2025
Peroxiredoxin 6: A Regulatory Target in Cellular Senescence and Age-Related Diseases
Wang H, Zhao Y, Zhou F, Chen F, Chen T, Wang J, Liu H, Sun C, Zhou R, Hu W, Lu C. Peroxiredoxin 6: A Regulatory Target in Cellular Senescence and Age-Related Diseases. Antioxidants And Redox Signaling 2025 PMID: 40495793, DOI: 10.1089/ars.2024.0793.Peer-Reviewed Original ResearchAge-related diseasesAcidic calcium-independent phospholipase A2Cellular senescenceLysophosphatidylcholine acyltransferaseModulating cellular senescenceRegulation of redox homeostasisRegulation of cellular senescenceEnzymatic functionOxidative stressPeroxiredoxin familyPhospholipid homeostasisRegulatory targetsTreatment of age-related diseasesCalcium-independent phospholipase A2Redox homeostasisRegulatory mechanismsIntracellular regulationRedox balancePrdx6Peroxiredoxin 6Physiological functionsExpression antioxidant enzymesSenescenceSenescent cellsPeroxiredoxinAssociation of DNA damage response signals and oxidative stress status with nivolumab efficacy in patients with Head and Neck Squamous Cell Carcinoma
Papanikolaou C, Economopoulou P, Spathis A, Kotsantis I, Gavrielatou N, Anastasiou M, Moutafi M, Kyriazoglou A, Foukas G, Lelegiannis I, Rimm D, Panayiotides I, Foukas P, Souliotis V, Psyrri A. Association of DNA damage response signals and oxidative stress status with nivolumab efficacy in patients with Head and Neck Squamous Cell Carcinoma. British Journal Of Cancer 2025, 1-12. PMID: 40410274, DOI: 10.1038/s41416-025-03032-2.Peer-Reviewed Original ResearchHead and neck squamous cell carcinomaPeripheral blood mononuclear cellsNeck squamous cell carcinomaSquamous cell carcinomaCell carcinomaNon-respondersHead and neck squamous cell carcinoma patientsResponse to immune checkpoint inhibitorsRecurrent/metastatic HNSCC patientsImmune checkpoint inhibitorsResponse to nivolumabDesign of clinical trialsBlood mononuclear cellsOxidative stressDNA repair capacityNon-invasive biomarkersNivolumab efficacyNivolumab therapyNivolumab trialsCheckpoint inhibitorsHNSCC patientsOxidative stress statusMethodsOxidative stressMacrophage compartmentMononuclear cellsOxidative Stress in People Living With HIV: Are Diverse Supplement Sources the Solution?
Amegashie E, Sikeola R, Tagoe E, Paintsil E, Torpey K, Quaye O. Oxidative Stress in People Living With HIV: Are Diverse Supplement Sources the Solution? Health Science Reports 2025, 8: e70824. PMID: 40330761, PMCID: PMC12054717, DOI: 10.1002/hsr2.70824.Peer-Reviewed Original ResearchHuman immunodeficiency virusAntiretroviral therapyMemory CD4 T cell responsesCD4 T cell responsesReducing human immunodeficiency virusOxidative stressAnimal modelsAntiretroviral therapy controlsLatent HIV infectionHIV-positive smokersT cell responsesReactive oxygen speciesCell linesT cell agingOxidation protein productsLow levels of antioxidantsIncreased oxidative stressWell-being of PLWHAntioxidant levelsHIV infectionImmunodeficiency virusOxidative stress levelsImmune overactivationOxygen speciesOverproduction of reactive oxygen speciesTherapeutic Efficacy of Mesenchymal Stem Cells in Modulating Oxidative Stress in Puromycin-Induced Nephropathy
