2024
Association Between the Decipher Genomic Classifier and Prostate Cancer Outcome in the Real-world Setting
Leapman M, Ho J, Liu Y, Filson C, Zhao X, Hakansson A, Proudfoot J, Davicioni E, Martin D, An Y, Seibert T, Lin D, Spratt D, Cooperberg M, Sprenkle P, Ross A. Association Between the Decipher Genomic Classifier and Prostate Cancer Outcome in the Real-world Setting. European Urology Oncology 2024 PMID: 39098389, DOI: 10.1016/j.euo.2024.07.010.Peer-Reviewed Original ResearchDecipher genomic classifierRisk of metastasisBiochemical recurrenceRadical prostatectomyGenomic classifierDecipher testProstate cancerProstate Risk Assessment Postsurgical ScoreRisk of biochemical recurrencePatient's prostate cancerRisk of cancer recurrencePathological risk factorsProstate cancer outcomesCox proportional hazards regressionRetrospective cohort studyElectronic health record dataReal-world settingsProportional hazards regressionHealth record dataReal-world practice settingsProstate biopsyRP specimensOncological outcomesPrognostic significanceMedian ageA Rare Pediatric Mandibular Mass: Diagnosis, Treatment and Reconstruction: A Case Report
Susan S, Gorman L, Santore E, Boldikova D, Ibrahim G, Kravchenko D, Khan M, Johnson D, Mehra S, Laskin W, Eskendri J. A Rare Pediatric Mandibular Mass: Diagnosis, Treatment and Reconstruction: A Case Report. Oral Surgery Oral Medicine Oral Pathology And Oral Radiology 2024, 138: e63. DOI: 10.1016/j.oooo.2024.04.096.Peer-Reviewed Original ResearchSclerosing epithelioid fibrosarcomaFibular free flap reconstructionHigh risk of metastasisAggressive clinical courseMetastasis 9 monthsRisk of metastasisEpisodes of recurrenceFree flap reconstructionMalignant fibroblastic neoplasmExcisional surgeryClinical courseFlap reconstructionHyalinized stromaAdjunctive therapyPoor prognosisSurgical siteEpithelioid cellsTreatment planningMiddle aged adultsTreatment protocolsFibroblastic neoplasmRight mandibleHigh riskMUC4 immunoreactivityLower extremitiesEvolutionary Medicine
Stearns S, Medzhitov R. Evolutionary Medicine. 2024 DOI: 10.1093/oso/9780192871978.001.0001.Peer-Reviewed Original ResearchRisk of metastasisPlacental invasionSolid tumorsEvolution of reproductionMental disordersAdaptive therapyPublic healthVaccine developmentEvolution of agingSick personEvolutionary historyEvolutionary insightsPhage therapyPathogen emergenceIndependent evolutionEvolutionary hypothesesHealthEvolutionary aspectsTherapyCancerDiseaseEvolutionary medicineMedical researchChildbirthVascular mimicry as a facilitator of melanoma brain metastasis
Provance O, Oria V, Tran T, Caulfield J, Zito C, Aguirre-Ducler A, Schalper K, Kluger H, Jilaveanu L. Vascular mimicry as a facilitator of melanoma brain metastasis. Cellular And Molecular Life Sciences 2024, 81: 188. PMID: 38635031, PMCID: PMC11026261, DOI: 10.1007/s00018-024-05217-z.Peer-Reviewed Original ResearchConceptsVascular mimicryBrain metastasesMouse model of metastatic melanomaIncreased risk of metastasisAssociated with tumor volumeMelanoma brain metastasesRisk of metastasisSurvival of miceFuture treatment regimensCell line modelsTumor suppressor pathwayMetastatic melanomaTumor volumeSolid tumorsTreatment regimensTumor typesPoor prognosisHippo tumor suppressor pathwayIncreased riskMouse modelDownstream targets YAPMelanomaMetastasisSuppressor pathwayTumor
2023
Validation of the Prognostic Usefulness of the Gene Expression Profiling Test in Patients with Uveal Melanoma
Miguez S, Lee R, Chan A, Demkowicz P, Jones B, Long C, Abramson D, Bosenberg M, Sznol M, Kluger H, Goldbaum M, Francis J, Pointdujour-Lim R, Bakhoum M. Validation of the Prognostic Usefulness of the Gene Expression Profiling Test in Patients with Uveal Melanoma. Ophthalmology 2023, 130: 598-607. PMID: 36739981, PMCID: PMC10619207, DOI: 10.1016/j.ophtha.2023.01.020.Peer-Reviewed Original ResearchConceptsMetastasis-free survivalRisk of metastasisClass 2 tumorsAdditional prognostic valueRate of metastasisPrognostic usefulnessTumor sizeTumor characteristicsPrognostic valueUveal melanomaGene expression profile testingMemorial Sloan-Kettering Cancer CenterGEP classificationCox hazard regression analysisYale-New Haven HospitalHazards regression analysisGene expression profiling testsNew Haven HospitalClass 1 tumorsGEP class 2Class 1AMean followTumor thicknessCancer CenterSurveillance protocol
2021
E-Cigarettes Promote Macrophage-Tumor Cells Crosstalk: Focus on Breast Carcinoma Progression and Lung Metastasis
