2025
Brain Signatures of Very Early Cognitive Decline in Asymptomatic Middle‐Aged Offspring of People With Alzheimer's Disease
Ramsingh N, Lin H, Ouyang Y, Ravona‐Springer R, Livny A, Soleimani L, Bendlin B, Matatov A, Niv T, Shamir T, Ganmore I, Heymann A, Sano M, Azuri J, Beeri M. Brain Signatures of Very Early Cognitive Decline in Asymptomatic Middle‐Aged Offspring of People With Alzheimer's Disease. International Journal Of Geriatric Psychiatry 2025, 40: e70060. PMID: 40050014, DOI: 10.1002/gps.70060.Peer-Reviewed Original ResearchConceptsSuperior longitudinal fasciculusCortical volumeCortical brain volumesWhite matterAlzheimer's Prevention studyEarly cognitive declineBrain signaturesBrain regionsCognitive changesWM microstructureMiddle-aged adultsBrain volumeLongitudinal fasciculusCognitive declinePreclinical cognitive changesOffspring of peopleBrain tractsPatient's offspringTarget individualsEarly interventionCorpus callosumParental historyBrainAlzheimer's diseaseLinear regression modelsDeterminants of 5-year survival in patients with advanced NSCLC with PD-L1≥50% treated with first-line pembrolizumab outside of clinical trials: results from the Pembro-real 5Y global registry
Cortellini A, Brunetti L, Di Fazio G, Garbo E, Pinato D, Naidoo J, Katz A, Loza M, Neal J, Genova C, Gettinger S, Kim S, Jayakrishnan R, Zarif T, Russano M, Pecci F, Di Federico A, Awad M, Alessi J, Montrone M, Owen D, Signorelli D, Fidler M, Li M, Camerini A, De Giglio A, Young L, Vincenzi B, Metro G, Passiglia F, Yendamuri S, Guida A, Ghidini M, Awosika N, Napolitano A, Fulgenzi C, Grisanti S, Grossi F, D’Incecco A, Josephides E, Van Hemelrijck M, Russo A, Gelibter A, Spinelli G, Verrico M, Tomasik B, Giusti R, Newsom-Davis T, Bria E, Sebastian M, Rost M, Forster M, Mukherjee U, Landi L, Mazzoni F, Aujayeb A, Dupont M, Curioni-Fontecedro A, Chiari R, Pantano F, Morabito A, Leonetti A, Friedlaender A, Addeo A, Zoratto F, De Tursi M, Cantini L, Roca E, Mountzios G, Della Gravara L, Kalvapudi S, Inno A, Bironzo P, Di Marco Barros R, O’Reilly D, Bell J, Karapanagiotou E, Monnet I, Baena J, Macerelli M, Majem M, Agustoni F, Cortinovis D, Tonini G, Minuti G, Bennati C, Mezquita L, Gorría T, Servetto A, Beninato T, Russo G, Rogado J, Moliner L, Biello F, Nana F, Dingemans A, Aerts J, Ferrara R, Torri V, Abu Hejleh T, Takada K, Naqash A, Garassino M, Peters S, Wakelee H, Nassar A, Ricciuti B. Determinants of 5-year survival in patients with advanced NSCLC with PD-L1≥50% treated with first-line pembrolizumab outside of clinical trials: results from the Pembro-real 5Y global registry. Journal For ImmunoTherapy Of Cancer 2025, 13: e010674. PMID: 39904562, PMCID: PMC11795382, DOI: 10.1136/jitc-2024-010674.Peer-Reviewed Original ResearchConceptsNon-small cell lung cancerAdvanced non-small cell lung cancerProgrammed cell death ligand 1Eastern Cooperative Oncology Group performance statusData cut-offLong-term efficacyIndividual patient-level dataMedian OSPembrolizumab monotherapySurvival rateProgressive diseaseDiscontinued treatment due to progressive diseaseTreated with first-line pembrolizumabClinical trialsPredictors of 5-year survivalFirst-line pembrolizumab monotherapyCell death ligand 1Pre-existing autoimmune diseaseFirst-line pembrolizumabKEYNOTE-024 trialPD-L1 TPSPermanently discontinue treatmentDeath-ligand 1Efficacy of pembrolizumabMedian follow-upSex-Specific Clinical and Genetic Factors Associated With Adverse Outcomes in Hypertrophic Cardiomyopathy