Iizuka Y, Sasaki M, Terada K, Sakai T, Nagaoka Y, Fukumura S, Kocsis J, Tsugawa T, Honmou O. Therapeutic Efficacy of Mesenchymal Stem Cells in Modulating Oxidative Stress in Puromycin-Induced Nephropathy. Pathophysiology 2025, 32: 19. PMID: 40407599, PMCID: PMC12101160, DOI: 10.3390/pathophysiology32020019.Peer-Reviewed Original ResearchMesenchymal stem cellsQuantitative real-time reverse-transcription PCRMSC infusionNephrotic syndromePAN injectionModulating oxidative stressIntravenously infused mesenchymal stem cellsIntravenous infusion of mesenchymal stem cellsInfusion of mesenchymal stem cellsStem cellsInfused mesenchymal stem cellsOxidative stressEfficacy of mesenchymal stem cellsPodocyte structureSprague-Dawley ratsGFP-labeled mesenchymal stem cellsTherapeutic efficacy of mesenchymal stem cellsOxidative stress modulationPotential therapeutic approachReal-time reverse-transcription PCRCreatinine levelsReduce proteinuriaIntravenous infusionUrinary albuminTherapeutic efficacyGene-dose effect of the glutathione biosynthesis gene on ascorbate deficiency in mice
Strand R, Orlicky D, Chen Y. Gene-dose effect of the glutathione biosynthesis gene on ascorbate deficiency in mice. Biochemical And Biophysical Research Communications 2025, 766: 151900. PMID: 40294460, PMCID: PMC12058385, DOI: 10.1016/j.bbrc.2025.151900.Peer-Reviewed Original ResearchConceptsGene-dose effectAscorbate deficiencyTissue GSH levelsDouble-knockoutVitamin CDietary vitamin CAllele dosage effectGlutamate-cysteine ligaseMiceClinical interplayGSH levelsOxidative stressBrain tissueRedox imbalanceGCLMDosage effectBrain functionDeficiencyGlutathione biosynthesis genesIncreased vulnerabilityBrainPhenotypic outcomesModifier subunitRedox balanceGSH biosynthesisArginine Therapy for Pain in Sickle Cell Disease: A Phase‐2 Randomized, Placebo‐Controlled Trial
Morris C, Hatabah D, Korman R, Gillespie S, Bakshi N, Brown L, Harris F, Leake D, Rees C, Khemani K, Vichinsky E, Locke A, Wynn B, Griffiths M, Wilkinson H, Kumari P, Sudmeier L, Shiva S, Dampier C. Arginine Therapy for Pain in Sickle Cell Disease: A Phase‐2 Randomized, Placebo‐Controlled Trial. American Journal Of Hematology 2025, 100: 1119-1131. PMID: 40270092, PMCID: PMC12148696, DOI: 10.1002/ajh.27692.Peer-Reviewed Original ResearchConceptsPlacebo-controlled trialPatient-reported outcomesArginine therapyArginine bioavailabilityPain scoresVaso-occlusive pain episodesParenteral opioid useTertiary-care children's hospitalPlasma protein carbonyl levelsDose-dependent increasePost hoc sensitivity analysisOxidative stressSickle cell diseaseMeasures of oxidative stressDecreased oxidative stressOpioid-sparingStandard-dosePlacebo groupPlacebo-controlledPatient 3Primary endpointLoading-doseOpioid usePain episodesClinical outcomesPancreatic β-cell apoptosis caused by apolipoprotein C3-rich low-density lipoprotein is attenuated by kansuinine A through oxidative stress inhibition
