2025
Delineating Empirically Plausible Causal Pathways to Suicidality Among People at Clinical High Risk for Psychosis
Bronstein M, Kummerfeld E, Bearden C, Cornblatt B, Walker E, Woods S, Mathalon D, Perkins D, Cadenhead K, Addington J, Cannon T, Vinogradov S. Delineating Empirically Plausible Causal Pathways to Suicidality Among People at Clinical High Risk for Psychosis. Journal Of Psychopathology And Clinical Science 2025, 134: 239-250. PMID: 39913476, DOI: 10.1037/abn0000969.Peer-Reviewed Original ResearchConceptsClinical high riskNorth American Prodrome Longitudinal StudyClinical high-risk samplesAttenuated psychosis symptomsPathways to suicideSuicide risk reductionPsychosis symptomsCausal pathwaysDepressed moodPsychosisIntervention effortsSelf-deprecationSuicideLongitudinal studyMeasurement time pointsStudy timepointsHigh riskSymptomsInterventionHopelessnessMoodTime pointsDepressionIndividualsDirect causesEvaluation and adaptation of a two-way text messaging intervention in the WIC breastfeeding peer counseling program: A qualitative analysis
Martinez-Brockman J, Granner J, Buchanan B, Acosta L, Lonczak M, Goeschel L, Xu X, Curry L, Nunez-Smith M, Pérez-Escamilla R. Evaluation and adaptation of a two-way text messaging intervention in the WIC breastfeeding peer counseling program: A qualitative analysis. PLOS ONE 2025, 20: e0313779. PMID: 39787090, PMCID: PMC11717301, DOI: 10.1371/journal.pone.0313779.Peer-Reviewed Original ResearchConceptsProgram impact pathwayCritical Quality Control PointsLow-income womenPeer counseling programPeer counselorsSpecial Supplemental Nutrition ProgramSupplemental Nutrition ProgramContinuity of careCounseling programQuality control pointsLactation AdviceDischarge supportIn-depth interviewsWIC mothersWIC programNutrition ProgramFeasibility trialWICCounseling supportLactation consultantsPeer counselingInfant healthQualitative studyCausal pathwaysBuy-inEvaluating the Exposome Score for Schizophrenia in a Transdiagnostic Psychosis Cohort: Associations With Psychosis Risk, Symptom Severity, and Personality Traits
Kromenacker B, Yassin W, Keshavan M, Parker D, Thakkar V, Pearlson G, Keedy S, McDowell J, Gershon E, Ivleva E, Hill S, Clementz B, Tamminga C. Evaluating the Exposome Score for Schizophrenia in a Transdiagnostic Psychosis Cohort: Associations With Psychosis Risk, Symptom Severity, and Personality Traits. Schizophrenia Bulletin 2025, sbae219. PMID: 39777534, DOI: 10.1093/schbul/sbae219.Peer-Reviewed Original ResearchES-SCZSymptom severityExposome scoreModel of personalityPersonality factor scoresBipolar-Schizophrenia NetworkExpression of psychosisMood symptom severityMore severe symptomsFamily socioeconomic statusPatterns of associationDecreased conscientiousnessIncreased neuroticismPsychosis cohortPsychosis samplePsychosis groupPsychotic diagnosesInvestigate causal pathwaysPsychosis riskBipolar disorderPersonality traitsCausal pathwaysWithin-group associationsPsychosisFactor scoresA genetic exploration of the relationship between posttraumatic stress disorder and cardiovascular diseases
Lukas E, Veeneman R, Smit D, Ahluwalia T, Vermeulen J, Pathak G, Polimanti R, Verweij K, Treur J. A genetic exploration of the relationship between posttraumatic stress disorder and cardiovascular diseases. Translational Psychiatry 2025, 15: 1. PMID: 39755697, PMCID: PMC11700205, DOI: 10.1038/s41398-024-03197-z.Peer-Reviewed Original ResearchPosttraumatic stress disorderMendelian randomizationCardiovascular diseaseCausal pathwaysData of genome-wide association studiesGenetic liabilityMultivariable Mendelian randomizationWaist-to-hip ratioPotential mediatorsWaist-to-hipRisk of cardiovascular diseaseGenome-wide association studiesPotential causal pathwaysPrevent cardiovascular diseaseStress disorderIncreased risk of cardiovascular diseaseGenomic structural equationSignificant genetic correlationsPsychosocial factorsEffects of posttraumatic stress disorderAssociation studiesIncreased riskPosttraumatic stress disorder patientsCausal effectsTraumatic events
