2025
Virtual Patient-PCP-Hospitalist Care Transition Meeting Before Hospital Discharge
Li J, Reuter M, Schmidt J, Moore N, Forget N, Carron J, Ernest J, Williams M. Virtual Patient-PCP-Hospitalist Care Transition Meeting Before Hospital Discharge. JAMA Network Open 2025, 8: e2515848. PMID: 40512492, PMCID: PMC12166488, DOI: 10.1001/jamanetworkopen.2025.15848.Peer-Reviewed Original ResearchConceptsPrimary care practitionersAcceptability of Intervention MeasureIntervention appropriateness measureQuality improvement studyImprovement studyPerceptions of care coordinationCenters for Medicare & Medicaid ServicesHospital dischargeHealth care systemIncrease patient confidenceOpen-ended questionsFamily caregiversCare coordinationRelational EmpathyDischarge planningPatient feedbackCare practitionersCare questionsCare systemPatients' perceptionsMedicaid ServicesPatient confidenceHospital settingHospitalistsMain OutcomesOtoacoustic Emissions Testing to Identify Hearing Loss in the ICU: A Feasibility Study
Kaushik R, Reed N, Ferrante L. Otoacoustic Emissions Testing to Identify Hearing Loss in the ICU: A Feasibility Study. Critical Care Explorations 2025, 7: e1223. PMID: 40028925, PMCID: PMC11878990, DOI: 10.1097/cce.0000000000001223.Peer-Reviewed Original ResearchConceptsOtoacoustic emission testingOtoacoustic emissionsHearing lossHearing impairmentIdentification of hearing lossAbsence of otoacoustic emissionsTreatment of hearing lossPost-ICU recoveryPrimary outcome of feasibilityOlder ICU survivorsOutcomes of feasibilitySevere hearing impairmentMedical ICUAssociated with deliriumICU survivorsTertiary medical centerImprove communicationResponse to auditory stimulationTest completionAverage timePrimary outcomeMedical CenterIllness severityComplete dataAuditory stimulationChronotherapeutic intervention targeting emotion regulation brain circuitry, symptoms, and suicide risk in adolescents and young adults with bipolar disorder: a pilot randomised trial
Kim J, Sankar A, Marks R, Carrubba E, Lecza B, Quatrano S, Spencer L, Constable R, Pittman B, Lebowitz E, Silverman W, Swartz H, Blumberg H. Chronotherapeutic intervention targeting emotion regulation brain circuitry, symptoms, and suicide risk in adolescents and young adults with bipolar disorder: a pilot randomised trial. BMJ Mental Health 2025, 28: e301338. PMID: 39971594, PMCID: PMC11840897, DOI: 10.1136/bmjment-2024-301338.Peer-Reviewed Original ResearchConceptsBipolar disorderEmotion regulationSuicide riskBrain circuitryChronotherapeutic interventionsEmotional face stimuliLeft amygdala responseRisk of bipolar disorderTargeting emotion regulationReduce suicide riskHigher suicide riskYoung adultsFunctional MRI dataPost-treatment improvementAmygdala responsePotential intervention targetsEmotion dysregulationMania symptomsMood episodesFace stimuliCircuitry dysfunctionRegulation therapyDaily rhythmsWeekly sessionsSelf-monitoringImplementation of Brief Submaximal Cardiopulmonary Testing in a High-Volume Presurgical Evaluation Clinic: Feasibility Cohort Study
Carr Z, Agarkov D, Li J, Charchaflieh J, Brenes-Bastos A, Freund J, Zafar J, Schonberger R, Heerdt P. Implementation of Brief Submaximal Cardiopulmonary Testing in a High-Volume Presurgical Evaluation Clinic: Feasibility Cohort Study. JMIR Perioperative Medicine 2025, 8: e65805. PMID: 39773953, PMCID: PMC11888076, DOI: 10.2196/65805.Peer-Reviewed Original ResearchMeSH KeywordsAgedCohort StudiesExercise TestFeasibility StudiesFemaleHumansMaleMiddle AgedPreoperative CareRisk AssessmentConceptsDuke Activity Status IndexPeak oxygen uptakePeak METsEvaluation clinicParticipant satisfactionOxygen uptakeSubmaximal cardiopulmonary exercise testingFunctional capacity assessmentLow functional capacityCardiopulmonary exercise testingPerceived exertionMET assessmentStructured surveyCapacity surveyMedian patient satisfactionProvider-drivenExercise testMean session timePearson correlation coefficientSurvey scoresCardiopulmonary testFunctional capacityPatient satisfactionCohort studyInclusion criteriaSafety and feasibility of concomitant scalp cooling and limb cryocompression to prevent paclitaxel-induced alopecia and neuropathy
