2025
Transcatheter vs Surgical Aortic Valve Replacement in Lower-Risk Patients An Updated Meta-Analysis of Randomized Controlled Trials
Reddy R, Howard J, Mack M, Reardon M, Jørgensen T, Hørsted Thyregod H, Toff W, Van Mieghem N, Vora A, Makkar R, Kapadia S, Forrest J, Leon M, Ahmad Y. Transcatheter vs Surgical Aortic Valve Replacement in Lower-Risk Patients An Updated Meta-Analysis of Randomized Controlled Trials. Journal Of The American College Of Cardiology 2025, 85: 926-940. PMID: 40044297, DOI: 10.1016/j.jacc.2024.12.031.Peer-Reviewed Original ResearchMeSH KeywordsAortic ValveAortic Valve StenosisHeart Valve Prosthesis ImplantationHumansRandomized Controlled Trials as TopicRisk FactorsTranscatheter Aortic Valve ReplacementConceptsSurgical aortic valve replacementTranscatheter aortic valve replacementLower-risk patientsAortic valve replacementPooled survival analysisValve replacementIndividual participant dataPairwise meta-analysesFollow-upMeta-analysis of randomized controlled trialsLonger-term clinical outcomesReduced hazard of deathSevere aortic stenosisFixed effect assumptionsComposite of deathLonger-term follow-upAll-cause deathMean survival time modelsMeta-analysesHazard of deathRate of strokeRandomized controlled trialsSurvival time modelFrailty termProportional odds modelComparison of Outcomes Between Low-Risk Aortic Valve Replacement Trials and a Surgical Registry
Mori M, Shioda K, Waldron C, Huang C, Gaudino M, George I, Takayama H, Geirsson A. Comparison of Outcomes Between Low-Risk Aortic Valve Replacement Trials and a Surgical Registry. JAMA Network Open 2025, 8: e2453267. PMID: 39761046, PMCID: PMC11704974, DOI: 10.1001/jamanetworkopen.2024.53267.Peer-Reviewed Original ResearchConceptsSurgical aortic valve replacementLow-risk trialsSTS ACSDLow riskSociety of Thoracic Surgeons Adult Cardiac Surgery DatabaseSAVR armPARTNER 3Evolut Low Risk TrialAdult Cardiac Surgery DatabaseCompare 30-day mortalityConcomitant cardiac operationsCardiac Surgery DatabaseLow surgical riskMortality rateAortic valve replacementSevere aortic stenosisStroke rateIncidence of patientsTrial exclusion criteriaRisk of mortalitySAVR cohortCross-sectional studyComparison of outcomesIncidence of strokeNontrial setting
2024
Reinterventions After CoreValve/Evolut Transcatheter or Surgical Aortic Valve Replacement for Treatment of Severe Aortic Stenosis
Grubb K, Lisko J, O'Hair D, Merhi W, Forrest J, Mahoney P, Van Mieghem N, Windecker S, Yakubov S, Williams M, Chetcuti S, Deeb G, Kleiman N, Althouse A, Reardon M. Reinterventions After CoreValve/Evolut Transcatheter or Surgical Aortic Valve Replacement for Treatment of Severe Aortic Stenosis. JACC Cardiovascular Interventions 2024, 17: 1007-1016. PMID: 38573257, DOI: 10.1016/j.jcin.2024.01.292.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAortic ValveAortic Valve StenosisFemaleHeart Valve ProsthesisHeart Valve Prosthesis ImplantationHumansIncidenceMalePostoperative ComplicationsProsthesis DesignRandomized Controlled Trials as TopicRetreatmentRisk AssessmentRisk FactorsSeverity of Illness IndexTime FactorsTranscatheter Aortic Valve ReplacementTreatment OutcomeConceptsSurgical aortic valve replacementTranscatheter aortic valve replacementIncidence of reinterventionAortic valve replacementCumulative incidence of reinterventionValve replacementValve reinterventionCumulative incidenceCoreValve transcatheter aortic valve replacementLow incidence of reinterventionSurgical aortic valve replacement patientsSingle-arm studyFirst-generation CoreValveEvolut R/ProParavalvular regurgitationReinterventionRandomized trialsLow incidenceCoreValvePooled dataTranscatheterIncidenceTreatmentYearsEndocarditisLiving in disadvantaged neighborhoods linked to less intervention for severe aortic stenosis
