2025
Sex Differences in Natural History and Health Outcomes Among Individuals With Tic Disorders
Dy-Hollins M, Chibnik L, Tracy N, Osiecki L, Budman C, Cath D, Grados M, King R, Lyon G, Rouleau G, Sandor P, Singer H, Sharma N, Mathews C, Scharf J. Sex Differences in Natural History and Health Outcomes Among Individuals With Tic Disorders. Neurology 2025, 104: e210249. PMID: 39813627, PMCID: PMC11735146, DOI: 10.1212/wnl.0000000000210249.Peer-Reviewed Original ResearchConceptsTourette syndromeTic disordersTime to diagnosisSex differencesVocal tic disorderLonger time to diagnosisGeneralized estimating equation regression modelsSymptom onsetAnalyze sex differencesEquation regression modelsTic severityClinical measuresTouretteParticipantsRegression modelsFamily relationshipsPersistent motorSymptomsDisordersResearch studies
2024
P27.10.B FACTORS INFLUENCING TIMELY DIAGNOSIS IN NEUROLYMPHOMATOSIS
Doubrovinskaia S, Egert A, Karschnia P, Scheffler G, Huttner A, Fulbright R, Baehring J, Kaulen L. P27.10.B FACTORS INFLUENCING TIMELY DIAGNOSIS IN NEUROLYMPHOMATOSIS. Neuro-Oncology 2024, 26: v138-v139. PMCID: PMC11485484, DOI: 10.1093/neuonc/noae144.472.Peer-Reviewed Original ResearchNon-Hodgkin's lymphomaPeripheral nervous systemNerve root lesionsDiagnostic intervalRelapse of NHLSymptom onsetAssociated with early diagnosisTertiary referral centerAtypical clinical presentationRoot lesionsCerebrospinal fluid examinationDiagnostic work-upYale Cancer CenterPainful polyneuropathyAsymmetric neuropathyClinical presentationReferral centerFluid examinationQuality control databaseDiagnostic delayFDG-PETPrimary diseaseUnivariate analysisConventional CTNeurolymphomatosisHigh-Sensitivity Troponin: Finding a Meaningful Delta
Wright C, Wright D, Hu J, Gallegos C. High-Sensitivity Troponin: Finding a Meaningful Delta. Journal Of Cardiovascular Development And Disease 2024, 11: 318. PMID: 39452288, PMCID: PMC11508916, DOI: 10.3390/jcdd11100318.Peer-Reviewed Original ResearchEuropean Society of CardiologyHs-cTnCardiac biomarkersMyocardial injuryFourth Universal Definition of Myocardial InfarctionHigh-sensitivity cardiac troponinUniversal Definition of Myocardial InfarctionChest pain syndromeAmerican College of Cardiology/American Heart AssociationHs-cTn assaysHs-cTn valuesFourth Universal DefinitionDefinition of myocardial infarctionClinical risk scoreAcute myocardial injurySociety of CardiologyStandard cardiac biomarkersInterpretation of dynamic changesChest painPain syndromeOptimal time frameCardiac troponinRule-outHeart AssociationSymptom onsetThe role of parvalbumin interneuron dysfunction across neurodegenerative dementias
Smeralda C, Pandit S, Turrini S, Reilly J, Palmisano A, Sprugnoli G, Hampel H, Benussi A, Borroni B, Press D, Rotenberg A, El Fakhri G, Koch G, Rossi S, Santarnecchi E. The role of parvalbumin interneuron dysfunction across neurodegenerative dementias. Ageing Research Reviews 2024, 101: 102509. PMID: 39306248, DOI: 10.1016/j.arr.2024.102509.Peer-Reviewed Original ResearchInterneuron dysfunctionCortical hyperexcitabilityTherapeutic targetCortical excitation/inhibition balanceRhythm disruptionFast-spikingPV+ cellsBasket neuronsPotential therapeutic targetInhibitory interneuronsExcitation/inhibition balanceOscillatory disruptionsSymptom onsetNovel biomarkersHyperexcitabilityDysfunctionNeuronal deathOscillatory activityDementia with Lewy bodiesPathophysiological frameworkClinical symptom onsetFrontotemporal dementiaAdjunctive Intravenous Argatroban or Eptifibatide for Ischemic Stroke