Bandla A, Wong R, Santhanakrishnan P, Magarajah G, Yee Y, Ng W, Ow S, Chan G, Choo J, Lim S, Wong A, Vijayan J, Paxman R, Lee Y, Hui F, Hairom Z, Ang E, Loprinzi C, Thakor N, Lee S, Kumarakulasinghe N, Lim J, Sundar R. Safety and feasibility of concomitant scalp cooling and limb cryocompression to prevent paclitaxel-induced alopecia and neuropathy. Supportive Care In Cancer 2025, 33: 180. PMID: 39937296, PMCID: PMC11821790, DOI: 10.1007/s00520-024-08982-6.Peer-Reviewed Original ResearchConceptsChemotherapy-induced alopeciaChemotherapy-induced peripheral neuropathyScalp coolingHealthy volunteersCancer patientsPrevention of chemotherapy-induced alopeciaCIPN preventionPrevent chemotherapy-induced peripheral neuropathyEORTC QualityWeekly paclitaxel chemotherapyQoL scoresStandard-of-careBody temperature changesCryocompressionCore body temperature changesWeekly paclitaxelCTCAE v4.0Paclitaxel chemotherapyPhysician gradingLimbPatient toleranceAdverse eventsPeripheral neuropathyChemotherapyCryotherapyInfant sleep state coded from respiration and its relationship to the developing functional connectome: A feasibility study
Mueller I, Rodriguez R, Pini N, Holland C, Ababio R, Inala S, Delapenha K, Mahmoodi V, Khaitova M, Hao X, Fifer W, Scheinost D, Spann M. Infant sleep state coded from respiration and its relationship to the developing functional connectome: A feasibility study. Developmental Cognitive Neuroscience 2025, 72: 101525. PMID: 39965287, PMCID: PMC11876745, DOI: 10.1016/j.dcn.2025.101525.Peer-Reviewed Original ResearchMeSH KeywordsBrainConnectomeFeasibility StudiesFemaleHumansInfantMagnetic Resonance ImagingMaleRespirationSleepSex Differences in Response to a 12-Week Resistance Training Exercise Intervention After Cardiac Surgery: A Proof-of-Concept Intervention Trial
Safdar B, Jarman A, Madsen T, DeLamielleure L, Zhou B, Axtell R, Geirsson A, Mangi A. Sex Differences in Response to a 12-Week Resistance Training Exercise Intervention After Cardiac Surgery: A Proof-of-Concept Intervention Trial. Clinical Therapeutics 2025, 47: 299-306. PMID: 39904658, DOI: 10.1016/j.clinthera.2025.01.002.Peer-Reviewed Original ResearchConceptsResistance training programExercise interventionResistance training exercise interventionResistance-based exercise programsTraining programFunctional capacityMeasurement of hand grip strengthTraditional cardiac rehabilitationResistance-based exerciseHand grip strengthTrends of improvementAcute cardiac eventsExercise programCardiac rehabilitationAerobic exerciseCardiac surgeryIntervention armCardiopulmonary rehabilitationFeasibility trialGrip strengthExercise parametersIntervention trialsControl armSecondary outcomesMeasured pre-
2024
Improving School Mental Health via National Learning Collaboratives With State and Local Teams: Components, Feasibility, and Initial Impacts
