2023
Idiopathic myointimal hyperplasia of the mesenteric veins: A systematic review and individual patient data regression analysis
Rozner R, Gisriel S, Damianos J, Grimshaw A, Rizwan R, Nawaz A, Chan K, Wan D, Pantel H, Bhutta A, Fenster M, Brandt L, Barbieri A, Robert M, Feuerstadt P, Li D. Idiopathic myointimal hyperplasia of the mesenteric veins: A systematic review and individual patient data regression analysis. Journal Of Gastroenterology And Hepatology 2023, 38: 1040-1046. PMID: 37086041, DOI: 10.1111/jgh.16193.Peer-Reviewed Original ResearchConceptsIdiopathic myointimal hyperplasiaColonic ischemiaMesenteric veinRectal bleedingRectal involvementMyointimal hyperplasiaSystematic reviewYounger ageMultivariate logistic regression analysisCurative surgical resectionInferior mesenteric veinPre-surgical identificationLogistic regression analysisRegression analysisIschemic colitisAbdominal painMucosal ulcerationEndoscopic findingsSelect patientsSurgical resectionUncommon causeDiagnostic delaySurgical treatmentClinical featuresHospital records
2022
Recommendations on the Appropriate Management of Steroids and Discharge Planning During and After Hospital Admission for Moderate-Severe Ulcerative Colitis: Results of a RAND Appropriateness Panel
Dulai P, Rai V, Raffals L, Lukin D, Hudesman D, Kochhar G, Damas O, Sauk J, Levy A, Sofia M, Tuskey A, Deepak P, Yarur A, Afzali A, Ananthakrishnan A, Cross R, Hanauer S, Siegel C. Recommendations on the Appropriate Management of Steroids and Discharge Planning During and After Hospital Admission for Moderate-Severe Ulcerative Colitis: Results of a RAND Appropriateness Panel. The American Journal Of Gastroenterology 2022, 117: 1288-1295. PMID: 35416799, PMCID: PMC9437635, DOI: 10.14309/ajg.0000000000001775.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsModerate-severe flaresUlcerative colitisAntitumor necrosis factor therapyModerate-severe ulcerative colitisNecrosis factor therapyRAND appropriateness panelMethylprednisolone 40Naive patientsPostdischarge managementSteroid dosingStool frequencyRectal bleedingTherapy initiationAdverse eventsFactor therapyInpatient managementPostdischarge careHospital admissionLower endoscopyDischarge planningLower riskPatientsDischarge criteriaAppropriate managementHigh doses
2021
A Practical Clinical Approach to the Management of High-Risk Ulcerative Colitis.
Rubin D, Traboulsi C, Rai V. A Practical Clinical Approach to the Management of High-Risk Ulcerative Colitis. Gastroenterology & Hepatology 2021, 17: 59-66. PMID: 34035764, PMCID: PMC8132723.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsUlcerative colitisDisease activityRecurrent disease activityLong-term remissionManagement of patientsGoal of treatmentPractical clinical approachPatient's risk levelRange of symptomsAbdominal painRectal bleedingFulminant diseasePrognostic factorsSurgical optionsTherapeutic choiceInpatient settingPatientsClinical approachDrug mechanismsDisease responseRemissionColitisTreatmentObjective measuresCritical appraisal
2020