Butters A, Arnott C, Sweeting J, Claggett B, Cuomo A, Abrams D, Ashley E, Day S, Helms A, Lampert R, Lin K, Michels M, Miller E, Olivotto I, Owens A, Parikh V, Pereira A, Rossano J, Ryan T, Saberi S, Stendahl J, Ware J, Atherton J, Semsarian C, Lakdawala N, Ho C, Ingles J. Sex-Specific Clinical and Genetic Factors Associated With Adverse Outcomes in Hypertrophic Cardiomyopathy. Circulation Genomic And Precision Medicine 2025, 18: e004641. PMID: 39851041, DOI: 10.1161/circgen.124.004641.Peer-Reviewed Original ResearchConceptsRisk of heart failureSex-specific hazard ratiosHazard ratioHypertrophic cardiomyopathyAdverse outcomesHeart failureSex interaction termsFactors associated with adverse outcomesRisk of atrial fibrillationVentricular arrhythmiasCox proportional hazards modelsSarcomeric Human Cardiomyopathy RegistryManagement of hypertrophic cardiomyopathyProportional hazards modelInvestigate sex-related differencesSex differencesHeart failure riskRisk scoreHigher heart failureModerate riskHazards modelRisk factorsCardiomyopathy RegistryDeath riskImprove outcomesPredicting Mortality in Patients Hospitalized With Acute Myocardial Infarction: From the National Cardiovascular Data Registry
Faridi K, Wang Y, Minges K, Smilowitz N, McNamara R, Kontos M, Wang T, Connors A, Clary J, Osborne A, Pereira L, Curtis J, Blankinship K, Mayfield J, Abbott J. Predicting Mortality in Patients Hospitalized With Acute Myocardial Infarction: From the National Cardiovascular Data Registry. Circulation Cardiovascular Quality And Outcomes 2025, 18: e011259. PMID: 39801472, PMCID: PMC11919567, DOI: 10.1161/circoutcomes.124.011259.Peer-Reviewed Original ResearchConceptsNational Cardiovascular Data Registry Chest Pain-MI RegistryIn-hospital mortalityAcute myocardial infarctionChest Pain-MI RegistryOut-of-hospital cardiac arrestRisk scoreRisk-standardized modelsNational Cardiovascular Data RegistryAcute MI hospitalizationsPatient characteristicsMyocardial infarctionContemporary risk modelsIn-hospital mortality rateMI hospitalizationST-segment elevation MIIndependent predictor of mortalityMortality risk predictionSystolic blood pressureMortality riskPredictors of mortalityHospital volumePatient prognosticationData RegistryRisk modelSimplified risk scoreAge‐associated differences in FIRES: Characterizing prodromal presentation and long‐term outcomes via the web‐based NORSE/FIRES Family Registry
Kazazian K, Gaspard N, Hirsch L, Kellogg M, Hocker S, Wong N, Farias‐Moeller R, Eschbach K, Gofton T. Age‐associated differences in FIRES: Characterizing prodromal presentation and long‐term outcomes via the web‐based NORSE/FIRES Family Registry. Epilepsia 2025, 66: e35-e40. PMID: 39804054, PMCID: PMC11908657, DOI: 10.1111/epi.18260.Peer-Reviewed Original ResearchConceptsFamily RegistryFebrile infection-related epilepsy syndromeAnti-seizure medicationsSelf-reported qualityQuality of lifePediatric patientsLong-term outcomesWeb-based registryProdromal symptomsAnxiety outcomesPoor cognitionAnti-seizure medication useClinical presentationSeizure burdenAdult survivorsProdromal presentationInternational web-based registryBad moodRegistryAge groupsRefractory status epilepticusAdultsCognitive outcomesOutcomesAge-associated differencesDefining Thresholds for Meaningful Health Status Changes Following Transfemoral Carotid Artery Stenting
Kluger J, Romain G, Mena‐Hurtado C, Grubman S, Pajarillo C, Cleman J, Scierka L, Smolderen K. Defining Thresholds for Meaningful Health Status Changes Following Transfemoral Carotid Artery Stenting. Catheterization And Cardiovascular Interventions 2025, 105: 927-937. PMID: 39789704, DOI: 10.1002/ccd.31410.Peer-Reviewed Original ResearchConceptsMinimal clinically important differenceHealth status changesHealth statusSF-36Visual analog scaleEQ-5DDistribution-based MCIDPhysical component scoreCarotid artery stentingDisease-specific instrumentHealth status improvementTransfemoral carotid artery stentingSymptom statusClinically important differenceTF-CASStatus changesGeneric instrumentsArtery stentingRegistry dataComponent scoresImportant differencePatients no changeStatus improvementAsymptomatic carotid stenosisHealthComparison of Outcomes Between Low-Risk Aortic Valve Replacement Trials and a Surgical Registry
