2024
Large Language Models as an Inexpensive and Effective Extra Set of Eyes in Radiology Reporting.
Forman H. Large Language Models as an Inexpensive and Effective Extra Set of Eyes in Radiology Reporting. Radiology 2024, 311: e240844. PMID: 38625009, DOI: 10.1148/radiol.240844.Peer-Reviewed Original ResearchExternal Disruption of Ocular Development in Utero
Kim H, Sarrafpour S, Teng C, Liu J. External Disruption of Ocular Development in Utero. The Yale Journal Of Biology And Medicine 2024, 97: 41-48. PMID: 38559457, PMCID: PMC10964818, DOI: 10.59249/rrmm8911.Peer-Reviewed Original ResearchConceptsOcular developmentOcular embryologyEnglish-language articlesIntrauterine infectionMaternal nutritionClinical significanceGenetic signaling pathwaysWeb of ScienceAnimal modelsHormonal factorsHuman studiesMultifactorial naturePregnancySignaling pathwayGoogle ScholarReviewIntrauterineEmbryologyLimited resourcesGestationUteroPathophysiologyFactorsInfectionPubMed
2023
Ocular complications of plasma cell dyscrasias
Singh R, Singhal S, Sinha S, Cho J, Nguyen A, Dhingra L, Kaur S, Sharma V, Agarwal A. Ocular complications of plasma cell dyscrasias. European Journal Of Ophthalmology 2023, 33: 1786-1800. PMID: 36760117, PMCID: PMC10472748, DOI: 10.1177/11206721231155974.Peer-Reviewed Original ResearchConceptsPlasma cell dyscrasiaMonoclonal gammopathyMultiple myelomaMalignant plasma cellsEfficacious treatment strategiesSearch of PubMedOcular presentationOcular complicationsTreating ophthalmologistClinical suspicionAsymptomatic patientsOphthalmological signsWaldenstrom's macroglobulinemiaSystemic findingsOphthalmologic disordersPre-malignantUnderlying diseasePosterior segmentPlasma cellsSkin changesTreatment strategiesOver-secretionEarly diagnosisCochrane DatabaseSystemic amyloidosis
2022
Mechanical Property Comparison of 23-, 25-, and 27-Gauge Vitrectors across Vitrectomy Systems
Lai J, Patel V, Watane A, Fils A, Pakravan P, Huang C, Patel N, Sridhar J, Yannuzzi N. Mechanical Property Comparison of 23-, 25-, and 27-Gauge Vitrectors across Vitrectomy Systems. Ophthalmology Retina 2022, 6: 1001-1008. PMID: 35569764, PMCID: PMC9637701, DOI: 10.1016/j.oret.2022.05.004.Peer-Reviewed Original ResearchEyes wide open: Regulation of arousal by temporal expectations
Shalev N, Nobre A. Eyes wide open: Regulation of arousal by temporal expectations. Cognition 2022, 224: 105062. PMID: 35217263, PMCID: PMC9112164, DOI: 10.1016/j.cognition.2022.105062.Peer-Reviewed Original ResearchConceptsLevel of arousalTemporal predictionLevels of behavioral performanceModulation of arousalRegulation of arousalTemporal structure of eventsAnticipation of upcoming stimuliTonic level of arousalBehavioral performanceUpcoming stimuliStructure of eventsArousal modulationBehavioral benefitsElevated arousalIncreased arousalModulate arousalTemporal expectationsArousalArousal levelAdaptive modulationTonic levelOxidative stress induces inflammation of lens cells and triggers immune surveillance of ocular tissues
