC) and World Health Organization (WHO) expert consensus proposal. Modern Pathology 2018, 31: 1770-1786. PMID: 30140036, PMCID: PMC6265262, DOI: 10.1038/s41379-018-0110-y.Peer-Reviewed Original ResearchConceptsNeuroendocrine neoplasmsNeuroendocrine tumorsInternational Agency for Research on CancerExpression of neuroendocrine markersKi-67 labeling indexClassification of neuroendocrine neoplasmsWorld Health OrganizationPresence of necrosisOrgan systemsPrognostic factorsCarcinoid tumorsPrognostic differencesNeuroendocrine markersKi-67Mitotic countTumor biologyLabeling indexAnatomical sitesOrgan-specific differencesAnatomical locationConsensus conferenceNeoplasmsTumorClassification criteriaCancerWell differentiated grade 3 pancreatic neuroendocrine tumors compared with related neoplasms: A morphologic study
Sigel C, Silva V, Reid M, Chhieng D, Basturk O, Sigel K, Daniel T, Klimstra D, Tang L. Well differentiated grade 3 pancreatic neuroendocrine tumors compared with related neoplasms: A morphologic study. Cancer Cytopathology 2018, 126: 326-335. PMID: 29451738, PMCID: PMC5992011, DOI: 10.1002/cncy.21982.Peer-Reviewed Original ResearchConceptsGrade 3 neoplasmsGrade 2 neoplasmsPancreatic neuroendocrine neoplasmsSmooth nuclear contoursNeuroendocrine neoplasmsPlasmacytoid morphologyPD-LNuclear contoursCytologic featuresMedian Ki-67 proliferation indexGrade 2Grade 3 neuroendocrine carcinomasKi-67 proliferation indexKi-67 labeling indexSmall cell typeFine-needle aspirationCell typesNeuroendocrine tumorsCytomorphologic featuresKi-67Proliferation indexGrade 3Labeling indexNeoplasmsAbundant cytoplasm
2015
Relative Effectiveness of Letrozole Compared With Tamoxifen for Patients With Lobular Carcinoma in the BIG 1-98 Trial
Metzger Filho O, Giobbie-Hurder A, Mallon E, Gusterson B, Viale G, Winer EP, Thürlimann B, Gelber RD, Colleoni M, Ejlertsen B, Debled M, Price KN, Regan MM, Coates AS, Goldhirsch A. Relative Effectiveness of Letrozole Compared With Tamoxifen for Patients With Lobular Carcinoma in the BIG 1-98 Trial. Journal Of Clinical Oncology 2015, 33: 2772-2779. PMID: 26215945, PMCID: PMC4550691, DOI: 10.1200/jco.2015.60.8133.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntineoplastic Agents, HormonalAntineoplastic Combined Chemotherapy ProtocolsAromatase InhibitorsBiomarkers, TumorBreast NeoplasmsCarcinoma, Ductal, BreastCarcinoma, LobularChemotherapy, AdjuvantDisease-Free SurvivalFemaleHumansKi-67 AntigenLetrozoleMiddle AgedNitrilesReceptor, ErbB-2TamoxifenTreatment OutcomeTriazolesConceptsInvasive ductal carcinomaInvasive lobular carcinomaDisease-free survivalLobular carcinomaDFS eventsDuctal carcinomaLA subtypeBreast International Group (BIG) 1Early-stage invasive ductal carcinomaClassic invasive lobular carcinomaHER2-negative invasive ductal carcinomaKi-67 labeling indexLow proliferative activityMagnitude of benefitAdjuvant letrozoleMedian followBIG 1ILC subsetsMultivariable modelCox modelGroup 1LetrozoleCarcinomaLabeling indexPatientsPoorly Differentiated Neuroendocrine Carcinoma of the Pancreas
Basturk O, Klimstra D. Poorly Differentiated Neuroendocrine Carcinoma of the Pancreas. 2015, 147-153. DOI: 10.1007/978-3-319-17235-4_17.Peer-Reviewed Original ResearchPD-NECsNeuroendocrine tumorsNeuroendocrine carcinomaPoor-differentiated neuroendocrine carcinomasKi-67 labeling indexDegree of mitotic activityCell neuroendocrine carcinomaWHO classification systemCell carcinomaTumor entitiesPancreatic carcinomaKi-67Labeling indexRb/p16 pathwayFatal tumorCarcinomaGenetic changesTumorMitotic activityImmunohistochemical labelingPancreasGastrointestinal tractLung