Bohnenkamp J, Robinson P, Connors E, Carter T, Orenstein S, Reaves S, Hoover S, Lever N. Improving School Mental Health via National Learning Collaboratives With State and Local Teams: Components, Feasibility, and Initial Impacts. Evaluation & The Health Professions 2024, 47: 402-419. PMID: 39604109, DOI: 10.1177/01632787241288850.Peer-Reviewed Original ResearchConceptsSchool mental healthLearning collaborativeMental healthEffective quality improvement strategiesSchool mental health promotionSchool mental health systemsEvidence-informed best practicesYouth mental health crisisHealth quality improvementMental health promotionLearning collaborative modelNational learning collaborativeQuality improvement strategiesMental health supportMental health systemHealth System ChangeUniversity of Maryland School of MedicineMental health crisisAdolescent mental healthHealth promotionHealth supportHealth systemSchool of MedicineTreatment servicesQuality improvementIntensive, Real-Time Data Collection of Psychological and Physiological Stress During a 96-Hour Field Training Exercise at a Senior Military College: Feasibility and Acceptability Cohort Study
Pojednic R, Welch A, Thornton M, Garvey M, Grogan T, Roberts W, Ash G. Intensive, Real-Time Data Collection of Psychological and Physiological Stress During a 96-Hour Field Training Exercise at a Senior Military College: Feasibility and Acceptability Cohort Study. JMIR Formative Research 2024, 8: e60925. PMID: 39422988, PMCID: PMC11530722, DOI: 10.2196/60925.Peer-Reviewed Original ResearchConceptsField training exercisePhysical fitnessArmy Reserve Officers' Training Corps cadetsDiagnosis of mental health disordersTraining exercisesPsychological resiliencePoor physical fitnessReserve Officer Training Corps cadetsSelf-reported injuriesMental health disordersField-based trainingData collectionDaily wear timeMilitary field training exercisePhysical readinessTesting adherenceParticipant acceptabilityWear timeHealth disordersMilitary readinessAcceptability surveyOccupational stressorsCohort studyProspective pilot studyEconomic burdenDevelopment and feasibility of the peer and nurse-led HIV Self-Testing Education and Promotion (STEP) intervention among social networks of men in Dar es Salaam, Tanzania: application of the ADAPT-ITT model
Conserve D, Abu-Ba’are G, Janson S, Mhando F, Munisi G, Drezgic B, Rehani A, Sims W, Ritchwood T, Choko A, Mushy S, Johnson C, Jennings Mayo-Wilson L, Komba A, Urasa P, Nelson L, Mbita G. Development and feasibility of the peer and nurse-led HIV Self-Testing Education and Promotion (STEP) intervention among social networks of men in Dar es Salaam, Tanzania: application of the ADAPT-ITT model. BMC Health Services Research 2024, 24: 1166. PMID: 39358728, PMCID: PMC11445879, DOI: 10.1186/s12913-024-11586-9.Peer-Reviewed Original ResearchMeSH KeywordsAdultFeasibility StudiesHealth PromotionHIV InfectionsHumansMaleMiddle AgedPeer GroupPilot ProjectsSelf-TestingSocial NetworkingTanzaniaYoung AdultConceptsHIV self-testingFollow-up servicesADAPT-ITT modelHealthcare facilitiesADAPT-ITTPeer educatorsPromote HIV self-testingHIV self-test kitsDistribution of HIVST kitsTanzania HIV Impact SurveyIncrease HIV testingImplementation science projectSocial networks of menFollow-up surveyNational testing strategySelf-test resultsHIV testingHIVST kitsSelf-testingCommunity settingsMethodsThe developmentHIV statusDar es SalaamImpact SurveyNetworks of menCombining electronic health records data from a clinical research network with registry data to examine long-term outcomes of interventions and devices: an observational cohort study