Adeoye O, Broderick J, Derdeyn C, Grotta J, Barsan W, Bentho O, Berry S, Concha M, Davis I, Demel S, Elm J, Gentile N, Graves T, Hoffman M, Huang J, Ingles J, Janis S, Jasne A, Khatri P, Levine S, Majjhoo A, Panagos P, Pancioli A, Pizzella S, Ranasinghe T, Sabagha N, Sivakumar S, Streib C, Vagal A, Wilson A, Wintermark M, Yoo A, Barreto A. Adjunctive Intravenous Argatroban or Eptifibatide for Ischemic Stroke. New England Journal Of Medicine 2024, 391: 810-820. PMID: 39231343, PMCID: PMC11528349, DOI: 10.1056/nejmoa2314779.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAnticoagulantsArginineCombined Modality TherapyDrug Therapy, CombinationEptifibatideFemaleFibrinolytic AgentsHumansIncidenceInfusions, IntravenousIntracranial HemorrhagesIschemic StrokeMaleMiddle AgedPeptidesPipecolic AcidsPlatelet Aggregation InhibitorsSingle-Blind MethodSulfonamidesThrombectomyThrombolytic TherapyTreatment OutcomeConceptsSymptomatic intracranial hemorrhageIntravenous argatrobanIntravenous thrombolysisAcute ischemic strokeIntracranial hemorrhageIschemic strokeIncidence of symptomatic intracranial hemorrhageSymptom onsetIschemic stroke treated with intravenous thrombolysisAcute ischemic stroke treated with intravenous thrombolysisStroke treated with intravenous thrombolysisAssociated with increased mortalityRankin Scale scoreInitiation of thrombolysisControlled clinical trialsTreatment of acute ischemic strokePlacebo groupEptifibatide groupEfficacy outcomesArgatroban groupStandard treatmentAdjunctive treatmentPlaceboClinical trialsArgatrobanTenecteplase versus alteplase for acute ischaemic stroke in the elderly patients: a post hoc analysis of the TRACE-2 trial
Xiong Y, Wang L, Pan Y, Wang M, Schwamm L, Duan C, Campbell B, Li S, Hao M, Wu N, Cao Z, Wu S, Li Z, Wang Y. Tenecteplase versus alteplase for acute ischaemic stroke in the elderly patients: a post hoc analysis of the TRACE-2 trial. Stroke And Vascular Neurology 2024, 10: 112-119. PMID: 38858097, PMCID: PMC11877429, DOI: 10.1136/svn-2023-003048.Peer-Reviewed Original ResearchSymptomatic intracranial haemorrhageAcute ischaemic strokeModified Rankin ScaleElderly patientsPost hoc analysisAlteplase groupTenecteplase groupHoc analysisAlternative to alteplaseModified Rankin scale 0Ischaemic strokeRisk-benefit profileNon-inferiority clinical trialBenefit-risk profileEfficacy outcomesProportion of participantsReperfusion therapyIntracranial haemorrhageClinical trialsRankin ScaleSymptom onsetTenecteplaseAlteplaseIntravenous thrombolyticsSafety outcomes“Eventually…Your Body Just Can't No More”
Keirns N, Rosen R, Burg M, Gathright E, Ouaddi S, Tripolone J, Breault C, Salmoirago-Blotcher E. “Eventually…Your Body Just Can't No More”. The Journal Of Cardiovascular Nursing 2024, 40: 163-169. PMID: 39913262, DOI: 10.1097/jcn.0000000000001106.Peer-Reviewed Original ResearchConceptsPatient narrativesWeeks of hospital dischargeThematic content analysisChronic circumstancesAcute eventSemistructured interviewsHospital dischargeQualitative explorationInterview recordsContent analysisTakotsubo syndromeEmergency roomEmotional aspectsSymptom onsetParticipantsInterviewsChronic stressDevelopment of TSPatientsTS onsetOnsetMild cognitive impairment among LRRK2 and GBA1 patients with Parkinson's disease
Thaler A, Livne V, Rubinstein E, Omer N, Faust-Socher A, Cohen B, Giladi N, Shirvan J, Cedarbaum J, Gana-Weisz M, Goldstein O, Orr-Urtreger A, Alcalay R, Mirelman A. Mild cognitive impairment among LRRK2 and GBA1 patients with Parkinson's disease. Parkinsonism & Related Disorders 2024, 123: 106970. PMID: 38691978, DOI: 10.1016/j.parkreldis.2024.106970.Peer-Reviewed Original ResearchMild cognitive impairmentIdiopathic PDMovement Disorder SocietyIncidence of mild cognitive impairmentFrequency of mild cognitive impairmentDiagnosis of mild cognitive impairmentCognitive impairmentLRRK2-PDLevel I criteriaParkinson's diseaseLevel II criteriaCarriers of mutationsMotor symptom onsetHoehn and YahrGBA1-PDCognitive batteryGender-matched controlsCognitive domainsEarly-stage PDI criteriaClinical characteristicsPD cohortDisorder SocietySymptom onsetHealthy adultsThe Challenge of Examining Social Determinants of Health in People Living With Tourette Syndrome
