2021
Spatial Analysis and Clinical Significance of HLA Class-I and Class-II Subunit Expression in Non–Small Cell Lung Cancer
Datar IJ, Hauc SC, Desai S, Gianino N, Henick B, Liu Y, Syrigos K, Rimm DL, Kavathas P, Ferrone S, Schalper KA. Spatial Analysis and Clinical Significance of HLA Class-I and Class-II Subunit Expression in Non–Small Cell Lung Cancer. Clinical Cancer Research 2021, 27: 2837-2847. PMID: 33602682, PMCID: PMC8734284, DOI: 10.1158/1078-0432.ccr-20-3655.Peer-Reviewed Original ResearchConceptsNon-small cell lung cancerNK cell infiltrationReduced T cellCell lung cancerHLA class IIT cellsLung cancerHLA classClinical significanceSubunit expressionHLA class II downregulationΒ2MClass IIHLA genesHuman leukocyte antigen classShorter overall survivalTumor microenvironment compositionClass II β chainImmune contextureOverall survivalLung malignancyNatural killerPatient survivalCell infiltrationClinicopathologic variables
2020
Radiologic-Pathologic Correlation for Nondiagnostic CT-Guided Lung Biopsies Performed for the Evaluation of Lung Cancer.
Ma Y, Byrne SC, Gange C, Hunsaker AR, Hammer MM. Radiologic-Pathologic Correlation for Nondiagnostic CT-Guided Lung Biopsies Performed for the Evaluation of Lung Cancer. American Journal Of Roentgenology 2020, 215: 116-120. PMID: 32160056, DOI: 10.2214/ajr.19.22244.Peer-Reviewed Original ResearchConceptsLung biopsyPathology resultsThoracic radiologistsRepeat biopsyAtypical cellsHerder modelCT-guided lung biopsyRadiologic-pathologic concordanceNormal lung tissuesCases of inflammationLung malignancyRetrospective studyFinal diagnosisLung cancerLung tissuePathologic correlationBiopsyMalignancyROC curvePneumoniaPatientsLower ratesHigh rateRadiologistsScores
2019
Expression and clinical significance of PD-L1, B7-H3, B7-H4 and TILs in human small cell lung Cancer (SCLC)
Carvajal-Hausdorf D, Altan M, Velcheti V, Gettinger SN, Herbst RS, Rimm DL, Schalper KA. Expression and clinical significance of PD-L1, B7-H3, B7-H4 and TILs in human small cell lung Cancer (SCLC). Journal For ImmunoTherapy Of Cancer 2019, 7: 65. PMID: 30850021, PMCID: PMC6408760, DOI: 10.1186/s40425-019-0540-1.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overB7 AntigensB7-H1 AntigenBiomarkers, TumorFemaleFluorescent Antibody TechniqueHumansKaplan-Meier EstimateLung NeoplasmsLymphocytes, Tumor-InfiltratingMaleMiddle AgedNeoplasm GradingNeoplasm StagingPrognosisRetrospective StudiesSmall Cell Lung CarcinomaV-Set Domain-Containing T-Cell Activation Inhibitor 1ConceptsSmall cell lung cancerCell lung cancerB7-H4B7-H3Lung cancerPD-L1Non-small cell lung cancerBackgroundSmall cell lung cancerAnti-tumor immune responseHuman small cell lung cancerQuantitative immunofluorescenceB7 family ligandsLevels of TILsMultiplexed quantitative immunofluorescenceLevels of CD3Effector T cellsImmune checkpoint blockersPromising clinical activityTissue microarray formatLymphocyte subsetsCheckpoint blockersOverall survivalLung malignancyClinicopathological variablesMarker levels
2015
Synchronous pulmonary malignancies: atypical presentation of mantle cell lymphoma masking a lung malignancy
Masha L, Zinchuk A, Boosalis V. Synchronous pulmonary malignancies: atypical presentation of mantle cell lymphoma masking a lung malignancy. Rare Tumors 2015, 7: 5929. PMID: 26500732, PMCID: PMC4600994, DOI: 10.4081/rt.2015.5929.Peer-Reviewed Case Reports and Technical NotesMantle cell lymphomaCell lymphomaAtypical presentationLarge pleural effusionAtypical epithelial cellsLung primaryLung malignancySystemic manifestationsPleural effusionPleural biopsyUndifferentiated carcinomaNew diagnosisLymphomaMalignancyEpithelial cellsPatientsPresentationChemotherapyBiopsyCarcinomaEffusionLymphocytesClonal populationsDiagnosisResection of oligometastatic lung cancer to the pancreas may yield a survival benefit in select patients – A systematic review
DeLuzio MR, Moores C, Dhamija A, Wang Z, Cha C, Boffa DJ, Detterbeck FC, Kim AW. Resection of oligometastatic lung cancer to the pancreas may yield a survival benefit in select patients – A systematic review. Pancreatology 2015, 15: 456-462. PMID: 25900320, DOI: 10.1016/j.pan.2015.03.014.Peer-Reviewed Original ResearchConceptsNon-small cell lung cancerOligometastatic lung cancerCurative-intent resectionLung cancerSystematic reviewMedian survivalSurvival benefitPancreatic metastasisPrimary lung malignancyOverall median survivalSignificant survival benefitCox regression analysisCell lung cancerMeta-Analyses (PRISMA) guidelinesPreferred Reporting ItemsSurveillance CTPalliative surgeryMetachronous presentationPancreatic headSelect patientsSurgical therapyLung malignancyKaplan-MeierPatientsReporting Items