Mao J, Matheny M, Smolderen K, Mena-Hurtado C, Sedrakyan A, Goodney P. Combining electronic health records data from a clinical research network with registry data to examine long-term outcomes of interventions and devices: an observational cohort study. BMJ Open 2024, 14: e085806. PMID: 39327057, PMCID: PMC11429269, DOI: 10.1136/bmjopen-2024-085806.Peer-Reviewed Original ResearchConceptsElectronic health recordsElectronic health record dataClinical Research NetworkAmputation-free survivalPeripheral vascular interventionsResearch NetworkINSIGHT Clinical Research NetworkNew York CityHealth record dataIncreased riskLong-term outcomes of interventionsSecondary outcome measuresOutcomes of interventionsIncreased risk of deathYork CityRisk of deathObservational cohort studyHealth recordsRegistry dataClinical registryVascular Quality Initiative registryCohort studyOutcome assessmentRecord dataLong-term outcomesA Qualitative Study on the Impact and Feasibility of a Simulation-Based Program for Shared Decision-Making in Non–Small Cell Lung Cancer Care
Hakim H, Alexander C, Rudell E, Ingram M, Agrawal T, Peterson P, Davies M, Adelson K, Oliver B. A Qualitative Study on the Impact and Feasibility of a Simulation-Based Program for Shared Decision-Making in Non–Small Cell Lung Cancer Care. The Permanente Journal 2024, 28: 212-222. PMID: 39269215, PMCID: PMC11404665, DOI: 10.7812/tpp/23.152.Peer-Reviewed Original ResearchConceptsShared decision-makingOncology cliniciansSDM principlesPerceptions of shared decision-makingImprove health care outcomesPatient-centred care modelComprehensive cancer care centerLeadership buy-inPatient-centered careHealth care outcomesLung cancer careParticipants perceived benefitsHealth care environmentTeam member rolesNon-small cell lung cancer careThematic analysis of interview dataCancer care centerSimulation-based programAnalysis of interview dataCare modelCare outcomesCancer carePatient-centeredPatient experienceCare environmentFeasibility of using real-world data to emulate substance use disorder clinical trials: a cross-sectional study
Janda G, Jeffery M, Ramachandran R, Ross J, Wallach J. Feasibility of using real-world data to emulate substance use disorder clinical trials: a cross-sectional study. BMC Medical Research Methodology 2024, 24: 187. PMID: 39198727, PMCID: PMC11351457, DOI: 10.1186/s12874-024-02307-1.Peer-Reviewed Original ResearchMeSH KeywordsClinical Trials as TopicCross-Sectional StudiesElectronic Health RecordsFeasibility StudiesHumansSubstance-Related DisordersConceptsElectronic health record dataElectronic health recordsSubstance use disordersCross-sectional studyAdministrative claimsEligibility criteriaTrials evaluating treatmentPublic health systemClinical trialsIntroductionReal-world evidenceSafety of medical productsHealth recordsHealth systemReal-world dataTrial emulationPrimary end pointInsurance claimsPhase 2Placebo comparatorActive comparatorInterventionEligibilityEnd pointsTrialsExtended-Release 7-Day Injectable Buprenorphine for Patients With Minimal to Mild Opioid Withdrawal
D’Onofrio G, Herring A, Perrone J, Hawk K, Samuels E, Cowan E, Anderson E, McCormack R, Huntley K, Owens P, Martel S, Schactman M, Lofwall M, Walsh S, Dziura J, Fiellin D. Extended-Release 7-Day Injectable Buprenorphine for Patients With Minimal to Mild Opioid Withdrawal. JAMA Network Open 2024, 7: e2420702. PMID: 38976265, PMCID: PMC11231806, DOI: 10.1001/jamanetworkopen.2024.20702.Peer-Reviewed Original ResearchConceptsClinical Opiate Withdrawal ScaleExtended-release buprenorphineOpioid use disorderPrecipitated withdrawalOpioid withdrawalOpioid use disorder treatmentCow scoreClinical Opiate Withdrawal Scale scoreAdverse eventsNonrandomized trialsSevere opioid use disorderDays of opioid useOpiate Withdrawal ScaleModerate to severe opioid use disorderFormulation of buprenorphineOpioid use disorder careWithdrawal ScaleUse disorderAssociated with medicationsNonprescribed opioidsPain scoresExtended-releaseInjection painOpioid useAdult patientsMulticenter early United States feasibility study and periprocedural safety of LVIS EVO for the treatment of unruptured intracranial aneurysms
