2025
Transcriptomic landscape of cumulus cells from patients <38 years old with a history of poor ovarian response (POR) treated with platelet-rich plasma (PRP)
Roberts L, Herlihy N, Reig A, Titus S, Garcia-Milian R, Knight J, Yildirim R, Margolis C, Cakiroglu Y, Tiras B, Whitehead C, Werner M, Seli E. Transcriptomic landscape of cumulus cells from patients <38 years old with a history of poor ovarian response (POR) treated with platelet-rich plasma (PRP). Aging 2025, 17: 431-447. PMID: 39976580, PMCID: PMC11892918, DOI: 10.18632/aging.206202.Peer-Reviewed Original ResearchConceptsPlatelet-rich plasmaTreated with platelet-rich plasmaCumulus cellsPoor ovarian responseLive birthsGene expressionIntraovarian injection of autologous platelet-rich plasmaPatients treated with platelet-rich plasmaInjection of autologous platelet-rich plasmaHistory of poor ovarian responseAutologous platelet-rich plasmaPlatelet-rich plasma treatmentDiminished ovarian reserveCell-to-cell signalingRNA sequencing librariesCause of infertilityDifferential expression analysisFalse discovery rate thresholdIntraovarian injectionOvarian reserveFailed implantsSequencing librariesOvarian responseTranscriptomic landscapeRNA sequencingEnhanced ovarian FKBP51 expression is associated with ovarian aging: a molecular insight for age-related fertility in women
Sarkar P, Moore M, Ozmen A, Cetinkaya-Un B, Julie V, Imudia A, Lockwood C, Kayisli U, Guzeloglu-Kayisli O. Enhanced ovarian FKBP51 expression is associated with ovarian aging: a molecular insight for age-related fertility in women. F&S Science 2025, 6: 152-163. PMID: 39837475, DOI: 10.1016/j.xfss.2025.01.004.Peer-Reviewed Original ResearchDiminished ovarian reserveControlled ovarian stimulationNormal ovarian reserveOvarian stromal tissuePicrosirius red stainingCumulus cellsOvarian reserveOvarian agingFKBP51 expressionStromal tissueAssociated with ovarian agingHuman ovaryFKBP51 levelsPost-menopausalFollicular fluidOvarian tissueYoung womenReproductive ageWomen of advanced reproductive agePremature ovarian agingLevels of FKBP51Diagnosis of diminished ovarian reservePre-menopausal womenAdvanced reproductive ageDelay ovarian aging
2024
Inflammation and Ovarian Function in Reproductive‐Aged Women
Long A, Steiner A, Thompson A, Jahnke H, Harris B, Jukic A. Inflammation and Ovarian Function in Reproductive‐Aged Women. American Journal Of Human Biology 2024, 37: e24196. PMID: 39623697, PMCID: PMC11671284, DOI: 10.1002/ajhb.24196.Peer-Reviewed Original ResearchFollicle-stimulating hormoneC-reactive proteinAnti-Mullerian hormoneOvarian functionInhibin BOvarian reserveFollicular phase follicle-stimulating hormoneMarkers of immune activationBiomarker of ovarian functionTime to ConceiveInhibin B levelsDiminished ovarian reserveAnti-Mullerian hormone levelsCross-sectional analysis of dataPolycystic ovarian syndromeCohort study sampleSecondary cross-sectional analysisNatural-logInhibin B.Menstrual cycleImmune activationLogistic regression modelsFollicular phaseHormone levelsHigher inflammationTherapeutic management in women with a diminished ovarian reserve: a systematic review and meta-analysis of randomized controlled trials
Conforti A, Carbone L, Di Girolamo R, Iorio G, Guida M, Campitiello M, Ubaldi F, Rienzi L, Vaiarelli A, Cimadomo D, Ronsini C, Longobardi S, D'Hooghe T, Esteves S, Alviggi C. Therapeutic management in women with a diminished ovarian reserve: a systematic review and meta-analysis of randomized controlled trials. Fertility And Sterility 2024, 123: 457-476. PMID: 39332623, DOI: 10.1016/j.fertnstert.2024.09.038.Peer-Reviewed Original ResearchDiminished ovarian reserveLive birth rateOvarian reserveRandomized controlled trialsClinical management of womenHigher live birth ratesAssociated with higher live birth ratesMeta-analysis of randomized controlled trialsControlled trialsInvestigate adjuvant treatmentsManagement of womenLow-dose gonadotropinsLuteal phase stimulationBirth ratePOSEIDON criteriaCorifollitropin alfaAdjuvant treatmentGonadotropin regimensGnRH antagonistClomiphene citrateLuteinizing hormoneTherapeutic managementTestosterone supplementationClinical managementRandomized trialsLooking into the future: a machine learning powered prediction model for oocyte return rates after cryopreservation