Dy-Hollins M, Carr S, Essa A, Osiecki L, Lackland D, Voeks J, Mejia N, Sharma N, Budman C, Cath D, Grados M, King R, Lyon G, Rouleau G, Sandor P, Singer H, Chibnik L, Mathews C, Scharf J. The Challenge of Examining Social Determinants of Health in People Living With Tourette Syndrome. Pediatric Neurology 2024, 155: 55-61. PMID: 38608551, PMCID: PMC11132913, DOI: 10.1016/j.pediatrneurol.2024.02.008.Peer-Reviewed Original ResearchParental educational attainmentEthnic minority groupsEducational attainmentSocial determinants of healthExamining social determinants of healthNon-Hispanic White individualsDeterminants of healthDiagnosis ageNon-Hispanic whitesMinority groupsHispanic individualsWhite individualsSignificant disparitiesLogistic regressionParental educationNon-whiteComorbid conditionsNon-parametric testsEthnicityGroup differencesSymptom onsetOutcomesParticipantsResearch studiesTourette syndromeTemporal biomarker concentration patterns during the early course of acute coronary syndrome
Eggers K, Batra G, Lindahl B, Lakic T, Lindbäck J, Budaj A, Cornel J, Giannitsis E, Katus H, Storey R, Becker R, Siegbahn A, Wallentin L. Temporal biomarker concentration patterns during the early course of acute coronary syndrome. Clinical Chemistry And Laboratory Medicine 2024, 62: 1167-1176. PMID: 38341860, DOI: 10.1515/cclm-2023-1253.Peer-Reviewed Original ResearchAcute coronary syndromeST-elevation myocardial infarctionSymptom onsetNSTE-ACSHs-cTnTGDF-15Concentrations of high-sensitivity cardiac troponin TNon-ST-elevation acute coronary syndromeHigh-sensitivity cardiac troponin TPro-B-type natriuretic peptideBiomarker patternsAcute coronary syndrome patientsGrowth differentiation factor 15Cardiac troponin TC-reactive proteinPathophysiological processesBiomarker concentrationsClinically useful informationPlatelet inhibitionNatriuretic peptideHs-cTnICoronary syndromeTroponin TEarly courseAssociated with timeOverestimation of Severe Acute Respiratory Syndrome Coronavirus 2 Household Transmission in Settings of High Community Transmission: Insights From an Informal Settlement Community in Salvador, Brazil
Ticona J, Nery N, Hitchings M, Belitardo E, Fofana M, Dorión M, Victoriano R, Cruz J, Santana J, de Moraes L, Cardoso C, Ribeiro G, Reis M, Khouri R, Costa F, Ko A, Cummings D. Overestimation of Severe Acute Respiratory Syndrome Coronavirus 2 Household Transmission in Settings of High Community Transmission: Insights From an Informal Settlement Community in Salvador, Brazil. Open Forum Infectious Diseases 2024, 11: ofae065. PMID: 38516384, PMCID: PMC10957159, DOI: 10.1093/ofid/ofae065.Peer-Reviewed Original ResearchSARS-CoV-2Household transmissionRT-PCR positive casesSecondary attack rateAttack rateSARS-CoV-2 infectionSARS-CoV-2 Omicron variantRisk of infectionCommunity acquisitionTherapeutic optionsCOVID-19-related symptomsCase-finding studyHousehold contactsAcquisition of SARS-CoV-2Increased riskSymptom onsetSecondary infectionBooster vaccinationSevere outcomesBiweekly visitsHighest attack rateRT-PCRInfectionCOVID-19 severe outcomesOmicron BAAbstract 106: Circulating Interleukin-6 Levels Early During Active Stroke Estimate Time of Stroke Onset: Potential New Clinical Biomarker Tool From a Mobile Stroke Unit