Thompson B, Davidson EA, Chen Y, Orlicky DJ, Thompson DC, Vasiliou V. Oxidative stress induces inflammation of lens cells and triggers immune surveillance of ocular tissues. Chemico-Biological Interactions 2022, 355: 109804. PMID: 35123994, PMCID: PMC9136680, DOI: 10.1016/j.cbi.2022.109804.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcysteineAnimalsButhionine SulfoximineCell LineChemokine CCL7CytokinesDown-RegulationEpithelial CellsEpithelial-Mesenchymal TransitionEyeGlutamate-Cysteine LigaseImmunity, InnateLens, CrystallineLeukocytesMiceMice, Inbred C57BLMice, KnockoutOxidative StressReactive Oxygen SpeciesUp-RegulationConceptsPosterior capsule opacificationCytokine expressionKO miceImmune surveillanceOxidative stressLens epithelial cellsOcular structuresLens cellsDevelopment of PCOEpithelial cellsInnate immune cellsExpression of cytokinesEx vivo inductionOcular surface tissuesExpression of markersImmune response genesCON miceControl miceCapsule opacificationImmune cellsPostnatal dayΑ-SMAMouse modelOcular tissuesVivo induction
2021
Addressing Disparities in Ophthalmic Research
Nwanyanwu K, Scott AW, Elam AR. Addressing Disparities in Ophthalmic Research. JAMA Ophthalmology 2021, 139: 1261-1262. PMID: 34673894, DOI: 10.1001/jamaophthalmol.2021.4203.Peer-Reviewed Original ResearchThe multisensory cocktail party problem in adults: Perceptual segregation of talking faces on the basis of audiovisual temporal synchrony
Lewkowicz D, Schmuckler M, Agrawal V. The multisensory cocktail party problem in adults: Perceptual segregation of talking faces on the basis of audiovisual temporal synchrony. Cognition 2021, 214: 104743. PMID: 33940250, DOI: 10.1016/j.cognition.2021.104743.Peer-Reviewed Original ResearchConceptsAudiovisual temporal synchronyTalking facePerceptual segregationTemporal synchronySpeech utterancesCocktail party problemMultisensory coherenceTalker's eyesAudible utterancesSame speech utteranceEye trackingParty problemSocial interactionUtterancesFaceSynchronyParticipantsAdultsScanning strategyVersionSceneFindingsPreferencesCoherenceAn evidence-based approach to nontraumatic ocular complaints in children.
Iqbal A, Langhan ML, Rotruck J, Soma G. An evidence-based approach to nontraumatic ocular complaints in children. Pediatric Emergency Medicine Practice 2021, 18: 1-28. PMID: 33476507.Peer-Reviewed Original Research
2020
High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue
Liu Y, Yang M, Deng Y, Su G, Enninful A, Guo CC, Tebaldi T, Zhang D, Kim D, Bai Z, Norris E, Pan A, Li J, Xiao Y, Halene S, Fan R. High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue. Cell 2020, 183: 1665-1681.e18. PMID: 33188776, PMCID: PMC7736559, DOI: 10.1016/j.cell.2020.10.026.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutomationBrainCluster AnalysisDNA Barcoding, TaxonomicDNA, ComplementaryEmbryo, MammalianEyeFemaleGene Expression Regulation, DevelopmentalGenomicsHuman Umbilical Vein Endothelial CellsHumansMice, Inbred C57BLMicrofluidicsOrgan SpecificityReproducibility of ResultsRNA, MessengerSingle-Cell AnalysisTranscriptomeConceptsDeterministic barcodingNext-generation sequencingSingle-cell transcriptomesGene expression profilesMajor tissue typesDBiT-seqDNA barcodesDevelopmental biologyExpression profilesEarly organogenesisCancer biologyCell typesBarcodingTissue typesSequencingBarcodesBiologyRapid identificationSets of barcodesTranscriptomeParallel microfluidic channelsOrganogenesisEmbryosProteinTissue pixelsQuantifying Sample Collection and Processing Impacts on Fiber-Based Tear Fluid Chemical Analysis
Barmada A, Shippy S. Quantifying Sample Collection and Processing Impacts on Fiber-Based Tear Fluid Chemical Analysis. Translational Vision Science & Technology 2020, 9: 23-23. PMID: 33024616, PMCID: PMC7521181, DOI: 10.1167/tvst.9.10.23.Peer-Reviewed Original ResearchOpening or closing eyes at rest modulates the functional connectivity of V1 with default and salience networks
