2025
A single-cell atlas of circulating immune cells over the first 2 months of age in extremely premature infants
Olaloye O, Gu W, Gehlhaar A, Sabuwala B, Eke C, Li Y, Kehoe T, Farmer R, Gabernet G, Lucas C, Tsang J, Lakhani S, Taylor S, Tseng G, Kleinstein S, Konnikova L. A single-cell atlas of circulating immune cells over the first 2 months of age in extremely premature infants. Science Translational Medicine 2025, 17: eadr0942. PMID: 40043141, DOI: 10.1126/scitranslmed.adr0942.Peer-Reviewed Original ResearchConceptsExtremely premature infantsFull-term infantsT cellsMonths of lifePremature infantsImmune cellsMemory CD4<sup>+</sup> T cellsCD4<sup>+</sup> T cellsMemory-like T cellsAnalysis of immune cellsNaive CD4<sup>+</sup>Peripheral T cell developmentWeeks of gestationCord blood samplesNatural killer cellsT helper 1B cell receptor sequencesT cell developmentCycling T cellsMonths of ageSingle-cell suspensionsAmount of bloodSusceptibility to infectionCD4<sup>+</sup>Killer cellsPrenatal Cannabis Use and Depressive Symptoms
Pitt T, Allshouse A, Kim P, McMillin G, Silver R, Chung J, Grobman W, Haas D, Mercer B, Parry S, Reddy U, Saade G, Simhan H, Metz T. Prenatal Cannabis Use and Depressive Symptoms. Obstetrics And Gynecology 2025, 145: 417-425. PMID: 40014863, PMCID: PMC11925678, DOI: 10.1097/aog.0000000000005860.Peer-Reviewed Original ResearchConceptsAssociated with later depressive symptomsCannabis exposureDepressive symptomsCannabis useTHC-COOHAssociated with increased depressive symptomsAssociated with greater oddsAssociated with depressive symptomsFirst-trimesterExposed to cannabisPregnancy outcome dataWeeks of gestationFirst-trimester exposureGreater oddsCannabis metabolitesSecondary analysisCannabisAssociated with increased oddsExploratory analysisUrine immunoassayTrimesterHigher levelsPrimary outcomePregnancyAcademic centers
2024
Continuous Glucose Monitoring among Infants Born Very Preterm: Evidence for Accuracy in Neonatal Intensive Care
Bonet J, Guiducci S, Res G, Brigadoi S, Sen S, Montaldo P, Priante E, Santoro N, Trevisanuto D, Baraldi E, Dalla Man C, Galderisi A. Continuous Glucose Monitoring among Infants Born Very Preterm: Evidence for Accuracy in Neonatal Intensive Care. The Journal Of Pediatrics 2024, 278: 114416. PMID: 39579867, DOI: 10.1016/j.jpeds.2024.114416.Peer-Reviewed Original ResearchBlood glucoseContinuous glucose monitoringSensor glucoseNeonatal intensive care unitInfants born pretermWeeks of gestationNeonatal intensive careIntensive care unitVery pretermGlucose monitoringCare unitIntensive carePoint-of-care blood glucoseInfantsPretermNeonatesPaired measurementsCGM accuracyHoursBirthweightGestationGlucoseBirthWeeksProphylactic Red Cell Exchange: Preventing Complications in Pregnant Patients with Sickle Cell Disease
Sariipek N, Horstman E, Tormey C, Yurtsever N. Prophylactic Red Cell Exchange: Preventing Complications in Pregnant Patients with Sickle Cell Disease. Blood 2024, 144: 5340-5340. DOI: 10.1182/blood-2024-198650.Peer-Reviewed Original ResearchRed cell exchangeManagement of pregnancy-related complicationsSickle cell diseasePre-eclampsiaPregnancy-related complicationsCesarean sectionCell diseaseApgar scoreHealthy infantsPainful crisesBilateral retinal vein occlusionAmerican Society for Apheresis guidelinesSpectra Optia apheresis systemHematocrit levelsEmergency cesarean sectionRetinal artery occlusionRetinal vein occlusionBilateral renal infarctionSickle cell-related complicationsHistory of retinopathyPrevent pre-eclampsiaSecond-line therapyTransient vision lossWeeks of gestationPregnancy related complicationsCffDNA screening for Niemann–pick disease, type C1: a case series
