2024
Maresin-1 Ameliorates Sepsis-Induced Microglial Activation Through Modulation of the P38 MAPK Pathway
Dai M, Sun S, Dai Y, Dou X, Yang J, Chen X, Yang D, Lin Y. Maresin-1 Ameliorates Sepsis-Induced Microglial Activation Through Modulation of the P38 MAPK Pathway. Neurochemical Research 2024, 50: 26. PMID: 39565476, DOI: 10.1007/s11064-024-04280-z.Peer-Reviewed Original ResearchConceptsSepsis-induced neuroinflammationM1-type microgliaPro-inflammatory markersPhosphorylation of p38 MAPKP38 MAPK pathwayP38 MAPKDysregulated immune response to infectionMouse cecum ligationImmune response to infectionExpression of pro-inflammatory markersInhibited phosphorylation of p38 MAPKInduce neuronal degenerationMAPK pathwayPuncture (CLP)-induced sepsis modelPotential therapeutic roleP38 MAPK inhibitor SB203580Combination of SB203580Response to infectionMicroglial cell markersLife-threatening diseaseMAPK inhibitor SB203580Co-administrationCell markersCLP modelCecum ligation
2023
GWAS-identified bipolar disorder risk allele in the FADS1/2 gene region links mood episodes and unsaturated fatty acid metabolism in mutant mice
Yamamoto H, Lee-Okada H, Ikeda M, Nakamura T, Saito T, Takata A, Yokomizo T, Iwata N, Kato T, Kasahara T. GWAS-identified bipolar disorder risk allele in the FADS1/2 gene region links mood episodes and unsaturated fatty acid metabolism in mutant mice. Molecular Psychiatry 2023, 28: 2848-2856. PMID: 36806390, PMCID: PMC10615742, DOI: 10.1038/s41380-023-01988-2.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesFatty acid desaturaseLarge-scale genome-wide association studiesMutant miceFatty acid metabolismUnsaturated fatty acid metabolismAssociation studiesDocosahexaenoic acidGene regionHeterozygous mutant miceBipolar disorderEicosapentaenoic acidSusceptibility allelesRisk allelesShorter immobility timeBehavioral despair testAcid metabolismWild-typeAbnormal circadian rhythmTreatment of BDMood stabilizer lithiumModel of BDFADS1/2AllelesLipid composition
2022
17R/S-Benzo-RvD1, a synthetic resolvin D1 analogue, attenuates neointimal hyperplasia in a rat model of acute vascular injury
Kim AS, Werlin EC, Kagaya H, Chen M, Wu B, Mottola G, Jan M, Conte MS. 17R/S-Benzo-RvD1, a synthetic resolvin D1 analogue, attenuates neointimal hyperplasia in a rat model of acute vascular injury. PLOS ONE 2022, 17: e0264217. PMID: 35226675, PMCID: PMC8884511, DOI: 10.1371/journal.pone.0264217.Peer-Reviewed Original ResearchConceptsSpecialized lipid mediatorsNeointimal hyperplasiaVascular injuryRAW 264.7 cellsEndothelial cellsCarotid angioplastyPhagocytic activityAcute arterial injuryPro-resolving activitiesAcute vascular injuryCytokine-stimulated endothelial cellsP65 nuclear translocationAnti-migratory activityMurine RAW 264.7 cellsArterial injuryPersistent inflammationResolvin D1Ki67 expressionNeointimal areaSimilar efficacyLeukocyte recruitmentRat modelKi-67Lipid mediatorsNuclear translocation assays
2021
Effects of plant-based versus marine-based omega-3 fatty acids and sucrose on brain and liver fatty acids in a mouse model of chemotherapy
