2023
Evaluation of toxicity profile of kratom (Mitragyna speciosa Korth) decoction in rats
Hassan Z, Singh D, Suhaimi F, Chear N, Harun N, See C, Kaur G, Mat N, Bakar S, Yusof N, Kasinather V, Chawarski M, Murugaiyah V, Ramanathan S. Evaluation of toxicity profile of kratom (Mitragyna speciosa Korth) decoction in rats. Regulatory Toxicology And Pharmacology 2023, 143: 105466. PMID: 37536550, DOI: 10.1016/j.yrtph.2023.105466.Peer-Reviewed Original ResearchConceptsDays of treatmentToxicity profileFemale Sprague-Dawley ratsOpioid replacement therapyLow platelet countEnd of treatmentSprague-Dawley ratsEvidence of toxicityOccurrence of mortalityPlatelet countDawley ratsHematology profileBody weightMitragyna speciosa KorthBrain tissueHistopathology analysisHistological investigationHerbal drug preparationsDecoctionUric acidDrug preparationTherapeutic propertiesKidneyMortalityRatsEffects of Ethanolic and Aqueous Extracts of Garcinia gardneriana Leaves in an In Vivo Experimental Model Induced by a Hyperlipidic Diet
do Espirito Santo B, Santana L, Kato W, de Araújo F, Tatara M, Croda J, Bogo D, de Cássia Freitas K, de Cássia Avellaneda Guimarães R, Hiane P, Pott A, de Oliveira Filiú W, de Faria B, de Oliveira Figueiredo P, do Nascimento V, Ayres F, de Oliveira Bastos P. Effects of Ethanolic and Aqueous Extracts of Garcinia gardneriana Leaves in an In Vivo Experimental Model Induced by a Hyperlipidic Diet. Nutrients 2023, 15: 1308. PMID: 36986038, PMCID: PMC10051817, DOI: 10.3390/nu15061308.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDiet, High-FatEthanolFatty LiverGarciniaMicePlant ExtractsPlants, MedicinalWaterConceptsMonocyte chemoattractant protein-1 concentrationsChemoattractant protein-1 concentrationsNon-communicable chronic diseasesExperimental modelProtein-1 concentrationsHigh-fat dietHigh-density lipoproteinPossible metabolic alterationsVivo experimental modelsEffect of ethanolicAqueous extractTotal cholesterolInterleukin-10Microvesicular steatosisHepatic steatosisInsulin resistanceBlood glucoseSwiss miceHyperlipidic dietChronic diseasesDensity lipoproteinMetabolic alterationsControl groupWeight gainEthanolic extract
2022
Safety Considerations for Natural Products Commonly Used By Patients with Allergic Disease
Soffer G, Shroff P, Horwitz R. Safety Considerations for Natural Products Commonly Used By Patients with Allergic Disease. The Journal Of Allergy And Clinical Immunology In Practice 2022, 10: 3131-3138. PMID: 36174919, DOI: 10.1016/j.jaip.2022.09.025.Peer-Reviewed Original ResearchMeSH KeywordsBiological ProductsComplementary TherapiesDietary SupplementsHumansPlants, MedicinalVitaminsConceptsConventional medical therapyHealth care providersMedical therapyAllergic diseasesClinical commentaryAdverse reactionsDrug Administration requirementsCare providersSide effectsAlternative medicinePatientsDietary supplementsU.S. FoodAllergyAdministration requirementsMedicinal plantsNatural productsTherapyCliniciansSafety considerationsDisease
2021
Self-reported medicinal plant use by Ghanaian women during pregnancy is associated with poor neonatal health
Busse C, Wilson M, Bakari A, Moyer C. Self-reported medicinal plant use by Ghanaian women during pregnancy is associated with poor neonatal health. Journal Of Public Health 2021, 44: 319-328. PMID: 33782702, DOI: 10.1093/pubmed/fdab033.Peer-Reviewed Original ResearchMeSH KeywordsBirth WeightCross-Sectional StudiesFemaleGhanaHumansInfantInfant HealthInfant, NewbornPlants, MedicinalPregnancySelf ReportConceptsHerb useGhanaian womenUrban government hospitalNon-usersConditional logistic regressionCross-sectional studyAssociated with poor neonatal outcomesUrban African womenLow Apgar scoreHerb usersSingleton birthsNeonatal healthPoor neonatal outcomeSociodemographic variablesGovernment hospitalsMaternal interviewsBaby's birthweightMother's ageLogistic regressionNeonatal outcomesApgar scorePregnant womenChart reviewNeonatal birthweightWomen
2020
Herbal Medicines in Glaucoma Treatment.
