2023
1901. High Prevalence of Latent Tuberculosis Infection in a Malaysian Prison
Zhang L, Shenoi S, Kamarulzaman A, Dhaliwal S, Ahmad A, Altice F. 1901. High Prevalence of Latent Tuberculosis Infection in a Malaysian Prison. Open Forum Infectious Diseases 2023, 10: ofad500.1729. PMCID: PMC10677608, DOI: 10.1093/ofid/ofad500.1729.Peer-Reviewed Original ResearchLatent tuberculosis infectionPrevalence of LTBIRisk of LTBITB preventive therapyIndependent risk factorTuberculin skin testC-reactive proteinActive TBPreventive therapyTuberculosis infectionRisk factorsHigh prevalenceMultivariable logistic regressionOpioid use disorderRisk of hepatotoxicityChest X-rayDrug use historyPaucity of dataLTBI treatmentHCV infectionHepatitis CHepatitis BMedian ageBlood testsSkin testPassive transfer of alloantibodies through breast milk as a mediator of hemolytic anemia
Abels E, Jacobs J, Prior D, Willets L, Sostin N, Tormey C, Binns T. Passive transfer of alloantibodies through breast milk as a mediator of hemolytic anemia. Transfusion 2023, 63: 2188-2196. PMID: 37706556, DOI: 10.1111/trf.17548.Peer-Reviewed Original ResearchConceptsMaternal breast milkBreast milkNeonatal circulationRed blood cellsPassive transferAntiviral IgG antibodiesResolution of anemiaPaucity of dataNeonatal red blood cellsIntravenous immunoglobulinMaternal alloantibodiesMaternal antibodiesPlacental transferRBC antibodiesIgG antibodiesHemolytic diseaseHemolytic anemiaPlasma titersAlloantibodiesHDFNBlood cellsAntibodiesSignificant decreasePatientsAnemiaInsight Into the Optimal Timing of Percutaneous Coronary Intervention and Transcatheter Aortic Valve Replacement
Park D, Simonato M, Ahmad Y, Banks A, Lowenstern A, Nanna M. Insight Into the Optimal Timing of Percutaneous Coronary Intervention and Transcatheter Aortic Valve Replacement. Current Problems In Cardiology 2023, 49: 102050. PMID: 37643698, PMCID: PMC10924682, DOI: 10.1016/j.cpcardiol.2023.102050.Peer-Reviewed Original ResearchTranscatheter aortic valve replacementPercutaneous coronary artery interventionAcute kidney injuryAortic valve replacementKidney injuryValve replacementPercutaneous coronary interventionCoronary artery diseaseCoronary artery interventionPaucity of dataHospital mortalityNonhome dischargeCoronary interventionSecondary outcomesSelect patientsArtery diseaseArtery interventionClinical outcomesHigher oddsPCI timingPatientsReadmissionOptimal timingSame daySignificant differencesBurden of bone disease in chronic pancreatitis: A systematic review and meta-analysis
Chhoda A, Hernandez-Woodbine M, Addo N, Nasir S, Grimshaw A, Gunderson C, Ahmed A, Freedman S, Sheth S. Burden of bone disease in chronic pancreatitis: A systematic review and meta-analysis. World Journal Of Gastroenterology 2023, 29: 1374-1394. PMID: 36925454, PMCID: PMC10011962, DOI: 10.3748/wjg.v29.i8.1374.Peer-Reviewed Original ResearchConceptsPrevalence of osteopeniaChronic pancreatitisFragility fracturesBone diseaseCP patientsClinical featuresPooled prevalenceSystematic reviewBaseline clinical featuresSignificant bone diseasePrevalence of osteoporosisBody mass indexCause of morbidityBone mineralization parametersRandom-effects modelPaucity of dataWeb of SciencePERT useSmoking exposureSystemic inflammationTherapy useMass indexTrue burdenCochrane LibraryMean ageFirst nosocomial infections in children supported by veno-arterial extracorporeal membrane oxygenation (VA-ECMO)
Cousin V, Rodriguez-Vigouroux R, Karam O, Rimensberger P, Posfay-Barbe K. First nosocomial infections in children supported by veno-arterial extracorporeal membrane oxygenation (VA-ECMO). BMC Pediatrics 2023, 23: 89. PMID: 36823601, PMCID: PMC9948414, DOI: 10.1186/s12887-023-03908-3.Peer-Reviewed Original ResearchConceptsVA-ECMO supportPediatric intensive care unitMedian timeClinical signsMedian PICU LOSNosocomial infection occurrenceUrinary tract infectionVentilator-associated pneumoniaExtracorporeal membrane oxygenationIntensive care unitPaucity of dataPICU lengthPICU LOSRefractory shockVA-ECMOTract infectionsMedian ageMembrane oxygenationSternotomy infectionsCare unitRetrospective studySevere infectionsFirst infectionMortality rateInfection occurrence