Mori M, Shioda K, Waldron C, Huang C, Gaudino M, George I, Takayama H, Geirsson A. Comparison of Outcomes Between Low-Risk Aortic Valve Replacement Trials and a Surgical Registry. JAMA Network Open 2025, 8: e2453267. PMID: 39761046, PMCID: PMC11704974, DOI: 10.1001/jamanetworkopen.2024.53267.Peer-Reviewed Original ResearchConceptsSurgical aortic valve replacementLow-risk trialsSTS ACSDLow riskSociety of Thoracic Surgeons Adult Cardiac Surgery DatabaseSAVR armPARTNER 3Evolut Low Risk TrialAdult Cardiac Surgery DatabaseCompare 30-day mortalityConcomitant cardiac operationsCardiac Surgery DatabaseLow surgical riskMortality rateAortic valve replacementSevere aortic stenosisStroke rateIncidence of patientsTrial exclusion criteriaRisk of mortalitySAVR cohortCross-sectional studyComparison of outcomesIncidence of strokeNontrial setting
2024
Quality of Cancer Recurrence Data in the National Cancer Database: A Reappraisal of Reporting Readiness
Chan K, Palis B, Cotler J, Janczewski L, Zhu X, Boffa D, Park K, Boughey J, Plichta J, In H, Nogueira L, Yabroff R, Hawhee V, Merriman K, Habermann E, Williams V, Mason K, Mullett T, Weigel R, Nelson H. Quality of Cancer Recurrence Data in the National Cancer Database: A Reappraisal of Reporting Readiness. Annals Of Surgical Oncology 2024, 32: 1553-1564. PMID: 39739153, DOI: 10.1245/s10434-024-16801-9.Peer-Reviewed Original ResearchConceptsCancer registry staffData missingnessNational Cancer DatabaseSouthern geographic regionsMulti-method studyPhysician documentationStaff surveyData quality concernsRegistry staffNon-metastatic cancerClinical documentationOutcomes researchData abstractionInadequate documentationCancer DatabasePrimary cancerOverall low rateCancer recurrenceBackgroundThis studyNational Cancer Database analysisMissingnessRecurrence dataSurveyDocumentation of recurrenceGeographic regionsLipid-Lowering Therapy Use When Indicated and Subsequent Ischemic Stroke Severity.
Gordon-Kundu B, Peyravi R, Garg A, Baker A, Salas S, Levien M, Faridi K, de Havenon A, Krumholz H, Sheth K, Forman R, Sharma R. Lipid-Lowering Therapy Use When Indicated and Subsequent Ischemic Stroke Severity. Journal Of The American Heart Association 2024, 14: e033365. PMID: 39699007, DOI: 10.1161/jaha.123.033365.Peer-Reviewed Original ResearchConceptsPrescribed lipid-lowering therapyNational Institutes of Health Stroke Scale scoreAcute ischemic strokeLipid-lowering therapyStroke Scale scoreStroke severityGuidelines-Stroke registryAtherosclerotic cardiovascular disease eventsCardiovascular disease eventsScale scoreGuideline-recommended criteriaSevere stroke symptomsStudy assessed usePropensity score subclassificationLipid-lowering therapy useNational InstituteLogistic regression modelsCholesterol management guidelinesPoststroke disabilityElevated low-density lipoprotein cholesterolInstitutional GetSmall vessel diseaseTime of acute ischemic strokeLarge-artery atherosclerosisLow-density lipoprotein cholesterolReal-world evidence on the benefits of optimal itch relief and skin clearance in atopic dermatitis management: a study from the TARGET-DERM AD registry
Silverberg J, Calimlim B, Grada A, Bunick C, Gooderham M, Shi V, Obi C, Knapp K, Munoz B, Crawford J, Paller A. Real-world evidence on the benefits of optimal itch relief and skin clearance in atopic dermatitis management: a study from the TARGET-DERM AD registry. Journal Of Dermatological Treatment 2024, 35: 2428729. PMID: 39662888, DOI: 10.1080/09546634.2024.2428729.Peer-Reviewed Original ResearchMulticenter Analysis of the Relationship Between Operative Team Familiarity and Safety and Efficiency Outcomes in Cardiac Surgery
Bauer T, Janda A, Wu X, Ling C, Shook D, Querejeta-Roca G, Shann K, Smith T, Mathis M, Kaneko T, Sundt T, Schonberger R, Harrington S, Dias R, Pagani F, Likosky D, Yule S, Caldwell M, Corso J, Louis N, Krein S, Manojlovich M, Stakich-Alpirez K, Sturmer D, Yalamuri S, Lawton J, Abernathy J, Cleveland J, Clendenen N, Justison G, Fried M, Nemeh H, Fitzsimons M, Dickinson T, Stulak J, de la Cruz K. Multicenter Analysis of the Relationship Between Operative Team Familiarity and Safety and Efficiency Outcomes in Cardiac Surgery. Circulation Cardiovascular Quality And Outcomes 2024, 17: e011065. PMID: 39689169, PMCID: PMC11654451, DOI: 10.1161/circoutcomes.124.011065.