Kowalski R, Ledreux A, Violette J, Neumann R, Grotta J, Ornelas D, Thompson J, Monte A, Dylla L, Coughlan C, Yu X, Graner M, Jones W. Abstract 106: Circulating Interleukin-6 Levels Early During Active Stroke Estimate Time of Stroke Onset: Potential New Clinical Biomarker Tool From a Mobile Stroke Unit. Stroke 2024, 55: a106-a106. DOI: 10.1161/str.55.suppl_1.106.Peer-Reviewed Original ResearchInterleukin-6 levelsMobile stroke unitInterleukin-6Symptom onsetLesion volumeAcute strokeHealthy controlsMobile stroke unit patientsDevelopment of immunomodulatory therapiesMedian interleukin-6Circulating interleukin-6 levelsMeasurement of interleukin-6Associated with lesion volumeMedian initial NIHSS scoreDWI lesion volumeCirculating interleukin-6Plasma interleukin-6Stroke patientsOnset timeIL-6 responseTime of stroke onsetImmunomodulatory therapyMedian ageThrombolysis windowNIHSS score
2023
Clinical Trial Protocol for BEACH: A Phase 2a Study of MW189 in Patients with Acute Nontraumatic Intracerebral Hemorrhage
Avadhani R, Ziai W, Thompson R, Mould W, Lane K, Nanni A, Iacobelli M, Sharrock M, Sansing L, Van Eldik L, Hanley D. Clinical Trial Protocol for BEACH: A Phase 2a Study of MW189 in Patients with Acute Nontraumatic Intracerebral Hemorrhage. Neurocritical Care 2023, 40: 807-815. PMID: 37919545, PMCID: PMC10959780, DOI: 10.1007/s12028-023-01867-2.Peer-Reviewed Original ResearchIntracerebral hemorrhageNontraumatic intracerebral hemorrhageCerebral edemaFunctional outcomeCause mortalitySymptom onsetAcute central nervous system injuryAcute spontaneous intracerebral hemorrhageEnd pointCentral nervous system injuryDays post randomizationExploratory end pointsPhase 2a studyPlacebo-controlled trialSecondary end pointsAcute brain injuryAcute intracerebral hemorrhageFuture larger trialsPhase 1 studyPerihematomal edema volumeNervous system injurySpontaneous intracerebral hemorrhageInflammatory cytokine concentrationsRate of deathClinical trial protocolABO-Incompatible Platelet Transfusion Is Associated with Ischemic Lesions on Brain MRI in Patients with Intracerebral Hemorrhage
Poyraz F, Ridha M, Simonetto M, Kumar A, Hess E, Magid-Bernstein J, Connolly E, Ghoshal S, Agarwal S, Park S, Claassen J, Hod E, Roh D. ABO-Incompatible Platelet Transfusion Is Associated with Ischemic Lesions on Brain MRI in Patients with Intracerebral Hemorrhage. Blood 2023, 142: 1288. DOI: 10.1182/blood-2023-186171.Peer-Reviewed Original ResearchABO-incompatible platelet transfusionsAcute ischemic brain lesionsIschemic brain lesionsIschemic lesionsPlatelet transfusionsICH patientsBrain MRIPlatelet unitsICH hospitalizationsICH severityBrain lesionsICH symptom onsetIncompatible platelet transfusionsProspective cohort studyAcute ischemic lesionsSpontaneous ICH patientsIntracerebral hemorrhage outcomesConsecutive spontaneous ICH patientsPatient's blood typeCerebral microthrombosisCohort studySymptom onsetRegression modelsClinical outcomesImpaired hemostasisClustering Schizophrenia Genes by Their Temporal Expression Patterns Aids Functional Interpretation
van der Meer D, Cheng W, Rokicki J, Fernandez-Cabello S, Shadrin A, Smeland O, Ehrhart F, Gülöksüz S, Pries L, Lin B, Rutten B, van Os J, O’Donovan M, Richards A, Steen N, Djurovic S, Westlye L, Andreassen O, Kaufmann T, Aguilar E, Akdede B, Alptekin K, Altınyazar V, Amoretti S, Andric-Petrovic S, Arango C, Arrojo M, Atbaşoğlu C, Bernardo M, Binbay T, Bobes J, Cankurtaran E, Carracedo A, Cihan B, Delespaul P, García-Portilla M, González-Peñas J, Guloksuz S, Gümüş-Akay G, Jiménez-López E, Ulusoy Kaymak S, Kenis G, Lin B, López G, Luykx J, Maric N, Mezquida G, Mihaljevic M, Mirjanic T, Parellada M, Pries K, Rivero O, Rutten B, Saiz P, Can Saka M, Sanjuan J, Luis Santos J, Soygür H, Üçok A, Ulaş H, van Os J, Yalınçetin B, Alizadeh B, van Amelsvoort