2022
The effect of social determinants of health on utilization of surgical treatment for hepatocellular carcinoma patients
Murthy S, Ortiz A, DuBois T, Sorice K, Nguyen M, Castellanos J, Pinheiro P, Gonzalez E, Lynch S. The effect of social determinants of health on utilization of surgical treatment for hepatocellular carcinoma patients. The American Journal Of Surgery 2022, 225: 715-723. PMID: 36344305, DOI: 10.1016/j.amjsurg.2022.10.011.Peer-Reviewed Original ResearchConceptsStage I patientsHepatocellular carcinomaI patientsSocial determinantsOdds of surgeryReceipt of surgeryHepatocellular carcinoma patientsMultilevel logistic regression modelsPaucity of dataLogistic regression modelsCarcinoma patientsSurgical treatmentBlack patientsCancer RegistryCancer outcomesHCC patientsSDOH domainsSDoH variablesInfluence treatmentLower oddsPatientsSurgeryHealthcare professionalsSDOHInsurance accessCoronary Orbital Atherectomy in Patients With Severe Aortic Stenosis.
Donatelle M, Agasthi P, Parise H, Igyarto Z, Martinsen B, Leon M, Beohar N. Coronary Orbital Atherectomy in Patients With Severe Aortic Stenosis. Journal Of Invasive Cardiology 2022, 34: e696-e700. PMID: 36200995, DOI: 10.25270/jic/22.00066.Peer-Reviewed Original ResearchConceptsSevere aortic stenosisNon-AS cohortAortic stenosisNon-AS patientsSuccessful stent placementOrbital atherectomyStent placementOA useHospital major adverse cardiovascular eventsSevere calcific coronary artery diseaseCalcific coronary artery diseaseConcomitant severe aortic stenosisMajor adverse cardiovascular eventsCoronary orbital atherectomyIdeal revascularization strategyAdverse cardiovascular eventsMount Sinai Medical CenterProspective randomized trialsGlomerular filtration rateCoronary artery diseaseSinai Medical CenterPaucity of dataAngiographic complicationsMACE rateCardiovascular eventsSurgical Management of Tibialis Anterior Tendon Ruptures: A Systematic Review and Proposed Treatment Algorithm
Weiss M, Azam M, Ubillus H, Gianakos A, Kirschner N, Walls R, Kennedy J. Surgical Management of Tibialis Anterior Tendon Ruptures: A Systematic Review and Proposed Treatment Algorithm. Foot & Ankle Orthopaedics 2022, 7: 2473011421s01000. PMCID: PMC9703547, DOI: 10.1177/2473011421s01000.Peer-Reviewed Original ResearchTibialis anterior tendonAppropriate surgical treatmentSurgical treatmentSystematic reviewSurgical managementTreatment algorithmSurgical interventionDirect repairTibialis Anterior Tendon RuptureAnkle-hindfoot scoreLevel II evidenceFunctional outcome scoresBetter clinical outcomesDifferent surgical interventionsQuality of evidenceLevel of evidenceMeta-Analyses (PRISMA) guidelinesPreferred Reporting ItemsPaucity of dataTwo-sample t-testAllograft cohortPostoperative AOFASSurgery criteriaTendon ruptureAnterior tendonElevated tacrolimus levels after treatment with nirmatrelvir/ritonavir (Paxlovid) for COVID-19 infection in a child with a kidney transplant
Young C, Papiro T, Greenberg JH. Elevated tacrolimus levels after treatment with nirmatrelvir/ritonavir (Paxlovid) for COVID-19 infection in a child with a kidney transplant. Pediatric Nephrology 2022, 38: 1-2. PMID: 35982345, PMCID: PMC9388350, DOI: 10.1007/s00467-022-05712-0.Peer-Reviewed Original ResearchConceptsCOVID-19 infectionSupratherapeutic tacrolimus levelsTacrolimus levelsKidney transplantCase reportPediatric kidney transplant recipientsElevated tacrolimus levelsKidney transplant recipientsPotent CYP3A4 inhibitorEmergency use authorizationDrug-drug interactionsPaucity of dataCytochrome P450 systemImmunosuppressant medicationsTransplant recipientsSerum creatininePediatric patientsCalcineurin inhibitorsKidney functionCYP3A4 inhibitorsConcomitant useTacrolimusTherapeutic goalsRitonavirDrug AdministrationHigh rates of macrolide and fluoroquinolone resistance in human campylobacteriosis in the Middle East and North Africa
