2025
Contemporary Use and Clinical Significance of Initial Triple Versus Double Therapy After Percutaneous Coronary Intervention for Myocardial Infarction in Patients With Atrial Fibrillation.
Park D, McLean B, Akman Z, Li D, Babapour G, Nanna M. Contemporary Use and Clinical Significance of Initial Triple Versus Double Therapy After Percutaneous Coronary Intervention for Myocardial Infarction in Patients With Atrial Fibrillation. Journal Of The American Heart Association 2025, 14: e038589. PMID: 40401606, DOI: 10.1161/jaha.124.038589.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnticoagulantsAspirinAtrial FibrillationClinical RelevanceDrug Therapy, CombinationDual Anti-Platelet TherapyFemaleHemorrhageHospital MortalityHumansMaleMiddle AgedMyocardial InfarctionPercutaneous Coronary InterventionPlatelet Aggregation InhibitorsRetrospective StudiesTime FactorsTreatment OutcomeConceptsPercutaneous coronary interventionST-segment elevation myocardial infarctionDouble therapyTriple therapyClinical adverse eventsIn-hospital mortalityAtrial fibrillationPost-PCIMyocardial infarctionIntracranial hemorrhageAdverse eventsCourse of triple therapyCoronary interventionStent thrombosisInverse probability of treatment weightingProbability of treatment weightingHigh-risk subgroupsMultivariate logistic regressionAssociated with higher oddsRandomized trial evidenceNo significant differenceVizient Clinical DatabaseClinical significancePrescribing patternsCompare outcomesScalp rhythmic epileptiform discharges in focal cortical dysplasia: A clinicopathological study
Xu S, Ming W, Hong B, Zhou J, Jin B, Lv J, Zheng Z, Jiang H, Shen C, Wang Z, Wang Y, Ding M, Xu J, Wang S, Zheng Y. Scalp rhythmic epileptiform discharges in focal cortical dysplasia: A clinicopathological study. Clinical Neurophysiology 2025, 174: 10-16. PMID: 40179633, DOI: 10.1016/j.clinph.2025.03.031.Peer-Reviewed Original ResearchConceptsRhythmic epileptiform dischargesFocal cortical dysplasia type 2Focal cortical dysplasiaFavorable surgical outcomeSurgical outcomesCortical dysplasiaEpileptiform dischargesAssociated with favorable surgical outcomesType 2Focal cortical dysplasia patientsChloride transportScalp electroencephalogramResection surgeryInterictal patternsClinical significanceClinical variablesPathologic correlationClinicopathological studyExtratemporal regionsPatientsAbnormal expressionPathological cellsPathological substrateDysplasiaElectroencephalogramBiological and clinical significance of tumour-infiltrating lymphocytes in the era of immunotherapy: a multidimensional approach
Lopez de Rodas M, Villalba-Esparza M, Sanmamed M, Chen L, Rimm D, Schalper K. Biological and clinical significance of tumour-infiltrating lymphocytes in the era of immunotherapy: a multidimensional approach. Nature Reviews Clinical Oncology 2025, 22: 163-181. PMID: 39820025, DOI: 10.1038/s41571-024-00984-x.Peer-Reviewed Original ResearchConceptsTumor-infiltrating lymphocytesImmune-checkpoint inhibitorsTumor-infiltrating lymphocyte subpopulationsClinical significance of tumor-infiltrating lymphocytesPredictive value of tumor-infiltrating lymphocytesSignificance of tumor-infiltrating lymphocytesStudy of tumor-infiltrating lymphocytesImmune-checkpoint inhibitor therapyImmune-mediated tumor eliminationEra of immunotherapyT cell dysfunctionBiomarkers of responseSolid tumor typesImmunotherapeutic approachesAntigen-reactiveTumor microenvironmentTumor typesClinical outcomesTumor eliminationClinical significanceSingle-cell transcriptomicsPredictive valueAnticancer mechanismClinical implicationsResistance mechanismsThe Buford complex: a review of embryology, imaging, technical considerations, and clinical significance
