Efficacy and Safety of Apixaban for Pediatric Patients Requiring Anticoagulation for Treatment of Venous Thromboembolism
Driscoll J, O'Brien S, Newburger J, Mitchell L, Holzhauer S, Ahuja S, Rubio A, Gaitonde P, Robertson A, Polinsky M, Masiukiewicz U, Brandao L. Efficacy and Safety of Apixaban for Pediatric Patients Requiring Anticoagulation for Treatment of Venous Thromboembolism. Blood 2024, 144: 295-295. DOI: 10.1182/blood-2024-198612.Peer-Reviewed Original ResearchDeep vein thrombosisStandard of careLow-molecular-weight heparinVitamin K antagonistsStandard of care groupPulmonary embolismAdverse eventsApixaban groupApixaban concentrationsBleeding eventsPediatric patientsSafety profileIncidence of treatment-emergent adverse eventsLow risk of VTE recurrenceUnfractionated heparinTreatment-emergent adverse eventsRisk of VTE recurrenceStandard of care therapyAge groupsTreatment of venous thromboembolismVTE-related deathSafety of apixabanRecurrent VTE eventsTreatment of VTEMinor bleeding eventsRandomized study of temporary diaphragm pacing for enhanced recovery after surgery in cardiac surgery patients at risk of prolonged mechanical ventilation
Hungate J, Onders R, Diasty M, Abu-Omar Y, Arora R, Baeza C, Elgudin Y, Gray K, Markowitz A, Pelletier M, Ribeiro I, Vega P, Rushing G, Sabik J. Randomized study of temporary diaphragm pacing for enhanced recovery after surgery in cardiac surgery patients at risk of prolonged mechanical ventilation. JTCVS Open 2024, 22: 76-84. PMID: 39780786, PMCID: PMC11704535, DOI: 10.1016/j.xjon.2024.09.031.Peer-Reviewed Original ResearchProlonged mechanical ventilationStandard of care groupRisk of prolonged mechanical ventilationMechanical ventilationCardiac surgeryDiaphragmatic pacingDiaphragm pacingTreatment groupsRandomized trialsHistory of chronic obstructive pulmonary diseaseLeft ventricular ejection fractionIntra-aortic balloon pumpDecrease mechanical ventilationCardiac surgery patientsVentricular ejection fractionHigh-risk patientsMulticenter randomized trialCare groupEnhanced recoveryChronic obstructive pulmonary diseaseRelative risk reductionIntensive care unitStandard of carePredictive enrichment strategiesObstructive pulmonary disease
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