2013
Reticulon 4B (Nogo‐B) facilitates hepatocyte proliferation and liver regeneration in mice
Gao L, Utsumi T, Tashiro K, Liu B, Zhang D, Swenson ES, Iwakiri Y. Reticulon 4B (Nogo‐B) facilitates hepatocyte proliferation and liver regeneration in mice. Hepatology 2013, 57: 1992-2003. PMID: 23299899, PMCID: PMC3628958, DOI: 10.1002/hep.26235.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell ProliferationEpidermal Growth FactorHepatectomyHepatocyte Growth FactorHepatocytesInterleukin-6LiverLiver RegenerationMaleMiceMice, Inbred C57BLMice, KnockoutModels, AnimalMyelin ProteinsNogo ProteinsSignal TransductionSTAT3 Transcription FactorTime FactorsTransforming Growth Factor betaConceptsHepatocyte growth factorRole of NogoInterleukin-6Hepatocyte proliferationLiver regenerationEpidermal growth factorReticulon 4BTGF-β1Growth factorKi67 labeling indexB knockout miceHepatic stellate cellsReal-time polymerase chain reactionQuantitative real-time polymerase chain reactionIL-6/signal transducerGrowth factor βTime-dependent mannerRemnant liverKO miceLiver fibrosisPolymerase chain reactionInhibitor of DNAStellate cellsKnockout miceLabeling index
2012
Regional Differences in Gallbladder Cancer Pathogenesis: Insights from a Comparison of Cell Cycle-Regulatory, PI3K, and Pro-Angiogenic Protein Expression
Butte J, Torres J, Veras E, Matsuo K, Gönen M, D’Angelica M, Waugh E, Meneses M, Inayama Y, Fong Y, DeMatteo R, De La Fuente H, Endo I, Klimstra D, Jarnagin W. Regional Differences in Gallbladder Cancer Pathogenesis: Insights from a Comparison of Cell Cycle-Regulatory, PI3K, and Pro-Angiogenic Protein Expression. Annals Of Surgical Oncology 2012, 20: 1470-1481. PMID: 23212762, PMCID: PMC4048130, DOI: 10.1245/s10434-012-2761-0.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overChileCyclin-Dependent Kinase Inhibitor p21FemaleGallbladder NeoplasmsHumansJapanKaplan-Meier EstimateKi-67 AntigenMaleMiddle AgedMultivariate AnalysisNeoplasm StagingProliferating Cell Nuclear AntigenProto-Oncogene Proteins c-mdm2United StatesVascular Endothelial Growth Factor Receptor-2ConceptsMedian disease-specific survivalCell cycle-regulatoryGallbladder cancerEarly tumorsProtein expressionDisease-specific survival of patientsKi-67 labeling indexIncidence of gallbladder cancerDisease-specific survivalGallbladder cancer pathogenesisSurvival of patientsAbsence of p21MethodsImmunohistochemical expressionCurative intentClinicopathological variablesAngiogenesis-relatedKi-67Labeling indexP27 expressionProtein expression patternsTumorMSKCCMDM2 overexpressionCancer pathogenesisPathogenetic differencesCholesterol metabolite, 5-cholesten-3β-25-diol-3-sulfate, promotes hepatic proliferation in mice
Zhang X, Bai Q, Kakiyama G, Xu L, Kim JK, Pandak WM, Ren S. Cholesterol metabolite, 5-cholesten-3β-25-diol-3-sulfate, promotes hepatic proliferation in mice. The Journal Of Steroid Biochemistry And Molecular Biology 2012, 132: 262-270. PMID: 22732306, PMCID: PMC3463675, DOI: 10.1016/j.jsbmb.2012.06.001.