2024
Maladaptive health factors as potential mediators for the association between posttraumatic stress disorder and cardiovascular disease: A sex-stratified analysis in the U.S. adult population
Pierce S, Reynolds K, Sommer J, El-Gabalawy R, Pietrzak R, Sumner J, Mota N. Maladaptive health factors as potential mediators for the association between posttraumatic stress disorder and cardiovascular disease: A sex-stratified analysis in the U.S. adult population. Journal Of Psychiatric Research 2024, 177: 102-108. PMID: 39002531, DOI: 10.1016/j.jpsychires.2024.06.028.Peer-Reviewed Original ResearchHealth risk factorsPosttraumatic stress disorderRisk factorsPotential mediatorsCardiovascular diseaseLow physical activityCross-sectional surveyNatural effect modelsSex-stratified analysesU.S. adult populationCardiovascular disease riskStress disorderPhysical activityNational Epidemiologic SurveyLogistic regression analysisHealth factorsEvaluate health risk factorsU.S. adultsHigher BMICausal pathwaysPrevention strategiesEffects of posttraumatic stress disorderWave 3Adult populationSubstance use0757 Association of Insomnia with Objective Short Sleep Duration and Other Phenotypes with Mortality in Older Persons
Miner B, Pan Y, Cho G, Knauert M, Yaggi H, Gill T, Stone K, Ensrud K, Zeitzer J, Yaffe K, Doyle M. 0757 Association of Insomnia with Objective Short Sleep Duration and Other Phenotypes with Mortality in Older Persons. Sleep 2024, 47: a324-a325. DOI: 10.1093/sleep/zsae067.0757.Peer-Reviewed Original ResearchAssociated with increased mortality riskAssociation of insomniaMortality riskOlder personsShort sleep durationOsteoporotic fracturesAdjusted modelsStudy of Osteoporotic FracturesSleep durationHigher mortality riskCox proportional hazards modelsMen Sleep StudyNormal sleepProportional hazards modelAssociated with mortalitySevere sleep-disordered breathingUnadjusted modelsUnadjusted analysisCausal pathwaysSleep-disordered breathingFollow-up timePrevalence ratesReference groupHazards modelRisk phenotypesCausal Pathways Between the Acute Experience of Violence During Pregnancy and Fetal Intrauterine Growth Restriction: A Cohort Study
Blumrich L, Silva L, Barreto V, Rohde L, Polanczyk G, Miguel E, Grisi S, Fleitlich-Bilyk B, Ferraro A. Causal Pathways Between the Acute Experience of Violence During Pregnancy and Fetal Intrauterine Growth Restriction: A Cohort Study. Journal Of Women's Health 2024, 33: 765-773. PMID: 38551182, DOI: 10.1089/jwh.2023.0645.Peer-Reviewed Original ResearchIntrauterine growth restrictionAssociated with intrauterine growth restrictionGrowth restrictionProspective population-based birth cohortCausal pathwaysFetal intrauterine growth restrictionPopulation-based birth cohortExperiences of violenceNegative health consequencesAcute experimentsHealth consequences of violenceEmergency careGestational depressionGestational trimesterLow birthweightBirth cohortAlcohol consumptionCohort studyBlood pressurePregnancyConsequences of violencePath analysis modelMediation analysisCohortAdequate fitA systematic review of the effects of chronic, slow-onset climate change on mental health