Moran J, Joo P, Vasavada K, Cheng R, Levitt S, Manzi J, Patel S, Cecere R, Porrino J, Katz L, Jimenez A, Medvecky M. The Buford complex: a review of embryology, imaging, technical considerations, and clinical significance. JSES Reviews Reports And Techniques 2025, 5: 243-250. PMID: 40321863, PMCID: PMC12047549, DOI: 10.1016/j.xrrt.2024.12.005.Peer-Reviewed Original ResearchSuperior labrum anterior-posteriorBuford complexMiddle glenohumeral ligamentClinical significanceCord-like middle glenohumeral ligamentBenign anatomical variantAnterosuperior labral tearReview of embryologyCongenital variantPreoperative imagingGeneral adult populationTechnical considerationsAnatomical variantsLabral tearsShoulder instabilityHigh riskLabral variantsAnterosuperior labrumExternal rotationAdult populationAnterior-posteriorGlenohumeral ligamentEarly childhoodTearsBuford
2024
Cyclic Alternating EEG Patterns: From Sleep to Encephalopathy
Misirocchi F, Mutti C, Hirsch L, Parrino L, Florindo I. Cyclic Alternating EEG Patterns: From Sleep to Encephalopathy. Journal Of Clinical Neurophysiology 2024, 41: 485-494. PMID: 39186585, DOI: 10.1097/wnp.0000000000001082.Peer-Reviewed Original ResearchConceptsCyclic alternating patternStandardized Critical Care EEG TerminologyCritical care EEG terminologyNon-rapid eye movement sleepAmerican Clinical Neurophysiology SocietyEye movement sleepCritically ill patientsEEG terminologyPrognostic significancePrognostic valueMovement sleepClinical significanceImpact of confounding factorsSleep instabilityCritical care settingIll patientsClinical importanceEEG activityEEG phenomenaSedative agentsElectrophysiological biomarkersAlternating patternEncephalopathySleepCare settingsHuman AKR1C3 binds agonists of GPR84 and participates in an expanded polyamine pathway
Dudkina N, Park H, Song D, Jain A, Khan S, Flavell R, Johnson C, Palm N, Crawford J. Human AKR1C3 binds agonists of GPR84 and participates in an expanded polyamine pathway. Cell Chemical Biology 2024, 32: 126-144.e18. PMID: 39163853, PMCID: PMC11748234, DOI: 10.1016/j.chembiol.2024.07.011.Peer-Reviewed Original ResearchHuman aldo-keto reductase family 1 member C3Mammalian fatty acid synthaseDNA double-strand break responseDouble-strand break responseAldo-keto reductase family 1 member C3Associated with poor prognosisPolyamine pathwayFatty acid synthesisFatty acid synthaseAcid synthaseAKR1C3 activityPoor prognosisBiochemical roleAcid synthesisClinical significanceLigand screeningFerroptosis resistanceDNA damageAKR1C3Metabolic diseasesDiverse cancersDNANADPHAgonists of GPR84GPR84Differentiation of Prior SARS-CoV-2 Infection and Postacute Sequelae by Standard Clinical Laboratory Measurements in the RECOVER Cohort.
Erlandson K, Geng L, Selvaggi C, Thaweethai T, Chen P, Erdmann N, Goldman J, Henrich T, Hornig M, Karlson E, Katz S, Kim C, Cribbs S, Laiyemo A, Letts R, Lin J, Marathe J, Parthasarathy S, Patterson T, Taylor B, Duffy E, Haack M, Julg B, Maranga G, Hernandez C, Singer N, Han J, Pemu P, Brim H, Ashktorab H, Charney A, Wisnivesky J, Lin J, Chu H, Go M, Singh U, Levitan E, Goepfert P, Nikolich J, Hsu H, Peluso M, Kelly J, Okumura M, Flaherman V, Quigley J, Krishnan J, Scholand M, Hess R, Metz T, Costantine M, Rouse D, Taylor B, Goldberg M, Marshall G, Wood J, Warren D, Horwitz L, Foulkes A, McComsey G. Differentiation of Prior SARS-CoV-2 Infection and Postacute Sequelae by Standard Clinical Laboratory Measurements in the RECOVER Cohort. Annals Of Internal Medicine 2024, 177: 1209-1221. PMID: 39133923, PMCID: PMC11408082, DOI: 10.7326/m24-0737.Peer-Reviewed Original ResearchPostacute sequelae of SARS-CoV-2 infectionSARS-CoV-2 infectionLaboratory markersSARS-CoV-2Laboratory valuesUrinary albumin-creatinine ratioClinical laboratory markersStandard clinical laboratory testsAlbumin-creatinine ratioClinical laboratory valuesHemoglobin A<sub>1c</sub> (HbA<sub>1c</sub>Clinically useful biomarkersClinical laboratory testsClinical laboratory measurementsPropensity score adjustmentSequelae of SARS-CoV-2 infectionPreexisting diabetesIndex dateMeasured 6 monthsClinical significanceNational Institutes of HealthStudy visitsEnrollment siteRisk factorsClinical biomarkersThe Impact of High-Potency Synthetic Opioids on Pharmacotherapies for Opioid Use Disorder: A Scoping Review