Ram C, Yousef S, Ma W, Vallabhajosyula I, Singh S, Agarwal R, Milewski R, Assi R, Patel P, Williams M, Geirsson A, Vallabhajosyula P. Living in disadvantaged neighborhoods linked to less intervention for severe aortic stenosis. Scientific Reports 2024, 14: 4952. PMID: 38418864, PMCID: PMC10902341, DOI: 10.1038/s41598-024-52660-w.Peer-Reviewed Original ResearchMeSH KeywordsAortic ValveAortic Valve StenosisEchocardiographyFemaleHeart Valve ProsthesisHeart Valve Prosthesis ImplantationHumansRetrospective StudiesRisk FactorsSeverity of Illness IndexTreatment OutcomeConceptsAortic valve replacementSevere aortic stenosisAfrican American raceArea Deprivation IndexAortic stenosisSevere ASArea deprivation index rankAortic valve replacement ratesAmerican raceAortic valve interventionPresentation of sepsisDiagnosis of ASADI groupValve replacementValve interventionDeprived neighbourhoodsAV interventionDisadvantaged neighborhoodsPatientsFemale genderDeprivation indexHigh-ADI groupLow-ADI groupStenosisRaceImpact of concomitant surgical interventions on outcomes of septal myectomy in obstructive hypertrophic cardiomyopathy
Altibi A, Sapru A, Ghanem F, Zhao Y, Alani A, Cigarroa J, Nazer B, Song H, Masri A. Impact of concomitant surgical interventions on outcomes of septal myectomy in obstructive hypertrophic cardiomyopathy. International Journal Of Cardiology 2024, 400: 131790. PMID: 38242508, DOI: 10.1016/j.ijcard.2024.131790.Peer-Reviewed Original ResearchMeSH KeywordsAgedCardiomyopathy, HypertrophicCoronary Artery BypassHeart Valve Prosthesis ImplantationHospital MortalityHumansTreatment OutcomeUnited StatesConceptsObstructive hypertrophic cardiomyopathyMitral valve replacementCoronary artery bypass graftingConcomitant surgical interventionIn-hospital mortalitySeptal myectomyAdverse in-hospital eventsIn-hospital eventsSurgical interventionMV repairValve replacementHypertrophic cardiomyopathyOutcomes of septal myectomyAssociated with increased in-hospital mortalityOutcomes of patientsAortic valve replacementIn-hospital adverse eventsAdverse clinical eventsIsolated SMArtery bypass graftingIn-hospital deathNational Readmission DatabaseSymptomatic patientsMedical therapyAdverse events
2023
Clinical and Hemodynamic Outcomes of Balloon-Expandable Mitral Valve-in-Valve Positioning and Asymmetric Deployment The VIVID Registry
Simonato M, Whisenant B, Unbehaun A, Kempfert J, Ribeiro H, Kornowski R, Erlebach M, Bleiziffer S, Windecker S, Pilgrim T, Tomii D, Guerrero M, Ahmad Y, Forrest J, Montorfano M, Ancona M, Adam M, Wienemann H, Finkelstein A, Villablanca P, Codner P, Hildick-Smith D, Ferrari E, Petronio A, Shamekhi J, Presbitero P, Bruschi G, Rudolph T, Cerillo A, Attias D, Nejjari M, Abizaid A, Felippi de Sá Marchi M, Horlick E, Wijeysundera H, Andreas M, Thukkani A, Agrifoglio M, Iadanza A, Baer L, Nanna M, Dvir D. Clinical and Hemodynamic Outcomes of Balloon-Expandable Mitral Valve-in-Valve Positioning and Asymmetric Deployment The VIVID Registry. JACC Cardiovascular Interventions 2023, 16: 2615-2627. PMID: 37968032, DOI: 10.1016/j.jcin.2023.08.047.Peer-Reviewed Original ResearchConceptsLeft ventricular outflow tractLeft ventricular outflow tract obstructionAssociated with residual stenosisResidual stenosisDepth of implantationValve stenosisValve Academic Research Consortium definitionsAssociated with LVOT obstructionAcademic Research Consortium definitionsMitral valve-in-valveVentricular outflow tractMitral valve stenosisValve-in-valveCore lab evaluationLVOT obstructionOutflow tractHemodynamic outcomesSuboptimal hemodynamicsClinical endpointsSAPIEN 3Atrial implantsBalloon-expandableStenosisObstructionImplantationChronological comparison of TAVI and SAVR stratified to surgical risk: a systematic review, meta-analysis, and meta-regression
