2025
Brain Signatures of Very Early Cognitive Decline in Asymptomatic Middle‐Aged Offspring of People With Alzheimer's Disease
Ramsingh N, Lin H, Ouyang Y, Ravona‐Springer R, Livny A, Soleimani L, Bendlin B, Matatov A, Niv T, Shamir T, Ganmore I, Heymann A, Sano M, Azuri J, Beeri M. Brain Signatures of Very Early Cognitive Decline in Asymptomatic Middle‐Aged Offspring of People With Alzheimer's Disease. International Journal Of Geriatric Psychiatry 2025, 40: e70060. PMID: 40050014, DOI: 10.1002/gps.70060.Peer-Reviewed Original ResearchConceptsSuperior longitudinal fasciculusCortical volumeCortical brain volumesWhite matterAlzheimer's Prevention studyEarly cognitive declineBrain signaturesBrain regionsCognitive changesWM microstructureMiddle-aged adultsBrain volumeLongitudinal fasciculusCognitive declinePreclinical cognitive changesOffspring of peopleBrain tractsPatient's offspringTarget individualsEarly interventionCorpus callosumParental historyBrainAlzheimer's diseaseLinear regression modelsBrain connectivity correlates of the impact of a digital intervention for individuals with subjective cognitive decline on depression and IL-18
Catalogna M, Somerville Y, Saporta N, Nathansohn-Levi B, Shelly S, Edry L, Zagoory-Sharon O, Feldman R, Amedi A. Brain connectivity correlates of the impact of a digital intervention for individuals with subjective cognitive decline on depression and IL-18. Scientific Reports 2025, 15: 6863. PMID: 40011544, PMCID: PMC11865443, DOI: 10.1038/s41598-025-91457-3.Peer-Reviewed Original ResearchMeSH KeywordsBrainCognitive Behavioral TherapyCognitive DysfunctionDepressionFemaleHumansInterleukin-18Magnetic Resonance ImagingMaleMiddle AgedMindfulnessPilot ProjectsConceptsBrain connectivityCognitive declineResting-state functional connectivityEffect sizeCognitive behavioral therapyLate-life depressionSelf-reported depressionMedium effect sizeDigital interventionsInterventions targeting mental healthMood regulationBehavioral therapyDepressive symptomsDecreased connectivityPost-intervention changesFunctional connectivityTwo-week interventionCognitive functionSpatial cognitionDepression scoresBrain healthBehavioral outcomesBrain functionPsychological techniquesPsychological healthThe REpeated ASSEssment of SurvivorS in intracerebral haemorrhage: protocol for a multicentre, prospective observational study
Ziai W, Woo D, Sansing L, Hanley D, Ostapkovich N, Triene K, Gilkerson L, Thompson R, Walborn N, Lane K, McBee N, Langefeld C, Howard T, Vagal A, Flaherty M, Consortium F. The REpeated ASSEssment of SurvivorS in intracerebral haemorrhage: protocol for a multicentre, prospective observational study. BMJ Open 2025, 15: e094322. PMID: 39915023, PMCID: PMC11800296, DOI: 10.1136/bmjopen-2024-094322.Peer-Reviewed Original ResearchConceptsMinimally invasive surgeryIntracerebral haemorrhageInvasive surgeryNon-surgical standard of careProspective observational studySpontaneous intracerebral haemorrhageStandard of careRepeated assessmentsCognitive declineICH volumeInstitutional review boardHaematoma volumeMISTIE IIITreated patientsInflammatory stateTreatment strategiesEthnic/Racial VariationsRt-PAAssessment of survivorsObservational studyRate of cognitive declineUniversity Institutional Review BoardHaemorrhageReview boardPeer-reviewed journalsProfile of non-invasive physical health indicators associated with cognitive performance in Chinese older adults: evidence from the China Health and Retirement Longitudinal Study