Bilateral Signet-ring Stromal Tumor of the Ovary: A Case Report With Next-generation Sequencing Analysis and FOXL2 Mutation Testing
Chen PH, Hui P, Buza N. Bilateral Signet-ring Stromal Tumor of the Ovary: A Case Report With Next-generation Sequencing Analysis and FOXL2 Mutation Testing. International Journal Of Gynecological Pathology 2020, 39: 193-198. PMID: 30676431, DOI: 10.1097/pgp.0000000000000579.Peer-Reviewed Case Reports and Technical NotesConceptsSignet-ring stromal tumorStromal tumorsNext-generation sequencing analysisBilateral solid ovarian tumorsBilateral ovarian massesFOXL2 mutation testingSolid ovarian tumorSignet ring cell morphologySmooth muscle actinUnderlying genetic abnormalitiesPCR-Sanger sequencingNuclear beta-catenin expressionHandful of casesHeterogenous pathogenesisAbdominal distentionRectal bleedingTotal hysterectomyStromal neoplasmsOvarian massesOvarian tumorsCase reportBeta-catenin expressionSequencing analysisMuscle actinTumorsFeasibility and safety of research sigmoid colon biopsy in a cohort of Thai men who have sex with men with acute HIV-1
Chintanaphol M, Sacdalan C, Pinyakorn S, Rerknimitr R, Ridtitid W, Prueksapanich P, Sereti I, Schuetz A, Crowell TA, Colby DJ, Robb ML, Phanuphak N, Ananworanich J, Spudich SS, Kroon E. Feasibility and safety of research sigmoid colon biopsy in a cohort of Thai men who have sex with men with acute HIV-1. Journal Of Virus Eradication 2020, 6: 7-10. PMID: 32175085, PMCID: PMC7043900, DOI: 10.1016/s2055-6640(20)30011-x.Peer-Reviewed Original ResearchAcute HIV-1 infectionGut-associated lymphoid tissueHIV-1 reservoirSigmoid colon biopsiesAdverse eventsAE riskSigmoid colonColon biopsiesHIV-1CD4 T-cell depletionCD4 T-cell countAcute HIV-1Mild rectal bleedingAdverse event incidenceT-cell countsHigh viral replicationT-cell depletionHIV-1 infectionHIV-1 RNATime of biopsyIncidence rate ratiosRectal bleedingAbdominal discomfortEvent incidenceViral load
2019
The Combination of Patient-Reported Clinical Symptoms and an Endoscopic Score Correlates Well with Health-Related Quality of Life in Patients with Ulcerative Colitis
Aniwan S, Bruining DH, Park SH, Al-Bawardy B, Kane SV, Prabhu N, Kisiel JB, Raffals LE, Papadakis KA, Pardi DS, Tremaine WJ, Loftus EV. The Combination of Patient-Reported Clinical Symptoms and an Endoscopic Score Correlates Well with Health-Related Quality of Life in Patients with Ulcerative Colitis. Journal Of Clinical Medicine 2019, 8: 1171. PMID: 31387259, PMCID: PMC6723355, DOI: 10.3390/jcm8081171.Peer-Reviewed Original ResearchShort Inflammatory Bowel Disease QuestionnaireMayo endoscopic subscorePatient-reported outcomesUlcerative colitisClinical symptomsPatient-reported clinical symptomsChronic Illness Therapy-FatigueInflammatory Bowel Disease QuestionnaireProspective cross-sectional studyConsecutive UC patientsActivity Impairment QuestionnaireBowel Disease QuestionnaireHealth-related qualityFuture clinical trialsCross-sectional studyCombination of patientQuality of lifeStool frequencyDisease QuestionnaireEndoscopic scoreEndoscopic subscorePrimary endpointRectal bleedingUC patientsHRQoL scores