Pham K, DeFina S, Wang H. E-Cigarettes Promote Macrophage-Tumor Cells Crosstalk: Focus on Breast Carcinoma Progression and Lung Metastasis. Exploratory Research And Hypothesis In Medicine 2021, 6: 60-66. PMID: 35419501, PMCID: PMC9005083, DOI: 10.14218/erhm.2021.00002.Peer-Reviewed Original ResearchTumor-associated macrophagesBreast cancerMetastasis of BCTumor microenvironmentC motif chemokine ligand 5Enhanced tumor malignancyRisk of metastasisConventional cigarette smokingAggressive breast cancerChemokine ligand 5Breast carcinoma progressionCig vapingDNA damaging effectsCigarette smokingLung metastasesImmune cellsAggressive phenotypeBC progressionMacrophage activationCig useMetastasisTumor malignancyCarcinoma progressionE-cigsE-cigarettes
2018
Low Frequency of Lymph Node Metastases in Patients in the United States With Early-stage Gastric Cancers That Fulfill Japanese Endoscopic Resection Criteria
Hanada Y, Choi AY, Hwang JH, Draganov PV, Khanna L, Sethi A, Bartel MJ, Goel N, Abe S, De Latour RA, Park K, Melis M, Newman E, Hatzaras I, Reddy SS, Farma JM, Liu X, Schlachterman A, Kresak J, Trapp G, Ansari N, Schrope B, Lee JY, Dhall D, Lo S, Jamil LH, Burch M, Gaddam S, Gong Y, Del Portillo A, Tomizawa Y, Truong CD, Brewer Gutierrez OI, Montgomery E, Johnston FM, Duncan M, Canto M, Ahuja N, Lennon AM, Ngamruengphong S. Low Frequency of Lymph Node Metastases in Patients in the United States With Early-stage Gastric Cancers That Fulfill Japanese Endoscopic Resection Criteria. Clinical Gastroenterology And Hepatology 2018, 17: 1763-1769. PMID: 30471457, DOI: 10.1016/j.cgh.2018.11.031.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAgedAged, 80 and overCarcinoma, Signet Ring CellEndoscopic Mucosal ResectionFemaleGastrectomyHumansJapanLymph NodesLymphatic MetastasisMaleMiddle AgedNeoplasm GradingNeoplasm InvasivenessNeoplasm StagingPractice Guidelines as TopicRetrospective StudiesStomach NeoplasmsTumor BurdenUnited StatesConceptsFrequency of lymphEarly gastric cancerEndoscopic resectionLymph node metastasisLymph nodesGastric cancerLymphovascular invasionNode metastasisGastric adenocarcinomaEarly gastric cancer lesionsEarly-stage gastric cancerEndoscopic resection criteriaLymph node dissectionTertiary care centerRisk of lymphRisk of metastasisGastric cancer lesionsDefinitive therapyNode dissectionResection criteriaSurgical resectionAsian patientsRetrospective studySubmucosal invasionRisk factors
2016
Risk of metastasis and orbital recurrence in advanced retinoblastoma eyes treated with systemic chemoreduction versus primary enucleation
Berry JL, Kogachi K, Aziz HA, McGovern K, Zolfaghari E, Murphree AL, Jubran R, Kim JW. Risk of metastasis and orbital recurrence in advanced retinoblastoma eyes treated with systemic chemoreduction versus primary enucleation. Pediatric Blood & Cancer 2016, 64: e26270. PMID: 28221729, PMCID: PMC7034314, DOI: 10.1002/pbc.26270.Peer-Reviewed Original ResearchMeSH KeywordsAntineoplastic Combined Chemotherapy ProtocolsCarboplatinCombined Modality TherapyEtoposideEye EnucleationFemaleFollow-Up StudiesHumansInfantMaleNeoplasm Recurrence, LocalNeoplasm StagingOrbital NeoplasmsPrognosisRetinal NeoplasmsRetinoblastomaRetrospective StudiesRisk FactorsSalvage TherapyVincristineConceptsPrimary enucleation groupSystemic chemoreductionHigh-risk pathologyMetastatic diseaseOrbital recurrencePrimary enucleationAdvanced retinoblastomaEnucleation groupTreatment failureHigh-risk pathologic featuresChildren's Hospital Los AngelesPrimary outcome measureRisk of metastasisSalvage therapySecondary enucleationRetrospective reviewE retinoblastomaMedian timePathologic featuresRetinoblastoma eyesTreatment modalitiesPoor responseOutcome measuresChemoreductionSubsequent enucleation
2014
Molecular Imaging of Tumor Hypoxia with Positron Emission Tomography
Kelada OJ, Carlson DJ. Molecular Imaging of Tumor Hypoxia with Positron Emission Tomography. Radiation Research 2014, 181: 335-349. PMID: 24673257, PMCID: PMC5555673, DOI: 10.1667/rr13590.1.Peer-Reviewed Original ResearchConceptsTumor hypoxiaOncology communityTumor hypoxic volumeImportant prognostic factorOverall treatment responseRisk of metastasisTypes of tumorsEmission Tomography ImagingPositron emission tomography (PET) imagingClinical oncology communityPositron emission tomographyConventional cancer therapiesMagnitude of hypoxiaPrognostic factorsCancer patientsTreatment responseField of PETChemotherapy resistanceEmission tomographyClinical settingRadiolabelled agentsCancer typesPatientsHypoxia tracerHypoxia
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