Wei X, Li C, Liu D, Chen J, Ju Y, Liu J, Liu B, Zhang Y. Profile of non-invasive physical health indicators associated with cognitive performance in Chinese older adults: evidence from the China Health and Retirement Longitudinal Study. BMC Public Health 2025, 25: 420. PMID: 39894807, PMCID: PMC11789399, DOI: 10.1186/s12889-025-21479-z.Peer-Reviewed Original ResearchConceptsPhysical health indicatorsHealth indicatorsMild cognitive impairmentOlder adultsChina HealthCognitive performanceRight grip strengthChinese older adultsScreening of cognitive declineCognitive domainsLongitudinal cohort designCognitive performance domainsSubgroup analysisDomains of cognitive performancePhysical functionBackgroundExisting studiesGrip strengthCohort designLinear regression modelsMultiple linear regression modelStandardised interviewMethodsThe present studyResultsPulmonary functionSex-specific factorsGeneral cognitionIntegrated healthy lifestyle even in late-life mitigates cognitive decline risk across varied genetic susceptibility
Wang J, Chen C, Zhou J, Xu Z, Xu L, Li X, Zhong Z, Lv Y, Shi X. Integrated healthy lifestyle even in late-life mitigates cognitive decline risk across varied genetic susceptibility. Nature Communications 2025, 16: 539. PMID: 39789005, PMCID: PMC11718162, DOI: 10.1038/s41467-024-55763-0.Peer-Reviewed Original ResearchConceptsFavorable lifestyleRate of cognitive declineGenetic riskCognitive declineUnfavorable lifestyleHealthy lifestyleAssociations of combined lifestyle factorsChinese Longitudinal Healthy Longevity SurveyCombined lifestyle factorsHigh genetic riskDimensions of cognitionCognitive decline riskAccelerated cognitive declineLongevity SurveyLifestyle factorsCognitive domainsLate-lifeOlder adultsCognitive functionDeclining riskLifestyleGenetic susceptibilityGenetic factorsRiskCognitionExposure to School Racial Segregation and Late-Life Cognitive Outcomes
Lin Z, Wang Y, Gill T, Chen X. Exposure to School Racial Segregation and Late-Life Cognitive Outcomes. JAMA Network Open 2025, 8: e2452713. PMID: 39752159, PMCID: PMC11699536, DOI: 10.1001/jamanetworkopen.2024.52713.Peer-Reviewed Original ResearchConceptsCross-sectional studyCognitive scoresOlder adultsTelephone Interview for Cognitive StatusBlack participantsLate-life cognitive outcomesWhite participantsSchool racial segregationCognitive impairmentHealth and Retirement StudyNon-Hispanic whitePrevalence of cognitive impairmentAssociated with late-life cognitionEducational attainmentUS older adultsLikelihood of cognitive impairmentNon-Hispanic blacksLate-life cognitionCognitive outcomesNationally representative sampleLater-life cognitionMultilevel regression analysisStudy of BlackDementia occurrenceHealth inequalities
2024
Plasma Aβ42/Aβ40 is sensitive to early cerebral amyloid accumulation and predicts risk of cognitive decline across the Alzheimer's disease spectrum