Fouks Y, Bortoletto P, Chang J, Penzias A, Vaughan D, Sakkas D. Looking into the future: a machine learning powered prediction model for oocyte return rates after cryopreservation. Reproductive BioMedicine Online 2024, 50: 104432. PMID: 39642702, DOI: 10.1016/j.rbmo.2024.104432.Peer-Reviewed Original ResearchSociety for Assisted Reproductive TechnologyDiminished ovarian reserveStored oocytesUS fertility clinicsAge-related infertilityAssisted reproductive technologyFertility clinicsLikelihood of patientsOocyte cryopreservationUnexplained infertilityInfertility diagnosisOvarian reservePatient agePatient demographicsTreatment indicationsPatient counselingReproductive technologyFertility diagnosisPatientsOocytesGender-relatedInfertilitySelf-financingClinicDiagnosisReproductive Health Assessment and Reports of Fertility Counseling in Pediatric and Adolescent Patients with Sickle Cell Disease After Hematopoietic Cell Transplantation
George S, Veludhandi A, Xiang Y, Liu K, Stenger E, Arnold S, Mehta A, Schirmer D, Spencer J, Guilcher G, Bhatia M, Abraham A, Gomez-Lobo V, Krishnamurti L, Meacham L. Reproductive Health Assessment and Reports of Fertility Counseling in Pediatric and Adolescent Patients with Sickle Cell Disease After Hematopoietic Cell Transplantation. Transplantation And Cellular Therapy 2024, 30: 912.e1-912.e13. PMID: 38972510, PMCID: PMC11344653, DOI: 10.1016/j.jtct.2024.06.029.Peer-Reviewed Original ResearchHematopoietic cell transplantationSickle cell diseaseFollicle-stimulating hormone levelsPost-HCTParent-proxyConditioning regimensCell transplantationFertility counselingHormone levelsCell diseaseCyclophosphamide equivalent doseSickle cell disease patientsPremature ovarian insufficiencyElevated FSH levelsDiminished ovarian reserveAnti-Mullerian hormone levelsBone marrow stem cellsEffective method of educationGonadal hormone productionHealth Survey dataReproductive health assessmentReproductive health issuesMarrow stem cellsSibling donorOvarian insufficiencyAssessment of a Decade of Change in U.S. Assisted Reproductive Technology Cumulative Live-Birth Rates
Wang S, Seifer D. Assessment of a Decade of Change in U.S. Assisted Reproductive Technology Cumulative Live-Birth Rates. Obstetrics And Gynecology 2024, 143: 839-848. PMID: 38696814, DOI: 10.1097/aog.0000000000005598.Peer-Reviewed Original ResearchConceptsCumulative live birth rateLive birth rateAssisted reproductive technologyPreimplantation genetic testingInfertility diagnosisLive birthsOvulatory disordersGenetic testingReproductive technologyOdds of live birthMale factor infertilityFrozen embryo transferDiminished ovarian reserveClinical practiceRetrospective cohort studyAssociated with decreased oddsSART CORS databaseField of assisted reproductive technologyDemographic shiftsSART CORSOvarian reserveInfertility causeEmbryo transferCounseling patientsCohort studyAge-related increase in live-birth rates of first frozen thaw embryo versus first fresh transfer in initial assisted reproductive technology cycles without PGT
Wang S, Seifer D. Age-related increase in live-birth rates of first frozen thaw embryo versus first fresh transfer in initial assisted reproductive technology cycles without PGT. Reproductive Biology And Endocrinology 2024, 22: 42. PMID: 38615016, PMCID: PMC11015537, DOI: 10.1186/s12958-024-01210-0.Peer-Reviewed Original ResearchConceptsFrozen-thawed embryo transferCumulative live birth rateLive birth rateDiminished ovarian reservePreimplantation genetic testingMultivariate logistic regressionFresh transferLive birth outcomesLive birthsEmbryo transferAssisted reproductive technologyART cyclesEndometrial receptivityBirth outcomesFrozen-thawed embryo transfer cyclesOdds of live birthAssisted reproductive technology cyclesChance of live birthFresh embryo transferFrozen-thawed cyclesFrozen-thawed embryosMale factor infertilityRetrospective cohort studyEmbryo transfer methodsAge groups