Burrows K, Denckla C, Hahn J, Schiff J, Okuzono S, Randriamady H, Mita C, Kubzansky L, Koenen K, Lowe S. A systematic review of the effects of chronic, slow-onset climate change on mental health. Nature Mental Health 2024, 2: 228-243. DOI: 10.1038/s44220-023-00170-5.Peer-Reviewed Original ResearchMental healthNon-specific psychological distressAdverse mental health outcomesMental health indicatorsMental health outcomesMental health effectsMixed-methods studyMental health consequencesAnxiety symptomsHealth outcomesPsychological distressHealth indicatorsNegative emotionsQualitative studyCausal pathwaysNull findingsSystematic reviewSocietal factorsHealthQuantitative studyAnxietyDepressionSuicideEmotionsWeather-related disasters
2023
Racial disparities in complications following elective colon cancer resection: Impact of laparoscopic versus robotic approaches
Ahuja V, Paredes L, Leeds I, Perkal M, Tsutsumi A, Bhandarkar S, King J. Racial disparities in complications following elective colon cancer resection: Impact of laparoscopic versus robotic approaches. The American Journal Of Surgery 2023, 227: 85-89. PMID: 37806892, PMCID: PMC10842593, DOI: 10.1016/j.amjsurg.2023.09.038.Peer-Reviewed Original ResearchConceptsRC patientsLaparoscopic colectomyElective colon cancer resectionImpact of laparoscopicACS-NSQIP databaseColon cancer resectionMultivariable logistic regressionCancer resectionWhite patientsBlack patientsRobotic colectomyHigher complicationsOperative approachMinority patientsPatientsComplicationsColectomyLogistic regressionRobotic approachRacial disparitiesLaparoscopicCausal pathwaysLower ratesOutcomesMortality
2022
Evaluating the Mediating Role of Recall of Intervention Knowledge in the Relationship Between a Peer-Driven Intervention and HIV Risk Behaviors Among People Who Inject Drugs
Aroke H, Buchanan A, Katenka N, Crawford FW, Lee T, Halloran ME, Latkin C. Evaluating the Mediating Role of Recall of Intervention Knowledge in the Relationship Between a Peer-Driven Intervention and HIV Risk Behaviors Among People Who Inject Drugs. AIDS And Behavior 2022, 27: 578-590. PMID: 35932359, PMCID: PMC10408304, DOI: 10.1007/s10461-022-03792-5.Peer-Reviewed Original ResearchConceptsInjection-related risk behaviorsPeer-driven interventionRisk behaviorsIntervention knowledgeHIV injection risk behaviorsHIV risk behaviorsInjection risk behaviorsMarginal structural modelsPotential causal pathwaysHIV testingIndex participantsRisk ratioInverse probabilityIntervention NetworkInterventionPeer educatorsTotal effectCausal pathwaysVisitsDrugsFuture studiesParticipantsOutcomesDirect effectPWIDThe mediating role of combined lifestyle factors on the relationship between education and gastric cancer in the Stomach cancer Pooling (StoP) Project
Alicandro G, Bertuccio P, Collatuzzo G, Pelucchi C, Bonzi R, Liao LM, Rabkin CS, Sinha R, Negri E, Dalmartello M, Zaridze D, Maximovich D, Vioque J, Garcia de la Hera M, Tsugane S, Hidaka A, Hamada GS, López-Carrillo L, Hernández-Ramírez RU, Malekzadeh R, Pourfarzi F, Zhang ZF, Kurtz RC, Camargo MC, Curado MP, Lunet N, Boffetta P, La Vecchia C. The mediating role of combined lifestyle factors on the relationship between education and gastric cancer in the Stomach cancer Pooling (StoP) Project. British Journal Of Cancer 2022, 127: 855-862. PMID: 35624300, PMCID: PMC9427973, DOI: 10.1038/s41416-022-01857-9.Peer-Reviewed Original ResearchConceptsLifestyle factorsGastric cancerOdds ratioStomach cancer Pooling (StoP) ProjectWarrants further investigationNatural direct effectNatural indirect effectReduced riskPooling ProjectReference categoryGC casesLower educationComplete dataCausal pathwaysCancerFurther investigationDirect effectMediation analysisLow levelsIndirect effectsPotential pathwaysMediation effectFactorsPathway