Costumero V, Bueichekú E, Adrián-Ventura J, Ávila C. Opening or closing eyes at rest modulates the functional connectivity of V1 with default and salience networks. Scientific Reports 2020, 10: 9137. PMID: 32499585, PMCID: PMC7272628, DOI: 10.1038/s41598-020-66100-y.Peer-Reviewed Original Research
2019
Genetics and functions of the retinoic acid pathway, with special emphasis on the eye
Thompson B, Katsanis N, Apostolopoulos N, Thompson DC, Nebert DW, Vasiliou V. Genetics and functions of the retinoic acid pathway, with special emphasis on the eye. Human Genomics 2019, 13: 61. PMID: 31796115, PMCID: PMC6892198, DOI: 10.1186/s40246-019-0248-9.Peer-Reviewed Original ResearchConceptsRequirement of RAEmbryonic developmentRetinoic acidAnterior segment formationRetinoic acid pathwayRas signalingPotent morphogenEye developmentOptic cup formationPostnatal lethalitySegment formationAcid pathwayCup formationNormal developmentOptic vesicleMultistep processParacrine fashionPathwayRecent advancesMorphogensGenesGeneticsMutationsVesiclesLethality
2018
Inside bilingualism: Language background modulates selective attention to a talker's mouth
Birulés J, Bosch L, Brieke R, Pons F, Lewkowicz D. Inside bilingualism: Language background modulates selective attention to a talker's mouth. Developmental Science 2018, 22: e12755. PMID: 30251757, DOI: 10.1111/desc.12755.Peer-Reviewed Original ResearchConceptsTalker's mouthSpanish-learning infantsAudiovisual speech cuesClose languagesLanguage proximityLanguage backgroundEnglish monologuesMonolingual infantsSelective attentionTalker's eyesBilingualsLanguageCatalanGreater salienceSpeech cuesAudiovisual cuesSuch cuesCuesBilingualismMonologueEarly childhoodPrevious findingsAttentionTalkersGreat attentionPhenotypes of organ involvement in sarcoidosis
Schupp J, Freitag-Wolf S, Bargagli E, Mihailović-Vučinić V, Rottoli P, Grubanovic A, Müller A, Jochens A, Tittmann L, Schnerch J, Olivieri C, Fischer A, Jovanovic D, Filipovic S, Videnovic-Ivanovic J, Bresser P, Jonkers R, O'Reilly K, Ho L, Gaede K, Zabel P, Dubaniewicz A, Marshall B, Kieszko R, Milanowski J, Günther A, Weihrich A, Petrek M, Kolek V, Keane M, O'Beirne S, Donnelly S, Haraldsdottir S, Jorundsdottir K, Costabel U, Bonella F, Wallaert B, Grah C, Peroš-Golubičić T, Luisetti M, Kadija Z, Pabst S, Grohé C, Strausz J, Vašáková M, Sterclova M, Millar A, Homolka J, Slováková A, Kendrick Y, Crawshaw A, Wuyts W, Spencer L, Pfeifer M, Valeyre D, Poletti V, Wirtz H, Prasse A, Schreiber S, Krawczak M, Müller-Quernheim J. Phenotypes of organ involvement in sarcoidosis. European Respiratory Journal 2018, 51: 1700991. PMID: 29371378, DOI: 10.1183/13993003.00991-2017.Peer-Reviewed Original ResearchConceptsOrgan involvementIntrathoracic lymph node involvementAbdominal organ involvementLymph node involvementEuropean multicentre studySystemic granulomatous diseaseNew clinical phenotypeHitherto unknown etiologyAcute onsetExtrapulmonary involvementNode involvementSkin involvementFemale patientsMulticentre studyDisease involvementUnknown etiologyCaucasian patientsGranulomatous diseaseHomogenous cohortSarcoidosisPatientsClinical phenotypeStudy centersStandardised protocolDisease phenotype
2017
Fyn‐dependent phosphorylation of PlexinA1 and PlexinA2 at conserved tyrosines is essential for zebrafish eye development