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnesthesiologistsCardiac Surgical ProceduresCardiopulmonary BypassClinical CompetenceCooperative BehaviorFemaleHealth Knowledge, Attitudes, PracticeHumansInterdisciplinary CommunicationMaleMiddle AgedOperative TimeOutcome and Process Assessment, Health CarePatient Care TeamPatient SafetyPostoperative ComplicationsQuality Indicators, Health CareRegistriesRetrospective StudiesRisk AssessmentRisk FactorsSurgeonsTime FactorsTreatment OutcomeUnited StatesConceptsSociety of Thoracic SurgeonsCardiopulmonary bypass durationTeam familiarityBypass durationElectronic health record dataHealth record dataEffective team dynamicsSociety of Thoracic Surgeons morbidityCardiac Surgery RegistryComposite major morbidityCardiac surgical proceduresMortality measuresLinear regression modelsCrude analysisQuaternary hospitalRecord dataRisk adjustmentPrimary outcomePatient outcomesProcedural efficiencyMajor morbidityCardiac surgeryCardiac operationsMulticenter analysisPatient ageOutcomes of Adjunct Emergent Stenting Versus Mechanical Thrombectomy Alone: The RESCUE-ICAS Registry
Al Kasab S, Almallouhi E, Jumaa M, Inoa V, Capasso F, Nahhas M, Starke R, Fragata I, Bender M, Moldovan K, Yaghi S, Maier I, Grossberg J, Jabbour P, Psychogios M, Samaniego E, Burkhardt J, Jankowitz B, Abdalkader M, Hassan A, Altschul D, Mascitelli J, Regenhardt R, Wolfe S, Ezzeldin M, Limaye K, Grandhi R, Al Jehani H, Niazi M, Goyal N, Tjoumakaris S, Alawieh A, Abdelsalam A, Guada L, Ntoulias N, El-Ghawanmeh R, Batra V, Choi A, Zohdy Y, Nguyen S, Essibayi M, Naamani K, Koo A, Almekhlafi M, Raz E, Miller S, Mierzwa A, Zaidi S, Gudino A, Alsarah A, Azeem H, Mattingly T, Schartz D, Nelson A, Pinheiro C, Spiotta A, Kicielinski K, Lena J, Lajthia O, Hubbard Z, Zaidat O, Derdeyn C, Klein P, Nguyen T, de Havenon A. Outcomes of Adjunct Emergent Stenting Versus Mechanical Thrombectomy Alone: The RESCUE-ICAS Registry. Stroke 2024, 56: 390-400. PMID: 39576761, DOI: 10.1161/strokeaha.124.049038.Peer-Reviewed Original ResearchConceptsPatients treated with mechanical thrombectomyStent groupMechanical thrombectomySymptomatic hemorrhageEmergency stentingConsecutive patients treated with mechanical thrombectomyIntracranial stenosisRate of symptomatic hemorrhageRisk of symptomatic hemorrhageModified Rankin Scale scoreAssociated with better functional outcomesInverse probability of treatment weightingProbability of treatment weightingRankin Scale scoreInternational cohort studyLarge vessel occlusionAcute ischemic strokeThrombectomy-capable centersComplication rateResidual stenosisCohort studyIncreased riskInfarct volumePrimary outcomeFunctional outcomesInternational multi-institutional external validation of preoperative risk scores for 30-day in-hospital mortality in paediatric patients
Tangel V, Hoeks S, Stolker R, Brown S, Pryor K, de Graaff J, Committee M, Pace N, Domino K, Muehlschlegel J, Kheterpal S, Vaughan M, Mathis M, Jiang S, Obembe S, Freundlich R, Schonberger R, Kim D. International multi-institutional external validation of preoperative risk scores for 30-day in-hospital mortality in paediatric patients. British Journal Of Anaesthesia 2024, 133: 1222-1233. PMID: 39477712, DOI: 10.1016/j.bja.2024.09.003.Peer-Reviewed Original ResearchConceptsSurgical risk scoresPediatric risk assessmentArea under the receiver operating characteristic curveIn-hospital mortalityRisk scoreMulticenter Perioperative Outcomes GroupPreoperative risk scoreDecision curve analysisReceiver operating characteristic curvePhysical status scoreExternal validationAssess model discriminationRisk prediction scoreASA physical status scoreClinical decision-makingPaediatric patientsLow probability of mortalityDutch hospitalsOutcome groupPatient-specific risk scoresPrimary outcomeClustering of casesCurve analysisStatus scoreCharacteristic curveTwenty Years of Sustained Improvement in Quality of Care and Outcomes for Patients Hospitalized With Stroke or Transient Ischemic Attack: Data From The Get With The Guidelines-Stroke Program