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisCell CycleCell ProliferationCholesterolCholesterol EstersDNA ReplicationGene Expression RegulationHydrocarbons, FluorinatedHydroxycholesterolsLiverLiver X ReceptorsMiceMice, Inbred C57BLOrphan Nuclear ReceptorsSignal TransductionSulfonamidesSulfotransferasesTissue DistributionUp-RegulationConceptsLiver X receptorHepatic proliferationSynthetic LXR agonist T0901317LXR agonist T0901317PCNA labeling indexDose-dependent mannerSuppresses cell proliferationOxysterol sulfationOxysterol sulfotransferaseProliferation gene expressionAgonist T0901317Cholesterol metabolitesLabeling indexEndogenous ligandLiver proliferationX receptorHepatic DNA replicationHepatocyte proliferationSREBP-1cNovel regulatory pathwayPCR arrayCell proliferationAdministrationPotent regulatorOxysterolsCytosolic sulfotransferase 2B1b promotes hepatocyte proliferation gene expression in vivo and in vitro
Zhang X, Bai Q, Xu L, Kakiyama G, Pandak WM, Zhang Z, Ren S. Cytosolic sulfotransferase 2B1b promotes hepatocyte proliferation gene expression in vivo and in vitro. AJP Gastrointestinal And Liver Physiology 2012, 303: g344-g355. PMID: 22679001, PMCID: PMC3423104, DOI: 10.1152/ajpgi.00403.2011.Peer-Reviewed Original ResearchConceptsLiver X receptorMouse liver tissueLiver tissueSulfotransferase 2B1bLiver proliferationPCNA-positive cellsPrimary rat hepatocytesCell nuclear antigenOxysterol sulfotransferaseWestern blot analysisCell cycle regulatory gene expressionProliferation gene expressionTime-dependent mannerGene expressionC57BL/6 miceQuantitative real-time PCRReal-time PCRLXR activationDouble immunofluorescenceLabeling indexSelective cholesterolAntiproliferative factorPCNA expressionLipid metabolismIncreased expression
2011
Effect of Tumor Heterogeneity on the Assessment of Ki67 Labeling Index in Well-differentiated Neuroendocrine Tumors Metastatic to the Liver
Yang Z, Tang L, Klimstra D. Effect of Tumor Heterogeneity on the Assessment of Ki67 Labeling Index in Well-differentiated Neuroendocrine Tumors Metastatic to the Liver. The American Journal Of Surgical Pathology 2011, 35: 853-860. PMID: 21566513, DOI: 10.1097/pas.0b013e31821a0696.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBiomarkers, TumorBiopsyCarcinoma, NeuroendocrineFemaleHepatectomyHumansImage Processing, Computer-AssistedKaplan-Meier EstimateKi-67 AntigenLiver NeoplasmsMaleMiddle AgedNew YorkPrognosisReproducibility of ResultsRetrospective StudiesSurvival RateTissue Array AnalysisConceptsKi67 labeling indexWell-differentiated neuroendocrine tumorsMetastatic neuroendocrine tumorsNeuroendocrine tumorsKi67 indexKi67 gradeLabeling indexOverall survivalCore biopsyPatient survivalTumor heterogeneityIntratumoral heterogeneityStatistically significant prognostic valueSurgically resected liver metastasesVirtual biopsySignificant prognostic valueKaplan-Meier survival analysisProgression-free survivalWhole slidesEffect of tumor heterogeneityDisease-free survivalGastroenteropancreatic neuroendocrine tumorsNeedle core biopsyChoice of treatmentHigher proliferative rate
1999
Downregulation of p27KIP1 and Ki67/Mib1 Labeling Index Support the Classification of Thyroid Carcinoma Into Prognostically Relevant Categories
Tallini G, Garcia-Rostan G, Herrero A, Zelterman D, Viale G, Bosari S, Carcangiu M. Downregulation of p27KIP1 and Ki67/Mib1 Labeling Index Support the Classification of Thyroid Carcinoma Into Prognostically Relevant Categories. The American Journal Of Surgical Pathology 1999, 23: 678-685. PMID: 10366150, DOI: 10.1097/00000478-199906000-00007.