Trelle A, Young C, Vossler H, Benitez J, Cody K, Mendiola J, Swarovski M, Le Guen Y, Feinstein I, Butler R, Channappa D, Romero A, Park J, Shahid‐Besanti M, Corso N, Chau K, Smith A, Skylar‐Scott I, Yutsis M, Fredericks C, Tian L, Younes K, Kerchner G, Deutsch G, Davidzon G, Sha S, Henderson V, Longo F, Greicius M, Wyss‐Coray T, Andreasson K, Poston K, Wagner A, Mormino E, Wilson E. Plasma Aβ42/Aβ40 is sensitive to early cerebral amyloid accumulation and predicts risk of cognitive decline across the Alzheimer's disease spectrum. Alzheimer's & Dementia 2024, 21: e14442. PMID: 39713875, PMCID: PMC11848181, DOI: 10.1002/alz.14442.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseCognitive declinePositron emission tomographyAmyloid-betaTau accumulationAmyloid positivityHippocampal-dependent memoryAlzheimer's disease spectrumAmyloidAmyloid accumulationTau burdenAb accumulationRisk of cognitive declineSensitive to memoryTau positron emission tomographyAlzheimer's Disease Research CenterPredicting cognitive declineAlzheimerTauScalable biomarkersAD continuumCerebral amyloid accumulationCross-sectional associationsCI individualsAccumulationPortable, low-field magnetic resonance imaging for evaluation of Alzheimer’s disease
Sorby-Adams A, Guo J, Laso P, Kirsch J, Zabinska J, Garcia Guarniz A, Schaefer P, Payabvash S, de Havenon A, Rosen M, Sheth K, Gomez-Isla T, Iglesias J, Kimberly W. Portable, low-field magnetic resonance imaging for evaluation of Alzheimer’s disease. Nature Communications 2024, 15: 10488. PMID: 39622805, PMCID: PMC11612292, DOI: 10.1038/s41467-024-54972-x.Peer-Reviewed Original ResearchConceptsWhite matter hyperintensitiesMachine learning pipelineMild cognitive impairmentAlzheimer's diseaseWhite matter hyperintensities volumeLearning pipelineAssessment of patientsIncrease accessCognitive impairmentEvaluation of Alzheimer's diseaseDementiaLF-MRIPoint-of-care assessmentMagnetic resonance imagingHippocampal volumeResonance imagingImage qualityDiseaseReduce costsAnisotropic counterpartIncreasing availabilityManual segmentationGeneralizable and replicable brain-based predictions of cognitive functioning across common psychiatric illness
Chopra S, Dhamala E, Lawhead C, Ricard J, Orchard E, An L, Chen P, Wulan N, Kumar P, Rubenstein A, Moses J, Chen L, Levi P, Holmes A, Aquino K, Fornito A, Harpaz-Rotem I, Germine L, Baker J, Yeo B, Holmes A. Generalizable and replicable brain-based predictions of cognitive functioning across common psychiatric illness. Science Advances 2024, 10: eadn1862. PMID: 39504381, PMCID: PMC11540040, DOI: 10.1126/sciadv.adn1862.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBrainCognitionCognitive DysfunctionFemaleHumansMagnetic Resonance ImagingMaleMental DisordersMiddle AgedReproducibility of ResultsConceptsPrediction of cognitionCognitive functionPrediction of cognitive functionFunctional neuroimaging dataTransdiagnostic sampleComputational psychiatryPsychiatric illnessNeuroimaging dataCognitive impairmentCognitionPopulation-level datasetsPsychiatryAssociated with poor outcomesUK BiobankImpairmentBrainIllnessSymptomsPrediction studiesParticipantsPoor outcomeClinical studiesSamplesPlasma Glial Fibrillary Acid Protein and Phosphorated Tau 181 Association with Presynaptic Density-Dependent Tau Pathology at 18F-SynVesT-1 Brain PET Imaging.