Lulji Taraqaz B, Hsu Y, Tsai P, Li Y, Chen F, Yang W, Shen M. Pancreatic β-cell apoptosis caused by apolipoprotein C3-rich low-density lipoprotein is attenuated by kansuinine A through oxidative stress inhibition. Biomedicine & Pharmacotherapy 2025, 187: 118066. PMID: 40262236, DOI: 10.1016/j.biopha.2025.118066.Peer-Reviewed Original ResearchConceptsB cell apoptosisRat pancreatic B-cellsLow-density lipoproteinPathway analysisSignaling pathwayOxidative stressApoptosisImproved cell viabilityRIN-m5FB cellsLectin-like oxidized low-density lipoprotein receptor-1Pancreatic B-cellsHigh-fat dietCell viabilityInsulin toleranceAntiapoptotic propertiesKansuinine AMitigated apoptosisMechanism of actionMolecular dockingStress inhibitionPathwayLow-density lipoprotein receptor-1Improved glucoseHigh-fatTestosterone, 8‐Oxo‐2′‐Deoxyguanosine (8‐OHdG) and Cu/Zn Superoxide Dismutase (SOD) in Adult Shuar Males of Amazonian Ecuador: A Test for Evidence of Trade‐Offs Between Reproductive Effort and Oxidative Stress
Bribiescas R, Sancilio A, Amir D, Cepon‐Robins T, Gildner T, Liebert M, Madimenos F, Urlacher S, Snodgrass J, Sugiyama L. Testosterone, 8‐Oxo‐2′‐Deoxyguanosine (8‐OHdG) and Cu/Zn Superoxide Dismutase (SOD) in Adult Shuar Males of Amazonian Ecuador: A Test for Evidence of Trade‐Offs Between Reproductive Effort and Oxidative Stress. American Journal Of Human Biology 2025, 37: e70042. PMID: 40231632, DOI: 10.1002/ajhb.70042.Peer-Reviewed Original ResearchConceptsReproductive effortBiomarkers of oxidative stressEvidence of trade-offsCu/Zn superoxide dismutaseAssociated with biomarkers of oxidative stressSuperoxide dismutaseOxidative stressAmazonian EcuadorPopulation of adult malesMultivariate modelUrinary 8-hydroxy-2'-deoxyguanosineLow testosterone levelsMale animal modelsAssociated with biomarkersMultiple linear regression modelMeasures of oxidative stressHuman malesNo significant correlationNon-industrialized populationsAnthropometric measurementsTestosterone levelsSomatic maintenanceAdult malesAnimal modelsTrade-offsLipid Peroxidation and Glutathione Levels Among People Living With HIV Co‐infected With Human Coronaviruses in Ghana
Amegashie E, Kwayisi‐Darkwah C, Adusei‐Poku M, Sikeola R, Ativi L, Ahene A, Atampugbire G, Tagoe E, Paintsil E, Torpey K, Quaye O. Lipid Peroxidation and Glutathione Levels Among People Living With HIV Co‐infected With Human Coronaviruses in Ghana. Journal Of Medical Virology 2025, 97: e70301. PMID: 40110873, DOI: 10.1002/jmv.70301.Peer-Reviewed Original ResearchMeSH KeywordsAdultCoinfectionCoronavirus InfectionsCross-Sectional StudiesCyclopropanesDideoxyadenosineDideoxynucleosidesFemaleGhanaGlutathioneHeterocyclic Compounds, 3-RingHIV InfectionsHumansLipid PeroxidationMaleMalondialdehydeMiddle AgedOxazinesOxidative StressPiperazinesProspective StudiesPyridonesYoung AdultConceptsHuman immunodeficiency virusHuman immunodeficiency virus co-infectionCo-infectionGSH levelsART-experienced individualsPLWH co-infectedHuman coronavirusesHIV co-infectionHIV-negative individualsMalondialdehyde levelsOxidative stressOxidative stress markersIncreased MDA levelsCross-sectional studyOro-pharyngeal swabsImmunodeficiency virusGhanaian patientsMono-infectionReduced GSH levelsTreatment strategiesPlasma samplesDisease severityMDA levelsStress markersTailored monitoringA positron emission tomography tracer for the imaging of oxidative stress in the central nervous system