Ormiston K, Gaudier-Diaz MM, TinKai T, Fitzgerald J, Cole RM, Andridge R, Lustberg M, DeVries AC, Orchard T. Effects of plant-based versus marine-based omega-3 fatty acids and sucrose on brain and liver fatty acids in a mouse model of chemotherapy. Nutritional Neuroscience 2021, 25: 2650-2658. PMID: 34772330, PMCID: PMC9095756, DOI: 10.1080/1028415x.2021.1998296.Peer-Reviewed Original ResearchConceptsAlpha-linolenic acidDietary alpha-linolenic acidBrain PUFAsMouse modelDocosahexaenoic acidEicosapentaenoic acidLiver PUFABrain nOmega-3 fatty acidsChemotherapy-treated miceHigh ALA dietLow ALA intakeBrain fatty acidsUseful surrogate markerFatty acidsLiver docosahexaenoic acidToxic side effectsLiver fatty acidALA intakeNeurotrophic markersALA dietDHA dietSurrogate markerLower brainSide effects
2020
Exploring the molecular approach of COX and LOX in Alzheimer’s and Parkinson’s disorder
Kumar A, Behl T, Jamwal S, Kaur I, Sood A, Kumar P. Exploring the molecular approach of COX and LOX in Alzheimer’s and Parkinson’s disorder. Molecular Biology Reports 2020, 47: 9895-9912. PMID: 33263931, DOI: 10.1007/s11033-020-06033-x.Peer-Reviewed Original ResearchMeSH KeywordsAlzheimer DiseaseAnimalsArachidonic AcidBrainDocosahexaenoic AcidsHumansLipid MetabolismLipoxygenasesParkinson DiseaseProstaglandin-Endoperoxide SynthasesConceptsParkinson's diseaseDocosahexaenoic acidAlzheimer's diseaseArachidonic acidLipid mediatorsAnti-inflammatory actionAppropriate therapeutic optionPro-inflammatory eicosanoidsProduction of eicosanoidsResolution of inflammationRole of AACOX-2 enzymeLOX pathwayNeuroinflammatory responseNeuroinflammatory eventsTherapeutic optionsAD patientsCytokine secretionEpidemiological studiesLeukocyte traffickingNF-κBEicosanoid productionBrain disordersNeurological disordersCyclooxygenaseD‐series Resolvins activate Phospholipase D in phagocytes during inflammation and resolution
Ganesan R, Henkels KM, Shah K, De La Rosa X, Libreros S, Cheemarla NR, Serhan CN, Gomez‐Cambronero J. D‐series Resolvins activate Phospholipase D in phagocytes during inflammation and resolution. The FASEB Journal 2020, 34: 15888-15906. PMID: 33047359, PMCID: PMC7686130, DOI: 10.1096/fj.201903025rr.Peer-Reviewed Original ResearchConceptsD-series resolvinsPro-resolving lipid mediatorsIschemia-reperfusion injuryInflammatory response resultsReflow injuryMyeloperoxidase levelsRecruited macrophagesVascular inflammationCardiovascular diseasePhospholipase DPhagocyte functionLipid mediatorsInfectious agentsResolvin D5Therapeutic interventionsVivo modelResolvinsPLD2 expressionTissue repairInflammationInjuryNovel roleRvD5MiceMacrophages
2019
Oral Resolvin D1 attenuates early inflammation but not intimal hyperplasia in a rat carotid angioplasty model
Mottola G, Werlin EC, Wu B, Chen M, Chatterjee A, Schaller MS, Conte MS. Oral Resolvin D1 attenuates early inflammation but not intimal hyperplasia in a rat carotid angioplasty model. Prostaglandins And Other Lipid Mediators 2019, 146: 106401. PMID: 31841663, PMCID: PMC7265259, DOI: 10.1016/j.prostaglandins.2019.106401.Peer-Reviewed Original ResearchConceptsIntimal hyperplasiaResolvin D1Post-operative day 3Phagocytosis activityRat carotid angioplasty modelCAMP levelsLocal inflammatory responsePro-inflammatory genesArterial inflammationCarotid angioplastyOral gavageAcute inflammationVascular injuryThoracic aortaAngioplasty modelEarly inflammationInflammatory responseOral administrationPlasma concentrationsCarotid arteryRvD1Lipid mediatorsAnimal modelsDay 3InflammationPerinatal dietary omega-3 fatty acid deficiency reduces maternal nurturing behavior in rats: dissociation from elevated pro-inflammatory signaling