T, Cahn W, de Haan L, Schirmbeck F, van Os J, Veling W. Clustering Schizophrenia Genes by Their Temporal Expression Patterns Aids Functional Interpretation. Schizophrenia Bulletin 2023, 50: 327-338. PMID: 37824720, PMCID: PMC10919784, DOI: 10.1093/schbul/sbad140.Peer-Reviewed Original ResearchAge-matched healthy controlsBrain maturational processesIndependent clinical cohortsOnset of symptomsPolygenic riskCortical tissue samplesGenetic risk factorsDevelopment of schizophreniaHeritable brain disorderSymptom onsetHealthy controlsRisk factorsClinical cohortEarly neurodevelopmentPolygenic risk scoresRisk scoreImmune systemSchizophrenia diagnosisBrain disordersSchizophreniaNeuronal communicationStrong associationEarly adulthoodTissue samplesMaturational processesIntensive Blood Pressure Reduction is Associated with Reduced Hematoma Growth in Fast Bleeding Intracerebral Hemorrhage
Li Q, Morotti A, Warren A, Qureshi A, Dowlatshahi D, Falcone G, Sheth K, Shoamanesh A, Murthy S, Viswanathan A, Goldstein J. Intensive Blood Pressure Reduction is Associated with Reduced Hematoma Growth in Fast Bleeding Intracerebral Hemorrhage. Annals Of Neurology 2023, 95: 129-136. PMID: 37706569, DOI: 10.1002/ana.26795.Peer-Reviewed Original ResearchBlood pressure reductionIntensive Blood Pressure ReductionIntensive BP reductionIntracerebral hemorrhageHematoma growthBP reductionPressure reductionImproved functional independenceIntensive BP loweringLarge clinical trialsSpontaneous intracerebral hemorrhageAntihypertensive treatmentHemorrhage 2BP loweringSymptom onsetHematoma volumeHematoma expansionClinical trialsHigh riskTomography timePatientsFunctional independenceEarly useHemorrhageLower ratesDevelopment of a Definition of Postacute Sequelae of SARS-CoV-2 Infection
Thaweethai T, Jolley S, Karlson E, Levitan E, Levy B, McComsey G, McCorkell L, Nadkarni G, Parthasarathy S, Singh U, Walker T, Selvaggi C, Shinnick D, Schulte C, Atchley-Challenner R, Horwitz L, Foulkes A, Aberg J, Adolphi N, Ahirwar S, Ahmed S, Ahuja N, Aikawa M, Akerlundh A, Akintonwa T, Al-Jadiri A, Alekhina N, Algren H, Alshawabkeh A, Ammar N, Anand A, Anderson B, Aponte-Soto L, Aschner J, Atha M, Atz A, Aupperle R, Ayache M, Azziz-Baumgartner E, Bailey L, Baker F, Balaraman V, Bandy J, Banerjee D, Barch D, Bardes J, Barlocker J, Barr R, Baskin-Sommers A, Basu S, Battaglia T, Baucom L, Beamon C, Beaty C, Beckmann N, Berry J, Bhadelia N, Bhargava D, Bhuiyan S, Bian J, Bime C, Bjork J, Black L, Blish C, Block J, Bogie A, Bolliger D, Bonaventura W, Bose-Brill S, Bower M, Boyd A, Boyineni J, Bradfute S, Bramante C, Brannock M, Bremner J, Brosnahan S, Buchbinder N, Bueler E, Buhimschi I, Bukulmez H, Bunnell H, Buse J, Calhoun E, Cao T, Carrithers M, Carton T, Case A, Casey B, Casimero F, Castro L, Cato T, Ceger P, Cerullo C, Chang L, Chang A, Chebrolu P, Chen Y, Chen L, Chen B, Chestek D, Chew R, Chisolm D, Chow D, Chrisant M, Christakis D, Chute C, Cicek M, Clark C, Clark D, Clarke G, Clouser K, Connors T, Cook J, Coombs K, Cordon-Cardo C, Costello J, Cottrell L, Cowan K, Cowell L, Cranford S, Cronin J, Cummins M, Curry H, D'Sa V, Dabney S, Daniel C, Dapretto M, Darbar D, Darden P, Dasgupta R, Dasgupta S, Davis Blakley F, Dea K, Deakyne Davies S, Decker L, DeFronzo R, Dehority W, Deitchman A, del Alcazar J, Del Boccio P, del Rio C, Del Rios M, DeLisa J, Deoni S, Diaz M, Dickinson J, Dionne A, Diviak K, Donohue S, Downey M, Dozor A, Dreyer B, Dummer K, Durstenfeld M, Dworkin M, Edmonds S, Elias M, Elifritz J, Ellingworth E, Elliott A, Ellison A, Enger M, Espinosa J, Esquenazi-Karonika S, Evans M, Evans D, Facelli J, Fang C, Faustino E, Fayad Lara M, Feldman C, Fiks A, Fineman R, Finn A, Fischer M, Fitzgerald