2024
Assessing thresholds of resistance prevalence at which empiric treatment of gonorrhea should change among men who have sex with men in the US: A cost-effectiveness analysis
Yin X, Li Y, Rönn M, Li S, Yuan Y, Gift T, Hsu K, Salomon J, Grad Y, Yaesoubi R. Assessing thresholds of resistance prevalence at which empiric treatment of gonorrhea should change among men who have sex with men in the US: A cost-effectiveness analysis. PLOS Medicine 2024, 21: e1004424. PMID: 38976754, PMCID: PMC11262662, DOI: 10.1371/journal.pmed.1004424.Peer-Reviewed Original ResearchDrug susceptibility testingQuality-adjusted life yearsFirst-line therapyFirst-line antibioticsNet health benefitFirst-lineRetreatment regimensResistance prevalenceRapid drug susceptibility testingRate of treatment failureTreatment of gonorrheaIncidence of gonorrheaAssociated with gonorrheaEmpirical therapyTreatment failureEmpirical treatmentGonococcal infectionSusceptibility testingGonorrhea casesMSM populationGonorrheaCost-effectiveness analysisDiagnostic testsResistant strainsTherapy
2019
Clinical characteristics and outcomes of patients with Escherichia coli in airway samples
Schneer S, Khoury J, Adir Y, Stein N, Mishan P, Ken‐Dror S, Weber G, Meler R, Khateeb A, Shteinberg M. Clinical characteristics and outcomes of patients with Escherichia coli in airway samples. The Clinical Respiratory Journal 2019, 14: 205-213. PMID: 31799802, DOI: 10.1111/crj.13116.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAnti-Bacterial AgentsBronchiectasisCase-Control StudiesCommunity-Acquired InfectionsCross InfectionCystic FibrosisDrug Resistance, BacterialEscherichia coliEscherichia coli InfectionsFemaleHospitalizationHumansMaleMicrobial Sensitivity TestsMiddle AgedRespiratory Tract InfectionsSputumConceptsRespiratory secretionsResistant E. coliE. coli positive culturesResistant strainsMore hospitalization daysOutcomes of patientsGroup of patientsCommunity-acquired infectionsClinical characteristicsHospital daysPulmonary infectionHospitalization daysAmbulatory patientsPrevious hospitalizationAirway samplesPrognostic valueRespiratory pathogensCommon pathogensPositive culturesPatientsNosocomial pathogenAntibiotic classesAntimicrobial classesSecretionElevated mortalityPredicting the Impact of Typhoid Conjugate Vaccines on Antimicrobial Resistance
Kaufhold S, Yaesoubi R, Pitzer VE. Predicting the Impact of Typhoid Conjugate Vaccines on Antimicrobial Resistance. Clinical Infectious Diseases 2019, 68: s96-s104. PMID: 30845324, PMCID: PMC6405272, DOI: 10.1093/cid/ciy1108.Peer-Reviewed Original ResearchConceptsChronic carriersAntimicrobial-resistant infectionsProportion of casesTyphoid-endemic settingsTyphoid infectionVaccination coverageResistant infectionsFuture vaccination campaignsOne-way sensitivity analysesTyphoid Conjugate VaccineTransmission dynamic modelSalmonella enterica serovar TyphiEmpiric prescribingConjugate vaccineEnterica serovar TyphiIntroduction of typhoidTreatment strategiesVaccination campaignTotal casesHealth outcomesNumber of casesRate of recoveryInfectionResistant strainsTotal number
2017
Profiling gene expression of antimony response genes in Leishmania (Viannia) panamensis and infected macrophages and its relationship with drug susceptibility
Barrera MC, Rojas LJ, Weiss A, Fernandez O, McMahon-Pratt D, Saravia NG, Gomez MA. Profiling gene expression of antimony response genes in Leishmania (Viannia) panamensis and infected macrophages and its relationship with drug susceptibility. Acta Tropica 2017, 176: 355-363. PMID: 28843396, PMCID: PMC5633519, DOI: 10.1016/j.actatropica.2017.08.017.Peer-Reviewed Original ResearchConceptsLeishmania resistanceDrug susceptibilityDrug resistanceHost cell gene expressionClinical strainsCell gene expressionExpression of ABCA2THP-1 cellsPrimary human macrophagesLeishmania susceptibilityGene expressionAntimonial drugsCutaneous leishmaniasisInfected macrophagesLeishmania panamensisIntracellular amastigotesHuman macrophagesResistant strainsSusceptible parasitesAntimonialsIntracellular parasitesLeishmania speciesMacrophagesL. panamensisAQP-9