Dabbousi A, Osman M, Dabboussi F, Hamze M. High rates of macrolide and fluoroquinolone resistance in human campylobacteriosis in the Middle East and North Africa. Future Microbiology 2022, 17: 957-967. PMID: 35796073, DOI: 10.2217/fmb-2021-0302.Peer-Reviewed Original ResearchConceptsHuman campylobacteriosisRoutine stool cultureBacterial gastrointestinal infectionsClinical laboratoriesIncidence of campylobacteriosisPaucity of dataMain causative agentStool culturesGastrointestinal infectionsDiarrheal patientsMicrobiological diagnosisClinical importanceFluoroquinolone resistanceInfection prevalenceAntimicrobial resistanceZoonotic diseaseCausative agentCampylobacteriosisHigh rateAlarming ratePatientsCritical needEpidemiologyInfectionPrevalenceCytomegalovirus-related Complications and Management in Facial Vascularized Composite Allotransplantation: An International Multicenter Retrospective Cohort Study
Kauke-Navarro M, Panayi AC, Formica R, Marty F, Parikh N, Foroutanjazi S, Safi AF, Mardini S, Razonable RR, Morelon E, Gelb B, Rodriguez E, Lassus P, Pomahac B. Cytomegalovirus-related Complications and Management in Facial Vascularized Composite Allotransplantation: An International Multicenter Retrospective Cohort Study. Transplantation 2022, 106: 2031-2043. PMID: 35389381, DOI: 10.1097/tp.0000000000004132.Peer-Reviewed Original ResearchConceptsRetrospective cohort studyAntiviral prophylaxisCohort studyComposite allotransplantationInternational multicenter retrospective cohort studyMulticenter retrospective cohort studyCMV-related complicationsFirst year posttransplantHigh-risk transplantsMore rejection episodesHigh-risk groupFacial Vascularized Composite AllotransplantationAllograft-related complicationsVascularized Composite AllotransplantationPaucity of dataAllograft lossCMV diseaseCMV viremiaCytomegalovirus serostatusR serostatusRejection episodesCMV infectionPrompt treatmentActive surveillancePatients134 Racial Disparities in Healthcare Resource Utilization After Pediatric Cervical and/or Thoracic Spinal Injuries: Is it Black and White?
Elsamadicy A, Sandhu M, Freedman I, Koo A, Hengartner A, Reeves B, Havlik J, Sarkozy M, Kundishora A, Tuason D, DiLuna M. 134 Racial Disparities in Healthcare Resource Utilization After Pediatric Cervical and/or Thoracic Spinal Injuries: Is it Black and White? Neurosurgery 2022, 68: 39-39. DOI: 10.1227/neu.0000000000001880_134.Peer-Reviewed Original ResearchHealthcare resource utilizationAfrican American patientsMultivariate regression analysisAfrican American cohortHospital complicationsHospital LOSComplication ratePediatric patientsSpinal traumaRacial disparitiesGreater prevalenceLogistic multivariate regression analysisLength of ICUOverall complication rateThoracic spine injuriesAfrican American raceDiagnosis coding systemRegression analysisThoracic spinal injuryPaucity of dataAfrican American/BlackUnited States healthcare systemICU LOSHospital stayInjury presentations356 Patient-and-Hospital-Related Risk Factors for Non-Routine Discharge After Lumbar Decompression and Fusion for Spondylolisthesis
Elsamadicy A, Freedman I, Koo A, David W, Hengartner A, Havlik J, Hersh A, Pennington Z, Kolb L, Laurans M, Shin J, Sciubba D. 356 Patient-and-Hospital-Related Risk Factors for Non-Routine Discharge After Lumbar Decompression and Fusion for Spondylolisthesis. Neurosurgery 2022, 68: 84-84. DOI: 10.1227/neu.0000000000001880_356.Peer-Reviewed Original ResearchNon-routine dischargeSurgeons National Surgical Quality Improvement Program databaseNational Surgical Quality Improvement Program databaseNon-Hispanic black race/ethnicityQuality Improvement Program databaseICD-9-CM diagnosisBlack race/ethnicityMultivariate logistic regression modelDependent functional statusImprovement Program databaseRetrospective cohort studyProcedural Coding SystemQuality of careMultivariate regression analysisPaucity of dataLogistic regression modelsRace/ethnicityUnplanned readmissionCohort studyDischarge dispositionReadmission ratesAdult patientsAdverse eventsIndependent predictorsLonger LOSAssociation of intra-tumoral microbiome and response to immune checkpoint inhibitors (ICIs) in patients with metastatic renal cell carcinoma (mRCC).
