2025
Chapter 14 Molecular biology, genetic, and epigenetics of kidney tumor
Kazemi R, Rezaeian A, Deyhimfar R, Taheri D. Chapter 14 Molecular biology, genetic, and epigenetics of kidney tumor. 2025, 209-221. DOI: 10.1016/b978-0-443-27302-5.00003-6.Peer-Reviewed Original ResearchDNA damage repair genesKidney cancer developmentRenal cell carcinomaTumor suppressor genePlanning therapeutic strategiesRenal tumorsUrothelial carcinomaWilms tumorCell carcinomaRenal sarcomaKidney tumorsClinical manifestationsUrological cancersKidney cancerPredisposing genesSuppressor geneTherapeutic strategiesCancer developmentTumorRepair genesCancerCarcinomaKidneyGenetic basisGenetic changesThe evolving understanding of systemic mechanisms in organ-specific IgA nephropathy: a focus on gut-kidney crosstalk
Wang X, Zhou X, Qiao X, Falchi M, Liu J, Zhang H. The evolving understanding of systemic mechanisms in organ-specific IgA nephropathy: a focus on gut-kidney crosstalk. Theranostics 2025, 15: 656-681. PMID: 39744688, PMCID: PMC11671385, DOI: 10.7150/thno.104631.Peer-Reviewed Original ResearchConceptsGut-kidney crosstalkExploration of gut microbiotaGut microbiotaKidney diseaseMechanism of IgANIntestinal microbiomeSignaling pathwayIgA nephropathyInter-organ crosstalkEfficient therapeutic strategiesPrognosis of patientsProgression of IgANElaborate mechanismsTherapeutic strategiesIgAN pathogenesisIgANCrosstalkMicrobiomeMicrobiotaMultiple organsKidneyProbioticsNephropathyDiseaseMechanism
2024
External Validation of an Electronic Health Record-Based Diagnostic Model for Histological Acute Tubulointerstitial Nephritis.
Moledina D, Shelton K, Menez S, Aklilu A, Yamamoto Y, Kadhim B, Shaw M, Kent C, Makhijani A, Hu D, Simonov M, O'Connor K, Bitzel J, Thiessen-Philbrook H, Wilson F, Parikh C. External Validation of an Electronic Health Record-Based Diagnostic Model for Histological Acute Tubulointerstitial Nephritis. Journal Of The American Society Of Nephrology 2024 PMID: 39500309, DOI: 10.1681/asn.0000000556.Peer-Reviewed Original ResearchJohns Hopkins HospitalAcute tubulointerstitial nephritisValidation cohortKidney biopsyTubulointerstitial nephritisDiagnosis of acute tubulointerstitial nephritisProportion of biopsiesElectronic health recordsAnalyzed patientsDevelopment cohortBaseline prevalenceAccurate diagnosisBiopsyCohortHealth recordsClinician's abilityDiagnostic modelPotential predictorsNephritisAssess discriminationKidneyAUCAutosomal Dominant Polycystic Kidney Disease
Suarez M, Titan S, Dahl N. Autosomal Dominant Polycystic Kidney Disease. Advances In Kidney Disease And Health 2024, 31: 496-503. PMID: 39577883, DOI: 10.1053/j.akdh.2024.07.003.Peer-Reviewed Original ResearchConceptsAutosomal dominant polycystic kidney diseaseDelivery of personalized treatmentKidney diseaseKidney failureMinority of patientsDominant polycystic kidney diseaseEnd-stage kidney diseaseRisk of kidney failureCause of end-stage kidney diseasePolycystic kidney diseaseBlood pressure managementMassive hepatomegalySevere complicationsPolycystic liverIntracranial aneurysmsPersonalized treatmentNatural historyOrgan systemsDiseaseTreatmentKidneyPressure managementLiverSystem conditionsPreimplantationPig-to-human kidney xenotransplants using genetically modified minipigs
Wang Y, Chen G, Pan D, Guo H, Jiang H, Wang J, Feng H, He S, Du J, Zhang M, Li T, Wang Y, Yu H, Gan H, Wen Q, Song Z, Li D, Yu Y, Wang H, Li B, You Y, Zhou S, Wang M, Liu L, Xu L, Yang M, Pei H, Zhang K, Chen Z. Pig-to-human kidney xenotransplants using genetically modified minipigs. Cell Reports Medicine 2024, 5: 101744. PMID: 39317190, PMCID: PMC11513830, DOI: 10.1016/j.xcrm.2024.101744.Peer-Reviewed Original ResearchConceptsAntibody-mediated rejectionNatural killer (NK) cellsT cell-mediated rejectionCell-mediated rejectionHuman gene transferKidney function recoveryXenogeneic immune responsesTriple-gene knockoutPig-to-humanAcute rejectionCD40-CD154Pathway blockadeXenograft successMacrophage infiltrationXenograft functionImmunopathological changesKidney xenotransplantationBrain-dead patientsImmune responseDonor pigsFunctional recoveryClinical observationsImmunosuppressionGene transferKidneyThe role of international renal disaster preparedness working groups in difficult settings: bridge over troubled water