Lau S, Fawaz R, Rigobello R, Bawazeer S, Alajaji N, Faqeih E, Li Y, Feng Y, Xia F, Eng C, Abedalthagafi M. CffDNA screening for Niemann–pick disease, type C1: a case series. Frontiers In Medicine 2024, 11: 1390693. PMID: 39161410, PMCID: PMC11330825, DOI: 10.3389/fmed.2024.1390693.Peer-Reviewed Original ResearchNext-generation sequencingInvasive diagnostic testsCffDNA screeningNiemann-Pick diseaseCustom data analysis pipelineAmplicon next-generation sequencingAmplicon-based next-generation sequencingDisease-causing variantsType C1Biallelic pathogenic variantsData analysis pipelinesCell-free fetal DNADetect chromosomal abnormalitiesMaternal peripheral bloodDiagnostic testsWeeks of gestationNPC1 geneHigh-risk pregnanciesPathogenic variantsAnalysis pipelineFamilial variantFetal DNAProgressive neurodegenerationChromosomal abnormalitiesPeripheral bloodObstetric Complications and Birth Outcomes After Antenatal Coronavirus Disease 2019 (COVID-19) Vaccination
Vesco K, Denoble A, Lipkind H, Kharbanda E, DeSilva M, Daley M, Getahun D, Zerbo O, Naleway A, Jackson L, Williams J, Boyce T, Fuller C, Weintraub E, Vazquez-Benitez G. Obstetric Complications and Birth Outcomes After Antenatal Coronavirus Disease 2019 (COVID-19) Vaccination. Obstetrics And Gynecology 2024, 143: 794-802. PMID: 38626447, PMCID: PMC11090513, DOI: 10.1097/aog.0000000000005583.Peer-Reviewed Original ResearchConceptsSmall-for-gestational ageMessenger RNA COVID-19 vaccineGestational diabetes mellitusRisk of adverse pregnancy outcomesAdverse pregnancy outcomesPreterm birthGestational hypertensionAdjusted hazard ratiosCOVID-19 vaccine dosesPregnancy outcomesCOVID-19 vaccineAssociated with small-for-gestational ageIncreased risk of adverse pregnancy outcomesVaccine doseRisk of preterm birthMessenger RNARetrospective cohort study of individualsMRNA COVID-19 vaccineWeeks of gestationRetrospective cohort studyHistory of COVID-19Cohort study of individualsVaccine Safety DatalinkSingleton pregnanciesUnexposed pregnanciesCongenital Malformations of the Eye: A Pictorial Review and Clinico‐Radiological Correlations
Guarnera A, Valente P, Pasquini L, Moltoni G, Randisi F, Carducci C, Carboni A, Lucignani G, Napolitano A, Romanzo A, Longo D, Gandolfo C, Rossi-Espagnet M. Congenital Malformations of the Eye: A Pictorial Review and Clinico‐Radiological Correlations. Journal Of Ophthalmology 2024, 2024: 5993083. PMID: 38322500, PMCID: PMC10846927, DOI: 10.1155/2024/5993083.Peer-Reviewed Original ResearchOcular malformationsCongenital malformationsPictorial reviewWeeks of gestationClinico-radiological correlationOphthalmologic evaluationOphthalmological findingsMalformation severityImaging findingsMalformationsComplex syndromeQuality of lifeImaging protocolVision impairmentHeterogeneous spectrumAbnormalitiesClinical radiologistsEye formationGenetic conditionsEyesCausative eventChild growthComplete absenceImage featuresGestationSpeculum-free portable preterm imaging system
Boonya-Ananta T, Gonzalez M, Ajmal A, Du Le V, DeHoog E, Paidas M, Jayakumar A, Ramella-Roman J. Speculum-free portable preterm imaging system. Journal Of Biomedical Optics 2024, 29: 052918-052918. PMID: 38282917, PMCID: PMC10821769, DOI: 10.1117/1.jbo.29.5.052918.Peer-Reviewed Original ResearchConceptsNon-pregnant volunteersWeeks of gestationMortality rateNon-pregnant cervixCervical imagesPreterm birth riskStandard of careMaternal mortality rateUterine cervixPreterm birthPremature birthWomen's reproductive healthBirth riskCervixQuality of lifeDevelopmental impairmentReproductive healthBirthPatientsInfantsInfant mortality rateReducing infantInsertion sheathImaging probesPatient care