St. Clair R, Emerson S, D'Elia K, Weir M, Schmoker A, Ebert A, Ballif B. Fyn‐dependent phosphorylation of PlexinA1 and PlexinA2 at conserved tyrosines is essential for zebrafish eye development. The FEBS Journal 2017, 285: 72-86. PMID: 29091353, PMCID: PMC5760361, DOI: 10.1111/febs.14313.Peer-Reviewed Original ResearchConceptsTyrosine phosphorylationPhosphorylation sitesSignal transductionSrc family kinase FynTyrosine phosphorylation sitesSite to phenylalanineNonreceptor tyrosine kinaseEye developmental defectsCytoskeletal dynamicsMass spectrometry-based approachKinase FynCellular processesPoint mutationsSignaling eventsSignaling roleZebrafish eye developmentEye developmentTyrosine kinaseDevelopmental defectsPLXNA2Signaling mechanismsPhosphorylationZebrafish embryosTyrosineMutationsChemical Ocular Burn Epidemiology—Dealing with Missing Values—Reply
Haring R, Canner J, Schneider E. Chemical Ocular Burn Epidemiology—Dealing with Missing Values—Reply. JAMA Ophthalmology 2017, 135: 893. PMID: 28654975, DOI: 10.1001/jamaophthalmol.2017.1849.Peer-Reviewed Original ResearchFrontal temporal and parietal systems synchronize within and across brains during live eye-to-eye contact
Hirsch J, Zhang X, Noah JA, Ono Y. Frontal temporal and parietal systems synchronize within and across brains during live eye-to-eye contact. NeuroImage 2017, 157: 314-330. PMID: 28619652, PMCID: PMC5863547, DOI: 10.1016/j.neuroimage.2017.06.018.Peer-Reviewed Original ResearchConceptsEye contactInterpersonal interactionsSupplementary motor cortexSpecificity hypothesisFrontal clusterSubcentral areaLeft superior temporal gyrusInteractive brain hypothesisTwo-person neuroscienceLimited head motionSuperior temporal gyrusTwo-person interactionsConventional neuroimaging methodsNeural correlatesSocial cuesNeural processesBrain hypothesisNeural mechanismsNeural responsesParietal systemSupramarginal gyrusMutual gazeSynchrony hypothesisLanguage functionTemporal gyrusGenetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci
Aung T, Ozaki M, Lee MC, Schlötzer-Schrehardt U, Thorleifsson G, Mizoguchi T, Igo RP, Haripriya A, Williams SE, Astakhov YS, Orr AC, Burdon KP, Nakano S, Mori K, Abu-Amero K, Hauser M, Li Z, Prakadeeswari G, Bailey JNC, Cherecheanu AP, Kang JH, Nelson S, Hayashi K, Manabe SI, Kazama S, Zarnowski T, Inoue K, Irkec M, Coca-Prados M, Sugiyama K, Järvelä I, Schlottmann P, Lerner SF, Lamari H, Nilgün Y, Bikbov M, Park KH, Cha SC, Yamashiro K, Zenteno JC, Jonas JB, Kumar RS, Perera SA, Chan ASY, Kobakhidze N, George R, Vijaya L, Do T, Edward DP, de Juan Marcos L, Pakravan M, Moghimi S, Ideta R, Bach-Holm D, Kappelgaard P, Wirostko B, Thomas S, Gaston D, Bedard K, Greer WL, Yang Z, Chen X, Huang L, Sang J, Jia H, Jia L, Qiao C, Zhang H, Liu X, Zhao B, Wang YX, Xu L, Leruez S, Reynier P, Chichua G, Tabagari S, Uebe S, Zenkel M, Berner D, Mossböck G, Weisschuh N, Hoja U, Welge-Luessen UC, Mardin C, Founti P, Chatzikyriakidou A, Pappas T, Anastasopoulos E, Lambropoulos A, Ghosh A, Shetty R, Porporato N, Saravanan V, Venkatesh R, Shivkumar C, Kalpana N, Sarangapani S, Kanavi MR, Beni AN, Yazdani S, lashay A, Naderifar H, Khatibi N, Fea A, Lavia C, Dallorto L, Rolle T, Frezzotti P, Paoli D, Salvi E, Manunta P, Mori Y, Miyata K, Higashide T, Chihara E, Ishiko S, Yoshida A, Yanagi M, Kiuchi Y, Ohashi T, Sakurai T, Sugimoto T, Chuman H, Aihara M, Inatani M, Miyake M, Gotoh N, Matsuda F, Yoshimura N, Ikeda Y, Ueno M, Sotozono C, Jeoung JW, Sagong M, Park KH, Ahn J, Cruz-Aguilar M, Ezzouhairi SM, Rafei A, Chong YF, Ng XY, Goh