2023
Leukocyte telomere length and DNA methylome as biomarkers of ovarian reserve and embryo aneuploidy: the intricate relationship between somatic and reproductive aging
Garg A, Seli E. Leukocyte telomere length and DNA methylome as biomarkers of ovarian reserve and embryo aneuploidy: the intricate relationship between somatic and reproductive aging. Fertility And Sterility 2023, 121: 26-33. PMID: 37979607, DOI: 10.1016/j.fertnstert.2023.11.011.Peer-Reviewed Original ResearchConceptsPoor ovarian responseLeukocyte telomere lengthOvarian reserveTelomere lengthAssisted Reproductive TechnologyOvarian responseFollicular somatic cellsMethylome changesDNA methylomePrevalence of infertilityDiminished ovarian reserveSomatic cellsCellular agingEpigenetic clocksDNA methylation ageReproductive potentialReproductive declineOvarian agingSurrogate biomarkerCommon causeMethylomeART outcomesChronologic ageEmbryo aneuploidyReproductive functionVitamin D and infertility
Simpson S, Pal L. Vitamin D and infertility. Current Opinion In Obstetrics & Gynecology 2023, 35: 300-305. PMID: 37266579, DOI: 10.1097/gco.0000000000000887.Peer-Reviewed Original ResearchConceptsPolycystic ovarian syndromeVitamin DGynaecological disordersVitamin D serum levelsOvarian reserve parametersD serum levelsVitamin D deficiencyVitamin D statusDiminished ovarian reserveCommon gynaecological disorderReproductive health burdenHigher pregnancy rateD deficiencyD statusOvarian reserveOvarian syndromeInfertile womenSerum levelsUterine myomaMenstrual regularityEndometriosis patientsInsulin levelsUterine fibroidsHealth burdenPregnancy rateThe impact of air pollution and endocrine disruptors on reproduction and assisted reproduction
Seli D, Taylor H. The impact of air pollution and endocrine disruptors on reproduction and assisted reproduction. Current Opinion In Obstetrics & Gynecology 2023, 35: 210-215. PMID: 36924404, DOI: 10.1097/gco.0000000000000868.Peer-Reviewed Original ResearchConceptsDiminished ovarian reserveOvarian reserveInfertility treatmentAbnormal semen parametersAssisted reproduction outcomesHuman reproductive healthEstrogen-like activityFemale reproductive functionEndocrine disruptorsPregnancy rateUterine leiomyomaReproductive healthReproduction outcomesReproductive functionSemen parametersClinical implicationsLarge-scale studiesAssisted reproductionSperm concentrationPatientsAir pollutionHealth impactsEndocrineTreatmentBisphenol A
2022
Minimal Stimulation Using Gonadotropin-Releasing Hormone Antagonist is Associated with Higher Live Birth Rates: A National Study of 13,050 Cycles
Hurley E, Sun F, Zhang H, Polotsky A, Rios J. Minimal Stimulation Using Gonadotropin-Releasing Hormone Antagonist is Associated with Higher Live Birth Rates: A National Study of 13,050 Cycles. Women's Health Reports 2022, 3: 957-963. PMID: 36479370, PMCID: PMC9712044, DOI: 10.1089/whr.2022.0080.Peer-Reviewed Original ResearchHigher live birth rateLive birth rateGnRH antagonist useAntagonist useMinimal stimulationRank sum testHormone antagonistBirth rateImproved live birth ratesGonadotropin-releasing hormone antagonistCancelation rateCycle cancelation rateGnRH antagonist suppressionMinimal stimulation IVFTotal gonadotropin dosageDiminished ovarian reserveYears of ageWilcoxon rank sum testChi-square testNumber of embryosGonadotropin dosageOvarian reserveGnRH antagonistAntimullerian hormoneOlder women
2021
A pathogenic DMC1 frameshift mutation causes nonobstructive azoospermia but not primary ovarian insufficiency in humans