Wilde J, Sun Y, Simpson S, Hill E, Fu Z, Bian E, Kinkaid M, Villanueva P, Weybright A, Terrell W, Qureshi Z, Perera S, Sheppard H, Stone J, Kundu B, Kuan C, Neumann K. A positron emission tomography tracer for the imaging of oxidative stress in the central nervous system. Nature Biomedical Engineering 2025, 9: 716-729. PMID: 40044816, PMCID: PMC12092265, DOI: 10.1038/s41551-025-01362-3.Peer-Reviewed Original ResearchCentral nervous systemPositron emission tomographyInjection of sodium nitroprussideOxidative stressNervous systemClinical trials of antioxidantsMiddle cerebral arteryBlood-brain barrierTrials of antioxidantsPositron emission tomography tracersIntrastriatal injectionParametric mappingSodium nitroprussideCerebral arteryLongitudinally in vivoIn vivo quantificationQuantification of oxidative stressEmission tomographyPET imagingAntioxidant edaravoneDynamic PET imagesHuman plasmaDSP-1, the major fibronectin type-II protein of donkey seminal plasma is a small heat-shock protein and exhibits chaperone-like activity against thermal and oxidative stress
Alim S, Cheppali S, Pawar S, Swamy M. DSP-1, the major fibronectin type-II protein of donkey seminal plasma is a small heat-shock protein and exhibits chaperone-like activity against thermal and oxidative stress. Biochimica Et Biophysica Acta (BBA) - Proteins And Proteomics 2025, 1873: 141064. PMID: 39956303, DOI: 10.1016/j.bbapap.2025.141064.Peer-Reviewed Original ResearchConceptsChaperone-like activitySeminal plasmaFibronectin type IITetramer to monomersSperm capacitationSurface hydrophobicityMolecular chaperonesClient proteinsHeat shock proteinsBiophysical studiesAlcohol dehydrogenaseOxidative stressPhysiological ligandsShock proteinsProteinHead group moietySHspsBinding of phosphorylcholineCholine phospholipidsBindingFibronectinDehydrogenaseChaperoneSpermMammalsProtection against Amyloid‑β Aggregation and Ferroptosis/Oxytosis Toxicity by Arylpyrazolones: Alzheimer’s Disease Therapeutics
Soares P, Rahaman M, Maher P, Silverman R. Protection against Amyloid‑β Aggregation and Ferroptosis/Oxytosis Toxicity by Arylpyrazolones: Alzheimer’s Disease Therapeutics. ACS Medicinal Chemistry Letters 2025, 16: 294-300. PMID: 39967645, PMCID: PMC11831554, DOI: 10.1021/acsmedchemlett.4c00530.Peer-Reviewed Original ResearchPredictive and monitoring value of blood‐based biomarkers for apathy treatment in Alzheimer’s disease
Lanctôt K, Tumati S, Vieira D, Bawa K, Andreazza A, Scherer R, Rosenberg P, van Dyck C, Padala P, Brawman‐Mintzer O, Porsteinsson A, Lerner A, Craft S, Levey A, Burke W, Perin J, Shade D, Mintzer J, Herrmann N. Predictive and monitoring value of blood‐based biomarkers for apathy treatment in Alzheimer’s disease. Alzheimer's & Dementia 2025, 20: e095596. PMCID: PMC11712725, DOI: 10.1002/alz.095596.Peer-Reviewed Original ResearchTreatment responseBlood-based biomarkersBlood-based biomarkers of neurodegenerationNPI-aClinical predictorsAlzheimer's diseaseClinical predictors of responsePredictive value of biomarkersTumor necrosis factor-alphaOxidative stressNeurofilament lightAffecting treatment responsePredictors of responseNecrosis factor-alphaBiomarkers of neurodegenerationInterleukin (IL)-6Treatment response predictionMonths end pointAssociated with apathyValue of biomarkersNeuropsychiatric Inventory apathy subscalePresence of anxietyPeripheral inflammation
2024
Afamin Ameliorates Testosterone Propionate (TP)-Induced Oxidative Stress and Mitochondrial Damage in Human Ovarian Granulosa Tumor Cells (KGN) by Upregulating the Expression of SIRT1