2018
Rodenticide Causing Lower Gastrointestinal Bleeding: Resident Simulation
Sangal RB, Conlon LW. Rodenticide Causing Lower Gastrointestinal Bleeding: Resident Simulation. MedEdPORTAL 2018, 14: 10729. PMID: 30800929, PMCID: PMC6342433, DOI: 10.15766/mep_2374-8265.10729.Peer-Reviewed Educational MaterialsConceptsLower GI bleedingGastrointestinal bleedingGI bleedingAbnormal coagulationSkilled medical providersLower gastrointestinal bleedingLife-threatening conditionEmergency medicine providersAnticoagulation medicationRectal bleedingMore patientsHemorrhagic shockTreatment algorithmIntentional ingestionBlood productsMedicine providersBleedingDisease processTypes of GIBipolar disorderLower GIMedical providersRapid diagnosisPatientsAnticoagulationSphingolipid de novo biosynthesis is essential for intestine cell survival and barrier function
Li Z, Kabir I, Tietelman G, Huan C, Fan J, Worgall T, Jiang XC. Sphingolipid de novo biosynthesis is essential for intestine cell survival and barrier function. Cell Death & Disease 2018, 9: 173. PMID: 29415989, PMCID: PMC5833386, DOI: 10.1038/s41419-017-0214-1.Peer-Reviewed Original ResearchConceptsTamoxifen treatmentBarrier functionInflammatory bowel diseaseGoblet cell numbersCell survivalConcurrent diarrheaSPTLC2 expressionIntestinal cell survivalRectal bleedingBowel diseaseRate-limiting enzymeBody weightColon specimensGoblet cellsSerine palmitoyltransferaseSmall intestineDay 6MiceEarly lifeIntestineReduced lethalitySPT activityCell numberSPTLC2Survival
2015
St. John's Wort Attenuates Colorectal Carcinogenesis in Mice through Suppression of Inflammatory Signaling
Manna SK, Golla S, Golla JP, Tanaka N, Cai Y, Takahashi S, Krausz KW, Matsubara T, Korboukh I, Gonzalez FJ. St. John's Wort Attenuates Colorectal Carcinogenesis in Mice through Suppression of Inflammatory Signaling. Cancer Prevention Research 2015, 8: 786-795. PMID: 26069204, PMCID: PMC4584416, DOI: 10.1158/1940-6207.capr-14-0113.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnticarcinogenic AgentsAzoxymethaneCarcinogenesisCell Transformation, NeoplasticColonColorectal NeoplasmsDietDietary SupplementsDisease Models, AnimalExtracellular Signal-Regulated MAP KinasesHypericumInflammationMaleMiceNF-kappa BOligonucleotide Array Sequence AnalysisOligonucleotidesPlant ExtractsSignal TransductionConceptsDiet-fed miceSJW extractColorectal carcinogenesisAzoxymethane-induced colorectal carcinogenesisAIN-93G dietLong-term treatment regimensAzoxymethane-treated miceEffect of SJWNuclear factor kappa BBody weight lossWort extractTotal tumor volumeFactor kappa BSt. John's wort extractDose-dependent mannerAzoxymethane treatmentSJW administrationRectal bleedingOverall survivalTreatment regimensColorectal cancerProinflammatory processesTumor multiplicityLarge tumorsCholesterol levelsPhase II trial of abiraterone acetate (AA) treatment for metastatic prostate cancer (PC) patients with a PSA of more than four following initial androgen deprivation therapy: SWOG S1014.
