2025
Cannabis Legalization and Opioid Use Disorder in Veterans Health Administration Patients
Mannes Z, Wall M, Alschuler D, Malte C, Olfson M, Livne O, Fink D, Keyhani S, Keyes K, Martins S, Cerdá M, Sacco D, Gutkind S, Maynard C, Sherman S, Saxon A, Hasin D. Cannabis Legalization and Opioid Use Disorder in Veterans Health Administration Patients. JAMA Health Forum 2025, 6: e251369. PMID: 40512510, PMCID: PMC12166489, DOI: 10.1001/jamahealthforum.2025.1369.Peer-Reviewed Original ResearchConceptsVeterans Health AdministrationVeterans Health Administration patientsMedical cannabis lawsOpioid use disorderPrevalence of opioid use disorderClassification of DiseasesRecreational cannabis lawsChronic painVeterans Health Administration electronic health recordClinical ModificationConsistent with overall findingsState medical cannabis lawsInternational Statistical Classification of DiseasesReceipt of prescription opioidsStatistical Classification of DiseasesElectronic health recordsInternational Classification of DiseasesNon-Hispanic whitesOpioid use disorder diagnosisOpioid use disorder prevalenceInternational Statistical ClassificationDifference-in-differences analysisCannabis lawsUse disorderBurden of opioid use disorderA Digital Depression Treatment Program for Adults Treated in Primary Care
Dahne J, Wahlquist A, Carpenter M, Graboyes E, Lejuez C, Kustanowitz J, Natale N, Levins O, Player M, Diaz V. A Digital Depression Treatment Program for Adults Treated in Primary Care. JAMA Internal Medicine 2025, 185 PMID: 40227715, DOI: 10.1001/jamainternmed.2025.0494.Peer-Reviewed Original ResearchElectronic health recordsBeck Depression Inventory-IIPrimary care settingBehavioral activation interventionDepressive symptomsClinically significant improvementUsual careActivity interventionsCare settingsElectronic health record featuresElectronic health record integrationPatient Health Questionnaire-9Depression remissionModerate symptoms of depressionPrimary care providersPrimary care clinicsDepression treatment programTreating depressive symptomsSymptoms of depressionPrimary careSignificant improvementCare clinicsIntervention engagementCare providersScalable interventionsBenzodiazepine Initiation and the Risk of Falls or Fall-Related Injuries in Older Adults Following Acute Ischemic Stroke
Sun S, Lomachinsky V, Smith L, Newhouse J, Westover M, Blacker D, Schwamm L, Haneuse S, Moura L. Benzodiazepine Initiation and the Risk of Falls or Fall-Related Injuries in Older Adults Following Acute Ischemic Stroke. Neurology Clinical Practice 2025, 15: e200452. PMID: 40144887, DOI: 10.1212/cpj.0000000000200452.Peer-Reviewed Original ResearchFall-related injuriesRisk of fallsOlder adultsAcute ischemic strokeRisk differenceAcute ischemic stroke admissionsElectronic health recordsHypothetical randomized trialInverse probability weightingIschemic strokeRecovery periodHealth recordsBenzodiazepine initiationPoststroke periodConfounding biasImmortal timeMild strokeBenzodiazepine prescriptionsBZD useDay of admissionProbability weightingSubgroup analysisAnalyzed dataStrokeAdultsUpdate on the utilization of complementary therapies by adolescents with asthma in an urban population
Soffer G, Feinberg T, Kroll H, Reznik M. Update on the utilization of complementary therapies by adolescents with asthma in an urban population. Journal Of Asthma 2025, ahead-of-print: 1-9. PMID: 40040497, DOI: 10.1080/02770903.2025.2475451.Peer-Reviewed Original ResearchAsthma Control TestCAM useUtilization of complementary therapiesPrevalence of CAM usePrescription adherenceEfficacy of CAMHealth-promoting behaviorsPrimary care clinicsElectronic health recordsCAM utilizationCare clinicsActivity prescriptionHealth recordsAlternative medicineComplementary therapyAsthma managementLack of associationOutpatient specialtyAsthma controlSelf-reportAsthma severityLogistic regressionMind-bodyUrban adolescentsDemographic informationEvaluating Major Bleeding Risks with Concomitant Use of Direct Oral Anticoagulants and Selective Serotonin Reuptake Inhibitors in Nonvalvular Atrial Fibrillation Patients
