2023
Expedited Partner Therapy: A Multicomponent Initiative to Boost Provider Counseling
Markowitz M, Ackerman-Banks C, Oliveira C, Fashina O, Pathy S, Sheth S. Expedited Partner Therapy: A Multicomponent Initiative to Boost Provider Counseling. Sexually Transmitted Diseases 2023, 51: 15-21. PMID: 37921862, PMCID: PMC11413968, DOI: 10.1097/olq.0000000000001894.Peer-Reviewed Original ResearchMeSH KeywordsChlamydia InfectionsChlamydia trachomatisContact TracingCounselingGonorrheaHumansSexual PartnersUnited StatesConceptsPartner therapyProvider counselingMulticomponent initiativesQuasi-experimental interrupted time-series studyExpedited Partner TherapyInterrupted time series studyRecords of patientsFrequent reinfectionsInterrupted time series modelObstetric indicationsGynecology clinicTherapy prescriptionPatients' perceptionsPatient acceptanceChlamydia trachomatisPatient encountersNeisseria gonorrhoeaeTherapyRegistered NursesTime-series studyPublic insurancePatientsAcademic obstetricsCounselingSignificant increaseThe Estimated Lifetime Quality-Adjusted Life-Years Lost Due to Chlamydia, Gonorrhea, and Trichomoniasis in the United States in 2018
Li Y, You S, Lee K, Yaesoubi R, Hsu K, Gift T, Chesson H, Berruti A, Salomon J, Rönn M. The Estimated Lifetime Quality-Adjusted Life-Years Lost Due to Chlamydia, Gonorrhea, and Trichomoniasis in the United States in 2018. The Journal Of Infectious Diseases 2023, 227: 1007-1018. PMID: 36806950, PMCID: PMC10112678, DOI: 10.1093/infdis/jiad047.Peer-Reviewed Original ResearchMeSH KeywordsChlamydiaChlamydia InfectionsFemaleGonorrheaHumansMaleQuality-Adjusted Life YearsSexually Transmitted DiseasesTrichomonas InfectionsUnited StatesConceptsLifetime QALYsSubstantial health lossesDuration of infectionCost-effectiveness analysisGenital chlamydiaInfection interventionTotal QALYsIncident infectionsChronic sequelaeInfection helpGonorrheaAge groupsChlamydiaInfectionMultivariate sensitivity analysisHealth lossTrichomoniasisQALYWomenSequelaeUnited StatesPrevention policiesQALYsPopulation levelLifetime quality
2022
Host Cell Amplification of Nutritional Stress Contributes To Persistence in Chlamydia trachomatis
Pokorzynski N, Alla M, Carabeo R. Host Cell Amplification of Nutritional Stress Contributes To Persistence in Chlamydia trachomatis. MBio 2022, 13: e02719-22. PMID: 36377897, PMCID: PMC9765610, DOI: 10.1128/mbio.02719-22.Peer-Reviewed Original ResearchConceptsHost cell responsesInfected host cellsNutritional stressStress responseIntracellular environmentGTP biosynthesisHost cellsUniversal stress responseTranscriptional stress responseDual RNA sequencingConsequence of coevolutionEssential nutrient ironBacterial stress responseStress response mechanismsChlamydial growthGuanine nucleotide synthesisGenome reductionTryptophan starvationEukaryotic hostsIron starvationInfected epithelial cellsRNA sequencingNutrient ironIron limitationDistinct nutrientsDevelopment of a Psychometric Tool to Measure Community Solidarity Among Sexual Minorities: Evidence From a Pay-it-Forward Randomized Controlled Trial