Xian Y, Li S, Jiang T, Beon C, Poudel R, Thomas K, Reeves M, Smith E, Saver J, Sheth K, Messé S, Schwamm L, Fonarow G. Twenty Years of Sustained Improvement in Quality of Care and Outcomes for Patients Hospitalized With Stroke or Transient Ischemic Attack: Data From The Get With The Guidelines-Stroke Program. Stroke 2024, 55: 2599-2610. PMID: 39429153, PMCID: PMC11518659, DOI: 10.1161/strokeaha.124.048174.Peer-Reviewed Original ResearchConceptsGuidelines-Stroke programEvidence-based stroke careDoor-to-needle timeTransient ischemic attackGuidelines-Stroke hospitalsEvidence-based careQuality of careSmoking cessation counselingSustained improvementQuality improvement initiativesSkilled nursing facilityIndependence of patientsAcute ischemic strokeIschemic strokeRelevant to patientsIschemic attackDoor-to-puncture timeCessation counselingGuidelines-StrokeAssociated with sustained improvementStroke careDysphagia screeningNursing facilitiesHospital characteristicsImprovement initiativesOutcomes of Patients With Early and Locally Advanced Lung Cancer: Protocol for the Italian Lung Cancer Observational Study (LUCENT)
Bertolaccini L, Ciani O, Lucchi M, Zaraca F, Bertani A, Crisci R, Spaggiari L, Group L. Outcomes of Patients With Early and Locally Advanced Lung Cancer: Protocol for the Italian Lung Cancer Observational Study (LUCENT). JMIR Research Protocols 2024, 13: e57183. PMID: 39378423, PMCID: PMC11496920, DOI: 10.2196/57183.Peer-Reviewed Original ResearchConceptsLocally advanced lung cancerNon-small cell lung cancerOutcomes of patientsAdvanced lung cancerLung cancerWeb-based registryINTERNATIONAL REGISTERED REPORT IDENTIFIERObservational studySecondary objectivesSuboptimal response ratesEvolving treatment paradigmCell lung cancerLung cancer managementTraditional open surgeryInfluence treatment strategiesStudy's secondary objectivePatient-reported outcomesNational benchmarksOpen surgeryProcess of care indicatorsRisk-adjusted outcomesTreatment paradigmNSCLC treatmentCancer managementFollow-upCombining electronic health records data from a clinical research network with registry data to examine long-term outcomes of interventions and devices: an observational cohort study
Mao J, Matheny M, Smolderen K, Mena-Hurtado C, Sedrakyan A, Goodney P. Combining electronic health records data from a clinical research network with registry data to examine long-term outcomes of interventions and devices: an observational cohort study. BMJ Open 2024, 14: e085806. PMID: 39327057, PMCID: PMC11429269, DOI: 10.1136/bmjopen-2024-085806.Peer-Reviewed Original ResearchConceptsElectronic health recordsElectronic health record dataClinical Research NetworkAmputation-free survivalPeripheral vascular interventionsResearch NetworkINSIGHT Clinical Research NetworkNew York CityHealth record dataIncreased riskLong-term outcomes of interventionsSecondary outcome measuresOutcomes of interventionsIncreased risk of deathYork CityRisk of deathObservational cohort studyHealth recordsRegistry dataClinical registryVascular Quality Initiative registryCohort studyOutcome assessmentRecord dataLong-term outcomesOpen Burn Pit Exposure in Headache Disorder and Migraine
Sico J, Anthony S, Phadke M, Wang K, Skanderson M, Ney J, Seng E, Shapiro R, Sandbrink F, Scholten J, Graham G, Martini S, Fenton B. Open Burn Pit Exposure in Headache Disorder and Migraine. JAMA Network Open 2024, 7: e2431522. PMID: 39230902, PMCID: PMC11375476, DOI: 10.1001/jamanetworkopen.2024.31522.Peer-Reviewed Original ResearchConceptsBurn pit exposureVeterans Health Administration electronic health recordPit exposureHeadache disordersAdministration electronic health recordAnalytic sampleVeterans Health Administration facilitiesBurn pitsCohort studyVeterans Health AdministrationElectronic health recordsDose-dependent associationUS DepartmentHealth recordsRegistry participantsMilitary exposuresRetrospective cohort studyHealth AdministrationMain OutcomesHealth conditionsAdministration facilitiesRegistry questionnaireHighest quartilesIncident outcomesVeteransTrends in Invasive Melanoma Thickness in Norway, 1983-2019.