2014
Miltefosine and Antimonial Drug Susceptibility of Leishmania Viannia Species and Populations in Regions of High Transmission in Colombia
Fernández OL, Diaz-Toro Y, Ovalle C, Valderrama L, Muvdi S, Rodríguez I, Gomez MA, Saravia NG. Miltefosine and Antimonial Drug Susceptibility of Leishmania Viannia Species and Populations in Regions of High Transmission in Colombia. PLOS Neglected Tropical Diseases 2014, 8: e2871. PMID: 24853871, PMCID: PMC4031164, DOI: 10.1371/journal.pntd.0002871.Peer-Reviewed Original ResearchConceptsV. panamensisLine treatmentClinical strainsDrug susceptibilitySecond-line treatmentFirst-line treatmentEmergence of resistancePopulations of LeishmaniaViannia speciesResistant clinical strainsAntimony susceptibilityClinical evidenceMeglumine antimoniatePentavalent antimonialsDermal leishmaniasisEpidemiologic differencesLeishmania VianniaProxy markerIntracellular amastigotesMunicipality of TumacoResistant strainsMiltefosineDisparate susceptibilityDrugsL. panamensisIntra-Subtype Variation in Enteroadhesion Accounts for Differences in Epithelial Barrier Disruption and Is Associated with Metronidazole Resistance in Blastocystis Subtype-7
Wu Z, Mirza H, Tan KS. Intra-Subtype Variation in Enteroadhesion Accounts for Differences in Epithelial Barrier Disruption and Is Associated with Metronidazole Resistance in Blastocystis Subtype-7. PLOS Neglected Tropical Diseases 2014, 8: e2885. PMID: 24851944, PMCID: PMC4031124, DOI: 10.1371/journal.pntd.0002885.Peer-Reviewed Original ResearchConceptsEpithelial barrier disruptionBarrier disruptionDrug resistanceBlastocystis subtype 7Intra-subtype variationOccludin tight junction proteinsEpithelial barrier dysfunctionDiverse clinical outcomesParasite virulence factorsTight junction proteinsCaco-2 cellsClinical outcomesBarrier dysfunctionIntestinal disordersMetronidazole resistanceBlastocystis infectionSubtype 7Metronidazole susceptibilityHost responseIntestinal epitheliumEnteric pathogensNitrosative stressResistant strainsJunction proteinsLuminal stages
2013
Bayesian Estimation of Mixture Models with Prespecified Elements to Compare Drug Resistance in Treatment-Naïve and Experienced Tuberculosis Cases
Izu A, Cohen T, DeGruttola V. Bayesian Estimation of Mixture Models with Prespecified Elements to Compare Drug Resistance in Treatment-Naïve and Experienced Tuberculosis Cases. PLOS Computational Biology 2013, 9: e1002973. PMID: 23555210, PMCID: PMC3605089, DOI: 10.1371/journal.pcbi.1002973.Peer-Reviewed Original ResearchConceptsTreatment-experienced patientsDrug-resistant strainsMultiple drug-resistant strainsTreatment-naïve patientsDrug-resistant tuberculosisMycobacterium tuberculosis isolatesWorld Health OrganizationDrug resistance pathwaysTreatment-naïveTuberculosis casesTuberculosis isolatesWorldwide surveillanceDrug resistancePatientsHealth OrganizationResistant strainsResistant pathogensResistance pathwaysLow transmissibilityPathwayTuberculosis
2012
Schistosoma mansoni in Susceptible and Resistant Snail Strains Biomphalaria tenagophila: In Vivo Tissue Response and In Vitro Hemocyte Interactions
Nacif-Pimenta R, de Mattos AC, da Silva Orfanó A, Barbosa L, Pimenta PF, Coelho PM. Schistosoma mansoni in Susceptible and Resistant Snail Strains Biomphalaria tenagophila: In Vivo Tissue Response and In Vitro Hemocyte Interactions. PLOS ONE 2012, 7: e45637. PMID: 23049828, PMCID: PMC3458097, DOI: 10.1371/journal.pone.0045637.Peer-Reviewed Original ResearchConceptsS. mansoniInternal defense systemNon-self molecular patternsResistant snailsSchistosoma mansoniResistant strainsImmune defense mechanismsBiomphalaria tenagophilaThreat of infectionB. tenagophilaSnail strainsInitial infectionSusceptible snailsParasitic diseasesInfectionImmune defense responseMansoniMolecular patternsSusceptible strainsTissue responseTime courseCellular reactionsHost cellsCellular defenseVivo tissue response
2009
What is the mechanism for persistent coexistence of drug-susceptible and drug-resistant strains of Streptococcus pneumoniae?