Ma Y, Li Z, Wang Z, Yang A. Afamin Ameliorates Testosterone Propionate (TP)-Induced Oxidative Stress and Mitochondrial Damage in Human Ovarian Granulosa Tumor Cells (KGN) by Upregulating the Expression of SIRT1. Molecular Biology 2024, 58: 1250-1267. DOI: 10.1134/s0026893324060074.Peer-Reviewed Original ResearchPCOS micePolycystic ovary syndromeGranulosa tumor cellsLuteinizing hormoneTumor cellsKGN cellsTestosterone propionateDevelopment of metabolic syndromeOxidative stressWomen of reproductive ageLevels of afaminExpression of SIRT1Reactive oxygen speciesLH/follicle-stimulating hormonePolycystic ovary syndrome patientsEndocrine disorder affecting women of reproductive ageMitochondrial damageLevels of 8-hydroxydeoxyguanosineEndocrine disorder affecting womenTreatment of polycystic ovary syndromeMetabolic syndromeReproductive ageCystic folliclesEstrous cycleTP-induced oxidative stressIntracellular endothelial cell metabolism in vascular function and dysfunction
Citrin K, Chaube B, Fernández-Hernando C, Suárez Y. Intracellular endothelial cell metabolism in vascular function and dysfunction. Trends In Endocrinology And Metabolism 2024 PMID: 39672762, PMCID: PMC12159263, DOI: 10.1016/j.tem.2024.11.004.Peer-Reviewed Original ResearchFatty acid oxidationEndothelial cellsIntracellular metabolic pathwaysInner lining of blood vesselsVascular functionCell metabolismMetabolic pathwaysEndothelial cell metabolismLipid handlingDesign new therapiesRegulate vascular toneInfluence disease progressionAcid oxidationMetabolic signaturesVascular toneNew therapiesLining of blood vesselsDisease progressionLeukocyte adhesionMetabolic changesVascular diseaseOxidative stressBlood vesselsIncreased permeabilityWound healingUnderstanding the significance of oxygen tension on the biology of Plasmodium falciparum blood stages: From the human body to the laboratory
Nahid D, Coffey K, Bei A, Cordy R. Understanding the significance of oxygen tension on the biology of Plasmodium falciparum blood stages: From the human body to the laboratory. PLOS Pathogens 2024, 20: e1012514. PMID: 39298535, PMCID: PMC11412506, DOI: 10.1371/journal.ppat.1012514.Peer-Reviewed Original ResearchConceptsRed blood cellsIntraerythrocytic developmentReactive oxygen speciesPlasmodium falciparum blood stagesMultiple organ systemsP. falciparum mitochondrionStatus of hemoglobinBlood stagesPlasmodium falciparumReactive oxygen species productionO2-sensing mechanismIn vitro experimentsPlasmodiumBlood cellsOxygenation statusOrgan systemsFunctional changesParasite growthOxidative stressOxygen tensionMosquito hostCulture systemDeep tissuesOxygen speciesCYP2E1 in 1,4-dioxane metabolism and liver toxicity: insights from CYP2E1 knockout mice study
Wang Y, Charkoftaki G, Orlicky D, Davidson E, Aalizadeh R, Sun N, Ginsberg G, Thompson D, Vasiliou V, Chen Y. CYP2E1 in 1,4-dioxane metabolism and liver toxicity: insights from CYP2E1 knockout mice study. Archives Of Toxicology 2024, 98: 3241-3257. PMID: 39192018, PMCID: PMC11500436, DOI: 10.1007/s00204-024-03811-5.Peer-Reviewed Original ResearchCYP2E1-null miceLiver toxicityDrinking waterOxidative DNA damageLiver carcinogenAbstract1,4-DioxaneDNA damage repair responseImpaired DNA damage repairWater contaminationOxidative stressElevated oxidative stressEnvironmental pollutionKnockout mouse studiesDamage repair responseCYP2E1-nullMale wildtypeWT miceDNA damageDX exposureRisk assessmentRedox dysregulationCYP2E1 inductionLiver oxidative stressHigh dosesMouse studiesGlutathione synthesis in the mouse liver supports lipid abundance through NRF2 repression