Kayan Y, Almandoz J, Copelan A, Matouk C, Chaudry M, Altschul D, Essibayi M, Goren O, Yim B, Tsappidi S, Zhang Y, Hui F, Samaniego E, Gudino A, Siddiqui A, Jaikumar V, Puri A, Kühn A, Singh J, Ringer A, Hanel R, De Toledo O, Dabus G, Gooch M, Sizdahkhani S, Field N, Paul A. Multicenter early United States feasibility study and periprocedural safety of LVIS EVO for the treatment of unruptured intracranial aneurysms. Journal Of NeuroInterventional Surgery 2024, 17: jnis-2024-021900. PMID: 38906689, DOI: 10.1136/jnis-2024-021900.Peer-Reviewed Original ResearchConceptsLow-profile visualized intraluminal supportIntracranial aneurysmsHemorrhagic complicationsTreatment of unruptured intracranial aneurysmsComplete neck coverageAverage aneurysm sizeInstitutional review board approvalClass I occlusionReview board approvalAnterior communicating arteryTreatment of intracranial aneurysmsMiddle cerebral artery bifurcationUnruptured intracranial aneurysmsSelf-expanding stentsCerebral artery bifurcationLength of stayParent vessel sizePatient agePeriprocedural complicationsPeriprocedural safetyAneurysm locationAneurysm sizeAntiplatelet therapyBoard approvalIntraluminal supportSmartband-based smoking detection and real-time brief mindfulness intervention: findings from a feasibility clinical trial
Horvath M, Pittman B, O’Malley S, Grutman A, Khan N, Gueorguieva R, Brewer J, Garrison K. Smartband-based smoking detection and real-time brief mindfulness intervention: findings from a feasibility clinical trial. Annals Of Medicine 2024, 56: 2352803. PMID: 38823419, PMCID: PMC11146247, DOI: 10.1080/07853890.2024.2352803.Peer-Reviewed Original ResearchMeSH KeywordsAdultFeasibility StudiesFemaleHumansMaleMiddle AgedMindfulnessPatient ComplianceSmokingSmoking CessationText MessagingConceptsBrief mindfulness interventionsMindfulness exercisesTreatment startersMindfulness interventionSmoking interventionsOnline mindfulness trainingWhite non-HispanicMindfulness trainingTreatment fidelityFeasibility measuresHelpfulness ratingsNon-HispanicDaily smokersPredicting smokingReduce smokingExerciseSmokingCigarette smokingInterventionLow completenessAdherenceParticipantsSmartbandAcceptanceMindfulness“WOOP is my safe haven”: A qualitative feasibility and acceptability study of the Wish Outcome Obstacle Plan (WOOP) intervention for spouses of people living with early‐stage dementia
Mroz E, Schwartz A, Valeika S, Oettingen G, Marottoli R, David D, Hagaman A, Fedus D, Monin J. “WOOP is my safe haven”: A qualitative feasibility and acceptability study of the Wish Outcome Obstacle Plan (WOOP) intervention for spouses of people living with early‐stage dementia. International Journal Of Geriatric Psychiatry 2024, 39: e6092. PMID: 38687142, PMCID: PMC11448666, DOI: 10.1002/gps.6092.Peer-Reviewed Original ResearchConceptsSpouses of peopleLongitudinal semi-structured interviewsEarly-stage dementiaCodebook thematic analysisSemi-structured interviewsCare partnersIntervention deliveryBaseline strengthThematic analysisMeta-themesQualitative studyBehavioral interventionsAreas of improvementDementiaQualitative feasibilityMental exerciseInterventionSpousesWell-beingEmotional stressorsIntervention mechanismsParticipantsAcceptability studyWishesPeopleTesting the Feasibility and Acceptability of Using an Artificial Intelligence Chatbot to Promote HIV Testing and Pre-Exposure Prophylaxis in Malaysia: Mixed Methods Study.