Yoo K, Chao C, Lee J, Abu-Alfa A. The role of international renal disaster preparedness working groups in difficult settings: bridge over troubled water. Current Opinion In Nephrology & Hypertension 2024, 33: 636-640. PMID: 39234876, DOI: 10.1097/mnh.0000000000001024.Peer-Reviewed Original ResearchLiver and Kidney Transplantation in Elderly Patients
Guzzi J, Strand E, Ozturk B, Agarkov D, Deshpande R. Liver and Kidney Transplantation in Elderly Patients. Transplantology 2024, 5: 98-109. DOI: 10.3390/transplantology5020010.Peer-Reviewed Original ResearchCalcium signalling and transport in the kidney
Staruschenko A, Alexander R, Caplan M, Ilatovskaya D. Calcium signalling and transport in the kidney. Nature Reviews Nephrology 2024, 20: 541-555. PMID: 38641658, DOI: 10.1038/s41581-024-00835-z.Peer-Reviewed Original ResearchCalcium channelsCalcium levelsCalcium-binding proteinSerum calcium levelsOptimal bone mineralizationPolycystic kidney diseaseIntracellular signaling mechanismsIntracellular second messengersRegulate calcium levelsCalcium handlingSevere complicationsFiltered calciumKidney diseaseCalcium transportRenal cellsCalcium homeostasisCalcium signalingFormation of kidney stonesCalcium dysregulationPhysiological stimuliKidney stonesBone mineralizationKidneySecond messengersSignaling mechanismsThe development of lateral flow devices for urinary biomarkers to assess kidney health
D Souza S, Obeid W, Hernandez J, Hu D, Wen Y, Moledina D, Albert A, Gregg A, Wheeler A, Philbrook H, Parikh C. The development of lateral flow devices for urinary biomarkers to assess kidney health. Scientific Reports 2024, 14: 8516. PMID: 38609491, PMCID: PMC11014899, DOI: 10.1038/s41598-024-59104-5.Peer-Reviewed Original ResearchConceptsLateral flow deviceInterleukin-9Development of lateral flow devicesUrinary biomarkersDetection antibody concentrationSerum creatinine levelsKidney healthPaired antibodiesEnzyme Linked Immunosorbent AssayCreatinine levelsKidney injuryKidney functionOsteopontinImmunosorbent assayAntibody concentrationsMeasured biomarkersKidneyReal-time changesBiomarkersUse of LCP-Tacrolimus (LCPT) in Kidney Transplantation: A Delphi Consensus Survey of Expert Clinicians
Wiseman A, Alhamad T, Alloway R, Concepcion B, Cooper M, Formica R, Klein C, Kumar V, Leca N, Shihab F, Taber D, Mulnick S, Bushnell D, Hadi M, Bunnapradist S. Use of LCP-Tacrolimus (LCPT) in Kidney Transplantation: A Delphi Consensus Survey of Expert Clinicians. Annals Of Transplantation 2024, 29: e943498-1-e943498-13. PMID: 38526543, PMCID: PMC10944009, DOI: 10.12659/aot.943498.Peer-Reviewed Original ResearchConceptsLCP-tacrolimusImmediate-release tacrolimusKidney transplantationFirst-line optionKidney transplant recipientsRandomized clinical trialsDe novo settingTacrolimus formulationReview available dataEvidence-based recommendationsTrough levelsOnce-dailyTransplant recipientsClinical decision-makingOptimal doseClinical trialsExpert cliniciansConsensus statementTransplant expertsStrength of evidenceClinical practiceKidneyTacrolimusDe novoDelphi consensus surveyIntranasal administration of sugarcane ash causes chronic kidney disease in rats
Roncal-Jimenez C, Rogers K, Stem A, Wijkstrom J, Wernerson A, Fox J, Trabanino R, Brindley S, Garcia G, Miyazaki M, Miyazaki-Anzai S, Sasai F, Urra M, Cara-Fuentes G, Sánchez-Lozada L, Rodriguez-Iturbe B, Dawson J, Madero M, Brown J, Johnson R. Intranasal administration of sugarcane ash causes chronic kidney disease in rats. American Journal Of Physiology. Renal Physiology 2024, 326: f477-f484. PMID: 38234297, PMCID: PMC11207544, DOI: 10.1152/ajprenal.00251.2023.Peer-Reviewed Original ResearchChronic kidney diseaseKidney diseaseGroups of ratsSpleen of ratsChronic tubulointerstitial diseaseMild proteinuriaRenal functionTubulointerstitial inflammationIntranasal administrationDecreased stainingInduce CKDSegmental glomerulosclerosisKidney histologyTubulointerstitial diseaseKidney pathologyCollagen depositionRatsKidneyKidney tissueFibrosisWeeksCKDDiseaseInflammationLAMP-1PHENOTYPING REPAIR AFTER ACUTE KIDNEY INJURY: PRECISION MEDICINE TO CLINICAL TRIALS.