Yao S, Kocis P, Murphy T, Hwang W. Evaluating Major Bleeding Risks with Concomitant Use of Direct Oral Anticoagulants and Selective Serotonin Reuptake Inhibitors in Nonvalvular Atrial Fibrillation Patients. Pharmacoepidemiology 2025, 4: 6. DOI: 10.3390/pharma4010006.Peer-Reviewed Original ResearchDirect oral anticoagulantsNonvalvular atrial fibrillationNonvalvular atrial fibrillation patientsVitamin K antagonistsSerotonin reuptake inhibitorsHazard ratioBleeding eventsConcomitant useOral anticoagulantsReuptake inhibitorsFollow-upConfidence intervalsElectronic health recordsEstimate hazard ratiosCause-specific proportional hazards modelDOAC prescriptionsHAS-BLED scoreAtrial fibrillation patientsBaseline CHA2DS2-VASc scoreCHA2DS2-VASc scoreRetrospective cohort studyInverse probability of treatmentHealth recordsProportional hazards modelDrug-drug interactionsOpportunities and Challenges in Using Electronic Health Record Systems to Study Postacute Sequelae of SARS-CoV-2 Infection: Insights From the NIH RECOVER Initiative
Mandel H, Shah S, Bailey L, Carton T, Chen Y, Esquenazi-Karonika S, Haendel M, Hornig M, Kaushal R, Oliveira C, Perlowski A, Pfaff E, Rao S, Razzaghi H, Seibert E, Thomas G, Weiner M, Thorpe L, Divers J, Cohort R. Opportunities and Challenges in Using Electronic Health Record Systems to Study Postacute Sequelae of SARS-CoV-2 Infection: Insights From the NIH RECOVER Initiative. Journal Of Medical Internet Research 2025, 27: e59217. PMID: 40053748, PMCID: PMC11923460, DOI: 10.2196/59217.Peer-Reviewed Original ResearchConceptsElectronic health recordsElectronic health record dataPostacute sequelae of SARS-CoV-2 infectionSequelae of SARS-CoV-2 infectionElectronic health record systemsHealth record systemsLong COVIDHealth recordsEHR dataEpidemiological researchRecording systemPostacute sequelaeMultifaceted conditionNational InstituteSARS-CoV-2 infectionData sourcesCOVID researchCOVIDInitiationNationalOpportunitiesDataEpigenomic pathways from racism to preterm birth: secondary analysis of the Nulliparous Pregnancy Outcomes Study: monitoring Mothers-to-be (nuMoM2b) cohort study in the USA to examine how DNA methylation mediates the relationship between multilevel racism and preterm birth in black women: a study protocol
Barcelona V, Ray M, Zhao Y, Samari G, Wu H, Reho P, McNeil R, Reddy U. Epigenomic pathways from racism to preterm birth: secondary analysis of the Nulliparous Pregnancy Outcomes Study: monitoring Mothers-to-be (nuMoM2b) cohort study in the USA to examine how DNA methylation mediates the relationship between multilevel racism and preterm birth in black women: a study protocol. BMJ Open 2025, 15: e091801. PMID: 40037666, PMCID: PMC11881185, DOI: 10.1136/bmjopen-2024-091801.Peer-Reviewed Original ResearchConceptsNulliparous Pregnancy Outcomes StudyMonitoring Mothers-to-BeMothers-to-beBlack womenPregnancy Outcomes StudyParticipants' electronic health recordsPreterm birthSecondary analysisCohort studyGeocoded participant addressesSecondary analysis of dataStudy protocolElectronic health recordsStructural racism measuresUniversity Institutional Review BoardEffects of individual-Black pregnant womenOutcome studiesRacial residential segregationProspective cohort studyPregnancy-related morbidityParticipant's addressHealth recordsAdverse pregnancy outcomesWhite womenAssessment of health conditions from patient electronic health record portals vs self-reported questionnaires: an analysis of the INSPIRE study