Sung A, Zhang TP, Huang W, Tang W, Alexander M, Forastiere L, Kumar N, Hall BJ, Ransome Y, Dieckhaus KD, Wu D, Tucker JD, Yang F. Development of a Psychometric Tool to Measure Community Solidarity Among Sexual Minorities: Evidence From a Pay-it-Forward Randomized Controlled Trial. Sexually Transmitted Diseases 2022, 49: 628-634. PMID: 35675708, PMCID: PMC9378620, DOI: 10.1097/olq.0000000000001659.Peer-Reviewed Original ResearchConceptsTest uptakeMultivariable logistic regressionCross-sectional questionnaireControlled TrialsInfection testingIntervention armStudy armsChlamydia testSocial network supportHigher oddsChinese menHealth outcomesPsychometric toolsLogistic regressionMenPublic healthTrialsFuture studiesSexParticipantsArmUptakeGonorrheaFactorsMSMCombining Cellular Immunology With RNAseq to Identify Novel Chlamydia T-Cell Subset Signatures
Johnson RM, Asashima H, Mohanty S, Shaw AC. Combining Cellular Immunology With RNAseq to Identify Novel Chlamydia T-Cell Subset Signatures. The Journal Of Infectious Diseases 2022, 225: 2033-2042. PMID: 35172331, PMCID: PMC9159333, DOI: 10.1093/infdis/jiac051.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsB-LymphocytesCD4-Positive T-LymphocytesChlamydia InfectionsChlamydia trachomatisGenitaliaMiceMice, Inbred C57BLT-Lymphocyte SubsetsConceptsProtective T cell clonesAntibacterial effector mechanismsT cells residentB cell helpT cell clonesCytokine polarizationImmune miceIL-10Protective immunityVaccine trialsIL-13Surrogate biomarkerEffector mechanismsGenital tractT cellsVaccine candidatesChlamydia trachomatisCells residentHelper functionCellular immunologyMouse studiesHuman investigationsReproductive tractGranzyme A.Investigational data
2021
Modeling the Cost-Effectiveness of Express Multisite Gonorrhea Screening Among Men Who Have Sex With Men in the United States
Earnest R, Rönn MM, Bellerose M, Menon-Johansson AS, Berruti AA, Chesson HW, Gift TL, Hsu KK, Testa C, Zhu L, Malyuta Y, Menzies NA, Salomon JA. Modeling the Cost-Effectiveness of Express Multisite Gonorrhea Screening Among Men Who Have Sex With Men in the United States. Sexually Transmitted Diseases 2021, 48: 805-812. PMID: 33993161, PMCID: PMC8505150, DOI: 10.1097/olq.0000000000001467.Peer-Reviewed Original ResearchMeSH KeywordsChlamydia InfectionsCost-Benefit AnalysisGonorrheaHomosexuality, MaleHumansMaleMass ScreeningPrevalenceSexual and Gender MinoritiesUnited StatesConceptsGonococcal infectionAsymptomatic MSMAnatomic sitesUS MSMIncremental cost-effectiveness ratioMore anatomic sitesCost-effectiveness ratioExtragenital screeningGonorrhea ScreeningPhysical examinationSmall cost savingsAsymptomatic screeningProvider consultationRoutine screeningMore infectionsOnward transmissionVisit costsCumulative health effectsIntervention yearInfectionMSMHealth effectsDiagnostic costsCost-effective optionMen
2020
The Reply
Lam R, Jamidar PA, Aslanian HR, Muniraj T. The Reply. The American Journal Of Medicine 2020, 133: e612. PMID: 33004185, DOI: 10.1016/j.amjmed.2020.05.048.Peer-Reviewed Original ResearchA Secondary Mixed Methods Analysis of a Pay-it-Forward Gonorrhea/Chlamydia Testing Program Among Men Who Have Sex With Men in China.
Li KT, Huang W, Tang W, Wu F, Zhao Y, Wu D, Yang F, Zhang TP, Forastiere L, Alexander M, Kumar N, Tucker JD. A Secondary Mixed Methods Analysis of a Pay-it-Forward Gonorrhea/Chlamydia Testing Program Among Men Who Have Sex With Men in China. Sexually Transmitted Diseases 2020, 47: 395-401. PMID: 32149952, PMCID: PMC7230016, DOI: 10.1097/olq.0000000000001161.Peer-Reviewed Original ResearchPopulation-level Benefits of Extragenital Gonorrhea Screening Among Men Who Have Sex With Men: An Exploratory Modeling Analysis.