M, Flaherman V, Flotte T, Forsha D, Fortune M, Foxe J, Franks N, Freedman M, Freeland C, Friedman N, Fry G, Gage Witvliet M, Gallagher E, Gallagher R, Garavan H, Gaur S, Gee D, Gennaro M, Gerald L, Ghosh S, Giacino J, Girvin A, Godfrey S, Goldberg M, Goodman S, Gordon H, Gouripeddi R, Graham P, Granger J, Gray K, Greimes T, Gross R, Guthe N, Gutter E, Haasnoot S, Hadley E, Haendel M, Hafner S, Halabi K, Hanley P, Harahsheh A, Harkins M, Hartwig K, Hasbani K, Hasek S, Hauser K, Heath A, Hebson C, Heitzeg M, Hendrickson M, Henrich T, Hernandez-Romieu A, Hester C, Higginbotham M, Hill S, Hirabayashi K, Ho O, Hobart-Porter L, Hoffman M, Holtcamp M, Hong T, Horne B, Horowitz C, Hsia D, Hsu H, Hsue P, Huentelman M, Huerta B, Huling J, Hummel K, Iacono W, Ibanez A, Ibeawuchi C, Irby K, Ismail N, Jacobus J, Jacoby V, Jason L, Javia V, Jennette K, Jernigan T, Jiang S, Jing N, Johnny J, Johnson N, Johnson B, Johnson B, Jone P, Judd S, Juskowich J, Kabagambe E, Kaelber D, Kanjilal D, Kansal M, Kasmarcak T, Kaufman D, Kawakami R, Kellogg D, Kent D, Kewlani D, Khullar D, Kim K, Kim A, Kinser P, Kleinman L, Klerman E, Kluko M, Knight S, Kobayashi M, Kopp K, Koropsak M, Kosut J, Kraig E, Krausert A, Krieger A, Krishna H, Krishnamoorthy A, Krishnan S, Lahs J, Laird A, Laleau V, Lamendola-Essel M, Landeo-Gutierrez J, Lang S, Larson C, Lash J, Lasky-Su J, Laynor G, Lee S, Lee G, Lee F, Lee M, Leese P, Lefebvre R, Levreault A, Lewis K, Li L, Lim P, Lin J, Lisdahl K, Litvack M, Liu X, Lloyd J, Logue J, Loomba J, Lorman V, Lu Y, Ludwig K, Lutz A, Mack J, Mahmoud A, Maier C, Malakooti S, Malchenko S, Mallett G, Maranga G, Martel M, Martin-Herz S, Martinez-Lage M, Maughan C, Mauntel-Medici C, May H, Mayer K, Mazzotti D, McCallum C, McCrindle B, McCulloh R, McDonald D, McInnis S, McMurry J, Mejias A, Melamed J, Menchaca M, Mendelsohn A, Miele L, Miglis M, Milne C, Milner J, Mitchell R, Mittleman M, Mohandas S, Monteiro J, Monzon V, Moreno D, Morgan L, Morozyuk D, Morse K, Moyneur E, Mudumbi P, Müller-Oehring E, Muramatsu N, Musick H, Nagavedu K, Nahin E, Nambiar A, Natelson B, Neale M, Ness-Cochinwala M, Newburger J, Newman L, Nguyen A, Nichols L, Nolan S, Noland S, Novak R, O'Connor G, O'Keefe J, Ogbogu P, Oliveira C, Oster M, Padera R, Paik H, Pajor N, Pan H, Pant D, Partridge A, Patel P, Patel S, Patel K, Paulus M, Payne R, Pearman A, Peralta-Carcelen M, Perez N, Pfaff E, Pillers D, Pitsch C, Pliskin N, Portman M, Postelnicu R, Potter J, Prabhakar B, Prahalad P, Prasad B, Predki B, Preiss A, Prendergast H, Quinn D, Quintana Y, Rabideau D, Radosta J, Radwell J, Raissy H, Ramchandran R, Randall I, Rao S, Rapkiewicz A, Rasmussen S, Razzaghi H, Rebello C, Rebolledo P, Reddy N, Reddy U, Reedy C, Rehman J, Reichard R, Reid K, Reusch J, Rhee K, Rice M, Rizzo J, Roan N, Robarts P, Roberts T, Rochez N, Rodgers K, Rogerson C, Romero M, Rosas J, Rosenzweig E, Rothman R, Rouphael N, Russell M, Rutherfoord M, Sabati A, Sader S, Salehi M, Salisbury A, Sampson B, Sanil Y, Sato A, Saydah S, Schechter M, Schenck E, Schlepphorst K, Schuchard J, Schuh T, Sculley J, Seifert A, Sekar A, Selvarangan R, Seshadri S, Sesso H, Shah D, Shakti D, Shapiro N, Sharma S, Sharma K, Sharma S, Sharma K, Shaw G, Shemesh E, Shen Y, Shenkman E, Shiau S, Siciliano M, Simsir A, Smith V, Snowden J, Solomon I, Spikes L, Squeglia L, Srivastava S, St. Jean M, Stapleford K, Stein C, Stevenson M, Stewart de Ramirez S, Stiles L, Stock A, Stockwell M, Stone J, Stratford J, Stürmer T, Subbian V, Sun J, Suthar M, Sylvera A, Systrom D, Szmuszkovicz J, Talavera-Barber M, Tantisira K, Tartt N, Terlinde T, Teufel R, Thacker D, Thakrar M, Thibodeau S, Thomas G, Thomason M, Tong J, Torres R, Traenkner J, Tragus R, Trinity