Park D, An S, Kassab K, Jolly N, Attanasio S, Sawaqed R, Malhotra S, Doukky R, Vij A. Chronological comparison of TAVI and SAVR stratified to surgical risk: a systematic review, meta-analysis, and meta-regression. Acta Cardiologica 2023, 78: 778-789. PMID: 37294002, DOI: 10.1080/00015385.2023.2218025.Peer-Reviewed Original ResearchMeSH KeywordsAortic ValveAortic Valve InsufficiencyAortic Valve StenosisHeart Valve Prosthesis ImplantationHumansRisk FactorsTranscatheter Aortic Valve ReplacementTreatment OutcomeConceptsSurgical aortic valve replacementTranscatheter aortic valve implantationAll-cause mortalitySevere aortic regurgitationSevere paravalvular regurgitationSurgical riskAortic regurgitationPacemaker placementParavalvular regurgitationFollow-upAlternative to surgical aortic valve replacementAssociated with higher all-cause mortalityLong-term follow-upNewer-generation valvesRisk of all-cause mortalityPeriod of follow-upHigh surgical riskIntermediate surgical riskLow surgical riskMeta-regressionAortic valve replacementSevere aortic stenosisMeta-analysisLong-term outcomesScore-matched study1-Year Outcomes in a Pooled Cohort of Harmony Transcatheter Pulmonary Valve Clinical Trial Participants
Gillespie M, McElhinney D, Jones T, Levi D, Asnes J, Gray R, Cabalka A, Fujimoto K, Qureshi A, Justino H, Bergersen L, Benson L, Haugan D, Boe B, Cheatham J. 1-Year Outcomes in a Pooled Cohort of Harmony Transcatheter Pulmonary Valve Clinical Trial Participants. JACC Cardiovascular Interventions 2023, 16: 1917-1928. PMID: 37278682, DOI: 10.1016/j.jcin.2023.03.002.Peer-Reviewed Original ResearchMeSH KeywordsCardiac CatheterizationHeart Valve ProsthesisHeart Valve Prosthesis ImplantationHumansProspective StudiesPulmonary ValvePulmonary Valve InsufficiencyTreatment OutcomeVentricular Outflow ObstructionConceptsTranscatheter pulmonary valveRight ventricular outflow tractSevere pulmonary regurgitationPulmonary regurgitationPrimary analysisCardiac magnetic resonance imagingContinued Access StudyMild pulmonary regurgitationOne-year safetyMedian patient agePulmonary valve replacementLong-term valve performanceVentricular outflow tractFirst U.S. FoodClinical trial participantsMagnetic resonance imagingEligible patientsMost patientsPatient ageValve replacementHemodynamic outcomesPooled cohortPulmonary valveVentricular tachycardiaClinical indicationsImpact of aortic valve replacement in symptomatic low-risk patients with less than severe aortic stenosis
Ito S, Laham R, Nkomo V, Forrest J, Reardon M, Little S, Mumtaz M, Gada H, Bajwa T, Langholz D, Heiser J, Chawla A, Jenson B, Attizanni G, Markowitz A, Huang J, Oh J. Impact of aortic valve replacement in symptomatic low-risk patients with less than severe aortic stenosis. Open Heart 2023, 10: e002297. PMID: 37173100, PMCID: PMC10186477, DOI: 10.1136/openhrt-2023-002297.Peer-Reviewed Original ResearchMeSH KeywordsAortic ValveAortic Valve StenosisHeart Valve Prosthesis ImplantationHumansQuality of LifeTreatment OutcomeConceptsSevere aortic stenosisAortic valve replacementAortic stenosisSymptomatic patientsValve replacementKansas City Cardiomyopathy Questionnaire overall summary scoreEvolut Low Risk trialSurgical aortic valve replacementLow-risk trialsLow-risk patientsOverall summary scoreRate of deathQuality of lifeDisabling strokeEchocardiographic evidenceIsolated AVRHaemodynamic profileClinical outcomesHaemodynamic outcomesRisk trialsClinical trialsCalcium volumeSummary scoresPatientsCore laboratory measurementsReclassification of moderate aortic stenosis based on data-driven phenotyping of hemodynamic progression