Meza L, Choi Y, Govindarajan A, Dizman N, Zengin Z, Hsu J, Salgia N, Salgia S, Malhotra J, Chawla N, Chehrazi-Raffle A, Muddasani R, Castro D, Chan A, Zhang G, Byron S, Highlander S, Schork N, Pal S. Association of intra-tumoral microbiome and response to immune checkpoint inhibitors (ICIs) in patients with metastatic renal cell carcinoma (mRCC). Journal Of Clinical Oncology 2022, 40: 372-372. DOI: 10.1200/jco.2022.40.6_suppl.372.Peer-Reviewed Original ResearchMetastatic renal cell carcinomaImmune checkpoint inhibitorsClear cell histologyFirst-line treatmentRoutine clinical careRenal cell carcinomaT-testPaucity of dataStudent's t-testParaffin-embedded samplesICI respondersICI therapyCheckpoint inhibitorsCell histologyClinical responseOverall cohortLine treatmentImmunotherapeutic agentsCell carcinomaPoor riskSpecific bacteriaLarge cohortClinical careICI activityPrimary site
2021
Distribution of the workforce involved in cancer care: a systematic review of the literature ☆
Trapani D, Murthy S, Boniol M, Booth C, Simensen V, Kasumba M, Giuliani R, Curigliano G, Ilbawi A. Distribution of the workforce involved in cancer care: a systematic review of the literature ☆. ESMO Open 2021, 6: 100292. PMID: 34763251, PMCID: PMC8591344, DOI: 10.1016/j.esmoop.2021.100292.Peer-Reviewed Original ResearchConceptsCancer careSystematic reviewHigh-income countriesHealth providersMultidisciplinary cancer careMultidisciplinary cancer managementSkilled health workforceCross-sectional surveyPaucity of dataHealth care workforcePaucity of literatureFirst systematic reviewCancer nursesCancer patientsPediatric oncologySurgical oncologyHealth workersWorkforce densityCancer managementEligible papersCancer workforceHealth workforceHealth systemCare workforceWorkforce capacityRamifications of Postoperative Dysphagia on Health Care Resource Utilization Following Elective Anterior Cervical Discectomy and Interbody Fusion for Cervical Spondylotic Myelopathy
Elsamadicy AA, Koo AB, David WB, Freedman IG, Reeves BC, Ehresman J, Pennington Z, Sarkozy M, Laurans M, Kolb L, Shin JH, Sciubba DM. Ramifications of Postoperative Dysphagia on Health Care Resource Utilization Following Elective Anterior Cervical Discectomy and Interbody Fusion for Cervical Spondylotic Myelopathy. Clinical Spine Surgery A Spine Publication 2021, 35: e380-e388. PMID: 34321392, DOI: 10.1097/bsd.0000000000001241.Peer-Reviewed Original ResearchConceptsHealth care resource utilizationCervical spondylotic myelopathyElective anterior cervical discectomyPostoperative dysphagiaRetrospective cohort studyAnterior cervical discectomySpondylotic myelopathyNonroutine dischargeHospital stayCervical discectomyCohort studyRisk factorsOdds ratioHigher total costsICD-10-CM diagnosisSignificant independent risk factorsNationwide Inpatient Sample databaseMultivariate stepwise logistic regressionLonger hospital LOSLonger hospital stayIndependent risk factorPatient risk factorsStepwise logistic regressionPaucity of dataHospital LOSIncarceration and Cancer-Related Outcomes (ICRO) study protocol: using a mixed-methods approach to investigate the role of incarceration on cancer incidence, mortality and quality of care