J, Tronieri J, Troxel A, Truong J, Truong D, Tsevat J, Udosen M, Unterberger K, Utz P, Vaccarino V, Vallejos B, Vanden Hoek T, Vangeepuram N, Varma J, Vernon S, Vidal C, Vivensi S, Vohra A, Wagner L, Wang F, Warburton D, Warner M, Watkins R, Watson S, Webb R, Weeks R, Weiner M, Werzberger A, West S, Weyer J, Wheeler J, Wilkins K, Williams N, Williams C, Wimberly E, Winter T, Woller S, Wong R, Wood J, Wood J, Wood M, Wu Q, Xia Y, Xu J, Yang S, Yin H, Yin H, Yoo Y, Young C, Young N, Zang C, Zempsky W, Zhang B, Zhang Y, Zhang D, Zimmerman E, Andrefsky J, Marrazzo J, Dixon J, Gale L, Maholovich P, Sudhindra P, Thompson T, Sheehan E, Parada A, Knowlton K, Anderson J, McIntyre M, McCandless S, Montoya S, Davis D, Spanier E, Wodushek T, Sokol R, Maldonado Y, Jacobson K, Jia X, Scott J, Quintero O, Haddad F, Valantine H, Zamanian R, Pathak D, Boyce J, Facco F, Hankle S, Vargo J, Campbell D, Armstrong D, Mann M, Burrell N, Bartholomew A, Grobman W, Cackovic B, Klopfenstein B, Weigand S, Snow E, Fennig K, Esplin M, Lamb D, Nelsen A, Phipers J, Fischer L, Docter O, Brown J, DeMartino A, Allard D, Miller E, Bousleiman S, Loffredo M, Vanneman A, Beche I, Chan-Akeley R, Pacheco L, DeVolder J, Salazar A, Thibodeaux L, Cornwell J, Nounes A, Sweet E, Pierse A, Desantis B, Gill-Jones P, Hackney D, Chauhan S, Ortiz F, Treadway J, Rugerio J, Clark K, Leatherland M, Timlin S, Grinnan C, Ferrara J, Kominiarek M, Jones D, Reynolds T, Kearns K, Saffian E, Karasti M, Pizzi C, Filipczak A, Long E, Mitchell M, Barrett K, Mullowney C, Macones G, Alba G, Alicic R, Altman N, Anglin K, Argueta U, Ashktorab H, Baslet G, Bassett I, Bateman L, Bedi B, Bhattacharyya S, Bind M, Blomkalns A, Bonilla H, Brim H, Bush P, Castro M, Chan J, Charney A, Chen P, Chibnik L, Chu H, Clifton R, Costantine M, Cribbs S, Davila Nieves S, Deeks S, Duven A, Emery I, Erdmann N, Erlandson K, Ernst K, Farah-Abraham R, Farner C, Feuerriegel E, Fleurimont J, Fonseca V, Franko N, Gainer V, Gander J, Gardner E, Geng L, Gibson K, Go M, Goldman J, Grebe H, Greenway F, Habli M, Hafner J, Han J, Hanson K, Heath J, Hernandez C, Hess R, Hodder S, Hoffman M, Hoover S, Huang B, Hughes B, Jagannathan P, John J, Jordan M, Katz S, Kaufman E, Kelly J, Kelly S, Kemp M, Kirwan J, Klein J, Knox K, Krishnan J, Kumar A, Laiyemo A, Lambert A, Lanca M, Lee-Iannotti J, Logarbo B, Longo M, Luciano C, Lutrick K, Maley J, Mallett G, Marathe J, Marconi V, Marshall G, Martin C, Matusov Y, Mehari A, Mendez-Figueroa H, Mermelstein R, Metz T, Morse R, Mosier J, Mouchati C, Mullington J, Murphy S, Neuman R, Nikolich J, Ofotokun I, Ojemakinde E, Palatnik A, Palomares K, Parimon T, Parry S, Patterson J, Patterson T, Patzer R, Peluso M, Pemu P, Pettker C, Plunkett B, Pogreba-Brown K, Poppas A, Quigley J, Reddy U, Reece R, Reeder H, Reeves W, Reiman E, Rischard F, Rosand J, Rouse D, Ruff A, Saade G, Sandoval G, Santana J, Schlater S, Sciurba F, Shepherd F, Sherif Z, Simhan H, Singer N, Skupski D, Sowles A, Sparks J, Sukhera F, Taylor B, Teunis L, Thomas R, Thorp J, Thuluvath P, Ticotsky A, Tita A, Tuttle K, Urdaneta A, Valdivieso D, VanWagoner T, Vasey A, Verduzco-Gutierrez M, Wallace Z, Ward H, Warren D, Weiner S, Welch S, Whiteheart S, Wiley Z, Wisnivesky J, Yee L, Zisis S. Development of a Definition of Postacute Sequelae of SARS-CoV-2 Infection. JAMA 2023, 329: 1934-1946. PMID: 37278994, PMCID: PMC10214179, DOI: 10.1001/jama.2023.8823.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 infectionCohort studyPostacute sequelaeProspective observational cohort studyAcute symptom onsetObservational cohort studyProspective cohort studyAdjusted odds ratioDays of infectionSelf-reported symptomsSurvey 6 monthsNumber of infectionsBrain fogChest painChronic coughGastrointestinal symptomsSymptom onsetVaccination statusAcute infectionPostexertional malaiseClinical featuresLong COVIDNew symptomsOdds ratioAbnormal movementsClinical Features and Management of Acute and Chronic Radiation-Induced Colitis and Proctopathy