Cho I, Kim W, Kim S, Ko K, Seong Y, Kim D, Seo J, Shim C, Ha J, Mori M, Gupta A, You S, Hong G, Krumholz H. Reclassification of moderate aortic stenosis based on data-driven phenotyping of hemodynamic progression. Scientific Reports 2023, 13: 6694. PMID: 37095171, PMCID: PMC10125992, DOI: 10.1038/s41598-023-33683-1.Peer-Reviewed Original ResearchMeSH KeywordsAortic ValveAortic Valve StenosisEchocardiographyHeart Valve ProsthesisHeart Valve Prosthesis ImplantationHemodynamicsHumansRetrospective StudiesSeverity of Illness IndexTreatment OutcomeConceptsRapid progression groupModerate aortic stenosisAortic valve replacementSlow progression groupAortic stenosisProgression groupHemodynamic progressionRapid progressionMore rapid progressionLatent class trajectory modelingTransthoracic echocardiography studyBetween-group differencesData-driven phenotypingPressure gradient measurementAVR ratesModerate ASCause mortalityValve replacementEchocardiography studyAtrial fibrillationTTE studiesEchocardiographic dataRisk factorsPredictive valuePatientsAortic root allograft reoperations
Witten J, Umana-Pizano J, Houghtaling P, Insler J, Erten O, Nowicki E, Svensson L, Blackstone E, Unai S, Pettersson G. Aortic root allograft reoperations. Journal Of Thoracic And Cardiovascular Surgery 2023, 168: 440-452.e14. PMID: 37074251, DOI: 10.1016/j.jtcvs.2023.02.009.Peer-Reviewed Original ResearchConceptsStructural valve deteriorationAllograft reoperationInfective endocarditisValve deteriorationAllograft preservationAortic valve infective endocarditisRisk of reoperationReoperation techniquesOperative mortalityAllograft explantsSurgical approachExcellent outcomesAdverse eventsPerioperative eventsReoperationEndocarditisAllograftRisk factorsLower mortalityInvestigate outcomesMortalityOperative adverse eventsMorbidityPatientsOutcomesCor-Knot Use in SAVR Facilitates Coplanar Angle Adjustment During TAVR.
Hibino M, Palma Dallan L, Yoon S, Pelletier M, Ukaigwe A, Baeza C. Cor-Knot Use in SAVR Facilitates Coplanar Angle Adjustment During TAVR. Journal Of Invasive Cardiology 2023, 35: e108-e109. PMID: 36735874, DOI: 10.25270/jic/22.00156.Peer-Reviewed Original ResearchMeSH KeywordsAortic ValveAortic Valve StenosisFemaleHeart Valve ProsthesisHeart Valve Prosthesis ImplantationHumansRisk FactorsTranscatheter Aortic Valve ReplacementTreatment OutcomeConceptsCOR-KNOTMinimally invasive cardiac surgeryPreoperative computed tomography scansInvasive cardiac surgeryAortic pressure gradientTrifecta valveCardiac surgeryAortic annulusConduction abnormalitiesParavalvular leakageRenal injuryTomography scanMm HgTAVR proceduresSurgical anatomyOperative timeTAVR valvesTAVRNext dayControl pacingTranscatheter versus surgical aortic valve replacement in lower-risk and higher-risk patients: a meta-analysis of randomized trials
Ahmad Y, Howard J, Arnold A, Madhavan M, Cook C, Alu M, Mack M, Reardon M, Thourani V, Kapadia S, Thyregod H, Sondergaard L, Jørgensen T, Toff W, Van Mieghem N, Makkar R, Forrest J, Leon M. Transcatheter versus surgical aortic valve replacement in lower-risk and higher-risk patients: a meta-analysis of randomized trials. European Heart Journal 2023, 44: 836-852. PMID: 36660821, DOI: 10.1093/eurheartj/ehac642.Peer-Reviewed Original ResearchMeSH KeywordsAortic ValveAortic Valve StenosisHeart Valve Prosthesis ImplantationHumansRandomized Controlled Trials as TopicRisk FactorsStrokeTreatment OutcomeConceptsSurgical aortic valve replacementTranscatheter aortic valve implantationHigh-risk patientsLow-risk patientsComposite of deathAortic valve replacementValve replacementMAIN OUTCOMENew-onset atrial fibrillationSignificant differencesRandomized clinical trial dataAcute kidney injuryAortic valve implantationMain clinical outcomesRisk of deathClinical trial dataMajor bleedingKidney injurySecondary endpointsVascular complicationsValve implantationClinical outcomesParavalvular leakRandomized trialsAtrial fibrillationFeasibility and Safety of Exclusive Noncontrast Computed Tomography for Planning of Transcatheter Aortic Valve Implantation With Self-Expandable Valves