Wu J, Li B, Wang J, Huang Q, Chen X, You Z, He K, Guo Q, Li S, Huang Y, Guo T, Dai W, Xiang W, Chen W, Yang D, Zhao J, Guan Y, Xie F. Plasma Glial Fibrillary Acid Protein and Phosphorated Tau 181 Association with Presynaptic Density-Dependent Tau Pathology at 18F-SynVesT-1 Brain PET Imaging. Radiology 2024, 313: e233019. PMID: 39560478, PMCID: PMC11605102, DOI: 10.1148/radiol.233019.Peer-Reviewed Original ResearchConceptsP-tau-181Alzheimer's diseaseAD-related pathologyAmyloid-bPhosphor-tauTau pathologySynaptic densityTau accumulationSynaptic lossTauTau-PETDecreased synaptic densityGlial fibrillary acidic proteinPlasma glial fibrillary acidic proteinCortical thicknessAcidic proteinFibrillary acidic proteinRuijin HospitalProspective studyRelationship of plasmaBlood assayBlood markersPET/MRIBrain PET imagingPET imagingPlasma Proteomic Biomarkers in Alzheimer’s Disease and Cardiovascular Disease: A Longitudinal Study
Theeke L, Liu Y, Wang S, Luo X, Navia R, Xiao D, Xu C, Wang K, Initiative T. Plasma Proteomic Biomarkers in Alzheimer’s Disease and Cardiovascular Disease: A Longitudinal Study. International Journal Of Molecular Sciences 2024, 25: 10751. PMID: 39409080, PMCID: PMC11477191, DOI: 10.3390/ijms251910751.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAlzheimer DiseaseBiomarkersCardiovascular DiseasesCognitive DysfunctionFemaleHumansLongitudinal StudiesMaleProteomicsConceptsMild cognitive impairmentLinear mixed modelsAlzheimer's diseaseCardiovascular diseaseAlzheimer's Disease Neuroimaging InitiativeLongitudinal changesAssociated with longitudinal changesAssociation of ADAssociated with ADMultivariate linear mixed modelOlder adultsCardiovascular healthPlasma proteomic biomarkersRisk factorsCognitive declineCognitive impairmentLongitudinal studyProteomic biomarkersTamm-Horsfall proteinMixed modelsMemory-related brain potentials for visual objects in early AD show impairment and compensatory mechanisms
Xia J, Kutas M, Salmon D, Stoermann A, Rigatuso S, Farias S, Edland S, Brewer J, Olichney J. Memory-related brain potentials for visual objects in early AD show impairment and compensatory mechanisms. Cerebral Cortex 2024, 34: bhae398. PMID: 39390709, DOI: 10.1093/cercor/bhae398.Peer-Reviewed Original ResearchConceptsEvent-related brain potentialsAmnestic mild cognitive impairmentHippocampal occupancyBrain potentialsMemory abilityNegative ERP effectExecutive function abilitiesVisual memory abilityImpaired episodic memoryVerbal memory abilitiesAlzheimer's diseaseInvestigate neural mechanismsObject recognition taskVisual object recognitionVisual object recognition taskCognitively unimpaired participantsMild cognitive impairmentERP effectsNeuropsychological measuresExecutive functionEpisodic memoryHippocampal functionCompensatory mechanismsVisual memoryNeural mechanismsObjective and subjective experiences of childhood maltreatment and their relationships with cognitive deficits: a cohort study in the USA
Danese A, Widom C. Objective and subjective experiences of childhood maltreatment and their relationships with cognitive deficits: a cohort study in the USA. The Lancet Psychiatry 2024, 11: 720-730. PMID: 39147460, DOI: 10.1016/s2215-0366(24)00224-4.Peer-Reviewed Original ResearchConceptsMeasures of childhood maltreatmentExperiences of childhood maltreatmentMeasures of maltreatmentChildhood maltreatmentCognitive deficitsRetrospective reports of childhood maltreatmentReports of childhood maltreatmentSelf-reportNational Institute of Mental HealthInstitute of Mental HealthPervasive cognitive deficitsNon-verbal intelligenceMeasures of neglectRetrospective self-reportsVerbal intelligenceAutobiographical memoryExecutive functionMaltreated childrenCognitive abilitiesPsychopathologyCognitive testsCognitive functionGroup differencesProcessing speedRetrospective reportsThe White Matter Integrity and Functional Connection Differences of Fornix (Cres)/Stria Terminalis in Individuals with Mild Cognitive Impairment Induced by Occupational Aluminum Exposure