Cao D, Shi F, Guo C, Liu Y, Lin Z, Zhang J, Li R, Yao Y, Liu K, Ng E, Yeung W, Wang T. A pathogenic DMC1 frameshift mutation causes nonobstructive azoospermia but not primary ovarian insufficiency in humans. Molecular Human Reproduction 2021, 27: gaab058. PMID: 34515795, DOI: 10.1093/molehr/gaab058.Peer-Reviewed Original ResearchConceptsNonobstructive azoospermiaWhole-exome sequencingDiminished ovarian reserveFrameshift mutationMicrosurgical testicular sperm extractionTesticular sperm extractionNon-consanguineous familyHomozygous frameshift mutationFailure of follicle developmentPathogenic frameshift variantGenetic factorsRecessive inheritance modeKnockout mouse studiesReduced antral follicle numbersSperm extractionFrameshift variantPathogenic genesLoss of functionMetaphase II oocytesPrimary ovarian insufficiencyInheritance modeDMC1Antral follicle numbersHuman oogenesisSpermatogenesisAssociation of Germline BRCA Pathogenic Variants With Diminished Ovarian Reserve: A Meta-Analysis of Individual Patient-Level Data
Turan V, Lambertini M, Lee D, Wang E, Clatot F, Karlan B, Demeestere I, Bang H, Oktay K. Association of Germline BRCA Pathogenic Variants With Diminished Ovarian Reserve: A Meta-Analysis of Individual Patient-Level Data. Journal Of Clinical Oncology 2021, 39: 2016-2024. PMID: 33891474, PMCID: PMC8260903, DOI: 10.1200/jco.20.02880.Peer-Reviewed Original ResearchConceptsIndividual patient-level dataSerum AMH levelsDiminished ovarian reservePatient-level dataAMH levelsOvarian reservePathogenic variantsGermline BRCA pathogenic variantLow serum AMH levelsAnti-Müllerian hormone levelsOral contraceptive pill useLower AMH levelsDecreased ovarian reserveBody mass indexContraceptive pill useBRCA pathogenic variantsEvaluable womenMass indexMean ageHormone levelsBreast cancerAffected womenPill useMeta-AnalysisYoung womenAMH Highly Correlates With Cumulative Live Birth Rate in Women with Diminished Ovarian Reserve Independent of Age*
Tal R, Seifer DB, Tal R, Granger E, Wantman E, Tal O. AMH Highly Correlates With Cumulative Live Birth Rate in Women with Diminished Ovarian Reserve Independent of Age*. The Journal Of Clinical Endocrinology & Metabolism 2021, 106: 2754-2766. PMID: 33729496, DOI: 10.1210/clinem/dgab168.Peer-Reviewed Original ResearchConceptsCumulative live birth rateDiminished ovarian reserveLive birth rateSerum AMHLive birthsAge strataRetrieval cycleAntimüllerian hormone levelsReproductive technology cyclesCumulative live birthMain outcome measuresMultiple logistic regressionNumber of oocytesBirth rateRegression analysisPreimplantation genetic testingAddition of AMHPercentage of cyclesOvarian reserveIndependent predictorsOvarian responseHormone levelsRetrospective analysisOutcome measuresEmbryo transfer
2020
Embryo cryopreservation and utilization in the United States from 2004–2013
Christianson MS, Stern JE, Sun F, Zhang H, Styer AK, Vitek W, Polotsky AJ. Embryo cryopreservation and utilization in the United States from 2004–2013. F&S Reports 2020, 1: 71-77. PMID: 34223221, PMCID: PMC8244341, DOI: 10.1016/j.xfre.2020.05.010.Peer-Reviewed Original ResearchART cyclesFresh cyclesAssisted Reproductive Technology Clinical Outcomes Reporting SystemEmbryo transferSubsequent frozen embryo transferDonor oocyte cyclesAntimüllerian hormone levelsDiminished ovarian reserveFrozen embryo transferReproductive technology clinicsPreimplantation genetic testingAssisted Reproductive TechnologyNumber of embryosPercentage of womenOocyte cyclesOvarian reserveHistorical cohortHormone levelsRegistry dataRetrospective analysisTechnology clinicsGenetic testingExcess embryosEmbryo cryopreservationFrozen embryosThe relationship between H19 and parameters of ovarian reserve
Xia X, Burn MS, Chen Y, Karakaya C, Kallen A. The relationship between H19 and parameters of ovarian reserve. Reproductive Biology And Endocrinology 2020, 18: 46. PMID: 32404103, PMCID: PMC7218823, DOI: 10.1186/s12958-020-00578-z.Peer-Reviewed Original ResearchConceptsOvarian reserveDecreased ovarian reserveOocyte retrievalH19 expressionInfertility evaluationCumulus cellsTransvaginal oocyte retrievalDiminished ovarian reserveAnti-Mullerian hormoneDownregulation of H19H19 expression levelsGazi University SchoolParticipantsA totalAMH levelsSerum AMHIVF patientsOocyte yieldLow respondersBlood samplesNovel biomarkersExpression levelsFurther studiesPatientsUniversity SchoolH19
2019
Diminished ovarian reserve versus ovarian aging: overlaps and differences.