Khera R, Sawano M, Warner F, Coppi A, Pedroso A, Spatz E, Yu H, Gottlieb M, Saydah S, Stephens K, Rising K, Elmore J, Hill M, Idris A, Montoy J, O’Laughlin K, Weinstein R, Venkatesh A, Weinstein R, Gottlieb M, Santangelo M, Koo K, Derden A, Gottlieb M, Gatling K, Ahmed Z, Gomez C, Guzman D, Hassaballa M, Jerger R, Kaadan A, Venkatesh A, Spatz E, Kinsman J, Malicki C, Lin Z, Li S, Yu H, Mannan I, Yang Z, Liu M, Venkatesh A, Spatz E, Ulrich A, Kinsman J, Malicki C, Dorney J, Pierce S, Puente X, Salah W, Nichol G, Stephens K, Anderson J, Schiffgens M, Morse D, Adams K, Stober T, Maat Z, O’Laughlin K, Gentile N, Geyer R, Willis M, Zhang Z, Chang G, Lyon V, Klabbers R, Ruiz L, Malone K, Park J, Rising K, Kean E, Chang A, Renzi N, Watts P, Kelly M, Schaeffer K, Grau D, Cheng D, Shutty C, Charlton A, Shughart L, Shughart H, Amadio G, Miao J, Hannikainen P, Elmore J, Wisk L, L’Hommedieu M, Chandler C, Eguchi M, Roldan K, Moreno R, Rodriguez R, Wang R, Montoy J, Kemball R, Chan V, Chavez C, Wong A, Arreguin M, Hill M, Site R, Kane A, Nikonowicz P, Sapp S, Idris A, McDonald S, Gallegos D, Martin K, Saydah S, Plumb I, Hall A, Briggs-Hagen M. Assessment of health conditions from patient electronic health record portals vs self-reported questionnaires: an analysis of the INSPIRE study. Journal Of The American Medical Informatics Association 2025, 32: 784-794. PMID: 40036551, PMCID: PMC12012333, DOI: 10.1093/jamia/ocaf027.Peer-Reviewed Original ResearchElectronic health recordsSelf-report questionnairesSelf-reportHealth conditionsElectronic health record portalsElectronic health record platformsEHR elementsSelf-reported health conditionsElectronic health record dataSelf-reported conditionsAssessment of health conditionEvaluation of health conditionsPrevalence of conditionsPatient portalsTraditional self-reportPrevalence of comorbiditiesHealth recordsEHR dataEHR phenotypesDiagnosis codesHospitalization riskComputable phenotypeNationwide studyCohen's kappaPatient characteristicsEffectiveness of Breast Density Educational Interventions on Mammography Screening Adherence Among Underserved Latinas: A Randomized Controlled Trial
Austin J, Jenkins S, Suman V, Ridgeway J, Patel B, Ghosh K, Rhodes D, Borah B, Norman A, Ramos E, Jewett M, Gonzalez C, Hernandez V, Singh D, Breitkopf C, Vachon C. Effectiveness of Breast Density Educational Interventions on Mammography Screening Adherence Among Underserved Latinas: A Randomized Controlled Trial. Journal Of Women's Health 2025 PMID: 39969957, DOI: 10.1089/jwh.2024.0273.Peer-Reviewed Original ResearchFederally Qualified Health CentersRandomized controlled trialsAnnual mammogramsBreast densityAdherence ratesIncreased risk of breast cancerRisk of breast cancerMammography screening adherenceQualified Health CentersElectronic health recordsMammographically dense breastsScreening adherenceUnderserved LatinasMammography screeningHealth recordsBaseline mammogramEducational interventionHealth centersDense breastsInformation interventionLatinasControlled trialsMammogramsGroup assignmentSurvey responsesCapacity assessment for EHR-based medical device post-market surveillance for synthetic mid-urethral slings among women with stress urinary incontinence: a NEST consortium study
Matheny M, Perkins A, Rieger-Christ K, Ross J, Mao J, Sedrakyan A, Shah N, Winter R, Reynolds W, Mourtzinos A, Schulz W, Bartlett V, Solotke M, Pandya S, Aryal S, Cho A, Frankenberger E, Park D, Bostrom D, Robbins S, Yustein A, Chughtai B, Trabuco E. Capacity assessment for EHR-based medical device post-market surveillance for synthetic mid-urethral slings among women with stress urinary incontinence: a NEST consortium study. BMJ Surgery Interventions & Health Technologies 2025, 7: e000193. PMID: 39949784, PMCID: PMC11822424, DOI: 10.1136/bmjsit-2023-000193.Peer-Reviewed Original ResearchElectronic health record dataElectronic health recordsHealth systemStress urinary incontinenceSynthetic mesh implantsTertiary care academic medical centerSurgical approachManual chart reviewChart reviewAcademic medical centerMedical device surveillanceHealth recordsAdverse event surveillanceMesh implantationUrinary incontinenceDuration of surveillanceAscertainment rateMid-urethral sling (MUSOutcome measuresSynthetic mid-urethral slingsTreat stress urinary incontinenceDetermination of surgical approachEvent surveillanceRetrospective observational studyMedical CenterSpatial Correlates of Dementia and Disability After Intracerebral Hemorrhage.