Colijn C, Cohen T, Fraser C, Hanage W, Goldstein E, Givon-Lavi N, Dagan R, Lipsitch M. What is the mechanism for persistent coexistence of drug-susceptible and drug-resistant strains of Streptococcus pneumoniae? Journal Of The Royal Society Interface 2009, 7: 905-919. PMID: 19940002, PMCID: PMC2871802, DOI: 10.1098/rsif.2009.0400.Peer-Reviewed Original ResearchConceptsDrug-resistant strainsStreptococcus pneumoniaeInfectious diseasesDrug-susceptible strainsHigher reproduction numberCent prevalenceSubstantial prevalencePersistent coexistenceDrug resistanceMultiple infectionsAntimicrobial useResistant strainsBacterial spreadAntimicrobial resistancePrevalenceDiseasePneumoniaeOutcomesReproduction numberTreatmentHost interactionsPathogensCoinfection
2008
Latent Coinfection and the Maintenance of Strain Diversity
Colijn C, Cohen T, Murray M. Latent Coinfection and the Maintenance of Strain Diversity. Bulletin Of Mathematical Biology 2008, 71: 247. PMID: 19082663, PMCID: PMC2652765, DOI: 10.1007/s11538-008-9361-y.Peer-Reviewed Original Research
2007
Antiviral Resistance and the Control of Pandemic Influenza
Lipsitch M, Cohen T, Murray M, Levin BR. Antiviral Resistance and the Control of Pandemic Influenza. PLOS Medicine 2007, 4: e15. PMID: 17253900, PMCID: PMC1779817, DOI: 10.1371/journal.pmed.0040015.Peer-Reviewed Original ResearchConceptsResistant strainsPandemic influenzaInfluenza pandemicAntiviral resistanceTransmission-reducing measuresNext influenza pandemicAntiviral drug useUse of antiviralsStrains of influenzaSuboptimal vaccinesAntiviral treatmentInfluenza infectionRisk of resistanceDeterministic compartmental modelAntiviral agentsAntiviral drugsPandemic planningDrug useVaccine developmentDrug resistanceControl measuresAntiviralsInfluenzaPandemic spreadPandemic
2005
Potent 4-aminopiperidine based antimalarial agents
Brinner KM, Powles MA, Schmatz DM, Ellman JA. Potent 4-aminopiperidine based antimalarial agents. Bioorganic & Medicinal Chemistry Letters 2005, 15: 345-348. PMID: 15603951, DOI: 10.1016/j.bmcl.2004.10.069.Peer-Reviewed Original Research
2004
Parasitological resistance of Plasmodium falciparum to antimalarial drugs: what physicians should keep in mind.
Tinto H, Ouédraogo J, Traoré M, Guiguemdé T. Parasitological resistance of Plasmodium falciparum to antimalarial drugs: what physicians should keep in mind. Cahiers De Santé 2004, 14: 69-73. PMID: 15454363.Peer-Reviewed Original ResearchConceptsMalaria case managementParasitological resistanceAntimalarial drugsCase managementDrug resistancePlasmodium falciparum drug resistanceSemi-immune subjectsNon-immune subjectsMalaria drug resistanceAttitudes of physiciansSelective drug pressurePublic health practiceTherapeutic decisionsDrug pressureHost immunityParasitological resultsHealth practicesClinical levelPlasmodium falciparumResistant strainsPhysiciansDrugsLower proportionVivoClassification system
2000
Evaluation of 11C-colchicine for PET imaging of multiple drug resistance.
Levchenko A, Mehta B, Lee J, Humm J, Augensen F, Squire O, Kothari P, Finn R, Leonard E, Larson S. Evaluation of 11C-colchicine for PET imaging of multiple drug resistance. Journal Of Nuclear Medicine 2000, 41: 493-501. PMID: 10716325.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsATP Binding Cassette Transporter, Subfamily B, Member 1Carbon RadioisotopesColchicineDrug Resistance, MultipleFlow CytometryHumansMiceMice, Inbred BALB CModels, TheoreticalNeuroblastomaRatsRats, NudeTissue DistributionTomography, Emission-ComputedTransplantation, HeterologousTumor Cells, CulturedConceptsResistant tumorsPET imagingMultiple drug resistance phenotypeDrug-resistant variantsQuality of lifeCell linesMultiple drug resistanceResistant cell linesC cell lineP-gp actionDrug resistance phenotypeEarly diagnosisNude ratsFDG scansTumorsP-glycoproteinDrug resistanceBiodistribution experimentsCytotoxic agentsChemotherapeutic interventionResistant strainsCancer cellsIntracellular accumulationVivo experimentsScans
1999
Adherence: a necessity for successful HIV combination therapy.
Chesney M, Ickovics J, Hecht F, Sikipa G, Rabkin J. Adherence: a necessity for successful HIV combination therapy. AIDS 1999, 13 Suppl A: s271-8. PMID: 10885784.Peer-Reviewed Original ResearchConceptsCombination therapyHIV/AIDSHIV combination therapySuccessful treatment outcomeEmergence of resistancePatient adherenceClinical trialsDisease progressionLong-term benefitsRisk factorsHIV therapyTreatment outcomesTherapyAdherence researchResistant strainsHealth benefitsAdherenceIntervention programsVirus breakthroughAIDSIntervention effortsDifferent populationsValid methodFocused effortsHIV
1987
Immune serum from both susceptible and resistant strains of mice increases phagocytosis of Leishmania mexicana amazonensis by macrophages.
Reis M, Roters S, Barral-Netto M. Immune serum from both susceptible and resistant strains of mice increases phagocytosis of Leishmania mexicana amazonensis by macrophages. Acta Tropica 1987, 44: 339-42. PMID: 2892370.Peer-Reviewed Original Research
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