Hibino M, Yoon S, Dallan L, Pelletier M, Rushing G, Filby S, Elgudin Y, Ukaigwe A, Baeza C, Attizzani G. Feasibility and Safety of Exclusive Noncontrast Computed Tomography for Planning of Transcatheter Aortic Valve Implantation With Self-Expandable Valves. The American Journal Of Cardiology 2023, 190: 122-124. PMID: 36623398, DOI: 10.1016/j.amjcard.2022.12.018.Peer-Reviewed Original ResearchMeSH KeywordsAortic ValveAortic Valve StenosisFeasibility StudiesHeart Valve ProsthesisHeart Valve Prosthesis ImplantationHumansProsthesis DesignTomographyTranscatheter Aortic Valve ReplacementTreatment Outcome
2022
Meta-Analysis Comparing Valve-in-Valve Transcatheter Mitral Valve Replacement Versus Redo Surgical Mitral Valve Replacement in Degenerated Bioprosthetic Mitral Valve
Ismayl M, Abbasi M, Mostafa M, Aboeata A, Vora A, Ben-Dor I, Anavekar N, Goldsweig A. Meta-Analysis Comparing Valve-in-Valve Transcatheter Mitral Valve Replacement Versus Redo Surgical Mitral Valve Replacement in Degenerated Bioprosthetic Mitral Valve. The American Journal Of Cardiology 2022, 189: 98-107. PMID: 36521415, DOI: 10.1016/j.amjcard.2022.11.043.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAortic ValveBioprosthesisHeart Valve ProsthesisHeart Valve Prosthesis ImplantationHumansMitral ValvePostoperative ComplicationsProsthesis FailureReoperationRisk FactorsStrokeTreatment OutcomeConceptsMitral valve replacementRedo surgical mitral valve replacementHospital length of staySurgical mitral valve replacementBioprosthetic mitral valveRedo-SMVRViV-TMVRLength of stayPermanent pacemaker insertionShort hospital length of stayAcute kidney injuryDegenerated bioprosthetic mitral valvesValve replacementMitral valvePacemaker insertionKidney injuryOdds ratioValve-in-valve transcatheter mitral valve replacementTranscatheter mitral valve replacementMedian follow-upMitral valve dysfunctionMeta-analysisAssociated with better outcomesCo-morbidity burdenIn-hospital mortalityDirect relationship between transvalvular velocity and cardiac dysfunction, morbidity, and mortality in patients with aortic stenosis
Yousef S, Amabile A, Ram C, Singh S, Agarwal R, Milewski R, Assi R, Patel P, Krane M, Geirsson A, Vallabhajosyula P. Direct relationship between transvalvular velocity and cardiac dysfunction, morbidity, and mortality in patients with aortic stenosis. Journal Of Cardiac Surgery 2022, 37: 5052-5062. PMID: 36378856, DOI: 10.1111/jocs.17199.Peer-Reviewed Original ResearchMeSH KeywordsAortic ValveAortic Valve StenosisEchocardiographyHeart Valve Prosthesis ImplantationHumansSeverity of Illness IndexStroke VolumeTreatment OutcomeConceptsDegree of ASCardiac structural changesAortic stenosisSevere symptomatic aortic stenosisEnd-organ morbiditiesStructural cardiac changesSymptomatic aortic stenosisEnd-organ diseaseKaplan-Meier curvesRisk of mortalityTransvalvular flow velocityCochran-Armitage testCause mortalityPatient characteristicsCardiac changesCardiac dysfunctionPatient morbidityTransvalvular velocityCurrent guidelinesGroup BGroup ACaucasian raceHigh riskCox modelEarly interventionTotally endoscopic, robotic-assisted tricuspid valve repair with neochords.