Earnest R, Rönn M, Bellerose M, Gift T, Berruti A, Hsu K, Testa C, Zhu L, Malyuta Y, Menzies N, Salomon J. Population-level Benefits of Extragenital Gonorrhea Screening Among Men Who Have Sex With Men: An Exploratory Modeling Analysis. Sexually Transmitted Diseases 2020, 47: 484-490. PMID: 32355108, PMCID: PMC7903327, DOI: 10.1097/olq.0000000000001189.Peer-Reviewed Original ResearchMeSH KeywordsChlamydia InfectionsGonorrheaHomosexuality, MaleHumansMaleMass ScreeningNeisseria gonorrhoeaeRectumSexual and Gender MinoritiesConceptsExtragenital screeningMultisite infectionExtragenital sitesRectal screeningSite-specific prevalenceGonorrhea ScreeningPharyngeal sitesGonorrhea infectionExtragenital infectionsGonorrhea prevalencePopulation-level benefitsRectal sitesImproved screeningDisease controlInfectionPrevalenceIncidenceMenHigh rateSexScreeningRace groupsScreening levelsGonorrheaClinicPay-it-forward gonorrhoea and chlamydia testing among men who have sex with men in China: a randomised controlled trial
Yang F, Zhang TP, Tang W, Ong JJ, Alexander M, Forastiere L, Kumar N, Li KT, Zou F, Yang L, Mi G, Wang Y, Huang W, Lee A, Zhu W, Luo D, Vickerman P, Wu D, Yang B, Christakis NA, Tucker JD. Pay-it-forward gonorrhoea and chlamydia testing among men who have sex with men in China: a randomised controlled trial. The Lancet Infectious Diseases 2020, 20: 976-982. PMID: 32530426, PMCID: PMC8957706, DOI: 10.1016/s1473-3099(20)30172-9.Peer-Reviewed Original ResearchConceptsChlamydia testingTest uptakeCare armCare groupPreventive servicesEvidence-based preventive servicesChlamydia testing uptakeDoris Duke Charitable FoundationHIV testing sitesHIV testingPrimary outcomeSuperiority trialUS National InstitutesTesting uptakeForward armSuperiority marginChinese MSMGonorrheaIntervention effectsTropical diseasesMSMFree testingEstimated differenceNational InstituteCommunity-based organizationsComparison of Chlamydia outer membrane complex to recombinant outer membrane proteins as vaccine
Yu H, Karunakaran KP, Jiang X, Chan Q, Rose C, Foster LJ, Johnson RM, Brunham RC. Comparison of Chlamydia outer membrane complex to recombinant outer membrane proteins as vaccine. Vaccine 2020, 38: 3280-3291. PMID: 32151463, DOI: 10.1016/j.vaccine.2020.02.059.Peer-Reviewed Original ResearchConceptsChlamydial outer membrane complexRecombinant outer membrane proteinsImmune responseT-cell vaccine candidatesElementary bodiesReactive immune responsesC. muridarum elementary bodiesGenital infectionMajor outer membrane proteinTubal pathologyC. trachomatis serovarsVaccine efficacyOuter membrane proteinsSuperior efficacyVaccine candidatesBroad immunogenicityC. trachomatisVaccineAntibodiesSuperior protectionMultiple outer membrane proteinsOuter membrane complexPathologyEfficacyPolymorphic membrane proteinsA Multiregion Analysis of Shale Drilling Activity and Rates of Sexually Transmitted Infections in the United States
Johnson NP, Warren JL, Elliott EG, Niccolai LM, Deziel NC. A Multiregion Analysis of Shale Drilling Activity and Rates of Sexually Transmitted Infections in the United States. Sexually Transmitted Diseases 2020, 47: 254-260. PMID: 32168285, PMCID: PMC7077974, DOI: 10.1097/olq.0000000000001127.Peer-Reviewed Original ResearchA Class II-Restricted CD8γ13 T-Cell Clone Protects During Chlamydia muridarum Genital Tract Infection