Jegede O, De Aquino J, Hsaio C, Caldwell E, Funaro M, Petrakis I, Muvvala S. The Impact of High-Potency Synthetic Opioids on Pharmacotherapies for Opioid Use Disorder: A Scoping Review. Journal Of Addiction Medicine 2024, 18: 499-510. PMID: 39356620, PMCID: PMC11449257, DOI: 10.1097/adm.0000000000001356.Peer-Reviewed Original ResearchNonmedical opioid useOpioid use disorderOpioid useWithdrawal symptomsTreatment outcomesSymptoms prior to treatmentUse disorderRisk of precipitated withdrawalLow-dose buprenorphineSynthetic opioidsPotency synthetic opioidsConclusions Current evidencePrecipitated withdrawalRisk of overdoseDosing strategiesPharmacological interactionsClinical significanceDecreased riskWeb of ScienceOpioidInclusion criteriaCurrent evidenceClinical implicationsMOUDPainClinical Implications of C2 Lesion in IgA Nephropathy: A Cohort Study
Wang Z, Zhou X, Shi S, Liu L, Lv J, Zhang H. Clinical Implications of C2 Lesion in IgA Nephropathy: A Cohort Study. American Journal Of Nephrology 2024, 55: 529-538. PMID: 39074466, DOI: 10.1159/000540268.Peer-Reviewed Original ResearchConceptsEnd-stage kidney diseaseC2 lesionsCohort studyCox regressionMonths prior to biopsyPeking University First HospitalProportion of crescentsMultivariate Cox regressionProspective cohort studyEffective treatment strategiesKidney prognosisImmunosuppressive treatmentRenal prognosisT2 lesionsMean proteinuriaCombined steroidCrescentic lesionsOxford classificationGlomerular crescentsClinical prognosisUnivariate analysisPathological findingsClinical significanceIgA nephropathyKidney functionOral Contraceptives and the Risk of Psychiatric Side Effects: A Review
Ciarcia J, Huckins L. Oral Contraceptives and the Risk of Psychiatric Side Effects: A Review. Complex Psychiatry 2024, 10: 36-44. PMID: 39148498, PMCID: PMC11324216, DOI: 10.1159/000539515.Peer-Reviewed Original ResearchMood-related side effectsPsychiatric side effectsPsychiatric riskOral contraceptivesSide effectsSymptoms of depressionPrescription psychotropic medicationsOC usersMood side effectsSide effects of oral contraceptivesEffects of oral contraceptivesMood symptomsRisks of oral contraceptivesOC treatmentPsychotropic medicationsMood improvementPsychiatric disordersEating disordersProgestin-only pillsSubgroups of usersPlacebo usersRandomized controlled trialsCombination pillMoodClinical significancePathological concordance rate and outcomes by subtype in advanced papillary renal cell carcinoma
Tripathi A, Tangen C, Plets M, Li X, Tretiakova M, Humphrey P, Adeniran A, Barata P, Gulati S, Bergerot C, Pruthi D, Thompson I, Lara P, Lerner S, Pal S, Shuch B. Pathological concordance rate and outcomes by subtype in advanced papillary renal cell carcinoma. BJU International 2024, 134: 596-601. PMID: 39014969, DOI: 10.1111/bju.16403.Peer-Reviewed Original ResearchPapillary renal cell carcinomaPositive predictive valueRenal cell carcinomaLocal pathology reviewCentral reviewPathology reviewCell carcinomaAdvanced papillary renal cell carcinomaMetastatic papillary renal cell carcinomaPapillary renal cell carcinoma subtypesPatients treated with targeted therapyExpert genitourinary pathologistsPathological concordance rateLocal reviewGenitourinary pathologistsClinical benefitCabozantinibClinical significanceClinical valueSubtype assignmentConcordance rateType 1CarcinomaPatientsPredictive valueAccelerated Bacille Calmette-Guérin reactions: More than meets the eye