Amabile A, LaLonde MR, Mullan CW, Hameed I, Degife E, Krane M, Geirsson A, Agrawal A. Totally endoscopic, robotic-assisted tricuspid valve repair with neochords. Multimedia Manual Of Cardio-Thoracic Surgery 2022, 2022 PMID: 36314718, DOI: 10.1510/mmcts.2022.056.Peer-Reviewed Case Reports and Technical NotesMeSH KeywordsCardiac Surgical ProceduresCardiac Valve AnnuloplastyHeart Valve Prosthesis ImplantationHumansMitral ValveRobotic Surgical ProceduresTreatment OutcomeTricuspid ValveTricuspid Valve InsufficiencyDays at home after transcatheter or surgical aortic valve replacement in high-risk patients
Chung M, Butala N, Faridi K, Almarzooq Z, Liu D, Xu J, Song Y, Baron S, Shen C, Kazi D, Yeh R. Days at home after transcatheter or surgical aortic valve replacement in high-risk patients. American Heart Journal 2022, 255: 125-136. PMID: 36309128, DOI: 10.1016/j.ahj.2022.10.080.Peer-Reviewed Original ResearchMeSH KeywordsAgedAortic ValveAortic Valve StenosisHeart Valve Prosthesis ImplantationHumansMedicareRisk FactorsTime FactorsTranscatheter Aortic Valve ReplacementTreatment OutcomeUnited StatesConceptsSurgical aortic valve replacementTranscatheter aortic valve replacementHigh-risk patientsAortic valve replacementHigh-risk trialsValve replacementIndex hospitalizationRisk trialsLong-term acute care hospitalSelf-expanding bioprosthesisAcute care hospitalsSkilled nursing facilitiesPatient-centered perspectiveFirst yearIndex LOSTAVR patientsCare hospitalEmergency departmentObservation staysPostprocedural courseLandmark analysisMedicare feeNursing facilitiesService claimsPatientsRisk factors and mortality associated with permanent pacemaker after surgical or transcatheter aortic valve replacement: Early versus late implantation
Bin Mahmood SU, Mori M, Amabile A, Prescher L, Forrest J, Kaple R, Geirsson A, Mangi AA. Risk factors and mortality associated with permanent pacemaker after surgical or transcatheter aortic valve replacement: Early versus late implantation. Journal Of Cardiac Surgery 2022, 37: 4295-4300. PMID: 36131523, DOI: 10.1111/jocs.16938.Peer-Reviewed Original ResearchMeSH KeywordsAortic ValveAortic Valve StenosisHeart Valve Prosthesis ImplantationHumansPacemaker, ArtificialRetrospective StudiesRisk FactorsTranscatheter Aortic Valve ReplacementTreatment OutcomeConceptsMid-term mortalityAortic valve replacementRisk factorsPPM implantationTAVR proceduresValve replacementPermanent pacemakerCox proportional hazards analysisTranscatheter aortic valve replacementTranscatheter aortic valve replacement (TAVR) proceduresAortic valve replacement proceduresRight bundle branch blockYale-New Haven HospitalNon-PPM groupProportional hazards analysisSingle-center evaluationNumber of patientsBundle branch blockValve replacement proceduresFurther subgroup analysisNew Haven HospitalPPM placementTAVR cohortKaplan-MeierPatient populationContemporary diagnosis and management of severe tricuspid regurgitation
Zahr F, Chadderdon S, Song H, Sako E, Fuss C, Bailey S, Cigarroa J. Contemporary diagnosis and management of severe tricuspid regurgitation. Catheterization And Cardiovascular Interventions 2022, 100: 646-661. PMID: 36086951, DOI: 10.1002/ccd.30364.Peer-Reviewed Original ResearchMeSH KeywordsCardiac CatheterizationHeart Valve Prosthesis ImplantationHumansTreatment OutcomeTricuspid ValveTricuspid Valve Insufficiency
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