Asantewaa G, Tuttle E, Ward N, Kang Y, Kim Y, Kavanagh M, Girnius N, Chen Y, Rodriguez K, Hecht F, Zocchi M, Smorodintsev-Schiller L, Scales T, Taylor K, Alimohammadi F, Duncan R, Sechrist Z, Agostini-Vulaj D, Schafer X, Chang H, Smith Z, O’Connor T, Whelan S, Selfors L, Crowdis J, Gray G, Bronson R, Brenner D, Rufini A, Dirksen R, Hezel A, Huber A, Munger J, Cravatt B, Vasiliou V, Cole C, DeNicola G, Harris I. Glutathione synthesis in the mouse liver supports lipid abundance through NRF2 repression. Nature Communications 2024, 15: 6152. PMID: 39034312, PMCID: PMC11271484, DOI: 10.1038/s41467-024-50454-2.Peer-Reviewed Original ResearchConceptsGlutamate-cysteine ligase catalytic subunitLipid abundanceLipogenic enzyme expressionAbundance in vivoLipid productionCatalytic subunitRepress Nrf2Transcription factorsNrf2 repressionAdult tissuesSynthesis of GSHEnzyme expressionNon-redundantRedox bufferMouse liverLoss of GSHTriglyceride productionIn vivo modelsAbundanceGlutathione synthesisLiver balanceFat storesOxidative stressLipidDeletionO-077 EXPOSOME CHARACTERIZATION OF DIESEL ENGINE EXHAUST EXPOSURE
Lan Q, Vermeulen R, Rahman M, Dai Y, Hu W, Irving B, Lin X, Blechter B, Chaoyang D, Duan H, Wong J, Niu Y, Xu J, Chaoyang W, Meliefste K, Hosgood D, Ye M, Jia X, Meng T, Bin P, Silverman D, Zheng Y, Rothman N, Walker D. O-077 EXPOSOME CHARACTERIZATION OF DIESEL ENGINE EXHAUST EXPOSURE. Occupational Medicine 2024, 74: 0-0. DOI: 10.1093/occmed/kqae023.0598.Peer-Reviewed Original ResearchMetabolome-wide association studyAssociated with increased lung cancer riskHigh-resolution mass spectrometryAssociated with tumor developmentLung cancer riskMetabolic pathway enrichmentMolecular mechanismsTumor developmentCancer riskUrine mutagenicityEndothelial pathwaysUrinary mutagenicityLC-HRMSPlasma samplesMetabolic featuresGene expression analysisPlasma proteomePotential molecular mechanismsUntargeted analysisBiological alterationsMolecular featuresOxidative stressGenome-wide gene expressionBiological response profilesResponse profilesO-083 A METABOLOME-WIDE ASSOCIATION STUDY OF OCCUPATIONAL EXPOSURE TO FORMALDEHYDE
Rothman N, Lin X, Vermeulen R, Zhang L, Pinto-Pacheco B, Tang X, Hu W, Jones D, Guo W, Wen C, Huang Y, Reiss B, Guangdong L, Rappaport S, Smith M, Lan Q, Walker D. O-083 A METABOLOME-WIDE ASSOCIATION STUDY OF OCCUPATIONAL EXPOSURE TO FORMALDEHYDE. Occupational Medicine 2024, 74: 0-0. DOI: 10.1093/occmed/kqae023.0604.Peer-Reviewed Original ResearchEffects of exposure to FAFA exposureImmune system disordersSystemic metabolic processesAssociated with alterationsUntargeted liquid chromatographyPlasma metabolomeMetabolic pathway enrichment analysisNasopharyngeal cancerProstaglandin metabolismOccupational exposure to formaldehydeSystem disordersHuman studiesFatty acid uptakeOccupational exposureArachidonic acidCell proliferationExposure to FAOxidative stressCarnitine shuttleAcid uptakeMitochondrial dysfunctionBiological effectsExposure to formaldehydeAssociation studies
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