Villanueva P, Crawford N, Croda M, Croda J, Dalcolmo M, Jardim B, de Almeida Pinto Jardim T, Marshall H, Prat-Aymerich C, Sawka A, Sharma K, Troeman D, Warris A, Wood N, Messina N, Pittet L, Curtis N. Accelerated Bacille Calmette-Guérin reactions: More than meets the eye. Heliyon 2024, 10: e32510. PMID: 39027494, PMCID: PMC11255489, DOI: 10.1016/j.heliyon.2024.e32510.Peer-Reviewed Original ResearchInterferon-gamma release assayBacille Calmette-GuerinTB prevalence settingInjection site reactionsBCG reactionBCG vaccinationSite reactionsTB infectionLow TB prevalence countriesHistory of BCG vaccinationLocal injection site reactionsBacille Calmette-Guerin vaccineTB prevalence countriesInternational randomised trialLatent TB infectionDays of vaccinationSafety surveillance dataActive tuberculosisAdverse eventsBCG vaccineesMycobacterial exposureRelease assayClinical significanceTB symptomsFemale sexPericardial fluid troponin in cardiac surgery
Fatehi Hassanabad A, El-Sherbini A, Cherif I, Ahmad B, Gonzalez A, Pelletier M, Fedak P, El-Diasty M. Pericardial fluid troponin in cardiac surgery. Clinica Chimica Acta 2024, 559: 119722. PMID: 38734224, DOI: 10.1016/j.cca.2024.119722.Peer-Reviewed Original ResearchConceptsCardiac surgeryPericardial fluidTroponin levelsLevels of cardiac troponinPF levelsCardiac troponin levelsTroponin changesGoogle Scholar databasesTroponin concentrationsCardiac troponinProcedure typeClinical significancePrimary outcomeSurgerySecondary outcomesBiologically active factorsBlinded reviewersPreferred Reporting ItemsFull-text reviewTroponinInclusion criteriaPatientsPathological changesScholar databasesSystematic reviewA common polymorphism in the Intelectin-1 gene influences mucus plugging in severe asthma
Everman J, Sajuthi S, Liegeois M, Jackson N, Collet E, Peters M, Chioccioli M, Moore C, Patel B, Dyjack N, Powell R, Rios C, Montgomery M, Eng C, Elhawary J, Mak A, Hu D, Huntsman S, Salazar S, Feriani L, Fairbanks-Mahnke A, Zinnen G, Michel C, Gomez J, Zhang X, Medina V, Chu H, Cicuta P, Gordon E, Zeitlin P, Ortega V, Reisdorph N, Dunican E, Tang M, Elicker B, Henry T, Bleecker E, Castro M, Erzurum S, Israel E, Levy B, Mauger D, Meyers D, Sumino K, Gierada D, Hastie A, Moore W, Denlinger L, Jarjour N, Schiebler M, Wenzel S, Woodruff P, Rodriguez-Santana J, Pearson C, Burchard E, Fahy J, Seibold M. A common polymorphism in the Intelectin-1 gene influences mucus plugging in severe asthma. Nature Communications 2024, 15: 3900. PMID: 38724552, PMCID: PMC11082194, DOI: 10.1038/s41467-024-48034-5.Peer-Reviewed Original ResearchConceptsAirway epithelial cellsIntelectin-1Mucus pluggingGene expressionAirways of severe asthmaticsEpithelial cellsHuman airway epithelial cellsAirway epithelial brushingsMucus secretory cellsT2-high asthmaFormation of mucus plugsAssociated with protectionC-terminusGenetic variantsAirway mucus pluggingMolecular roleSecretory cellsSecreted componentsEpithelial brushingsT2-lowIL-13Mucus obstructionTarget pathwaysSevere asthmaticsClinical significanceAlcohol Use Disorder and Chronic Pain: An Overlooked Epidemic
De Aquino J, Sloan M, Nunes J, Costa G, Katz J, de Oliveira D, Ra J, Tang V, Petrakis I. Alcohol Use Disorder and Chronic Pain: An Overlooked Epidemic. American Journal Of Psychiatry 2024, 181: 391-402. PMID: 38706339, PMCID: PMC11521207, DOI: 10.1176/appi.ajp.20230886.Peer-Reviewed Original ResearchConceptsAlcohol use disorderChronic painAUD studiesChronic pain disordersChronic pain outcomesRisk of relapseAlcohol withdrawal syndromeAssessment of painHigher levels of alcohol consumptionLevels of alcohol consumptionWithdrawal syndromePain disordersPain outcomesAcute toleranceNeurobiological changesClinical significanceUse disorderPainClinical relevanceSelf-reportAlcohol intoxicationAlcohol consumptionGeneral populationMedical conditionsNarrative reviewTrends and predictors of Quality of Life in lung cancer survivors
