2025
20 Years of Aberrant Salience in Psychosis: What Have We Learned?
Corlett P, Fraser K. 20 Years of Aberrant Salience in Psychosis: What Have We Learned? American Journal Of Psychiatry 2025, appiajp20240556. PMID: 40134268, DOI: 10.1176/appi.ajp.20240556.Peer-Reviewed Original ResearchDopamine systemComputational cognitive neuroscienceAberrant salienceDelusion formationDopamine dysfunctionDopaminergic circuitsSalience hypothesisCognitive neuroscienceNeurochemical dysfunctionBehavioral neuroscientistsClinical phenomenologyCogent theoryDopaminePsychosisNovel predictionsBehavioral lociDelusionsAttention of cliniciansContemporary theoriesBelief formationHallucinationsBeliefsNeuroscienceDysfunctionNeuroscientists
2024
Imagination, Agency, and Predictive Processing
Corlett P. Imagination, Agency, and Predictive Processing. 2024, 60-78. DOI: 10.1093/oso/9780198872221.003.0004.Peer-Reviewed Original ResearchPredictive processing theoryTheories of delusionsPredictive coding theorySensory inputDelusion formationSource monitoringProcess theoryDelusionsMediated learningHallucinationsConscious experienceImaginative processesReality perceptionPrediction processNeurocomputer architectureBeliefsPerceptionDysfunction
2023
Association Between False Memories and Delusions in Alzheimer Disease
McLachlan E, Ocal D, Burgess N, Reeves S, Howard R, Weiner M, Aisen P, Petersen R, Jack C, Jagust W, Trojanowki J, Toga A, Beckett L, Green R, Saykin A, Morris J, Perrin R, Shaw L, Khachaturian Z, Carrillo M, Potter W, Barnes L, Bernard M, González H, Ho C, Hsiao J, Jackson J, Masliah E, Masterman D, Okonkwo O, Perrin R, Ryan L, Silverberg N, Fleisher A, Truran Sacrey D, Fockler J, Conti C, Veitch D, Neuhaus J, Jin C, Nosheny R, Ashford M, Flenniken D, Kormos A, Montine T, Rafii M, Raman R, Jimenez G, Donohue M, Gessert D, Salazar J, Zimmerman C, Cabrera Y, Walter S, Miller G, Coker G, Clanton T, Hergesheimer L, Smith S, Adegoke O, Mahboubi P, Moore S, Pizzola J, Shaffer E, Sloan B, Harvey D, Forghanian-Arani A, Borowski B, Ward C, Schwarz C, Jones D, Gunter J, Kantarci K, Senjem M, Vemuri P, Reid R, Fox N, Malone I, Thompson P, Thomopoulos S, Nir T, Jahanshad N, DeCarli C, Knaack A, Fletcher E, Tosun-Turgut D, Rossi Chen S, Choe M, Crawford K, Yushkevich P, Das S, Koeppe R, Reiman E, Chen K, Mathis C, Landau S, Cairns N, Householder E, Franklin E, Bernhardt H, Taylor-Reinwald L, Korecka M, Figurski M, Neu S, Nho K, Risacher S, Apostolova L, Shen L, Foroud T, Nudelman K, Faber K, Wilmes K, Thal L, Silbert L, Lind B, Crissey R, Kaye J, Carter R, Dolen S, Quinn J, Schneider L, Pawluczyk S, Becerra M, Teodoro L, Dagerman K, Spann B, Brewer J, Vanderswag H, Ziolkowski J, Heidebrink J, Zbizek-Nulph L, Lord J, Mason S, Albers C, Knopman D, Johnson K, Villanueva-Meyer J, Pavlik V, Pacini N, Lamb A, Kass J, Doody R, Shibley V, Chowdhury M, Rountree S, Dang M, Stern Y, Honig L, Mintz A, Ances B, Winkfield D, Carroll M, Stobbs-Cucchi G, Oliver A, Creech M, Mintun M, Schneider S, Geldmacher D, Natelson Love M, Griffith R, Clark D, Brockington J, Marson D, Grossman H, Goldstein M, Greenber J, Mitsis E, Shah R, Lamar M, Samuels P, Duara R, Greig-Custo M, Rodriguez R, Albert M, Onyike C, Farrington L, Rudow S, Brichko R, Kielb S, Smith A, Ashok Raj B, Fargher K, Sadowski M, Wisniewski T, Shulman M, Faustin A, Rao J, Castro K, Ulysse A, Chen S, Sheikh M, Singleton-Garvin J, Murali Doraiswamy P, Petrella J, James O, Wong T, Borges-Neto S, Karlawish J, Wolk D, Vaishnavi S, Clark C, Arnold S, Smith C, Jicha G, El Khouli R, Raslau F, Lopez O, Oakley M, Simpson D, Porsteinsson A, Martin K, Kowalski N, Keltz M, Goldstein B, Makino K, Seleem Ismail M, Brand C, Thai G, Pierce A, Yanez B, Sosa E, Witbracht M, Kelley B, Nguyen T, Womack K, Mathews D, Quiceno M, Levey A, Lah J, Hajjar I, Cellar J, Burns J, Swerdlow R, Brooks W, Silverman D, Kremen S, Apostolova L, Tingus K, Lu P, Bartzokis G, Woo E, Teng E, Graff-Radford N, Parfitt F, Poki-Walker K, Farlow M, Hake A, Matthews B, Brosch J, Herring S, van Dyck C, Mecca A, Good S, MacAvoy M, Carson R, Varma P, Chertkow H, Vaitekunis S, Hosein C, Black S, Stefanovic B, Heyn C, Robin Hsiung G, Kim E, Mudge B, Sossi V, Feldman H, Assaly M, Finger E, Pasternak S, Rachinsky I, Kertesz A, Drost D, Rogers J, Grant I, Muse B, Rogalski E, Robson J, Marsel Mesulam M, Kerwin D, Wu C, Johnson N, Liposki K, Weintraub S, Bonakdarpour B, Pomara N, Hernando R, Sarrael A, Rosen H, Miller B, Perry D, Scott Turner R, Johnson K, Reynolds B, McCann K, Poe J, Sperling R, Johnson K, Marshall G, Yesavage J, Taylor J, Chao S, Coleman J, White J, Lane B, Rosen A, Tinklenberg J, Belden C, Atri A, Clark K, Zamrini E, Sabbagh M, Killiany R, Stern R, Mez J, Kowall N, Budson A, Obisesan T, Ntekim O, Wolday S, Khan J, Nwulia E, Nadarajah S, Lerner A, Ogrocki P, Tatsuoka C, Fatica P, Maillard P, Olichney J, Carmichael O, Bates V, Capote H, Rainka M, Borrie M, Lee T, Bartha R, Johnson S, Asthana S, Carlsson C, Perrin A, Burke A, Scharre D, Kataki M, Tarawneh R, Hart D, Zimmerman E, Celmins D, Miller D, Boles L, Ekstam Smith K, Koleva H, Shim H, Won Nam K, Schultz S, Williamson J, Craft S, Cleveland J, Yang M, Sink K, Ott B, Drake J, Tremont G, Daielllo L, Ritter A, Bernick C, Munic D, O'Connelll A, Mintzer J, Wiliams A, Masdeu J, Shi J, Garcia A, Newhouse P, Potkin S, Salloway S, Malloy P, Correia S, Kittur S, Pearlson G, Blank K, Anderson K, Flashman L, Seltzer M, Hynes M, Santulli R, Relkin N, Chiang G, Lin M, Ravdin L, Lee A, Neylan T, Grafman J, Danowski S, Nguyen-Barrera C, Hayes J, Finley S, Bernstein M, Foster N, Kim S, Sood A, Blanchard K, Arfanakis K, Fleischman D, Varon D, Reist C, Sadowsky C, Martinez W, Villena T, Peskind E, Petrie E, Li G, Mackin S, Drake E, Nelson C, Bikford D, Butters M, Zmuda M, Reyes D, Ho Au Y, Scherer K, Catalinotto D, Stark S, Ong E, Fernandez D. Association Between False Memories and Delusions in Alzheimer Disease. JAMA Psychiatry 2023, 80: 700-709. PMID: 37223934, PMCID: PMC10209823, DOI: 10.1001/jamapsychiatry.2023.1012.Peer-Reviewed Original ResearchConceptsRey Auditory Verbal Learning TestFalse recognitionFalse memoriesRegional brain volumesWhole-brain voxel-based morphometry analysisAuditory Verbal Learning TestAlzheimer's Disease Neuroimaging InitiativeDisease Assessment ScalePresence of delusionsBrain regionsVerbal Learning TestFusiform gyrus volumeFalse recognition scoresHippocampal volumeLower regional brain volumesVoxel-based morphometry analysisCross-sectional studyDisease Neuroimaging InitiativeLogistic regression modelingSame brain regionsBrain volumeAlzheimer's diseaseLearning TestRight hippocampal volumeDelusion formation
2020
T70. DUAL-PROCESS THEORY, CONFLICT PROCESSING, AND DELUSIONAL BELIEF
Bronstein M, Pennycook G, Joormann J, Corlett P, Cannon T. T70. DUAL-PROCESS THEORY, CONFLICT PROCESSING, AND DELUSIONAL BELIEF. Schizophrenia Bulletin 2020, 46: s258-s258. PMCID: PMC7234109, DOI: 10.1093/schbul/sbaa029.630.Peer-Reviewed Original ResearchDual-process theoryReasoning biasesDelusional individualsAnalytic reasoningConflict processingProcessing deficitsDual-process perspectiveDual-process reasoningMaintenance of delusionsConflict detectionCognitive biasesDelusion formationNeurocognitive responsesDisconfirmatory evidenceDelusional beliefsPresence of conflictAnalytic thinkingIntuitive systemDeficitsAdditional engagementBiasesFuture researchDelusionsRecent theoriesCausal role
2012
Delusions
Corlett P. Delusions. 2012, 667-673. DOI: 10.1016/b978-0-12-375000-6.00126-9.Peer-Reviewed Original Research
2007
Disrupted prediction-error signal in psychosis: evidence for an associative account of delusions
Corlett PR, Murray GK, Honey GD, Aitken MR, Shanks DR, Robbins TW, Bullmore ET, Dickinson A, Fletcher PC. Disrupted prediction-error signal in psychosis: evidence for an associative account of delusions. Brain 2007, 130: 2387-2400. PMID: 17690132, PMCID: PMC3838942, DOI: 10.1093/brain/awm173.Peer-Reviewed Original ResearchConceptsDelusion formationDelusional beliefsPrediction error processingPrediction-error signallingPrediction error signalsAttentional allocationAssociative accountMaladaptive beliefsError processingAssociative learningNeurobiological theoriesBrain responsesCortex responsesIndividual's propensityBelief formationDelusionsBeliefsPrediction errorExtent of disruptionProcessingFMRILearningPsychosisExpectancyIndividualsFrom prediction error to psychosis: ketamine as a pharmacological model of delusions
Corlett PR, Honey GD, Fletcher PC. From prediction error to psychosis: ketamine as a pharmacological model of delusions. Journal Of Psychopharmacology 2007, 21: 238-252. PMID: 17591652, DOI: 10.1177/0269881107077716.Peer-Reviewed Original ResearchConceptsDelusion formationAssociative learning processesPrediction error signalsDevelopment of delusionsFormation of delusionsPre-psychotic periodAttentional disruptionAttentional disturbancesNeuropsychiatric modelsNeurobiological systemsPrediction errorExperience resultsLearning processIrrelevant detailsDelusionsError signalDrug ketaminePsychosisNumerous associationsPsychotic statesPerceptExpectationsPharmacological modelStimuliSymptom evolution
2006
Frontal Responses During Learning Predict Vulnerability to the Psychotogenic Effects of Ketamine: Linking Cognition, Brain Activity, and Psychosis
Corlett PR, Honey GD, Aitken MR, Dickinson A, Shanks DR, Absalom AR, Lee M, Pomarol-Clotet E, Murray GK, McKenna PJ, Robbins TW, Bullmore ET, Fletcher PC. Frontal Responses During Learning Predict Vulnerability to the Psychotogenic Effects of Ketamine: Linking Cognition, Brain Activity, and Psychosis. JAMA Psychiatry 2006, 63: 611-621. PMID: 16754834, DOI: 10.1001/archpsyc.63.6.611.Peer-Reviewed Original ResearchMeSH KeywordsAdultAssociation LearningBrief Psychiatric Rating ScaleCognition DisordersDelusionsDisease SusceptibilityDose-Response Relationship, DrugFemaleFrontal LobeHumansKetamineMagnetic Resonance ImagingMaleModels, TheoreticalPerceptual DisordersPlacebosProbabilityPsychiatric Status Rating ScalesPsychoses, Substance-InducedPsychotic DisordersConceptsDelusion formationPerceptual AberrationBrain activityError-dependent learningPharmacological functional magnetic resonanceAssociative learning taskFunctional magnetic resonance imagingAssociative learning processesDelusion-like beliefsFrontal cortical functionFunctional magnetic resonanceFull Scale IQUnderstanding of psychosisRight frontal cortexRight-handed volunteersNeurobiological accountsCognitive processesClinical Neuroscience InstituteFrontal activationAssociative learningFrontal responseBrain activationStructured Clinical InterviewLearning taskPsychotogenic effects
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