Chen Y, Rivier C, Mora S, Torres Lopez V, Payabvash S, Sheth K, Harloff A, Falcone G, Rosand J, Mayerhofer E, Anderson C. Spatial Correlates of Dementia and Disability After Intracerebral Hemorrhage. Journal Of The American Heart Association 2025, 14: e037930. PMID: 39921496, DOI: 10.1161/jaha.124.037930.Peer-Reviewed Original ResearchConceptsFollow-up telephone interviewsElectronic health recordsAssociated with disabilityAssociated with dementiaDevelopment of dementiaDevelopment of disabilityIncident dementiaAssociated with intracerebral hemorrhageIntracerebral hemorrhageHealth recordsTelephone interviewsDementia conversionCohort studyDementiaDisabilityLobar intracerebral hemorrhageIntracerebral hemorrhage locationIntracerebral hemorrhagic lesionsFunctional outcomesNoncontrast computed tomography scanCohortMedian follow-up timeRight posterior limbOutcomesLeft temporo-occipital regionMedication for Opioid Use Disorder for Hospitalized Patients at Six New York City Public Hospitals with an Addiction Consult Service.
Rostam-Abadi Y, McNeely J, Tarpey T, Fernando J, Appleton N, Fawole A, Mazumdar M, Kalyanaraman Marcello R, Cooke C, Dolle J, Siddiqui S, Schatz D, King C. Medication for Opioid Use Disorder for Hospitalized Patients at Six New York City Public Hospitals with an Addiction Consult Service. Journal Of Addiction Medicine 2025 PMID: 39908531, DOI: 10.1097/adm.0000000000001450.Peer-Reviewed Original ResearchNew York City public hospitalCity public hospitalsAddiction consult servicesPublic hospitalsDrivers of racial disparitiesPopulation-specific barriersElectronic health recordsYears post-implementationOpioid use disorder treatmentMajority of patientsHealth recordsPost-implementationAddiction careOpioid use disorderRacial disparitiesLogistic regressionInpatient departmentConsultation serviceClinical characteristicsEligible patientsMOUDOddsConsultationHospitalized patientsHospitalLong COVID Incidence Proportion in Adults and Children Between 2020 and 2024: An EHR-Based Study From the RECOVER Initiative
Mandel H, Yoo Y, Allen A, Abedian S, Verzani Z, Karlson E, Kleinman L, Mudumbi P, Oliveira C, Muszynski J, Gross R, Carton T, Kim C, Taylor E, Park H, Divers J, Kelly J, Arnold J, Geary C, Zang C, Tantisira K, Rhee K, Koropsak M, Mohandas S, Vasey A, Mosa A, Haendel M, Chute C, Murphy S, O'Brien L, Szmuszkovicz J, Guthe N, Santana J, De A, Bogie A, Halabi K, Mohanraj L, Kinser P, Packard S, Tuttle K, Hirabayashi K, Kaushal R, Pfaff E, Weiner M, Thorpe L, Moffitt R. Long COVID Incidence Proportion in Adults and Children Between 2020 and 2024: An EHR-Based Study From the RECOVER Initiative. Clinical Infectious Diseases 2025, ciaf046. PMID: 39907495, DOI: 10.1093/cid/ciaf046.Peer-Reviewed Original ResearchElectronic health recordsIncidence proportionIncidence estimatesComputable phenotypeEHR-based studiesLong COVIDPublic health priorityPost-acute sequelae of SARS-CoV-2 infectionHealth recordsSequelae of SARS-CoV-2 infectionHealth priorityProportion of individualsRetrospective cohort studyHarmonized definitionExcess incidenceCohort studyImprove preventionSARS-CoV-2 infectionResearch NetworkRisk factorsAdultsCOVID-19Control groupAcute SARS-CoV-2 infectionPediatric populationEvaluating the Bias, type I error and statistical power of the prior Knowledge-Guided integrated likelihood estimation (PIE) for bias reduction in EHR based association studies