2023
Neighborhood Socioeconomic Disadvantage and Abnormal Birth Weight
Venkatesh K, Yee L, Johnson J, Wu J, McNeil B, Mercer B, Simhan H, Reddy U, Silver R, Parry S, Saade G, Chung J, Wapner R, Lynch C, Grobman W. Neighborhood Socioeconomic Disadvantage and Abnormal Birth Weight. Obstetrics And Gynecology 2023, 142: 1199-1207. PMID: 37769319, PMCID: PMC10972636, DOI: 10.1097/aog.0000000000005384.Peer-Reviewed Original ResearchAbnormal birth weightNeighborhood socioeconomic disadvantageGestational ageBirth weightPregnant individualsADI quartileIncreased oddsSocioeconomic disadvantageWeeks of gestationPotential confounding variablesLogistic regression modelsHigher area deprivationSGA neonatesLGA neonatesMultinomial logistic regression modelsSingleton gestationsCohort enrollmentAnalytic populationParticipant's addressFetal sexConfounding variablesSecondary analysisArea deprivationNeonatesQuartileSodium intake and the development of hypertensive disorders of pregnancy
Bank T, Grasch J, Chung J, Mercer B, McNeil R, Parry S, Saade G, Shanks A, Silver R, Simhan H, Yee L, Reddy U, Grobman W, Frey H. Sodium intake and the development of hypertensive disorders of pregnancy. American Journal Of Obstetrics & Gynecology MFM 2023, 5: 101166. PMID: 37741626, DOI: 10.1016/j.ajogmf.2023.101166.Peer-Reviewed Original ResearchConceptsHypertensive disordersHigh sodium intakeSodium intakeChronic hypertensionNonpregnant populationLow platelet count syndromeNeonatal intensive care unitNulliparous Pregnancy Outcomes StudyElevated liver enzymesGestational age neonatesFood frequency questionnaireLow sodium intakeIncidence risk ratioIntensive care unitWeeks of gestationPregnancy Outcomes StudyLack of associationChi-square testGestational hypertensionNeonatal outcomesNonpregnant stateSodium restrictionFrequency questionnairePreterm birthSingleton pregnanciesDesirability of outcome ranking for obstetrical trials: illustration and application to the ARRIVE trial
SANDOVAL G, GROBMAN W, EVANS S, RICE M, CLIFTON R, CHAUHAN S, COSTANTINE M, GIBSON K, LONGO M, METZ T, MILLER E, PARRY S, REDDY U, ROUSE D, SIMHAN H, THORP J, TITA A, SAADE G, Network E. Desirability of outcome ranking for obstetrical trials: illustration and application to the ARRIVE trial. American Journal Of Obstetrics And Gynecology 2023, 230: 370.e1-370.e12. PMID: 37741532, PMCID: PMC10939984, DOI: 10.1016/j.ajog.2023.09.016.Peer-Reviewed Original ResearchElective inductionARRIVE trialCesarean deliverySecondary outcomesPrimary outcomeVaginal deliveryDesirability of outcomeEunice Kennedy Shriver National InstituteSpontaneous vaginal deliverySevere neonatal complicationsWeeks of gestationOperative vaginal deliveryBetter overall outcomesPerson-centred careNeonatal complicationsObstetric trialsExpectant managementPerinatal deathRandomized trialsDecreased riskPoor outcomeClinical trialsChild healthTreatment scoresOutcome rankingsPlacental Pathology Findings in Unexplained Pregnancy Losses
Thompson B, Holzer P, Kliman H. Placental Pathology Findings in Unexplained Pregnancy Losses. Reproductive Sciences 2023, 31: 488-504. PMID: 37725247, PMCID: PMC10827979, DOI: 10.1007/s43032-023-01344-3.Peer-Reviewed Original ResearchWeeks of gestationCommon pathologic featureSmall placentaPathologic featuresPregnancy lossChorionic villiPlacental pathology findingsUnexplained lossUnexplained pregnancy lossAntepartum stillbirthPlacental examinationUnexplained stillbirthPathology findingsUnexplained miscarriagePrevalent abnormalityPathologic diagnosisClinical databaseStillbirthMiscarriagePathology slidesDiagnostic categoriesGenetic abnormalitiesClassification systemPlacentaPotential mechanismsRisk Factors for Perinatal Transmission of Hepatitis C Virus