Zhang F, Li Y, Chen R, Shen P, Wang X, Meng H, Du J, Yang G, Liu B, Niu Q, Zhang H, Tan Y. The White Matter Integrity and Functional Connection Differences of Fornix (Cres)/Stria Terminalis in Individuals with Mild Cognitive Impairment Induced by Occupational Aluminum Exposure. ENeuro 2024, 11: eneuro.0128-24.2024. PMID: 39142823, PMCID: PMC11360986, DOI: 10.1523/eneuro.0128-24.2024.Peer-Reviewed Original ResearchConceptsMild cognitive impairmentFunctional connectivityCognitive impairmentNeural mechanismsRight inferior frontal gyrusResting-state functional magnetic resonance imagingFunctional magnetic resonance imagingInferior frontal gyrusRight anterior cingulateRight temporal poleFunctional connectivity differencesWhite matter integrityRight sagittal stratumFractional anisotropy valuesAnterior cingulateFrontal gyrusDiffusion tensor imagingMontreal Cognitive AssessmentTemporal poleWhite matterWM integrityPlasma Al concentrationParacingulate gyriCognitive AssessmentSagittal stratum4D dynamic spatial brain networks at rest linked to cognition show atypical variability and coupling in schizophrenia
Pusuluri K, Fu Z, Miller R, Pearlson G, Kochunov P, Van Erp T, Iraji A, Calhoun V. 4D dynamic spatial brain networks at rest linked to cognition show atypical variability and coupling in schizophrenia. Human Brain Mapping 2024, 45: e26773. PMID: 39045900, PMCID: PMC11267451, DOI: 10.1002/hbm.26773.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrainCognitive DysfunctionConnectomeFemaleHumansMagnetic Resonance ImagingMaleNerve NetSchizophreniaYoung AdultConceptsBrain networksFunctional magnetic resonance imagingAssociated with cognitive performanceDynamics of functional brain networksAssociated with cognitionFunctional brain networksVoxel-wise changesVolumetric couplingDynamical variablesCognitive performanceTypical controlsSchizophreniaCognitive impairmentNetwork pairsMagnetic resonance imagingPair of networksCognitionAtypical variabilityResonance imagingCouplingNetwork connectivityNetwork growthImpairmentBrainStatic networksLower Locus Coeruleus Integrity Signals Elevated Entorhinal Tau and Clinical Progression in Asymptomatic Older Individuals
Engels‐Domínguez N, Riphagen J, Van Egroo M, Koops E, Smegal L, Becker J, Prokopiou P, Bueichekú E, Kwong K, Rentz D, Salat D, Sperling R, Johnson K, Jacobs H. Lower Locus Coeruleus Integrity Signals Elevated Entorhinal Tau and Clinical Progression in Asymptomatic Older Individuals. Annals Of Neurology 2024, 96: 650-661. PMID: 39007398, PMCID: PMC11534559, DOI: 10.1002/ana.27022.Peer-Reviewed Original ResearchConceptsLocus coeruleus integrityClinical Dementia RatingBeta-amyloidHippocampal volumePositron emission tomographyClinical progressionAsymptomatic individualsReceiver operating characteristic analysisCortical tau depositionCox proportional hazards modelsLociAccumulation of pathologyBeta-amyloid burdenAsymptomatic older individualsMild cognitive impairmentTau depositionProportional hazards modelTau signalEC tauLocus coeruleusPET-negativeEntorhinal tauCognitive impairmentScreening instrumentCognitive declineA multicenter, randomized, double-blind, placebo-controlled ascending dose study to evaluate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamic (PD) effects of Posiphen in subjects with early Alzheimer’s Disease