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinoma, FollicularAdultAgedCarcinoma, PapillaryCell Cycle ProteinsCyclin-Dependent Kinase Inhibitor p27Cyclin-Dependent KinasesDisease-Free SurvivalDown-RegulationFemaleHumansImmunoenzyme TechniquesKi-67 AntigenMaleMicrotubule-Associated ProteinsMiddle AgedPrognosisThyroid NeoplasmsTumor Suppressor ProteinsConceptsKi67/MIB1 labeling indexLow p27Kip1 expressionMIB1 labeling indexThyroid carcinomaFollicular carcinomaP27Kip1 expressionPathologic featuresPrognostic groupsTumor differentiationLabeling indexFavorable pathologic featuresKi67/MIB1Unfavorable pathologic featuresAdverse prognostic factorLarger tumor sizeFollicular cell originDownregulation of p27Kip1Valuable prognostic indicatorCellular proliferationCellular proliferation patternsCyclin-dependent kinase inhibitor p27Kip1High proliferative rateLow p27Kip1Prognostic factorsTumor sizeExpression of p-27 (kip1) in Nevi and Melanomas
Morgan M, Cowper S. Expression of p-27 (kip1) in Nevi and Melanomas. American Journal Of Dermatopathology 1999, 21: 121-124. PMID: 10218670, DOI: 10.1097/00000372-199904000-00002.Peer-Reviewed Original ResearchConceptsExpression of p27Melanocytic lesionsSpitz neviDistribution of immunoreactivityP27 labeling indexMinority of casesCell cycle inhibitory proteinsChart reviewMalignant melanocytic lesionsClinical historyDiagnostic challengeBiologic behaviorHistopathologic criteriaLabeling indexCompound neviLogistic regressionHuman neoplasmsNeviNuclear stainingLesionsMelanomaP27Inhibitory proteinAccurate distinctionSkin
1995
Genesis of the retinal pigment epithelium in the macaque monkey
Rapaport D, Rakic P, Yasamura D, LaVail M. Genesis of the retinal pigment epithelium in the macaque monkey. The Journal Of Comparative Neurology 1995, 363: 359-376. PMID: 8847405, DOI: 10.1002/cne.903630303.Peer-Reviewed Original ResearchConceptsRetinal pigment epitheliumCell genesisRPE cellsPeripheral retinaRadiolabelled cellsPigment epitheliumRhesus monkey fetusesCells/Embryonic day 25Time of birthMonkey fetusesCentral retinaPostnatal monthPostnatal periodLabeling indexDay 204Macaque monkeysDay 25RetinaJuvenile retinaOptic cupEpitheliumHigh rateNeuroretinaLast cell
1985
The Response of Psoriatic Epidermis and Microvessels to Treatment with Topical Steroids and Oral Methotrexate
Braverman I, Sibley J. The Response of Psoriatic Epidermis and Microvessels to Treatment with Topical Steroids and Oral Methotrexate. Journal Of Investigative Dermatology 1985, 85: 584-586. PMID: 4067330, DOI: 10.1111/1523-1747.ep12283604.Peer-Reviewed Original ResearchConceptsOral methotrexateTopical steroidsLabeling indexPsoriatic epidermisInitial clinical improvementPlastic wrap occlusionTopical steroid therapyBasal cellsLack of responseGoeckerman treatmentSteroid therapyClinical relapseClinical improvementPsoriatic patientsPsoriatic plaquesSuccessful therapyDermal capillariesCapillary ultrastructureMethotrexateModerate acanthosisCapillary loopsSteroidsDermal papillaTherapyMicrovessels
1982
Role of the Microcirculation in the Treatment and Pathogenesis of Psoriasis
Braverman I, Sibley J. Role of the Microcirculation in the Treatment and Pathogenesis of Psoriasis. Journal Of Investigative Dermatology 1982, 78: 12-17. PMID: 7054305, DOI: 10.1111/1523-1747.ep12497850.Peer-Reviewed Original ResearchConceptsLabeling indexCapillary loopsButtock skinPathogenesis of psoriasisNormal labeling indexUntreated patientsPsoriatic patientsPUVA treatmentSerial biopsiesVascular proliferationEpidermal hyperplasiaAbnormal capillariesPatientsPsoriasisBasal cellsCapillary growthIndividual plaquesArterial capillariesBiopsyTreatmentSkinIdentical methodsDay intervalsPsoriaticsCapillaries
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