Puglisi L, Halberstam AA, Aminawung J, Gallagher C, Gonsalves L, Schulman-Green D, Lin HJ, Metha R, Mun S, Oladeru OT, Gross C, Wang EA. Incarceration and Cancer-Related Outcomes (ICRO) study protocol: using a mixed-methods approach to investigate the role of incarceration on cancer incidence, mortality and quality of care. BMJ Open 2021, 11: e048863. PMID: 34035109, PMCID: PMC8154989, DOI: 10.1136/bmjopen-2021-048863.Peer-Reviewed Original ResearchConceptsQuality of careCancer careCancer incidenceSequential explanatory mixed-methods study designCancer screening ratesConnecticut Tumor RegistrySocioeconomic statusMultivariable logistic regressionExplanatory mixed-methods study designCox survival modelsConnecticut DepartmentHuman Investigation CommitteePaucity of dataInstitutional review boardUniversity Institutional Review BoardMixed-methods study designTumor RegistryScreening ratesCancer mortalityInvasive cancerCancer outcomesCancer disparitiesStudy protocolHigh riskOutcome studiesIntracranial Complications From Immune Checkpoint Therapy in a Patient With NSCLC and Multiple Sclerosis: Case Report
Lu BY, Isitan C, Mahajan A, Chiang V, Huttner A, Mitzner JR, Wesley SF, Goldberg SB. Intracranial Complications From Immune Checkpoint Therapy in a Patient With NSCLC and Multiple Sclerosis: Case Report. JTO Clinical And Research Reports 2021, 2: 100183. PMID: 34590030, PMCID: PMC8474265, DOI: 10.1016/j.jtocrr.2021.100183.Peer-Reviewed Case Reports and Technical NotesImmune checkpoint inhibitorsMultiple sclerosisRadiation necrosisBrain lesionsWhole-brain radiation therapyImmune checkpoint therapyViable tumor cellsPaucity of dataBrain metastasesCheckpoint inhibitorsMetastatic NSCLCAdverse eventsCheckpoint therapyDurable responsesNeurologic declineRadiographic benefitIntracranial complicationsPathologic findingsAutoimmune disordersAutoimmune diseasesCase reportIntracranial diseaseRadiation therapyStereotactic radiosurgeryAnticancer benefitsRacial disparities in the survival of patients with indolent non‐Hodgkin lymphomas in the United States
Vaughn J, Spies D, Xavier A, Epperla N. Racial disparities in the survival of patients with indolent non‐Hodgkin lymphomas in the United States. American Journal Of Hematology 2021, 96: 816-822. PMID: 33864695, DOI: 10.1002/ajh.26198.Peer-Reviewed Original ResearchConceptsIndolent non-Hodgkin lymphomaSurvival of patientsHighest excess mortality ratesYoung black patientsBlack patientsNon-Hodgkin lymphomaExcess mortality ratesRelative survivalWhite patientsRacial disparitiesMortality rateExcess deathsLymphoplasmacytic lymphoma/Waldenström macroglobulinemiaFlexible parametric survival modelsAmerican Indians/Alaska NativesMarginal zone lymphomaAsian/Pacific IslandersSignificant racial differencesPaucity of dataAdult patientsDisease histologyPrimary outcomeParametric survival modelsMultivariable analysisWaldenström's macroglobulinemiaEvaluation of head and neck soft tissue sarcoma 8th edition pathologic staging system and proposal of a novel stage grouping system
Lee NCJ, Eskander A, Miccio JA, Park HS, Shah C, Rutenberg M, Hosni A, Husain ZA. Evaluation of head and neck soft tissue sarcoma 8th edition pathologic staging system and proposal of a novel stage grouping system. Oral Oncology 2021, 114: 105137. PMID: 33422859, DOI: 10.1016/j.oraloncology.2020.105137.Peer-Reviewed Original ResearchConceptsNeck soft tissue sarcomasTumor size cutNational Cancer DatabaseSoft tissue sarcomasMultivariable analysisTissue sarcomasFive-year overall survivalNeoadjuvant therapy patientsT1-3 tumorsEnd Results (SEER) databaseAdjacent structuresEvaluation of headPaucity of dataNCDB cohortSEER cohortPrimary surgeryOverall survivalWorsened survivalAdverse prognosticatorPrognostic differencesResults databaseStaging systemT4 classificationTumor stageCancer Database
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