Galasko D, Farlow M, Lucey B, Honig L, Elbert D, Bateman R, Momper J, Thomas R, Rissman R, Pa J, Aslanyan V, Balasubramanian A, West T, Maccecchini M, Feldman H. A multicenter, randomized, double-blind, placebo-controlled ascending dose study to evaluate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamic (PD) effects of Posiphen in subjects with early Alzheimer’s Disease. Alzheimer's Research & Therapy 2024, 16: 151. PMID: 38970127, PMCID: PMC11225352, DOI: 10.1186/s13195-024-01490-z.Peer-Reviewed Original ResearchConceptsOrally administered small moleculeFractional synthesis rateAscending dose studyDose-dependent loweringIRB-approved protocolEarly ADMini-Mental State ExamDose-dependent effectAlzheimer's diseaseBlood patchDouble-blindWell-toleratedCatheter placementPreclinical modelsLumbar punctureDose studyIntravenous infusionMild cognitive impairmentEvaluate safetyPlacebo participantsCognitive measuresStable isotope labeling kineticsActive drugClinical trialsADAS-Cog12In-Hospital Delirium and Disability and Cognitive Impairment After COVID-19 Hospitalization
Kaushik R, McAvay G, Murphy T, Acampora D, Araujo K, Charpentier P, Chattopadhyay S, Geda M, Gill T, Kaminski T, Lee S, Li J, Cohen A, Hajduk A, Ferrante L. In-Hospital Delirium and Disability and Cognitive Impairment After COVID-19 Hospitalization. JAMA Network Open 2024, 7: e2419640. PMID: 38954414, PMCID: PMC11220565, DOI: 10.1001/jamanetworkopen.2024.19640.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCognitive DysfunctionCOVID-19DeliriumFemaleHospitalizationHumansMaleMiddle AgedProspective StudiesSARS-CoV-2ConceptsIn-hospital deliriumChart-Based Delirium Identification InstrumentOlder adultsFunctional disabilityCOVID-19 hospitalizationCognitive impairmentCohort studyAssociated with increased functional disabilityHospitalized older adultsIncreased functional disabilityAssociation of deliriumPostdischarge follow-upRisk of deliriumTertiary care systemFollow-upPresence of cognitive impairmentProspective cohort studyLogistic regression modelsOlder survivorsCare systemIncreasing cognitive impairmentMain OutcomesCOVID-19Hospital dischargePrimary outcomeAsian Cohort for Alzheimer Disease (ACAD) Pilot Study
Peavy G, Võ N, Revta C, Lu A, Lupo J, Nam P, Nguyễn K, Wang L, Feldman H. Asian Cohort for Alzheimer Disease (ACAD) Pilot Study. Alzheimer Disease & Associated Disorders 2024, 38: 277-284. PMID: 39177172, PMCID: PMC11340683, DOI: 10.1097/wad.0000000000000631.Peer-Reviewed Original ResearchConceptsSubjective cognitive complaintsOlder Vietnamese AmericansVascular risk factorsMild cognitive impairmentVietnamese AmericansRisk factorsMeasuring subjective cognitive complaintsPilot studyCommunity advisory boardNongenetic risk factorsCommunity-based researchAD risk factorsAlzheimer's diseaseDepressive symptomsConsensus teamCognitive complaintsBilingual/bicultural staffAD riskAssessment toolAdvisory boardVietnamese communityExploratory analysisCognitive difficultiesCognitive impairmentParticipantsA deep spatio-temporal attention model of dynamic functional network connectivity shows sensitivity to Alzheimer’s in asymptomatic individuals
Wei Y, Abrol A, Lah J, Qiu D, Calhoun V. A deep spatio-temporal attention model of dynamic functional network connectivity shows sensitivity to Alzheimer’s in asymptomatic individuals. Annual International Conference Of The IEEE Engineering In Medicine And Biology Society (EMBC) 2024, 00: 1-4. PMID: 40039841, DOI: 10.1109/embc53108.2024.10781740.Peer-Reviewed Original ResearchMeSH KeywordsAgedAlzheimer DiseaseBrainCognitive DysfunctionDeep LearningFemaleHumansMagnetic Resonance ImagingMaleNerve NetConceptsDynamic functional network connectivityFunctional magnetic resonance imagingSpatio-temporal attention modelNetwork connectivityMild cognitive impairmentDeep learning advancesFunctional network connectivityMachine learning methodsSelf-attentionAttention modelAt-risk subjectsLearning methodsLearning advancesAlzheimer's diseaseNetwork dependence
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply