2025
Role of non-human primate models in accelerating research and developing countermeasures against Zika virus infection
Li A, Coffey L, Mohr E, Raper J, Chahroudi A, Ausderau K, Aliota M, Friedrich T, Mitzey A, Koenig M, Golos T, Jaeger H, Roberts V, Lo J, Smith J, Hirsch A, Streblow D, Newman C, O’Connor D, Lackritz E, Van Rompay K, Waldorf K, Workgroup Z, Waldorf K, Barrett A, Beasley D, Bennie J, Bourne N, Brault A, Cehovin A, Coelho C, Diamond M, Emperador D, Faria N, Fay P, Golding J, Harris E, Hasanin N, Jaenisch T, Ko A, Lackritz E, Leighton T, Leo Y, Mehr A, Memish Z, Méndez-Rico J, Moore K, Mura M, Ng L, Osterholm M, Ostrowsky J, Peeling R, Rabe I, Salje H, Staples J, Thomas S, Ulrich A, Vanhomwegen J, Wongsawat J. Role of non-human primate models in accelerating research and developing countermeasures against Zika virus infection. The Lancet Microbe 2025, 101030. PMID: 40024258, DOI: 10.1016/j.lanmic.2024.101030.Peer-Reviewed Original ResearchNon-human primate modelZika virus infectionZika virus researchPrimate modelVirus infectionCases of congenital microcephalyFetal brain injuryLaboratory-confirmed casesGestational ageZika virus strainsBrain injuryPerinatal complicationsZika virus epidemicTesting medical countermeasuresCongenital microcephalyGlobal health concernVirus researchDevelopmental abnormalitiesZika virusVirus strainsMedical countermeasuresCongenital brain injuryInfectionZikaVirus epidemicAssociations among rearing environment and the infant gut microbiome with early-life neurodevelopment and cognitive development in a nonhuman primate model (Macaca mulatta)
Daiy K, Wiley K, Allen J, Bailey M, Dettmer A. Associations among rearing environment and the infant gut microbiome with early-life neurodevelopment and cognitive development in a nonhuman primate model (Macaca mulatta). Journal Of Developmental Origins Of Health And Disease 2025, 16: e1. PMID: 39781670, PMCID: PMC11731890, DOI: 10.1017/s2040174424000400.Peer-Reviewed Original ResearchConceptsMother-peer-rearedNursery-rearedEmotional responsesInfant gut microbiomeCognitive developmentGut microbiomeNonhuman primate modelInfant emotional responsivenessLow emotional responsivenessInfant rhesus monkeysNeonatal neurobehavioral assessmentGut microbiome alpha diversityReward associationsCognitive flexibilityPattern of microbial compositionGut microbiome developmentPrimate modelCognitive functionImpact brainDifferential abundance analysisMicrobiome alpha diversityBehavioral developmentMotor maturityVisual orientationFactor analysis
2023
Interrogating the Etiology of Sporadic Alzheimer’s Disease Using Aging Rhesus Macaques: Cellular, Molecular, and Cortical Circuitry Perspectives
Datta D. Interrogating the Etiology of Sporadic Alzheimer’s Disease Using Aging Rhesus Macaques: Cellular, Molecular, and Cortical Circuitry Perspectives. The Journals Of Gerontology Series A 2023, 78: 1523-1534. PMID: 37279946, PMCID: PMC10460555, DOI: 10.1093/gerona/glad134.Peer-Reviewed Original ResearchConceptsPrimate dorsolateral prefrontal cortexSporadic Alzheimer's diseaseAlzheimer's diseaseDorsolateral prefrontal cortexRhesus macaquesPrefrontal cortexSignificant risk factorsHuman Alzheimer's diseaseAspartic acid (NMDA) receptorsNonhuman primate modelNovel therapeutic strategiesCalcium-buffering proteinsPattern of pathologyInflammatory cascadeTau pathologyNeuropathological cascadeSynaptic dysfunctionRisk factorsPrimate modelNeurofibrillary tanglesAmyloid plaquesDendritic spinesTherapeutic strategiesGenetic predispositionAnimal modelsRepeated Tick Infestations Impair Borrelia burgdorferi Transmission in a Non-Human Primate Model of Tick Feeding
Narasimhan S, Booth C, Philipp M, Fikrig E, Embers M. Repeated Tick Infestations Impair Borrelia burgdorferi Transmission in a Non-Human Primate Model of Tick Feeding. Pathogens 2023, 12: 132. PMID: 36678479, PMCID: PMC9861725, DOI: 10.3390/pathogens12010132.Peer-Reviewed Original ResearchNon-human primatesImmune responseLyme diseaseTick transmissionAnimal modelsGuinea pigsNon-human primate modelProtective immune responseTick feedingTick infestationRobust immune responseTick salivary antigensElicit immune responsesHuman Lyme diseaseClinical manifestationsHuman pathogensPrimate modelSalivary antigensNon-natural hostsVaccine targetsDiseaseVaccine discoveryTick resistanceBorreliaNatural host
2022
Intrathecal amyloid‐beta oligomer administration increases tau phosphorylation in the medial temporal lobe in the African green monkey: A nonhuman primate model of Alzheimer's disease
Wakeman DR, Weed MR, Perez SE, Cline EN, Viola KL, Wilcox KC, Moddrelle DS, Nisbett EZ, Kurian AM, Bell AF, Pike R, Jacobson PB, Klein WL, Mufson EJ, Lawrence MS, Elsworth JD. Intrathecal amyloid‐beta oligomer administration increases tau phosphorylation in the medial temporal lobe in the African green monkey: A nonhuman primate model of Alzheimer's disease. Neuropathology And Applied Neurobiology 2022, 48: e12800. PMID: 35156715, PMCID: PMC10902791, DOI: 10.1111/nan.12800.Peer-Reviewed Original ResearchConceptsAdult African green monkeysAfrican green monkeysMedial temporal lobeAlzheimer's diseaseMagnetic resonance imagingIntrathecal injectionHippocampal volumeTau phosphorylationTemporal lobeGreen monkeysNonhuman primatesAD-like neuropathologyAD-like pathologyHuman Alzheimer's diseaseNonhuman primate modelNew treatment strategiesTransgenic rodent modelsAmyloid-beta oligomersAβO injectionAT8 antibodyClinical outcomesAD pathologyClinical trialsPrimate modelTreatment strategies
2021
Social Rank, Behavioral Phenotypes and Kappa Opioid Receptor: PET Imaging Studies of Socially Housed Female and Male Monkey Models of Cocaine Use Disorder
Johnson B, Sai K, Nader S, Li S, Huang Y, Nader M. Social Rank, Behavioral Phenotypes and Kappa Opioid Receptor: PET Imaging Studies of Socially Housed Female and Male Monkey Models of Cocaine Use Disorder. The FASEB Journal 2021, 35 DOI: 10.1096/fasebj.2021.35.s1.03412.Peer-Reviewed Original ResearchKOR systemDynorphin/KOR systemBrain regionsCocaine reinforcementKappa opioid receptor systemPET imagingCocaine overdose deathsPositron emission tomography studyOpioid receptor systemKappa-opioid receptorsRecent positron emission tomography (PET) studyNonhuman primate modelEmission tomography studiesStress-induced relapseChronic social stressEffects of drugsCocaine use disorderPET imaging studiesBehavioral phenotypesAgonist tracersCocaine acquisitionSocial behaviorDynorphin levelsOpioid receptorsPrimate model
2020
Islet transplantation in the subcutaneous space achieves long-term euglycaemia in preclinical models of type 1 diabetes
Yu M, Agarwal D, Korutla L, May CL, Wang W, Griffith NN, Hering BJ, Kaestner KH, Velazquez OC, Markmann JF, Vallabhajosyula P, Liu C, Naji A. Islet transplantation in the subcutaneous space achieves long-term euglycaemia in preclinical models of type 1 diabetes. Nature Metabolism 2020, 2: 1013-1020. PMID: 32895576, PMCID: PMC7572844, DOI: 10.1038/s42255-020-0269-7.Peer-Reviewed Original ResearchConceptsIslet transplantationSubcutaneous spacePancreatic isletsNon-human primate modelSyngeneic islet transplantationType 1 diabetesTreatment of typeLack of neovascularizationPancreatic islet transplantationNew therapeutic paradigmHuman pancreatic isletsSustained normoglycaemiaGraft survivalHypoxic cell deathPrimate modelPreclinical modelsAnimal modelsTransplantationSubcutaneous transplantationTherapeutic paradigmDiabetesEuglycaemiaCell deathIsletsTransplantation methodologiesCorrigendum to “Icon immunoconjugate treatment results in regression of red lesions in a non-human primate (Papio anubis) model of endometriosis” [Reprod. Biol. 18 (2018) 109–114]
Hufnagel D, Goetz LG, Hu Z, Nyachieo A, D'Hooghe T, Fazleabas A, Duleba A, Krikun G, Taylor HS, Lockwood CJ. Corrigendum to “Icon immunoconjugate treatment results in regression of red lesions in a non-human primate (Papio anubis) model of endometriosis” [Reprod. Biol. 18 (2018) 109–114]. Reproductive Biology 2020, 20: 600. PMID: 32900640, DOI: 10.1016/j.repbio.2020.08.005.Peer-Reviewed Original ResearchPrimate model of chronic retinal neovascularization and vascular leakage
Patel C, Goody R, Hu W, Kurian A, James D, Torres R, Christie LA, Hohman T, Lawrence M. Primate model of chronic retinal neovascularization and vascular leakage. Experimental Eye Research 2020, 195: 108031. PMID: 32275921, PMCID: PMC7335215, DOI: 10.1016/j.exer.2020.108031.Peer-Reviewed Original ResearchConceptsGlial fibrillary acidic proteinVascular leakageVon Willebrand factorOptical coherence tomographyFluorescein angiographyRetinal neovascularizationPrimate modelCD105/endoglinNeovascular diseasesRetinal degenerationDL-alpha-aminoadipic acidBilateral intravitreal injectionsInner retinal edemaRetinal vascular leakageRetinal vascular pathologyVascular disease mechanismsColor fundus photographyMüller cell lossFibrillary acidic proteinExpression of vWFAfrican green monkeysCD68 immunoreactivityMacular telangiectasiaRetinal edemaIntravitreal injection
2019
Controlled-release mitochondrial protonophore (CRMP) reverses dyslipidemia and hepatic steatosis in dysmetabolic nonhuman primates
Goedeke L, Peng L, Montalvo-Romeral V, Butrico GM, Dufour S, Zhang XM, Perry RJ, Cline GW, Kievit P, Chng K, Petersen KF, Shulman GI. Controlled-release mitochondrial protonophore (CRMP) reverses dyslipidemia and hepatic steatosis in dysmetabolic nonhuman primates. Science Translational Medicine 2019, 11 PMID: 31578240, PMCID: PMC6996238, DOI: 10.1126/scitranslmed.aay0284.Peer-Reviewed Original ResearchConceptsControlled-release mitochondrial protonophoreNonalcoholic fatty liver diseaseCRMP treatmentHepatic triglyceridesDiet-induced rodent modelReversal of hypertriglyceridemiaFatty liver diseaseNonhuman primate modelMitochondrial protonophoreEndogenous glucose productionLow-density lipoproteinMitochondrial fat oxidationHepatic inflammationMetabolic syndromeFatty liverLiver diseaseHepatic steatosisInsulin resistanceAdverse reactionsPlasma triglyceridesPrimate modelOral administrationFood intakeHepatic mitochondrial oxidationRodent modelsSerum MicroRNA Biomarkers Regulated by Simvastatin in a Primate Model of Endometriosis
Cosar E, Mamillapalli R, Moridi I, Duleba A, Taylor HS. Serum MicroRNA Biomarkers Regulated by Simvastatin in a Primate Model of Endometriosis. Reproductive Sciences 2019, 26: 1343-1350. PMID: 29587611, PMCID: PMC6949973, DOI: 10.1177/1933719118765971.Peer-Reviewed Original ResearchConceptsEndometriosis groupPrimate modelSerum microRNA BiomarkersReproductive-aged womenSerum miRNA expressionTreatment of endometriosisNoninvasive diagnostic strategyMiR-150-5pNonhuman primate modelEstrogen-dependent diseaseReal-time polymerase chain reactionQuantitative real-time polymerase chain reactionTime polymerase chain reactionEndometriosis treatmentEndometriosis severitySimvastatin treatmentHuman endometriosisEndometriosisAccurate biomarkersHuman patientsMiR-451aControl expression levelsDiagnostic strategiesSpecific biomarkersSerum samples19-OR: Controlled-Release Mitochondrial Protonophore (CRMP) Reverses Hypertriglyceridemia and Hepatic Steatosis in Dysmetabolic Nonhuman Primates
GOEDEKE L, ROMERAL V, BUTRICO G, KAHN M, DUFOUR S, ZHANG X, CLINE G, PETERSEN K, CHNG K, SHULMAN G. 19-OR: Controlled-Release Mitochondrial Protonophore (CRMP) Reverses Hypertriglyceridemia and Hepatic Steatosis in Dysmetabolic Nonhuman Primates. Diabetes 2019, 68 DOI: 10.2337/db19-19-or.Peer-Reviewed Original ResearchControlled-release mitochondrial protonophoreSpouse/partnerCRMP treatmentInsulin resistanceDiet-induced rodent modelJanssen ResearchReversal of hypertriglyceridemiaNAFLD/NASHInflammation/fibrosisNonhuman primate modelMitochondrial protonophoreEndogenous glucose productionHepatic insulin resistanceHepatic acetyl-CoA contentAdvisory PanelMitochondrial fat oxidationMetabolic syndromeFatty liverHepatic steatosisAdverse reactionsHepatic triglyceridesAcetyl-CoA contentPrimate modelNovo Nordisk A/S.Food intakeHematological Effects of Non-Homogenous Ionizing Radiation Exposure in a Non-Human Primate Model
Jackson IL, Gibbs A, Poirier Y, Wathen L, Eley J, Draeger E, Gopalakrishnan M, Benjamin B, Vujaskovic Z. Hematological Effects of Non-Homogenous Ionizing Radiation Exposure in a Non-Human Primate Model. Radiation Research 2019, 191: 428-438. PMID: 30870098, DOI: 10.1667/rr15280.1.Peer-Reviewed Original ResearchConceptsLower half-body irradiationUpper half body irradiationHalf-body irradiationTotal body irradiationDose-volume effectsNon-human primatesBM toxicityRadiation exposureBone marrowClinical signs/symptomsRadiation dose-volume effectsNon-human primate modelHigh-grade feverSigns/symptomsBone marrow toxicityPeripheral blood samplesAcute radiation syndromeIonizing Radiation ExposureBlood-forming organsSevere neutropeniaRespiratory distressHematologic changesMarrow toxicityBM damagePrimate modelEndometrial cells contribute to preexisting endometriosis lesions in a mouse model of retrograde menstruation†
Tal A, Tal R, Pluchino N, Taylor HS. Endometrial cells contribute to preexisting endometriosis lesions in a mouse model of retrograde menstruation†. Biology Of Reproduction 2019, 100: 1453-1460. PMID: 30869747, PMCID: PMC6561859, DOI: 10.1093/biolre/ioz039.Peer-Reviewed Original ResearchConceptsRetrograde menstruationUterine cellsEndometrial tissueEndometriosis lesionsEndometrial cellsAdverse clinical manifestationsChronic pelvic painPathophysiology of endometriosisProgression of endometriosisC57BL/6J female miceNonhuman primate modelEndometrial tissue fragmentsEndometriotic processPelvic painClinical manifestationsEndometriotic lesionsInflammatory processIntraperitoneal injectionFemale micePrimate modelExtrauterine growthPeritoneal cavityEndometriosisMouse modelLesions
2018
Icon immunoconjugate treatment results in regression of red lesions in a non-human primate (Papio anubis) model of endometriosis
Hufnagel D, Goetz L, Hu Z, Nyachieo A, D’Hooghe T, Fazleabas A, Duleba A, Krikun G, Taylor HS, Lockwood CJ. Icon immunoconjugate treatment results in regression of red lesions in a non-human primate (Papio anubis) model of endometriosis. Reproductive Biology 2018, 18: 109-114. PMID: 29422377, DOI: 10.1016/j.repbio.2018.01.009.Peer-Reviewed Original ResearchMeSH KeywordsAdenoviridaeAdnexal DiseasesAmino Acid SubstitutionAnimalsEndometriosisFactor VIIFemaleGenetic TherapyGenetic VectorsHumansImmunoconjugatesImmunoglobulin Fc FragmentsImmunoglobulin GMolecular Targeted TherapyMutationNeovascularization, PathologicPapio anubisPelvisPeptide FragmentsRandom AllocationRecombinant Fusion ProteinsThromboplastinConceptsNon-human primatesNovel treatmentsTissue factorNon-human primate modelRegression of endometriosisEctopic endometrial tissueReproductive-aged womenEctopic endometrial lesionsWeekly intraperitoneal injectionsFactor VII/VIIaLesion vasculatureChronic painEndometrial lesionsEndometrial tissueEndometriosis lesionsLaparoscopic confirmationSurgical inductionIntraperitoneal injectionPrimate modelCommon conditionMurine modelEndometriosisTreatment groupsControl groupTreatment results