Jing N, Lu Y, Tong J, Weaver J, Ryan P, Xu H, Chen Y. Evaluating the Bias, type I error and statistical power of the prior Knowledge-Guided integrated likelihood estimation (PIE) for bias reduction in EHR based association studies. Journal Of Biomedical Informatics 2025, 163: 104787. PMID: 39904407, DOI: 10.1016/j.jbi.2025.104787.Peer-Reviewed Original ResearchConceptsType I errorIntegrated likelihood estimatorsElectronic health recordsUse-case analysisLikelihood estimationLow prevalence outcomesUse-casesBias reductionNaive methodEffect sizeSynthetic dataPhenotyping algorithmsEstimation biasReal-world scenariosStatistical inferenceSimulation studyAssociation effect sizesAccurate prior informationBinary outcomesPoint estimatesAssociation estimatesStatistical powerHealth recordsKnowledge-guidedOutcome prevalenceEfficacy of a Clinical Decision Support Tool to Promote Guideline-Concordant Evaluations in Patients With High-Risk Microscopic Hematuria: A Cluster Randomized Quality Improvement Project.
Matulewicz R, Tsuruo S, King W, Nagler A, Feuer Z, Szerencsy A, Makarov D, Wong C, Dapkins I, Horwitz L, Blecker S. Efficacy of a Clinical Decision Support Tool to Promote Guideline-Concordant Evaluations in Patients With High-Risk Microscopic Hematuria: A Cluster Randomized Quality Improvement Project. Journal Of Urology 2025, 101097ju0000000000004436. PMID: 39854625, DOI: 10.1097/ju.0000000000004436.Peer-Reviewed Original ResearchClinical decision supportQuality improvement projectIntervention armImprovement projectImplementation of clinical decision supportClinical decision support alertsMultisite academic medical centerClinical decision support toolPrimary outcomeElectronic health recordsBarriers to evaluationAcademic medical centerHigh riskCDS alertsCDS toolsUsual careHealth recordsHealth systemPatient completionGuideline-concordantAmbulatory sitesImaging ordersCompletion of imagingControl armPromotion evaluationEvaluation of a Machine Learning-Guided Strategy for Elevated Lipoprotein(a) Screening in Health Systems
Aminorroaya A, Dhingra L, Oikonomou E, Khera R. Evaluation of a Machine Learning-Guided Strategy for Elevated Lipoprotein(a) Screening in Health Systems. Circulation Genomic And Precision Medicine 2025, 18: e004632. PMID: 39846171, PMCID: PMC11835527, DOI: 10.1161/circgen.124.004632.Peer-Reviewed Original ResearchConceptsYale New Haven Health SystemHealth systemVanderbilt University Medical CenterHealth system electronic health recordUniversity Medical CenterCoronary Artery Risk DevelopmentMulti-Ethnic Study of AtherosclerosisElectronic health recordsMedical CenterUS health systemHealth system patientsAssociated with significantly higher oddsMulti-Ethnic StudyUS-based cohortStudy of AtherosclerosisSignificantly higher oddsHealth recordsUK BiobankAtherosclerosis RiskRisk DevelopmentHigher oddsElevated Lp(aUniversal screeningSystem patientsStudy cohortClassifying Unstructured Text in Electronic Health Records for Mental Health Prediction Models: Large Language Model Evaluation Study
Cardamone N, Olfson M, Schmutte T, Ungar L, Liu T, Cullen S, Williams N, Marcus S. Classifying Unstructured Text in Electronic Health Records for Mental Health Prediction Models: Large Language Model Evaluation Study. JMIR Medical Informatics 2025, 13: e65454. PMID: 39864953, PMCID: PMC11884378, DOI: 10.2196/65454.Peer-Reviewed Original ResearchConceptsElectronic health recordsMental health termsHealth termsClinical expertsEmergency departmentHealth recordsPhysical healthMental healthElectronic health record systemsHealth care provider organizationsMental health-related problemsElectronic health record data setsCare provider organizationsMental health cliniciansMental health disordersHealth-related problemsED episodesHealth cliniciansRecords of individualsState-of-the-artDiagnostic codesHealth disordersHospital readmissionProvider organizationsMortality riskRespiratory syncytial virus vaccine effectiveness among US veterans, September, 2023 to March, 2024: a target trial emulation study