2013
Lethality of Cardiovascular Events Highlights the Variable Impact of Complication Type Between Thoracoscopic and Open Pulmonary Lobectomies
Law TD, Boffa DJ, Detterbeck FC, Wang Z, Park HS, Kim AW. Lethality of Cardiovascular Events Highlights the Variable Impact of Complication Type Between Thoracoscopic and Open Pulmonary Lobectomies. The Annals Of Thoracic Surgery 2013, 97: 993-999. PMID: 24370204, DOI: 10.1016/j.athoracsur.2013.10.026.Peer-Reviewed Original ResearchConceptsOpen cohortNumber of complicationsVATS cohortComplication typePulmonary lobectomyUtilization Project Nationwide Inpatient Sample databaseNationwide Inpatient Sample databaseICD-9-CM codesOpen pulmonary lobectomyOpen thoracotomy approachPrimary lung malignancyPrimary lung cancerClinical Modification codesLogistic regression modelingGastrointestinal complicationsCardiovascular complicationsCardiovascular eventsPerioperative complicationsPerioperative mortalityPostoperative complicationsThoracotomy approachLung malignancyOpen lobectomyVATS lobectomyLung cancerA New Method to Predict Postoperative Lung Function: Quantitative Breath Sound Measurements
Detterbeck F, Gat M, Miller D, Force S, Chin C, Fernando H, Sonett J, Morice R. A New Method to Predict Postoperative Lung Function: Quantitative Breath Sound Measurements. The Annals Of Thoracic Surgery 2013, 95: 968-975. PMID: 23369350, DOI: 10.1016/j.athoracsur.2012.07.045.Peer-Reviewed Original ResearchConceptsPostoperative lung functionVibration response imagingLung functionLung resectionPPO valuesPostoperative pulmonary function testsPulmonary function testsRate of complicationsSingle-center studyCategorization of patientsPerfusion measurementsActual postoperative valuesRadiation-free methodRadiation-free alternativeLung malignancyLung scintigraphyFunction testsPostoperative valuesPatient assessmentRegional perfusionElevated riskPatientsLungPerfusion methodPerfusion
2009
The Emerging Role of Minimally Invasive Surgical Techniques for the Treatment of Lung Malignancy in the Elderly
Heerdt PM, Park BJ. The Emerging Role of Minimally Invasive Surgical Techniques for the Treatment of Lung Malignancy in the Elderly. Thoracic Surgery Clinics 2009, 19: 345-351. PMID: 20066946, DOI: 10.1016/j.thorsurg.2009.06.006.Peer-Reviewed Original ResearchElderly patientsLung cancerSurgical techniqueRisk/benefit relationshipPreoperative functional statusHealthy elderly patientsInvasive surgical techniquesNeoadjuvant therapyPerioperative morbidityPhysiologic reserveSurgical candidatesLung malignancyPerioperative stressConventional thoracotomyGeriatric patientsOncologic efficacyFunctional statusPopulation agesPatientsEmerging RoleCancerAgeTreatmentNormal processComorbidities
2008
The Emerging Role of Minimally Invasive Surgical Techniques for the Treatment of Lung Malignancy in the Elderly
Heerdt PM, Park BJ. The Emerging Role of Minimally Invasive Surgical Techniques for the Treatment of Lung Malignancy in the Elderly. Anesthesiology Clinics 2008, 26: 315-324. PMID: 18456216, DOI: 10.1016/j.anclin.2008.01.009.Peer-Reviewed Original ResearchConceptsPerioperative morbidityEarly-stage lung cancerVideo-assisted thoracoscopic lobectomyLung cancer surgeryInvasive operative techniquesInvasive surgical techniquesElderly patientsPulmonary resectionSurgical therapyLung malignancyPreoperative interventionSurgical treatmentCancer surgeryConventional thoracotomyOncologic efficacyThoracoscopic lobectomyGeriatric populationLung cancerAdvanced ageSurgical techniqueOperative techniqueClear associationEmerging RoleGeneral agingMorbidity
2005
Primary epithelial lung malignancies in the pediatric population
Lal D, Clark I, Shalkow J, Downey R, Shorter N, Klimstra D, La Quaglia M. Primary epithelial lung malignancies in the pediatric population. Pediatric Blood & Cancer 2005, 45: 683-686. PMID: 15714450, DOI: 10.1002/pbc.20279.Peer-Reviewed Original ResearchConceptsLung malignancyCarcinoid tumorsBasaloid carcinomaAdvanced diseaseMemorial Sloan-Kettering Cancer Center experienceTreated with multimodality therapyTreated with surgical resectionMemorial Sloan-Kettering Cancer CenterHistologic type of tumorDistant metastatic diseaseMedian follow-upFinal pathologic diagnosisPediatric age groupType of tumorProgression of diseaseYears of ageAdvanced locoregionalMetastatic diseaseMucoepidermoid carcinomaSurgical resectionLocalized diseaseMultimodal therapyBronchogenic carcinomaHistological typeMedian age
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