Asch R, Schurdak J, McNamara R. Perinatal dietary omega-3 fatty acid deficiency reduces maternal nurturing behavior in rats: dissociation from elevated pro-inflammatory signaling. Nutritional Neuroscience 2019, 24: 735-746. PMID: 31599208, PMCID: PMC7145725, DOI: 10.1080/1028415x.2019.1674507.Peer-Reviewed Original ResearchConceptsPro-inflammatory signalingFatty acid deficiencyLicking/groomingAcid deficiencyCON damsDietary omega-3 fatty acid deficiencyOmega-3 fatty acid deficiencyLower RBCMaternal nurturing behaviorAlpha-linolenic acidNurturing behaviorInflammatory measuresDHA levelsPassive nursingBlinded ratersPotential associationControl dietAcid levelsRatsNursingFatty acid compositionPupsDeficiencyDietSignalingSynaptic Connectivity and Cortical Maturation Are Promoted by the ω-3 Fatty Acid Docosahexaenoic Acid
Carbone BE, Abouleish M, Watters KE, Vogel S, Ribic A, Schroeder OH, Bader BM, Biederer T. Synaptic Connectivity and Cortical Maturation Are Promoted by the ω-3 Fatty Acid Docosahexaenoic Acid. Cerebral Cortex 2019, 30: 226-240. PMID: 31034037, DOI: 10.1093/cercor/bhz083.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCells, CulturedDendritesDocosahexaenoic AcidsMice, Inbred C57BLNeural PathwaysNeuronsSynapsesVisual AcuityVisual CortexConceptsVisual acuityDietary DHASynaptic connectivityFatty Acid Docosahexaenoic AcidVivo electrophysiological recordingsSize of synapsesEarly neuronal differentiationDose-dependent mannerFatty acid DHACortical maturationYoung miceAwake miceDendritic arborsCultured neuronsDHA's roleVisual cortexFunctional maturationPostsynaptic specializationsElectrophysiological recordingsCortical processingBrain developmentDocosahexaenoic acidAcid DHAPostnatal stagesNeuronal differentiationOmega-3 Fatty Acids and Genome-Wide Interaction Analyses Reveal DPP10–Pulmonary Function Association
Xu J, Gaddis N, Bartz T, Hou R, Manichaikul A, Pankratz N, Smith A, Sun F, Terzikhan N, Markunas C, Patchen B, Schu M, Beydoun M, Brusselle G, Eiriksdottir G, Zhou X, Wood A, Graff M, Harris T, Ikram M, Jacobs D, Launer L, Lemaitre R, O’Connor G, Oelsner E, Psaty B, Vasan R, Rohde R, Rich S, Rotter J, Seshadri S, Smith L, Tiemeier H, Tsai M, Uitterlinden A, Voruganti V, Xu H, Zilhão N, Fornage M, Zillikens M, London S, Barr R, Dupuis J, Gharib S, Gudnason V, Lahousse L, North K, Steffen L, Cassano P, Hancock D. Omega-3 Fatty Acids and Genome-Wide Interaction Analyses Reveal DPP10–Pulmonary Function Association. American Journal Of Respiratory And Critical Care Medicine 2019, 199: 631-642. PMID: 30199657, PMCID: PMC6396866, DOI: 10.1164/rccm.201802-0304oc.Peer-Reviewed Original ResearchMeSH KeywordsAgedalpha-Linolenic AcidBiomarkersDipeptidyl-Peptidases and Tripeptidyl-PeptidasesDocosahexaenoic AcidsEicosapentaenoic AcidFatty Acids, Omega-3Fatty Acids, UnsaturatedFemaleForced Expiratory VolumeGenome-Wide Association StudyHumansMaleMiddle AgedPolymorphism, Single NucleotideRespiratory Physiological PhenomenaSex FactorsSmokingVital CapacityConceptsSNP associationsGenome-wide interaction analysisHeart and Aging ResearchMeta-analysesCohort-specific resultsAssociated with lower FVCGenome-wide analysisGenomic Epidemiology ConsortiumAssociated with FEV<sub>1</sub> anPulmonary function testsEpidemiology ConsortiumFatty acidsEffect modificationFunctional associationN-3 PUFAPulmonary healthLower FVCGenetic susceptibilitySpirometric measurementsCohortPolyunsaturated fatty acidsAssociationMeasures of pulmonary function testsInteraction analysisFVC
2018