Bajema K, Yan L, Li Y, Argraves S, Rajeevan N, Fox A, Vergun R, Berry K, Bui D, Huang Y, Lin H, Hynes D, Lucero-Obusan C, Schirmer P, Cunningham F, Huang G, Aslan M, Ioannou G. Respiratory syncytial virus vaccine effectiveness among US veterans, September, 2023 to March, 2024: a target trial emulation study. The Lancet Infectious Diseases 2025 PMID: 39848264, DOI: 10.1016/s1473-3099(24)00796-5.Peer-Reviewed Original ResearchRespiratory syncytial virusRespiratory syncytial virus vaccinePositive RSV testVaccine effectivenessRSV testCare encountersSecondary outcomesEmergency departmentRSV-associated hospitalisationsMedian follow-upUS Food and Drug AdministrationHealth-care useVeterans Health AdministrationRespiratory illness seasonMatched index dateElectronic health recordsLower respiratory tract diseaseRSV-related illnessFood and Drug AdministrationDepartment of Veterans Affairs Cooperative Studies ProgramVeterans Affairs Cooperative Studies ProgramCooperative Studies ProgramRSV infectionMedian ageUS DepartmentAssociation of delayed asthma diagnosis with asthma exacerbations in children
Wi C, Ryu E, King K, Kwon J, Bublitz J, Park M, Chiarella S, Greenwood J, Pongdee T, Myers L, Nordlund B, Sohn S, Sagheb E, Kshatriya B, Watson D, Liu H, Sheares B, Davis C, Schulz W, Juhn Y. Association of delayed asthma diagnosis with asthma exacerbations in children. Journal Of Allergy And Clinical Immunology Global 2025, 4: 100409. PMID: 40008091, PMCID: PMC11851198, DOI: 10.1016/j.jacig.2025.100409.Peer-Reviewed Original ResearchElectronic health recordsDiagnosis of asthmaAsthma diagnosisAsthma exacerbationsRisk of AEPredetermined Asthma CriteriaDiagnosis of childhood asthmaChildhood asthma managementIncreased riskCox proportional hazards modelsIncreased risk of AECare qualityAsthma outcomesHealth recordsProportional hazards modelAsthma managementChildhood asthmaBirth cohortAsthma severityDiagnosis statusIndex dateIdentifying childrenPrimary outcomeNatural language processing algorithmsHazards modelIdentifying Metabolic Dysfunction-Associated Steatotic Liver Disease Using Natural Language Processing in a US National Cohort.
John B, Bastaich D, Mezzacappa C, Ferreira R, Hentschel A, Samos A, Mahmud N, Taddei T, Kaplan D, Serper M, Dahman B. Identifying Metabolic Dysfunction-Associated Steatotic Liver Disease Using Natural Language Processing in a US National Cohort. The American Journal Of Gastroenterology 2025 PMID: 39950372, DOI: 10.14309/ajg.0000000000003321.Peer-Reviewed Original ResearchElectronic health recordsCardiometabolic risk factorsAlcohol useChart reviewRetrospective study of participantsStudy of participantsLiver diseaseSteatotic liver diseaseIncreased alcohol intakeEligible veteransICD-9/10 codesHealth recordsNational cohortAlcohol intakeEvidence of hepatic steatosisEpidemiological studiesNatural language processing algorithmsRisk factorsStudy cohortOutcome studiesVeteransCohortClinical entityRetrospective studyMetabolic dysfunction
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