2020
Prevention of Firearm Injury through Policy and Law: The Social Ecological Model
Durkin A, Schenck C, Narayan Y, Nyhan K, Khoshnood K, Vermund SH. Prevention of Firearm Injury through Policy and Law: The Social Ecological Model. The Journal Of Law, Medicine & Ethics 2020, 48: 191-197. PMID: 33404312, DOI: 10.1177/1073110520979422.Peer-Reviewed Original ResearchConceptsSocial ecological modelFuture policy interventionsDifferent social contextsPublic health frameworkPolicy interventionsEcological modelSocial contextHigh-income nationsFirearm legislationLegal approachState levelHealth frameworkComplex causal pathwaysUnited StatesContextFirearm injuriesPolicyNationsCausal pathwaysLegislation
2019
A Peripheral Blood DNA Methylation Signature of Hepatic Fat Reveals a Potential Causal Pathway for Nonalcoholic Fatty Liver Disease
Ma J, Nano J, Ding J, Zheng Y, Hennein R, Liu C, Speliotes EK, Huan T, Song C, Mendelson MM, Joehanes R, Long MT, Liang L, Smith JA, Reynolds LM, Ghanbari M, Muka T, van Meurs JBJ, Alferink LJM, Franco OH, Dehghan A, Ratliff S, Zhao W, Bielak L, Kardia SLR, Peyser PA, Ning H, VanWagner LB, Lloyd-Jones DM, Carr JJ, Greenland P, Lichtenstein AH, Hu FB, Liu Y, Hou L, Murad S, Levy D. A Peripheral Blood DNA Methylation Signature of Hepatic Fat Reveals a Potential Causal Pathway for Nonalcoholic Fatty Liver Disease. Diabetes 2019, 68: 1073-1083. PMID: 30936141, PMCID: PMC6477898, DOI: 10.2337/db18-1193.Peer-Reviewed Original ResearchConceptsNonalcoholic fatty liver diseaseFatty liver diseaseHepatic fatDNA methylation signaturesLiver diseasePopulation-based cohort studyMethylation signaturesNew-onset T2DType 2 diabetesHepatic fat accumulationMendelian randomization analysisCohort studyPotential causal pathwaysRisk factorsFat accumulationAfrican ancestry participantsEuropean ancestry participantsAttractive biomarkerCytosine-guanine dinucleotidesAssociation of hypomethylationWhole bloodHispanic ancestryRandomization analysisSame CpGsCausal pathways
2018
Risk factors for relapse and recurrence of depression in adults and how they operate: A four-phase systematic review and meta-synthesis
Buckman J, Underwood A, Clarke K, Saunders R, Hollon S, Fearon P, Pilling S. Risk factors for relapse and recurrence of depression in adults and how they operate: A four-phase systematic review and meta-synthesis. Clinical Psychology Review 2018, 64: 13-38. PMID: 30075313, PMCID: PMC6237833, DOI: 10.1016/j.cpr.2018.07.005.Peer-Reviewed Original ResearchConceptsChildhood maltreatmentRecurrence of depressionModerate treatment responseMore enduring effectsMindfulness-based therapyCognitive diathesesCognitive controlAffective informationNeural mechanismsPsychological therapiesPsychosocial interventionsResidual symptomsEnduring effectPrescriptive indicesMaltreatmentFuture researchCausal pathwaysCausal mechanismsDepressionPrescriptive factorsLimbic pathwaysAdultsTreatment responseSymptomsConsequences
2016
Stillbirths: recall to action in high-income countries