Bade B, Zhao J, Li F, Tanoue L, Lazowski H, Alfano C, Silvestri G, Irwin M. Trends and predictors of Quality of Life in lung cancer survivors. Lung Cancer 2024, 191: 107793. PMID: 38640687, DOI: 10.1016/j.lungcan.2024.107793.Peer-Reviewed Original ResearchConceptsFunctional Assessment of Cancer Therapy - LungNon-small cell lung cancerHR-QOL scoresLung cancer survivorsHR-QOLAdvanced stage non-small cell lung cancerEarly-stage non-small cell lung cancerStage non-small cell lung cancerQuality of lifeCancer survivorsPhysical activityCell lung cancerEarly-stage diseasePredictors of quality of lifeHealth-related quality of lifeFollow-upHealth-related qualityHealthy weight maintenancePerformance statusAdvanced-stage non-small cell lung cancerLung cancerClinical significanceAssociated with older ageDiagnosed NSCLCTreatment-related side effectsNon-dominant, Lesional Posterior Quadrant Epilepsy
Herlopian A. Non-dominant, Lesional Posterior Quadrant Epilepsy. 2024, 633-652. DOI: 10.1007/978-3-031-23828-4_25.Peer-Reviewed Original ResearchArterio-venous malformationsIntracranial monitoringImpact of topiramatePosterior quadrantic epilepsyTreat pharmacoresistant epilepsySurgical outcomesTransient encephalopathyElectrographic seizuresSurgical interventionOutcome predictorsClinical significancePharmacoresistant epilepsyEpileptogenesis mechanismsEpilepsy patientsPatientsWada testAuditory hallucinationsLanguage reorganizationMalformationsEpilepsyCognitive functionOutcomesAuditory illusionTopiramateExternal Disruption of Ocular Development in Utero
Kim H, Sarrafpour S, Teng C, Liu J. External Disruption of Ocular Development in Utero. The Yale Journal Of Biology And Medicine 2024, 97: 41-48. PMID: 38559457, PMCID: PMC10964818, DOI: 10.59249/rrmm8911.Peer-Reviewed Original ResearchConceptsOcular developmentOcular embryologyEnglish-language articlesIntrauterine infectionMaternal nutritionClinical significanceGenetic signaling pathwaysWeb of ScienceAnimal modelsHormonal factorsHuman studiesMultifactorial naturePregnancySignaling pathwayGoogle ScholarReviewIntrauterineEmbryologyLimited resourcesGestationUteroPathophysiologyFactorsInfectionPubMedUnveiling biomarkers and therapeutic targets in IgA nephropathy through large-scale blood transcriptome analysis
Gan T, Qu L, Qu S, Qi Y, Zhang Y, Wang Y, Li Y, Liu L, Shi S, Lv J, Zhang H, Peng Y, Zhou X. Unveiling biomarkers and therapeutic targets in IgA nephropathy through large-scale blood transcriptome analysis. International Immunopharmacology 2024, 132: 111905. PMID: 38552291, DOI: 10.1016/j.intimp.2024.111905.Peer-Reviewed Original ResearchConceptsPeripheral blood mononuclear cellsIgAN patientsIgA nephropathyBlood transcriptome analysisNK cell mediated cytotoxicityChinese IgAN patientsImmune cell profilesB-cell receptor signalingBlood mononuclear cellsModel of IgANEvaluate clinical significancePotential specific markerPersonalized treatment optionsCell mediated cytotoxicityBlood transcriptome profilesClinically significant genesTreatment optionsMononuclear cellsClinical dataClinical significanceMediated cytotoxicityHealthy controlsIgANImmune responsePotential therapeutic agents
2023
Distinguishing probable atypical anorexia nervosa from weight loss alone in a national sample of U.S. Military Veterans: Disentangling the roles of weight suppression and cognitive concerns
Neff K, Buta E, Fenn L, Ramsey C, Snow J, Haskell S, Masheb R. Distinguishing probable atypical anorexia nervosa from weight loss alone in a national sample of U.S. Military Veterans: Disentangling the roles of weight suppression and cognitive concerns. International Journal Of Eating Disorders 2023, 57: 827-838. PMID: 38129986, DOI: 10.1002/eat.24116.Peer-Reviewed Original ResearchAtypical anorexia nervosaAtypical ANWeight suppressionAnorexia nervosaClinical entityWeight lossControl groupDietary restraintMental healthDistinct clinical entityPoor mental healthOnly groupU.S. military veteransClinical significanceHigh riskVeteran populationSecondary analysisWeight gainSpecialized interventionsMilitary veteransNervosaDisordersVeteransNational studyPathology
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