Johnson RM, Olivares-Strank N, Peng G. A Class II-Restricted CD8γ13 T-Cell Clone Protects During Chlamydia muridarum Genital Tract Infection. The Journal Of Infectious Diseases 2020, 221: 1895-1906. PMID: 31899500, PMCID: PMC7213565, DOI: 10.1093/infdis/jiz685.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCD8-Positive T-LymphocytesChlamydia InfectionsChlamydia muridarumClone CellsFemaleHistocompatibility Antigens Class IHumansMiceMice, Inbred C57BLConceptsGenital tract infectionCD8 T cellsT cell clonesChlamydia muridarum Genital Tract InfectionMHC class IIT cellsTract infectionsClass IIClass IAntigen-specific CD8 T cellsChlamydia genital tract infectionCD8 T cell clonesCD4 T cell numbersMajor histocompatibility complex class IAdoptive transfer studiesT cell numbersT cell responsesHistocompatibility complex class IComplex class IBacterial clearanceIL-13IL-5ImmunopathologyIntracellular pathogensInfection
2019
Discordance in the Epithelial Cell-Dendritic Cell Major Histocompatibility Complex Class II Immunoproteome: Implications for Chlamydia Vaccine Development
Karunakaran KP, Yu H, Jiang X, Chan QWT, Foster LJ, Johnson RM, Brunham RC. Discordance in the Epithelial Cell-Dendritic Cell Major Histocompatibility Complex Class II Immunoproteome: Implications for Chlamydia Vaccine Development. The Journal Of Infectious Diseases 2019, 221: 841-850. PMID: 31599954, PMCID: PMC7457330, DOI: 10.1093/infdis/jiz522.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, BacterialBacterial VaccinesCD4-Positive T-LymphocytesCell LineChlamydia InfectionsChlamydia muridarumChlamydia trachomatisDendritic CellsEpithelial CellsEpitopes, T-LymphocyteFemaleHeLa CellsHistocompatibility Antigens Class IHistocompatibility Antigens Class IIHost-Pathogen InteractionsHumansMiceMice, Inbred C57BLPeptidesConceptsCD4 T cellsDendritic cellsT cellsEpithelial cellsProtective immunityEffector phaseClass IChlamydia-specific CD4 T cellsPathogen-specific T cellsClass IIMajor histocompatibility complex (MHC) class II moleculesChlamydia vaccine developmentClearance of ChlamydiaClass II epitopesClass II moleculesMHC class IMucosal epithelial cellsInfected epithelial cellsImmune miceIntracellular bacterial pathogenChlamydia vaccineC trachomatisEpithelial cell linePresent epitopesChlamydia trachomatisPay-it-forward gonorrhea and chlamydia testing among men who have sex with men in China: a study protocol for a three-arm cluster randomized controlled trial
Zhang TP, Yang F, Tang W, Alexander M, Forastiere L, Kumar N, Li K, Zou F, Yang L, Mi G, Wang Y, Huang W, Lee A, Zhu W, Vickerman P, Wu D, Yang B, Christakis NA, Tucker JD. Pay-it-forward gonorrhea and chlamydia testing among men who have sex with men in China: a study protocol for a three-arm cluster randomized controlled trial. Infectious Diseases Of Poverty 2019, 8: 76. PMID: 31426869, PMCID: PMC6700988, DOI: 10.1186/s40249-019-0581-1.Peer-Reviewed Original ResearchConceptsGonorrhea/chlamydia testingChlamydia testingCare armPrimary outcomeTest uptakePreventive health services utilizationIncremental costHealth service utilizationHIV testing sitesThree-arm clusterChlamydia testing ratesStandard of carePrevious gonorrheaSecondary outcomesDisease clinicEligible participantsStudy protocolService utilizationTesting ratesAnal sexChinese menGonorrheaQuasi-experimental studyTesting sitesMSMWhy a Pelvic Exam is Needed to Diagnose Cervicitis and Pelvic Inflammatory Disease
Mealey K, Braverman P, Koenigs L. Why a Pelvic Exam is Needed to Diagnose Cervicitis and Pelvic Inflammatory Disease. Annals Of Emergency Medicine 2019, 73: 424-425. PMID: 30902176, DOI: 10.1016/j.annemergmed.2018.11.028.Commentaries, Editorials and LettersEviction From Renter-occupied Households and Rates of Sexually Transmitted Infections