Low Sucrose, Omega-3 Enriched Diet Has Region-Specific Effects on Neuroinflammation and Synaptic Function Markers in a Mouse Model of Doxorubicin-Based Chemotherapy
Orchard T, Gaudier-Diaz M, Phuwamongkolwiwat-Chu P, Andridge R, Lustberg M, Bomser J, Cole R, Belury M, DeVries A. Low Sucrose, Omega-3 Enriched Diet Has Region-Specific Effects on Neuroinflammation and Synaptic Function Markers in a Mouse Model of Doxorubicin-Based Chemotherapy. Nutrients 2018, 10: 2004. PMID: 30567351, PMCID: PMC6316589, DOI: 10.3390/nu10122004.Peer-Reviewed Original ResearchConceptsDHA dietSynaptic damageSecond injectionPro-inflammatory cytokines IL-1βChemotherapy-treated miceKC/GROCytokines IL-1βLong-term brainLow-sucrose dietTwo-injection regimenQuality of lifeSpecific brain regionsBrain DHARegion-specific effectsC57BL/6 miceCancer survivorsFunction markersIL-1βIL-6Synaptic markersIL-5Mouse modelNeuroinflammationSucrose dietChemotherapyAPOE and the Association of Fatty Acids With the Risk of Stroke, Coronary Heart Disease, and Mortality
Satizabal CL, Samieri C, Davis-Plourde KL, Voetsch B, Aparicio HJ, Pase MP, Romero JR, Helmer C, Vasan RS, Kase CS, Debette S, Beiser AS, Seshadri S. APOE and the Association of Fatty Acids With the Risk of Stroke, Coronary Heart Disease, and Mortality. Stroke 2018, 49: 2822-2829. PMID: 30571417, PMCID: PMC6310220, DOI: 10.1161/strokeaha.118.022132.Peer-Reviewed Original ResearchConceptsCoronary heart diseaseAPOE ε4 carriersRisk of strokeHeart diseaseSD unit increaseCause strokeIschemic strokeCause mortality eventsPlasma fatty acidsFatty acidsAPOE ε4 genotypeRandom-effects modelFatty acid levelsUnit increaseMeta-analysis resultsMetabolism of lipidsLinoleic acidCause mortalityMean agePotential confoundersCardiovascular healthRisk factorsAPOE genotypeCardiovascular diseaseDietary fatPerivascular delivery of resolvin D1 inhibits neointimal hyperplasia in a rabbit vein graft model
Wu B, Werlin EC, Chen M, Mottola G, Chatterjee A, Lance KD, Bernards DA, Sansbury BE, Spite M, Desai TA, Conte MS. Perivascular delivery of resolvin D1 inhibits neointimal hyperplasia in a rabbit vein graft model. Journal Of Vascular Surgery 2018, 68: 188s-200s.e4. PMID: 30064835, PMCID: PMC6252159, DOI: 10.1016/j.jvs.2018.05.206.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnti-Inflammatory AgentsBlood Vessel Prosthesis ImplantationCarotid Artery, CommonCell ProliferationChemotaxis, LeukocyteDisease Models, AnimalDocosahexaenoic AcidsDrug CarriersFemaleGelsGraft Occlusion, VascularHyperplasiaJugular VeinsNeointimaPoloxamerPolylactic Acid-Polyglycolic Acid CopolymerRabbitsTime FactorsConceptsRabbit vein graft modelLocal perivascular deliveryVein graftsPerivascular deliveryVein graft modelNeointimal hyperplasiaResolvin D1Macrophage infiltrationLipid mediatorsSpecialized proresolving lipid mediatorsGraft modelTotal leukocyte infiltrationMajor wound complicationsProresolving lipid mediatorsVein bypass graftsD-series resolvinsNew Zealand white rabbitsPotential therapeutic roleIpsilateral jugular veinCell proliferationZealand white rabbitsExcessive neointimal hyperplasiaVein graft hyperplasiaPerivascular fashionRvD1 treatmentTrypanosoma cruzi Produces the Specialized Proresolving Mediators Resolvin D1, Resolvin D5, and Resolvin E2