Ata B, Seyhan A, Seli E. Diminished ovarian reserve versus ovarian aging: overlaps and differences. Current Opinion In Obstetrics & Gynecology 2019, 31: 139-147. PMID: 30870184, DOI: 10.1097/gco.0000000000000536.Peer-Reviewed Original ResearchConceptsNormal ovarian reserveOvarian reservePregnancy lossOocyte qualityReproductive technology cyclesAge-matched womenDiminished ovarian reserveLow ovarian reserveFetal chromosomal abnormalitiesQuantitative declineFecundity of womenOvarian stimulationNatural conceptionOvarian agingPoor responseART treatmentAged womenYoung womenChromosomal abnormalitiesAvailable evidenceDecreased numberQualitative declineOocyte poolWomenBlastocyst development
2018
Diminished ovarian reserve and poor response to stimulation in patients <38 years old: a quantitative but not qualitative reduction in performance
Morin SJ, Patounakis G, Juneau CR, Neal SA, Scott RT, Seli E. Diminished ovarian reserve and poor response to stimulation in patients <38 years old: a quantitative but not qualitative reduction in performance. Human Reproduction 2018, 33: 1489-1498. PMID: 30010882, DOI: 10.1093/humrep/dey238.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAneuploidyBlastomeresDatabases, FactualEmbryo Culture TechniquesEmbryo TransferFemaleFertility Agents, FemaleFertilization in VitroHumansInfertility, FemaleLive BirthOvarian ReserveOvaryOvulationOvulation InductionPregnancyPregnancy RateRetrospective StudiesTreatment OutcomeConceptsPoor oocyte qualityOvarian reserveLive birth rateDiminished ovarian reserveOocyte yieldOocyte qualityBlastulation rateAMH levelsPoor respondersPoor responseFollicular depletionBirth rateEmbryo transferAneuploidy rateLower live birth ratesYoung womenSTUDY FUNDING/COMPETINGGood prognosis patientsOvarian reserve parametersOvarian reserve testingYoung poor respondersPoor ovarian responseRetrospective cohort studyLower oocyte yieldInterquartile range
2014
Assisted hatching and intracytoplasmic sperm injection are not associated with improved outcomes in assisted reproduction cycles for diminished ovarian reserve: an analysis of cycles in the United States from 2004 to 2011
Butts SF, Owen C, Mainigi M, Senapati S, Seifer DB, Dokras A. Assisted hatching and intracytoplasmic sperm injection are not associated with improved outcomes in assisted reproduction cycles for diminished ovarian reserve: an analysis of cycles in the United States from 2004 to 2011. Fertility And Sterility 2014, 102: 1041-1047.e1. PMID: 25086790, PMCID: PMC4184996, DOI: 10.1016/j.fertnstert.2014.06.043.Peer-Reviewed Original ResearchMeSH KeywordsChi-Square DistributionEmbryo Culture TechniquesEmbryo TransferFemaleHumansInfertility, FemaleLive BirthLogistic ModelsOdds RatioOvarian ReservePregnancyPregnancy RatePrimary Ovarian InsufficiencyRegistriesRetrospective StudiesRisk FactorsSperm Injections, IntracytoplasmicTime FactorsTreatment OutcomeUnited StatesConceptsDiminished ovarian reserveIntracytoplasmic sperm injectionElevated FSHLive birthsOvarian reserveART cyclesSperm injectionAssisted Reproductive Technology Clinic Outcome Reporting System databaseClinical pregnancy rateRetrospective cohort studyLive birth rateReproductive technology outcomesAssisted reproduction cyclesCombination of ICSIReporting System databaseCohort studyPrimary diagnosisImproved outcomesPregnancy rateMAIN OUTCOMELower oddsDiminished oddsFSHOnly indicationTechnology outcomes
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