Abu-Sbeih H, Tang T, Ali F, Ma W, Shatila M, Luo W, Tan D, Tang C, Richards D, Ge P, Thomas A, Wang Y. Clinical Features and Management of Acute and Chronic Radiation-Induced Colitis and Proctopathy. Cancers 2023, 15: 3160. PMID: 37370770, PMCID: PMC10296205, DOI: 10.3390/cancers15123160.Peer-Reviewed Original ResearchArgon plasma coagulationRadiation therapyMedical managementAPC treatmentSingle tertiary cancer centerRadiation-induced colitisManagement of AcuteNon-bloody diarrheaRetrospective observational studyTertiary cancer centerCancer patients' qualityLogistic regression analysisClinical characteristicsEndoscopic therapySymptom onsetPredominant symptomClinical featuresEndoscopic characteristicsPatients' qualityCancer CenterClinical variablesBloody diarrheaCancer patientsFemale sexFrequent findingEffectiveness of COVID-19 Treatment With Nirmatrelvir–Ritonavir or Molnupiravir Among U.S. Veterans: Target Trial Emulation Studies With One-Month and Six-Month Outcomes
Bajema K, Berry K, Streja E, Rajeevan N, Li Y, Mutalik P, Yan L, Cunningham F, Hynes D, Rowneki M, Bohnert A, Boyko E, Iwashyna T, Maciejewski M, Osborne T, Viglianti E, Aslan M, Huang G, Ioannou G. Effectiveness of COVID-19 Treatment With Nirmatrelvir–Ritonavir or Molnupiravir Among U.S. Veterans: Target Trial Emulation Studies With One-Month and Six-Month Outcomes. Annals Of Internal Medicine 2023, 176: m22-3565. PMID: 37276589, PMCID: PMC10243488, DOI: 10.7326/m22-3565.Peer-Reviewed Original ResearchConceptsVeterans Health AdministrationCOVID-19 symptom onsetCOVID-19-related outcomesSevere COVID-19Six-month outcomesCOVID-19 vaccinationCOVID-19 treatmentCOVID-19SARS-CoV-2Percent of participantsUntreated control participantsCause mortalitySymptom onsetMedian ageOral antiviralsVHA careOutpatient treatmentHospitalizationHealth AdministrationDay 31U.S. veteransVariant transmissionMost veteransVeterans AffairsOne monthEffectiveness of a Quality Improvement Intervention on Reperfusion Treatment for Patients With Acute Ischemic Stroke
Wang C, Gu H, Zong L, Zhang X, Zhou Q, Jiang Y, Li H, Meng X, Yang X, Wang M, Huo X, Wangqin R, Bei Y, Qi X, Liu X, Hu S, Wang Z, Zhao X, Wang Y, Liu L, Ma X, Morgan L, Xian Y, Schwamm L, Wang Y, Li Z, Yang Q, Chen G, Ma Q, Li X, Chen J, Zhao X, Wang H, Niu X, Xu J, Zhao L, Wang Z, Huang D, Jin X, Chen S, Li J, Yu J, Liu P, Li G, Hao Y, Yang G, Huang X, Zhou C, Yang J, Gu J, Sun P, Guo Z, Ma G, Chen G, Tang M, Wang N, Chen L, Li J, Li A, Li S, Cao M, Guo J, Ren Y, Li T, Zhang L, Xie Z, Dong J, Kong X, Liang H, Zhang Y. Effectiveness of a Quality Improvement Intervention on Reperfusion Treatment for Patients With Acute Ischemic Stroke. JAMA Network Open 2023, 6: e2316465. PMID: 37266940, PMCID: PMC10238948, DOI: 10.1001/jamanetworkopen.2023.16465.Peer-Reviewed Original ResearchConceptsAcute ischemic strokeQuality improvement interventionsTargeted quality improvement interventionsReperfusion therapy ratesProportion of patientsIschemic strokeEligible patientsStepped-wedge clusterSymptom onsetReperfusion therapyEndovascular thrombectomyImprovement interventionsTherapy ratesUsual careSecondary outcomesPrimary outcomeSecondary hospitalsClinical trialsIntravenous recombinant tissue plasminogen activatorModified Rankin Scale scoreRecombinant tissue plasminogen activatorRankin Scale scoreTissue plasminogen activatorEVT rateHospital mortality
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