SR, Chen Y, Yong VHK, Khan MI, Olawoye OO, Ashaye AO, Ugbede I, Onakoya A, Kizor-Akaraiwe N, Teekhasaenee C, Suwan Y, Supakontanasan W, Okeke S, Uche NJ, Asimadu I, Ayub H, Akhtar F, Kosior-Jarecka E, Lukasik U, Lischinsky I, Castro V, Grossmann RP, Megevand GS, Roy S, Dervan E, Silke E, Rao A, Sahay P, Fornero P, Cuello O, Sivori D, Zompa T, Mills RA, Souzeau E, Mitchell P, Wang JJ, Hewitt AW, Coote M, Crowston JG, Astakhov SY, Akopov EL, Emelyanov A, Vysochinskaya V, Kazakbaeva G, Fayzrakhmanov R, Al-Obeidan SA, Owaidhah O, Aljasim LA, Chowbay B, Foo JN, Soh RQ, Sim KS, Xie Z, Cheong AWO, Mok SQ, Soo HM, Chen XY, Peh SQ, Heng KK, Husain R, Ho SL, Hillmer AM, Cheng CY, Escudero-Domínguez FA, González-Sarmiento R, Martinon-Torres F, Salas A, Pathanapitoon K, Hansapinyo L, Wanichwecharugruang B, Kitnarong N, Sakuntabhai A, Nguyn HX, Nguyn GTT, Nguyn TV, Zenz W, Binder A, Klobassa DS, Hibberd ML, Davila S, Herms S, Nöthen MM, Moebus S, Rautenbach RM, Ziskind A, Carmichael TR, Ramsay M, Álvarez L, García M, González-Iglesias H, Rodríguez-Calvo PP, Fernández-Vega Cueto L, Oguz Ç, Tamcelik N, Atalay E, Batu B, Aktas D, Kasım B, Wilson MR, Coleman AL, Liu Y, Challa P, Herndon L, Kuchtey RW, Kuchtey J, Curtin K, Chaya CJ, Crandall A, Zangwill LM, Wong TY, Nakano M, Kinoshita S, den Hollander AI, Vesti E, Fingert JH, Lee RK, Sit AJ, Shingleton BJ, Wang N, Cusi D, Qamar R, Kraft P, Pericak-Vance MA, Raychaudhuri S, Heegaard S, Kivelä T, Reis A, Kruse FE, Weinreb RN, Pasquale LR, Haines JL, Thorsteinsdottir U, Jonasson F, Allingham RR, Milea D, Ritch R, Kubota T, Tashiro K, Vithana EN, Micheal S, Topouzis F, Craig JE, Dubina M, Sundaresan P, Stefansson K, Wiggs JL, Pasutto F, Khor CC. Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci. Nature Genetics 2017, 49: 993-1004. PMID: 28553957, PMCID: PMC6685441, DOI: 10.1038/ng.3875.Peer-Reviewed Original ResearchMeSH KeywordsAged, 80 and overAllelesAmino Acid OxidoreductasesAmino Acid SubstitutionAsian PeopleCalcium ChannelsCell AdhesionExfoliation SyndromeExtracellular MatrixEyeFemaleGene Expression ProfilingGenetic Predisposition to DiseaseGenome-Wide Association StudyHaplotypesHumansMaleMolecular ChaperonesMutation, MissensePoint MutationRNA, MessengerSpheroids, CellularConceptsGlobal genome-wide association studyAssociation studiesSusceptibility lociGenome-wide association studiesProtective rare variantsDisease-associated lociNew susceptibility lociFine-mapping analysisGenetic association studiesRare protective variantsLociProtective variantsRare variantsLOXL1VariantsWiggJapanese populationIdentification of target genes downstream of semaphorin6A/PlexinA2 signaling in zebrafish
Emerson S, St. Clair R, Waldron A, Bruno S, Duong A, Driscoll H, Ballif B, McFarlane S, Ebert A. Identification of target genes downstream of semaphorin6A/PlexinA2 signaling in zebrafish. Developmental Dynamics 2017, 246: 539-549. PMID: 28440030, PMCID: PMC6322676, DOI: 10.1002/dvdy.24512.Peer-Reviewed Original ResearchConceptsSignaling pathwayTarget genesMicroarray analysisIdentification of target genesRegulate proliferationRetinal precursor cellsGuidance signaling pathwayGene expression changesTranscriptional regulationEarly eye developmentGenesDisrupted proliferationExpression changesEye developmentNeuronal developmentNeuronal positioningUp-regulatedZebrafish embryosMorphantsPLXNA2Downstream effectsRASL11BPathwayZebrafish eyeSema6A
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