Rimal R, Robsahm T, Green A, Ghiasvand R, Rueegg C, Bassarova A, Gjersvik P, Weiderpass E, Aalen O, Møller B, Perrier F, Veierød M. Trends in Invasive Melanoma Thickness in Norway, 1983-2019. Acta Dermato Venereologica 2024, 104: adv26110. PMID: 39221835, DOI: 10.2340/actadv.v104.26110.Peer-Reviewed Original ResearchConceptsLong-term incidence trendsCancer Registry of NorwayIncidence time trendsTumor thicknessCancer RegistryIncidence trendsBirth cohortTime trendsPrevention strategiesMelanoma occurrenceAge groupsMelanoma RegistryT categoryMelanoma thicknessT1 melanomasPathology reportsYounger patientsAnatomical sitesIncreased incidenceMelanomaSex differencesTumorIncidencePatientsMenAnticoagulation Alone vs Anticoagulation Plus Aspirin or DAPT Following Left Atrial Appendage Occlusion
Reinhardt S, Gibson D, Hsu J, Kapadia S, Yeh R, Price M, Piccini J, Nair D, Christen T, Allocco D, Freeman J. Anticoagulation Alone vs Anticoagulation Plus Aspirin or DAPT Following Left Atrial Appendage Occlusion. Journal Of The American College Of Cardiology 2024, 84: 889-900. PMID: 39197978, DOI: 10.1016/j.jacc.2024.05.067.Peer-Reviewed Original ResearchConceptsLeft atrial appendage occlusionRate of adverse eventsAdverse eventsLAA closure deviceAppendage occlusionAntithrombotic strategiesP2Y<sub>12</sub> inhibitorsDays of follow-upMultivariable Cox proportional hazards regressionClosure deviceRisk of adverse eventsCox proportional hazards regressionWatchman FLX deviceDual antiplatelet therapyDevice-related thrombusProportional hazards regressionStroke/transient ischemic attackAntithrombotic regimensFLX deviceAntiplatelet therapyDOACsGroup patientsFollow-upMultivariate analysisHazards regressionHereditary antithrombin deficiency pilot project registry from the American Thrombosis and Hemostasis Network
DeSancho M, Suvar E, Roberts J, Tarantino M, Schwartz J, Callis J, Recht M. Hereditary antithrombin deficiency pilot project registry from the American Thrombosis and Hemostasis Network. Journal Of Thrombosis And Haemostasis 2024, 22: 3183-3190. PMID: 39151704, DOI: 10.1016/j.jtha.2024.07.026.Peer-Reviewed Original ResearchConceptsHereditary antithrombin deficiencyLow-molecular-weight heparinVenous thromboembolismOral anticoagulantsAT concentrateAdverse eventsIncreased risk of venous thromboembolismRisk factorsRisk of venous thromboembolismDirect oral anticoagulantsAmerican ThrombosisSeventy-nine patientsDeep vein thrombosisHemostasis NetworkRecurrent thrombosisConcentrate administrationPulmonary embolismAntithrombin deficiencyThrombotic eventsVein thrombosisProspective studyPredominant manifestationArterial thrombosisGlobal RegistryIncreased risk
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