Colas RA, Ashton AW, Mukherjee S, Dalli J, Akide-Ndunge OB, Huang H, Desruisseaux MS, Guan F, Jelicks LA, dos Santos F, Nagajyothi J, Zingman MA, Reyes J, Weiss LM, Serhan CN, Tanowitz HB. Trypanosoma cruzi Produces the Specialized Proresolving Mediators Resolvin D1, Resolvin D5, and Resolvin E2. Infection And Immunity 2018, 86: 10.1128/iai.00688-17. PMID: 29358332, PMCID: PMC5865043, DOI: 10.1128/iai.00688-17.Peer-Reviewed Original ResearchConceptsEnzyme-linked immunosorbent assayResolvin D1Chagas diseaseMediators of inflammationCD-1 miceRvD1 levelsChronic cardiomyopathyAcute myocarditisMyocardial inflammationProinflammatory eicosanoidsProresolving mediatorsChronic phasePathological featuresPlasma levelsLifelong infectionLipid mediatorsResolvin D5Host responseHuman infectionsBacterial infectionsRvD1InflammationInfectionImmunosorbent assayElevated levels
2017
Omega-3 fatty acid deficiency impairs frontostriatal recruitment following repeated amphetamine treatment in rats: A 7 Tesla in vivo phMRI study
McNamara R, Schurdak J, Asch R, Lindquist D. Omega-3 fatty acid deficiency impairs frontostriatal recruitment following repeated amphetamine treatment in rats: A 7 Tesla in vivo phMRI study. Nutritional Neuroscience 2017, 22: 587-595. PMID: 29286866, PMCID: PMC6251752, DOI: 10.1080/1028415x.2017.1419550.Peer-Reviewed Original ResearchConceptsDEF ratsFO ratsAMPH challengeAmphetamine treatmentDocosahexaenoic acidBOLD activationDHA levelsBilateral caudate putamenBrain DHA levelsErythrocyte DHA levelsNeuroplastic brain changesPharmacological magnetic resonanceBlood oxygen level-dependent (BOLD) responseAlpha-linolenic acidAttention deficit hyperactivity disorderLevel-dependent responsesGreater locomotor activityDeficit hyperactivity disorderDEF animalsBrain activation patternsPhMRI studiesAMPH injectionFatty acidsAMPH exposureBasal forebrainDeficits in Docosahexaenoic Acid Accrual during Adolescence Reduce Rat Forebrain White Matter Microstructural Integrity: An in vivo Diffusion Tensor Imaging Study
McNamara R, Schurdak J, Asch R, Peters B, Lindquist D. Deficits in Docosahexaenoic Acid Accrual during Adolescence Reduce Rat Forebrain White Matter Microstructural Integrity: An in vivo Diffusion Tensor Imaging Study. Developmental Neuroscience 2017, 40: 84-92. PMID: 29216635, DOI: 10.1159/000484554.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDiffusion Tensor ImagingDocosahexaenoic AcidsMaleNeurogenesisProsencephalonRatsRats, Long-EvansWhite MatterConceptsWhite matter integrityDEF ratsRight external capsuleTract-based spatial statisticsGreater radial diffusivityCON ratsExternal capsuleProinflammatory signalingDiffusion tensor imagingProinflammatory markersRadial diffusivityFO ratsMyelin basic protein mRNA expressionLower CRP levelsDiffusion tensor imaging studyVoxelwise tract-based spatial statisticsBrain white matter integrityWhite matter microstructural integrityCorpus callosum genuProtein mRNA expressionBrain DHAPeriadolescent developmentCRP levelsFatty acidsMale ratsGlutamate homeostasis in the adult rat prefrontal cortex is altered by cortical docosahexaenoic acid accrual during adolescence: An in vivo 1H MRS study
McNamara R, Asch R, Schurdak J, Lindquist D. Glutamate homeostasis in the adult rat prefrontal cortex is altered by cortical docosahexaenoic acid accrual during adolescence: An in vivo 1H MRS study. Psychiatry Research Neuroimaging 2017, 270: 39-45. PMID: 29049903, PMCID: PMC5671887, DOI: 10.1016/j.pscychresns.2017.10.003.Peer-Reviewed Original ResearchConceptsDEF ratsGlutamate homeostasisPrefrontal cortexFO ratsDHA levelsAdult rat prefrontal cortexVivo 1H MRS studyMarkers of excitotoxicityFatty acid-deficient dietAstrocyte glutamate transportersH-MRS scansAdult rat brainRat prefrontal cortexAdult prefrontal cortexGlutamine/glutamate ratioDietary-induced alterationsMajor psychiatric disordersBrain DHAGlutamate levelsDiet groupGLAST expressionGlutamine synthetase expressionMRS scansAdolescent ratsRat brainEffects of dietary-induced alterations in rat brain docosahexaenoic acid accrual on phospholipid metabolism and mitochondrial bioenergetics: An in vivo 31P MRS study