Cheah M, Gan Y, Altice F, Wickersham J, Shrestha R, Salleh N, Ng K, Azwa I, Balakrishnan V, Kamarulzaman A, Ni Z. Testing the Feasibility and Acceptability of Using an Artificial Intelligence Chatbot to Promote HIV Testing and Pre-Exposure Prophylaxis in Malaysia: Mixed Methods Study. JMIR Human Factors 2024, 11: e52055. PMID: 38277206, PMCID: PMC10858413, DOI: 10.2196/52055.Peer-Reviewed Original ResearchConceptsUptake of HIV testingHIV testingPre-exposure prophylaxisUnified Theory of AcceptanceFrequency of HIV testingTheory of AcceptanceAI chatbotsPromote HIV testingMental health supportHIV risk assessmentHIV prevention effortsHIV-related informationMixed methods studyPresence of stigmaUse of TechnologyConsequences of HIVEffort expectancySexually transmitted infectionsWeb-based surveyEngaging MSMArtificial intelligenceTranscribed verbatimPrEP uptakeHealth supportMental healthFeasibility and metabolic outcomes of a well-formulated ketogenic diet as an adjuvant therapeutic intervention for women with stage IV metastatic breast cancer: The Keto-CARE trial
Buga A, Harper D, Sapper T, Hyde P, Fell B, Dickerson R, Stoner J, Kackley M, Crabtree C, Decker D, Robinson B, Krystal G, Binzel K, Lustberg M, Volek J. Feasibility and metabolic outcomes of a well-formulated ketogenic diet as an adjuvant therapeutic intervention for women with stage IV metastatic breast cancer: The Keto-CARE trial. PLOS ONE 2024, 19: e0296523. PMID: 38166036, PMCID: PMC10760925, DOI: 10.1371/journal.pone.0296523.Peer-Reviewed Original ResearchMeSH Keywords3-Hydroxybutyric AcidBreast NeoplasmsDiet, KetogenicFeasibility StudiesFemaleHumansInsulin ResistanceInsulinsKetosisConceptsMetastatic breast cancerStage IV metastatic breast cancerKetogenic dietInsulin resistanceNutritional ketosisPlasma insulinBreast cancerBody compositionAdjuvant therapeutic interventionsMetabolic outcomesCancer patientsPlasma glucoseMetabolic effectsBody fatShort-term studiesBody weightPleiotropic mechanismsTherapeutic interventionsConsistent bloodPhase IMonthsWomenCancerAd libitumChemotherapy
2023
A feasibility study of the combination of intranasal insulin with oral semaglutide for cognition in older adults with metabolic syndrome at high dementia risk- Study rationale and design
Davidy T, Yore I, Cukierman-Yaffe T, Ravona-Springer R, Livny A, Lesman-Segev O, Azuri Y, Carmichael O, Kapogiannis D, Zetterberg H, Lin H, Sano M, Beeri M. A feasibility study of the combination of intranasal insulin with oral semaglutide for cognition in older adults with metabolic syndrome at high dementia risk- Study rationale and design. Mechanisms Of Ageing And Development 2023, 218: 111898. PMID: 38159613, DOI: 10.1016/j.mad.2023.111898.Peer-Reviewed Original ResearchConceptsMild cognitive impairmentIntranasal insulinCognitive benefitsCerebrovascular diseaseMetabolic syndromeIntent-to-treat sampleEfficacy of combination therapyPlacebo-controlled feasibility trialGLP-1 receptor agonistsOlder adultsCerebral glucose utilizationAdults aged >Cerebral blood flowNeurobiological markersOral semaglutideCombination therapyReceptor agonistsGlobal cognitionImprove cognitionSafety profileOlder adults aged >White matter hyperintensitiesSemaglutideCognitive impairmentGLP-1
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