Parikh C, Hernandez J. PHENOTYPING REPAIR AFTER ACUTE KIDNEY INJURY: PRECISION MEDICINE TO CLINICAL TRIALS. Transactions Of The American Clinical And Climatological Association 2024, 134: 37-46. PMID: 39135588, PMCID: PMC11316880.Peer-Reviewed Original ResearchConceptsAcute kidney injuryChronic kidney diseaseKidney injuryEpisodes of acute kidney injuryAssociated with long-term riskLong-term risk of readmissionLong-term sequelaeRepair biomarkersRisk of readmissionSubclinical inflammationPreclinical studiesUrine biomarkersResearch biopsiesDeceased donor kidneysClinical trialsKidney diseaseBlood pressureMedical managementDonor kidneysPragmatic clinical trialsKidney tissueTherapeutic developmentOrgan allocationPrecision medicineKidneyFuel oxygenates
Abu-Bakar A, Vasiliou V, Popovic Z, Inayat-Hussain S. Fuel oxygenates. 2024, 859-874. DOI: 10.1016/b978-0-12-824315-2.00736-3.Peer-Reviewed Original ResearchCentral nervous systemChronic progressive nephropathyRat kidney tumorsOccupational health hazardsNon-toxic dosesProgressive nephropathyRisk factorsKidney tumorsInhalation toxicityNervous systemEye irritationWeight gainToxicology studiesReversible effectHealth hazardsRecent seriesHuman odourNephropathyTumorsKidneyRatsDiseaseMiceLiverDoses
2023
Report From a Multidisciplinary Symposium on the Future of Living Kidney Donor Transplantation
Peters T, Fung J, Radcliffe-Richards J, Satel S, Roth A, McCormick F, Gershun M, Matas A, Roberts J, Morrison J, Chertow G, Lee L, Held P, Ojo A. Report From a Multidisciplinary Symposium on the Future of Living Kidney Donor Transplantation. Progress In Transplantation 2023, 33: 363-371. PMID: 37968881, DOI: 10.1177/15269248231212911.Peer-Reviewed Original ResearchConceptsKidney donationDonor kidney exchangeDonor renal transplantationDonor kidney transplantationDeceased donor kidneysKidney donor transplantationLive kidney donationKidney transplantationRenal transplantationDonor transplantationDonor kidneysKidney functionDonor evaluationKidney donorsOptimal treatmentTransplantationPermanent lossMultidisciplinary symposiumDonationKidney exchangeDonorsKidneyCliniciansCompelling stimulusA large-scale retrospective study enabled deep-learning based pathological assessment of frozen procurement kidney biopsies to predict graft loss and guide organ utilization
Yi Z, Xi C, Menon M, Cravedi P, Tedla F, Soto A, Sun Z, Liu K, Zhang J, Wei C, Chen M, Wang W, Veremis B, Garcia-Barros M, Kumar A, Haakinson D, Brody R, Azeloglu E, Gallon L, O'Connell P, Naesens M, Shapiro R, Colvin R, Ward S, Salem F, Zhang W. A large-scale retrospective study enabled deep-learning based pathological assessment of frozen procurement kidney biopsies to predict graft loss and guide organ utilization. Kidney International 2023, 105: 281-292. PMID: 37923131, PMCID: PMC10892475, DOI: 10.1016/j.kint.2023.09.031.Peer-Reviewed Original ResearchArterial intimal fibrosisGraft lossOrgan utilizationIntimal fibrosisSclerotic glomeruliLarge-scale retrospective studyGlomerular filtration rateDeceased donor kidneysPathologist scoresTransplant outcomesBiopsy findingsSurvival prediction modelWedge biopsyRisk stratificationRetrospective studyFiltration ratePathological assessmentDonor biopsiesNeedle biopsySimilar survivalHistological scoringUnnecessary organsDiscovery setKidneyLesion scoresHIV and Associated TB: A Lethal Association for Kidney Health?