Niccolai LM, Blankenship KM, Keene DE. Eviction From Renter-occupied Households and Rates of Sexually Transmitted Infections. Sexually Transmitted Diseases 2019, 46: 63-68. PMID: 30148755, PMCID: PMC6289707, DOI: 10.1097/olq.0000000000000904.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultChlamydia InfectionsFamily CharacteristicsFemaleGonorrheaHousingHumansMalePovertySexually Transmitted DiseasesUnited StatesYoung AdultConceptsMedian ratePredictors of STIRates of chlamydiaNumerous health outcomesTertile categoriesPotential confoundersSTI ratesSTI riskCounty-level associationsHealth outcomesInfection rateSimilar associationChlamydiaConfidence intervalsGonorrheaHigh rateLow-income individualsDescriptive statisticsHousing instabilityAssociation
2018
B Cell Presentation of Chlamydia Antigen Selects Out Protective CD4γ13 T Cells: Implications for Genital Tract Tissue-Resident Memory Lymphocyte Clusters
Johnson RM, Yu H, Strank N, Karunakaran K, Zhu Y, Brunham RC. B Cell Presentation of Chlamydia Antigen Selects Out Protective CD4γ13 T Cells: Implications for Genital Tract Tissue-Resident Memory Lymphocyte Clusters. Infection And Immunity 2018, 86: 10.1128/iai.00614-17. PMID: 29158429, PMCID: PMC5778355, DOI: 10.1128/iai.00614-17.Peer-Reviewed Original ResearchConceptsMemory lymphocyte clustersPeripheral blood mononuclear cellsT cell subsetsAntigen-presenting cellsT cell clonesB cell populationsT cellsLymphocyte clustersCell subsetsB cellsTissue-resident memory T cellsCD4 T-cell clonesCD4 T cell subsetsHuman peripheral blood mononuclear cellsCell clonesMemory T cellsBlood mononuclear cellsIL-13 responsesImmune B cellsB cell presentationCell populationsAdoptive transferImmune miceIntracellular bacterial pathogenChlamydia antigen
2017
Prevalence of Human Immunodeficiency Virus and Sexually Transmitted Infections Among Cisgender and Transgender Women Sex Workers in Greater Kuala Lumpur, Malaysia
Wickersham JA, Gibson BA, Bazazi AR, Pillai V, Pedersen CJ, Meyer JP, El-Bassel N, Mayer KH, Kamarulzaman A, Altice FL. Prevalence of Human Immunodeficiency Virus and Sexually Transmitted Infections Among Cisgender and Transgender Women Sex Workers in Greater Kuala Lumpur, Malaysia. Sexually Transmitted Diseases 2017, 44: 663-670. PMID: 28708696, PMCID: PMC5636657, DOI: 10.1097/olq.0000000000000662.Peer-Reviewed Original ResearchConceptsTransgender women sex workersHuman immunodeficiency virusInconsistent condom useCisgender women sex workersHIV prevalenceImmunodeficiency virusSex workersWomen sex workersDrug useCondom useHigh human immunodeficiency virusGlobal HIV prevalenceLast HIV testLifetime HIV testingPooled HIV prevalenceRespondent-driven samplingSTI prevalenceHIV testHIV burdenHIV testingMedian timeSTI preventionΧ testChlamydia trachomatisIndependent sample t-testIroning Out the Unconventional Mechanisms of Iron Acquisition and Gene Regulation in Chlamydia
Pokorzynski ND, Thompson CC, Carabeo RA. Ironing Out the Unconventional Mechanisms of Iron Acquisition and Gene Regulation in Chlamydia. Frontiers In Cellular And Infection Microbiology 2017, 7: 394. PMID: 28951853, PMCID: PMC5599777, DOI: 10.3389/fcimb.2017.00394.Peer-Reviewed Original ResearchConceptsGene regulationIron homeostasisAberrant morphological phenotypesIron biologyUnconventional mechanismObligate intracellular pathogensDeprivation of ironSpecies relativesTranscriptional regulatorsGenome sequenceTransporter subunitsIron acquisitionIron-dependent bacteriaVesicular modeChlamydial speciesMorphological phenotypesIntracellular environmentIntracellular pathogensImportance of ironRecent discoveryAvailability of ironHomeostasisRecent findingsBiologyPersistent phenotype
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