Flaig T, Tangen C, Hussain M, Agarwal N, Mitsiades N, Deshpande H, Vaishampayan U, Thompson I. Phase II trial of abiraterone acetate (AA) treatment for metastatic prostate cancer (PC) patients with a PSA of more than four following initial androgen deprivation therapy: SWOG S1014. Journal Of Clinical Oncology 2015, 33: 152-152. DOI: 10.1200/jco.2015.33.7_suppl.152.Peer-Reviewed Original ResearchAndrogen deprivation therapyProgression-free survivalMonths of ADTInitial androgen deprivation therapyTime of enrollmentDeprivation therapyPSA responsePoor prognosisGrade 3 adverse eventsMedian progression-free survivalMetastatic prostate cancer patientsAbiraterone acetate treatmentMetastatic PC patientsSecondary hormonal therapySubsequent median survivalPhase II trialProstate cancer patientsEligible patientsUndetectable PSAALT elevationEfficacy of AAHormonal therapyII trialPrimary endpointRectal bleeding
2014
Unusual Presentation of a Rectovestibular Fistula as Gastrointestinal Hemorrhage in a Postmenopausal Woman
Grechukhina O, Gressel GM, Taylor G, Schwartz JI, Welsh RJ. Unusual Presentation of a Rectovestibular Fistula as Gastrointestinal Hemorrhage in a Postmenopausal Woman. Case Reports In Obstetrics And Gynecology 2014, 2014: 578048. PMID: 25587474, PMCID: PMC4283261, DOI: 10.1155/2014/578048.Peer-Reviewed Case Reports and Technical NotesAnorectal malformationsRectovestibular fistulaPostmenopausal vaginal bleedingProfuse rectal bleedingSevere diverticular diseaseField of obstetricsGastrointestinal hemorrhagePostmenopausal patientsRare clinical circumstancesVaginal bleedingDiverticular diseasePostmenopausal periodPostmenopausal womenRectal bleedingGynecologic historyColonoscopic examinationEmergency departmentSpeculum examinationCase reportUnusual presentationClinical circumstancesImperforate anusHymenal ringUnclear historyEctopic anus
2008
Thrombospondin 1 and Its Mimetic Peptide ABT-510 Decrease Angiogenesis and Inflammation in a Murine Model of Inflammatory Bowel Disease
Punekar S, Zak S, Kalter V, Dobransky L, Punekar I, Lawler J, Gutierrez L. Thrombospondin 1 and Its Mimetic Peptide ABT-510 Decrease Angiogenesis and Inflammation in a Murine Model of Inflammatory Bowel Disease. Pathobiology 2008, 75: 9-21. PMID: 18334835, DOI: 10.1159/000113790.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseEnzyme-linked immunoabsorbent assayMicrovascular densityABT-510Bowel diseaseMyeloperoxidase activityDextran sulfate sodium (DSS) modelTSP-1Thrombospondin-1TSP-1-deficient miceDisease activity indexWorse clinical outcomesAnti-inflammatory propertiesGrade of inflammationHigher microvascular densityMMPs protein levelsDecrease angiogenesisAdjuvant therapyRectal bleedingCrypt damageDSS treatmentClinical outcomesMPO activityWT miceMiniosmotic pumps
2001
Argon plasma coagulation for rectal bleeding after prostate brachytherapy
Smith S, Wallner K, Dominitz J, Han B, True L, Sutlief S, Billingsley K. Argon plasma coagulation for rectal bleeding after prostate brachytherapy. International Journal Of Radiation Oncology • Biology • Physics 2001, 51: 636-642. PMID: 11597803, DOI: 10.1016/s0360-3016(01)01704-7.Peer-Reviewed Original ResearchConceptsArgon plasma coagulationSound Health Care SystemPersistent rectal bleedingRectal bleedingHealth care systemPlasma coagulationSupplemental external beam radiationVeterans AffairsCare systemDegree of proctitisProgressive tissue destructionExternal beam radiationFour-field techniqueProstate cancer patientsRectal V100Single gastroenterologistRadiation proctitisActive bleedingAPC therapyPersistent bleedingMost patientsSymptomatic patientsClinical courseCancer patientsComplete resolution
1996
Human Immunodeficiency Virus Infection in Mexico City
Coplan P, Gortmaker S, Hemandez-Avila M, Spiegelman D, Uribe-Zuūiga P, Mueller N. Human Immunodeficiency Virus Infection in Mexico City. American Journal Of Epidemiology 1996, 144: 817-827. PMID: 8890660, DOI: 10.1093/oxfordjournals.aje.a009016.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virus (HIV) infectionRectal bleedingImmunodeficiency virus infectionAnal wartsHIV infectionAnal intercourseRisk factorsVirus infectionIndependent risk factorReceptive anal intercourseLogistic regression modelingAnonymous HIVIntercourse episodesGenital ulcersHIV seroprevalenceHIV serostatusInsertive intercourseHIV transmissionOdds ratioBleedingEligible clientsPublic clinicsMultivariate analysisInfectionOlder age
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