Prasad M, Saade G, Clifton R, Sandoval G, Hughes B, Reddy U, Bartholomew A, Salazar A, Chien E, Tita A, Thorp J, Metz T, Wapner R, Sabharwal V, Simhan H, Swamy G, Heyborne K, Sibai B, Grobman W, El-Sayed Y, Casey B, Parry S, Rathore M, Diaz-Velasco R, Puga A, Wiznia A, Kovacs A, Garry D, Macones G. Risk Factors for Perinatal Transmission of Hepatitis C Virus. Obstetrics And Gynecology 2023, 142: 449-456. PMID: 37590978, PMCID: PMC10437102, DOI: 10.1097/aog.0000000000005306.Peer-Reviewed Original ResearchConceptsPerinatal transmissionHCV infectionRisk factorsPrimary outcomeHuman Development Maternal-Fetal Medicine Units NetworkMaternal-Fetal Medicine Units NetworkHepatitis C virus infectionEunice Kennedy Shriver National InstituteC virus infectionPerinatal transmission rateWeeks of gestationHigh viral loadHepatitis C virusMonths of lifePositive test resultsAntepartum bleedingViremic participantsVaginal bleedingHCV RNAViremic individualsViral loadC virusObservational studyVirus infectionDemonstrable viremiaAssociation of Daytime-Only, Nighttime-Only, and Compound Heat Waves With Preterm Birth by Urban-Rural Area and Regional Socioeconomic Status in China
Guo Y, Chen P, Xie Y, Wang Y, Mu Y, Zhou R, Niu Y, Shi X, Zhu J, Liang J, Liu Q. Association of Daytime-Only, Nighttime-Only, and Compound Heat Waves With Preterm Birth by Urban-Rural Area and Regional Socioeconomic Status in China. JAMA Network Open 2023, 6: e2326987. PMID: 37566422, PMCID: PMC10422195, DOI: 10.1001/jamanetworkopen.2023.26987.Peer-Reviewed Original ResearchConceptsCase-crossover studySocioeconomic statusPreterm birthNational Maternal Near Miss Surveillance SystemChina's National Maternal Near Miss Surveillance SystemRegional socioeconomic statusSingleton live birthsAssociated with higher riskAssociated with preterm birthGestational ageUrban-rural areasUrban-rural communitiesMaternal healthSingleton birthsMain OutcomesHeat wave exposureCompound heat wavesSocioeconomic regionsWeeks of gestationOdds ratioBirth dataMaternal ageConsecutive daysRural populationSurveillance systemPROMPT: Prospective Meta-analysis for Pessary Trials Study Protocol
Thom E, Saade G, Askie L, Ugwu L, Mol B, Vayssiere C, Norman J, Pajkrt E, Clifton R, Biggio J, Arnaud C, Berghella V, Canino M, Carreras E, Dugoff L, Hoffman M, Pacagnella R, Reddy U, Saccone G, van 't Hooft J, Dang V, Collaboration F. PROMPT: Prospective Meta-analysis for Pessary Trials Study Protocol. American Journal Of Perinatology 2023, 41: e2230-e2237. PMID: 37429323, PMCID: PMC10776795, DOI: 10.1055/s-0043-1771018.Peer-Reviewed Original ResearchShort cervical lengthPreterm birthIndividual patient dataShort cervixRandomized trialsPessary trialCervical lengthTwin gestationsSubsequent spontaneous preterm birthLong-term neurological disabilityOngoing randomized trialsSpontaneous preterm birthTrial study protocolWeeks of gestationProspective Meta-AnalysisSignificant health issueCervical supportNeonatal morbidityPreterm deliverySingleton gestationsSecondary outcomesFetal deathNeurological disabilityPrimary outcomeWeeks' gestationFetal growth restriction and small for gestational age as predictors of neonatal morbidity: which growth nomogram to use?