Flenady V, Wojcieszek A, Middleton P, Ellwood D, Erwich J, Coory M, Khong T, Silver R, Smith G, Boyle F, Lawn J, Blencowe H, Leisher S, Gross M, Horey D, Farrales L, Bloomfield F, McCowan L, Brown S, Joseph K, Zeitlin J, Reinebrant H, Cacciatore J, Ravaldi C, Vannacci A, Cassidy J, Cassidy P, Farquhar C, Wallace E, Siassakos D, Heazell A, Storey C, Sadler L, Petersen S, Frøen J, Goldenberg R, Flenady V, Frøen J, Kinney M, de Bernis L, Lawn J, Blencowe H, Heazell A, Leisher S, Ruidiaz J, Carvalho A, Dahlstrom J, East C, Fox J, Gibbons K, Ibiebele I, Kildea S, Gardener G, Lourie R, Wilson P, Gordon A, Jennings B, Kent A, McDonald S, Merchant K, Oats J, Walker S, Raven L, Schirmann A, de Montigny F, Guyon G, Blondel B, de Wall S, Bonham S, Corcoran P, Cregan M, Meany S, Murphy M, Fukui S, Gordijn S, Korteweg F, Cronin R, Mason V, Culling V, Usynina A, Pettersson K, Rådestad I, van Gogh S, Bichara B, Bradley S, Ellis A, Downe S, Draper E, Manktelow B, Scott J, Smith L, Stones W, Lavender T, Duke W, Fretts R, Gold K, McClure E, Reddy U. Stillbirths: recall to action in high-income countries. The Lancet 2016, 387: 691-702. PMID: 26794070, DOI: 10.1016/s0140-6736(15)01020-x.Peer-Reviewed Original ResearchMeSH KeywordsAttitude to HealthData AccuracyDelivery of Health CareDeveloped CountriesFemaleGestational AgeGlobal HealthHealth PolicyHealthcare DisparitiesHospice CareHumansIncomeInternational CooperationPerinatal MortalityPostnatal CarePractice Guidelines as TopicPregnancyPrenatal CareRisk FactorsStereotypingStillbirthConceptsHigh-income countriesStillbirth rateLate gestation stillbirthAdverse socioeconomic circumstancesIntrapartum stillbirthUnexplained stillbirthBereavement careStillbirthCare contributesStillborn childSocioeconomic circumstancesCausal pathwaysAdvantaged counterpartsDisadvantaged familiesEquity gapCareWomen
2013
Self-Management as a Mediator of Family Functioning and Depressive Symptoms With Health Outcomes in Youth With Type 1 Diabetes
Whittemore R, Liberti L, Jeon S, Chao A, Jaser SS, Grey M. Self-Management as a Mediator of Family Functioning and Depressive Symptoms With Health Outcomes in Youth With Type 1 Diabetes. Western Journal Of Nursing Research 2013, 36: 1254-1271. PMID: 24357648, PMCID: PMC4267676, DOI: 10.1177/0193945913516546.Peer-Reviewed Original ResearchConceptsQuality of lifeType 1 diabetesDepressive symptomsGlycemic controlYouth depressive symptomsDiabetes-related outcomesElevated depressive symptomsFamily functioningHealth outcomesSymptomsType 1Self-ManagementDiabetesSample of adolescentsCausal pathwaysAdolescentsOutcomesYoung adolescentsFamily conflict
2011
Microbial Communities of the Upper Respiratory Tract and Otitis Media in Children
Laufer AS, Metlay JP, Gent JF, Fennie KP, Kong Y, Pettigrew MM. Microbial Communities of the Upper Respiratory Tract and Otitis Media in Children. MBio 2011, 2: 10.1128/mbio.00245-10. PMID: 21285435, PMCID: PMC3031303, DOI: 10.1128/mbio.00245-10.Peer-Reviewed Original ResearchConceptsOtitis mediaUpper respiratory tractS. pneumoniaeRespiratory tractOtitis media treatmentRespiratory virus seasonS. pneumoniae colonizationOtitis media pathogensCross-sectional studyOtitis media susceptibilityPneumoniae colonizationDecreased riskPneumococcal colonizationNasal swabsFrequent causePrevention strategiesStreptococcus pneumoniaeDemographic dataProtective floraPneumoniaeSwabsChildrenCausal pathwaysTractRisk
2010
Ventilatory patterning in a mouse model of stroke
Koo BB, Strohl KP, Gillombardo CB, Jacono FJ. Ventilatory patterning in a mouse model of stroke. Respiratory Physiology & Neurobiology 2010, 172: 129-135. PMID: 20472101, PMCID: PMC3698953, DOI: 10.1016/j.resp.2010.05.008.Peer-Reviewed Original ResearchConceptsCheyne-Stokes respirationRespiratory rateCerebral infarctionMale A/J miceWhole-body plethysmographyAbsence of strokeLower respiratory rateBody plethysmographySham procedureSham animalsJ miceMinute ventilationVentilatory patternTidal volumeMouse modelBreathing patternAnimal modelsVentilatory dataStrokeBreathing instabilityInfarctionVentilationCausal pathwaysBreath volumeBreathing
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