2017
Listeria Placental Infection
Vázquez-Boland J, Krypotou E, Scortti M. Listeria Placental Infection. MBio 2017, 8: 10.1128/mbio.00949-17. PMID: 28655824, PMCID: PMC5487735, DOI: 10.1128/mbio.00949-17.Peer-Reviewed Original ResearchConceptsCongenital neonatal infectionsAdverse pregnancy outcomesAbsence of overt illnessSystemic bacterial infectionNonhuman primate modelFetal complicationsCausative agent of listeriosisNeonatal infectionPreterm birthPregnancy outcomesPregnant womenFood-borne infectionsBacterial infectionsPrimate modelTransplacental infectionInfectionOvert illnessMedical interventionsCausative agentListeriosisComplicationsMiscarriageStillbirthPathophysiologyBirthEffect of simvastatin on baboon endometriosis†
Taylor HS, Alderman M, D'Hooghe TM, Fazleabas AT, Duleba AJ. Effect of simvastatin on baboon endometriosis†. Biology Of Reproduction 2017, 97: 32-38. PMID: 28637327, PMCID: PMC6248548, DOI: 10.1093/biolre/iox058.Peer-Reviewed Original ResearchConceptsEffect of simvastatinEndometriotic lesionsRed lesionsMarkers of inflammationEndometrial stromal cellsDevelopment of endometriosisEstrogen receptor betaImmune system activationEstrogen receptor alphaMarkers of proliferationSteroid hormone responsesCell nuclear antigenEndometrial lesionsEndometrial tissueEutopic endometriumReproductive agePrimate modelWhite lesionsCommon disorderEstrogen receptorBaboon modelMurine modelTreatment groupsSystem activationReceptor alphaCryopreservation Maintains Functionality of Human iPSC Dopamine Neurons and Rescues Parkinsonian Phenotypes In Vivo
Wakeman D, Hiller B, Marmion D, McMahon C, Corbett G, Mangan K, Ma J, Little L, Xie Z, Perez-Rosello T, Guzman J, Surmeier D, Kordower J. Cryopreservation Maintains Functionality of Human iPSC Dopamine Neurons and Rescues Parkinsonian Phenotypes In Vivo. Stem Cell Reports 2017, 9: 149-161. PMID: 28579395, PMCID: PMC5511045, DOI: 10.1016/j.stemcr.2017.04.033.Peer-Reviewed Original ResearchConceptsParkinson's diseaseDopamine neuronsMidbrain dopamine neuronsStem cell therapyGrafted neuronsHost striatumCell-based therapiesPluripotent stem cell therapyFunctional deficitsPrimate modelFiber innervationParkinsonian phenotypeTherapeutic efficacyTransplantation studiesCell therapyNeuronsSignificant reversalTranslational developmentBehavioral assessmentClinical applicationTherapyElectrophysiological signaturesRatsDiseaseMinimal manipulation
2016
Longitudinal analysis of the lung microbiota of cynomolgous macaques during long-term SHIV infection
Morris A, Paulson J, Talukder H, Tipton L, Kling H, Cui L, Fitch A, Pop M, Norris K, Ghedin E. Longitudinal analysis of the lung microbiota of cynomolgous macaques during long-term SHIV infection. Microbiome 2016, 4: 38. PMID: 27391224, PMCID: PMC4939015, DOI: 10.1186/s40168-016-0183-0.Peer-Reviewed Original ResearchConceptsDevelopment of obstructive lung diseaseObstructive lung diseaseNon-human primate modelLung microbiomeSHIV infectionLung microbiotaRibosomal RNALung diseasePrimate modelNon-obstructive groupSHIV-infected animalsResponse to immunosuppressionBronchoalveolar lavage fluid samplesCynomolgous macaquesDevelopment of obstructive diseaseLavage fluid samplesMultiple other speciesSIV-HIVOral anaerobesOral bacteriaTropheryma whippleiObstructive diseaseCommunity compositionBacterial communitiesDisease onset
2015
Focal hepatic glycogenosis associated with metastatic insulinoma presenting as mass lesions
Vyas M, Zhang X, Morrow JS, Jain D, Salem RR, West AB. Focal hepatic glycogenosis associated with metastatic insulinoma presenting as mass lesions. Pathology - Research And Practice 2015, 212: 59-62. PMID: 26627264, DOI: 10.1016/j.prp.2015.11.006.Peer-Reviewed Original Research
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