Leon-Martinez D, Lundsberg L, Culhane J, Zhang J, Son M, Reddy U. Fetal growth restriction and small for gestational age as predictors of neonatal morbidity: which growth nomogram to use? American Journal Of Obstetrics And Gynecology 2023, 229: 678.e1-678.e16. PMID: 37348779, DOI: 10.1016/j.ajog.2023.06.035.Peer-Reviewed Original ResearchConceptsNeonatal composite outcomeComposite outcomeFetal growth restrictionGestational ageFetal weightWeeks of gestationPositive likelihood ratioGrowth restrictionNonanomalous singleton pregnanciesPoor neonatal outcomeRetrospective cohort studySingle academic centerWeeks of deliveryDays of deliveryFetal growth referencesElectronic medical recordsProportion of fetusesLikelihood ratioNeonatal morbidityNeonatal outcomesPerinatal outcomesCohort studySingleton pregnanciesNeonatal dataMedical recordsPregnant Patients with a Documented History of Penicillin Allergy and Associated Maternal and Neonatal Outcomes at a Tertiary Care Center
Azmy V, Lundsberg L, Culhane J, Kwah J, Partridge C, Son M. Pregnant Patients with a Documented History of Penicillin Allergy and Associated Maternal and Neonatal Outcomes at a Tertiary Care Center. American Journal Of Perinatology 2023, 41: e2051-e2057. PMID: 37211008, DOI: 10.1055/a-2096-5002.Peer-Reviewed Original ResearchPenicillin allergy historyNon-β-lactam antibioticsPenicillin allergyNeonatal outcomesPregnant patientsAllergy historyPregnant individualsElectronic medical recordsMedical recordsMultivariable analysisPostpartum endometritisHigh riskLactam antibioticsSignificant differencesBad obstetric outcomeRetrospective cohort studyTertiary care centerPostnatal hospital stayWeeks of gestationLarge academic hospitalAssociated maternalEligible deliveriesHospital stayMaternal outcomesObstetric outcomesPredicting primary cesarean delivery in pregnancies complicated by gestational diabetes mellitus
Ramos S, Lewkowitz A, Lord M, Has P, Danilack V, Savitz D, Werner E. Predicting primary cesarean delivery in pregnancies complicated by gestational diabetes mellitus. American Journal Of Obstetrics And Gynecology 2023, 229: 549.e1-549.e16. PMID: 37290567, PMCID: PMC10700654, DOI: 10.1016/j.ajog.2023.06.002.Peer-Reviewed Original ResearchConceptsGestational diabetes mellitusDiabetes mellitusHosmer-Lemeshow testRisk factorsPrimary CDCD riskThird trimesterEarly pregnancy body mass indexPregnancy body mass indexLarge tertiary care centerOlder maternal ageTertiary care centerTrial of laborCohort of patientsBody mass indexImportant clinical outcomesPrimary cesarean deliveryWeeks of gestationMultiple risk factorsCharacteristic curveLogistic regression modelsSimilar discriminatory abilityMultiparous patientsStepwise backward eliminationCesarean deliveryMaternal and Delivery Characteristics and Self-Reported Perceived Control During Labor
Mallett G, Hill K, Doherty L, Grobman W, Reddy U, Tita A, Silver R, Rice M, El-Sayed Y, Wapner R, Rouse D, Saade G, Thorp J, Chauhan S, Costantine M, Chien E, Casey B, Srinivas S, Swamy G, Simhan H, Macones G. Maternal and Delivery Characteristics and Self-Reported Perceived Control During Labor. Obstetrics And Gynecology 2023, 142: 117-124. PMID: 37290106, PMCID: PMC10330140, DOI: 10.1097/aog.0000000000005230.Peer-Reviewed Original ResearchConceptsBody mass indexWeeks of gestationLabor Agentry ScaleScale scoreLabor painPrivate health insuranceDelivery characteristicsLabor pain scoresPrevious pregnancy lossSpontaneous vaginal deliverySevere neonatal complicationsHealth insuranceMode of deliveryFinal multivariable modelMultivariable linear regressionSelf-administered questionnaireSelf-reported raceNeonatal complicationsExpectant managementPain scoresLabor inductionNonprivate insuranceOperative deliveryCesarean deliveryVaginal deliveryAntibiotic choice for Group B Streptococcus prophylaxis in mothers with reported penicillin allergy and associated newborn outcomes
Snider J, Mithal L, Kwah J, Rhodes N, Son M. Antibiotic choice for Group B Streptococcus prophylaxis in mothers with reported penicillin allergy and associated newborn outcomes. BMC Pregnancy And Childbirth 2023, 23: 400. PMID: 37254067, PMCID: PMC10228028, DOI: 10.1186/s12884-023-05697-0.Peer-Reviewed Original ResearchConceptsGroup B streptococcus prophylaxisReported penicillin allergyPenicillin allergyGBS prophylaxisLab drawsNeonatal outcomesNewborn outcomesAntibiotic administrationMedical recordsPregnant individualsIntrapartum group B streptococcus prophylaxisNeonatal intensive care unit admissionDesignThis retrospective cohort studyIntensive care unit admissionSelf-reported penicillin allergyNeonates of mothersCare unit admissionIntrapartum antibiotic prophylaxisRetrospective cohort studyWeeks of gestationMother-infant pairsMother-infant dyadsBeta-lactam antibioticsAntibiotic prophylaxisUnit admission
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