Lindquist D, Asch R, Schurdak J, McNamara R. Effects of dietary-induced alterations in rat brain docosahexaenoic acid accrual on phospholipid metabolism and mitochondrial bioenergetics: An in vivo 31P MRS study. Journal Of Psychiatric Research 2017, 95: 143-146. PMID: 28846858, PMCID: PMC5653412, DOI: 10.1016/j.jpsychires.2017.08.014.Peer-Reviewed Original ResearchConceptsMembrane phospholipid metabolismBrain DHA levelsDietary-induced alterationsDocosahexaenoic acidPhospholipid metabolismRat brainDHA levelsBrain docosahexaenoic acidMagnetic resonance spectroscopy studyAdult rat brainPeri-adolescent periodMitochondrial bioenergeticsDifferent psychiatric disordersAlpha-linolenic acidP MRS dataP-MRSDef dietFatty acidsSignificant group differencesMale ratsPhosphocreatine levelsAdult ratsPsychiatric disordersMRS studiesFO dietBiosynthesis of proresolving lipid mediators by vascular cells and tissues
Chatterjee A, Komshian S, Sansbury BE, Wu B, Mottola G, Chen M, Spite M, Conte MS. Biosynthesis of proresolving lipid mediators by vascular cells and tissues. The FASEB Journal 2017, 31: 3393-3402. PMID: 28442547, PMCID: PMC6207217, DOI: 10.1096/fj.201700082r.Peer-Reviewed Original ResearchMeSH KeywordsAntibodiesArachidonate 5-LipoxygenaseCells, CulturedCytokinesDocosahexaenoic AcidsEndothelial CellsGene Expression RegulationHumansInflammationLeukocytesLipid MetabolismMolecular StructureMyocytes, Smooth MuscleProtein TransportReceptors, Formyl PeptideReceptors, G-Protein-CoupledReceptors, LipoxinConceptsVascular smooth muscle cellsD-series resolvinsLipid mediatorsDocosahexaenoic acidVascular cellsEndothelial cellsRvD1 receptor ALX/FPR2Receptor ALX/FPR2Proresolving lipid mediatorsALX/FPR2Vascular injury responseHuman arteriesSmooth muscle cellsHuman saphenous vein endothelial cellsSaphenous vein endothelial cellsIntact human arteriesVein endothelial cellsResolvin D1Vascular healthNovel homeostatic mechanismCellular sourceInjury responseMonocyte adhesionMuscle cellsLiquid chromatography-tandem mass spectrometryIncreasing dietary EPA and DHA influence estimated fatty acid desaturase activity in systemic organs which is reflected in the red blood cell in mice
Davidson EA, Pickens CA, Fenton JI. Increasing dietary EPA and DHA influence estimated fatty acid desaturase activity in systemic organs which is reflected in the red blood cell in mice. International Journal Of Food Sciences And Nutrition 2017, 69: 183-191. PMID: 28697636, DOI: 10.1080/09637486.2017.1348494.Peer-Reviewed Original ResearchConceptsDietary eicosapentaenoic acidEnzyme activity estimatesRed blood cellsDocosahexaenoic acidEicosapentaenoic acidDesaturase activityBlood cellsPhospholipid FA compositionDelta-6 desaturaseDHA influencesFatty acid metabolismTissue FA compositionFatty acid desaturase activitySystemic organsAdipose tissuePercent of energyFA compositionDelta 5Acid metabolismMuscleTissueMiceDifferential influenceCellsLung
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