Kalyesubula R, Wearne N, Kubo M, Hussey N, Naicker S. HIV and Associated TB: A Lethal Association for Kidney Health? Seminars In Nephrology 2023, 43: 151470. PMID: 38245391, DOI: 10.1016/j.semnephrol.2023.151470.Peer-Reviewed Original ResearchHuman immunodeficiency virusKidney diseaseHIV/TB coinfectionAvoidance of drug-drug interactionsLower-middle-income countriesDrug dose adjustmentDecline of kidney functionKidney function monitoringDrug-drug interactionsMechanisms of kidney diseasesHIV/TB patientsLow-incomeDose adjustmentImmunodeficiency virusClinical presentationDiagnose CKDKidney transplantationKidney functionInfectious causesIncreased riskKidney healthGenetic susceptibilityFunction monitoringPatientsKidneyEvaluation of toxicity profile of kratom (Mitragyna speciosa Korth) decoction in rats
Hassan Z, Singh D, Suhaimi F, Chear N, Harun N, See C, Kaur G, Mat N, Bakar S, Yusof N, Kasinather V, Chawarski M, Murugaiyah V, Ramanathan S. Evaluation of toxicity profile of kratom (Mitragyna speciosa Korth) decoction in rats. Regulatory Toxicology And Pharmacology 2023, 143: 105466. PMID: 37536550, DOI: 10.1016/j.yrtph.2023.105466.Peer-Reviewed Original ResearchConceptsDays of treatmentToxicity profileFemale Sprague-Dawley ratsOpioid replacement therapyLow platelet countEnd of treatmentSprague-Dawley ratsEvidence of toxicityOccurrence of mortalityPlatelet countDawley ratsHematology profileBody weightMitragyna speciosa KorthBrain tissueHistopathology analysisHistological investigationHerbal drug preparationsDecoctionUric acidDrug preparationTherapeutic propertiesKidneyMortalityRatsSGLT2 inhibitors and diuretics in heart failure: clicking reset on the renal volume setpoint?
Borlaug B, Testani J. SGLT2 inhibitors and diuretics in heart failure: clicking reset on the renal volume setpoint? European Heart Journal 2023, 44: 2944-2946. PMID: 37220086, DOI: 10.1093/eurheartj/ehad345.Commentaries, Editorials and Letters63 A Case for Amorphous Silica Nanoparticle Exposure in the Development of Chronic Kidney Disease of Unknown Etiology
Rogers K, Stem A, Roncal C, Johnson R, Brown J. 63 A Case for Amorphous Silica Nanoparticle Exposure in the Development of Chronic Kidney Disease of Unknown Etiology. Annals Of Work Exposures And Health 2023, 67: i54-i55. DOI: 10.1093/annweh/wxac087.132.Peer-Reviewed Original ResearchProximal convoluted tubulesEpithelial-mesenchymal transitionProximal convoluted tubule cellsKidney biopsySilica nanoparticle exposureDisease of unknown etiologyChronic kidney diseaseParticle inductively coupled plasma mass spectrometryEffects of SiNPsUnknown etiologyPCT cellsVimentin stainingKidney diseaseNanoparticle exposureConvoluted tubulesKidney pathologyChronic kidney disease of unknown etiologyCKDu patientsReactive oxygen speciesCellular effectsBiopsyKidneyFocal injuryEtiologyOxygen speciesStrikingly conserved gene expression changes of polyamine regulating enzymes among various forms of acute and chronic kidney injury
Sieckmann T, Schley G, Ögel N, Kelterborn S, Boivin F, Fähling M, Ashraf M, Reichel M, Vigolo E, Hartner A, Lichtenberger F, Breiderhoff T, Knauf F, Rosenberger C, Aigner F, Schmidt-Ott K, Scholz H, Kirschner K. Strikingly conserved gene expression changes of polyamine regulating enzymes among various forms of acute and chronic kidney injury. Kidney International 2023, 104: 90-107. PMID: 37121432, DOI: 10.1016/j.kint.2023.04.005.Peer-Reviewed Original ResearchConceptsIschemia-reperfusion injuryKidney injuryKidney pathologyExperimental kidney injuryChronic kidney injuryUnilateral ureteral obstructionForms of injuryPolyamine synthesisCyclosporine treatmentArterial hypertensionKidney transplantationUreteral obstructionKidney levelsTissue injuryTubular castsHealthy kidneysHomeostasis contributesInjuryKidneyExperimental modelKidney cell linePutrescine contentReduced expressionGene expression changesTransplantation
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