Ige M, Liu J. Herbal Medicines in Glaucoma Treatment. The Yale Journal Of Biology And Medicine 2020, 93: 347-353. PMID: 32607093, PMCID: PMC7309662.Peer-Reviewed Original ResearchMeSH KeywordsBiological ProductsGinkgo bilobaGlaucomaHumansIntraocular PressurePlants, MedicinalTreatment OutcomeVaccinium myrtillusConceptsCourse of glaucomaIntraocular pressureGlaucoma patientsGlaucoma treatmentRetinal ganglion cell deathHerbal medicineMedical marijuanaGanglion cell deathStandard therapeutic agentsSignificant adverse effectsCurrent standardGinkgo bilobaSurgical therapyGlaucoma managementIrreversible blindnessGlaucomaAlternative medicineLarger studyHerbal remediesTherapeutic agentsAddictive potentialAdverse effectsLonger durationPatientsShort duration
2019
In-vitro evaluation of the antibacterial activity of the essential oils of Micromeria barbata, Eucalyptus globulus and Juniperus excelsa against strains of Mycobacterium tuberculosis (including MDR), Mycobacterium kansasii and Mycobacterium gordonae
El Omari K, Hamze M, Alwan S, Osman M, Jama C, Chihib N. In-vitro evaluation of the antibacterial activity of the essential oils of Micromeria barbata, Eucalyptus globulus and Juniperus excelsa against strains of Mycobacterium tuberculosis (including MDR), Mycobacterium kansasii and Mycobacterium gordonae. Journal Of Infection And Public Health 2019, 12: 615-618. PMID: 30738755, DOI: 10.1016/j.jiph.2019.01.058.Peer-Reviewed Original ResearchConceptsAntimycobacterial activityMultidrug-resistant M. tuberculosisDrug-resistant mycobacterial strainsResistant mycobacterial strainsMycobacterium sppHigh antimycobacterial activityAntimycobacterial drugsMycobacterium kansasiiM. tuberculosisMycobacterium tuberculosisLebanese plantsTuberculosisMycobacterium gordonaeMycobacterial growthMycobacterial strainsPublic healthMycobacterium tuberculosis subspM. barbataFirst studyAforementioned essential oilsEssential oilMedicinal plantsSignificant problemAntibacterial activityActivity
2018
The safe use of Doliocarpus dentatus in the gestational period: Absence of changes in maternal reproductive performance, embryo-fetal development and DNA integrity
Ishikawa R, Vani J, das Neves S, Rabacow A, Kassuya C, Croda J, Cardoso C, Monreal A, Antoniolli A, Cunha-Laura A, Oliveira R. The safe use of Doliocarpus dentatus in the gestational period: Absence of changes in maternal reproductive performance, embryo-fetal development and DNA integrity. Journal Of Ethnopharmacology 2018, 217: 1-6. PMID: 29408581, DOI: 10.1016/j.jep.2018.01.034.Peer-Reviewed Original ResearchConceptsFemale Swiss miceDoliocarpus dentatusSwiss miceEmbryofetal developmentGestational periodControl groupPregnant female Swiss miceEnd of pregnancyEmbryo-fetal developmentMaternal reproductive performanceReproductive performanceSafe useEmbryofoetal developmentUrinary retentionOral gavageAbsence of changesDNA integrityAntimycobacterial actionFetal developmentReproductive parametersFormation of micronucleiEthanolic extractPregnancySignificant differencesExperimental group
2016
Potential Use of Flavopiridol in Treatment of Chronic Diseases
Srikumar T, Padmanabhan J. Potential Use of Flavopiridol in Treatment of Chronic Diseases. Advances In Experimental Medicine And Biology 2016, 929: 209-228. PMID: 27771926, DOI: 10.1007/978-3-319-41342-6_9.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnti-Inflammatory AgentsAntineoplastic Agents, PhytogenicAntiviral AgentsApoptosisCardiovascular AgentsCell Cycle CheckpointsCell ProliferationChronic DiseaseDisease Models, AnimalDrug DiscoveryFlavonoidsHumansMolecular StructurePhytotherapyPiperidinesPlants, MedicinalSignal TransductionConceptsChronic diseasesElicit anti-inflammatory activityAberrant cell cycle activationNFκB-dependent signalingEffect of flavopiridolAnti-inflammatory activityArrests cell cycle progressionCell cycle activationInflammatory stimuliAnti-apoptotic genesAnti-proliferative activityCell cycle progressionDiseaseInhibits expressionCycle activationFlavopiridolCycle progressionCDK inhibitorsPotential useGrowth-arrested cellsRecent studiesRNA polymerase II activationTreatmentP-TEFb complexActivationAnti-inflammatory, antioxidant and anti-Mycobacterium tuberculosis activity of viridiflorol: The major constituent of Allophylus edulis (A. St.-Hil., A. Juss. & Cambess.) Radlk.
Trevizan L, do Nascimento K, Santos J, Kassuya C, Cardoso C, do Carmo Vieira M, Moreira F, Croda J, Formagio A. Anti-inflammatory, antioxidant and anti-Mycobacterium tuberculosis activity of viridiflorol: The major constituent of Allophylus edulis (A. St.-Hil., A. Juss. & Cambess.) Radlk. Journal Of Ethnopharmacology 2016, 192: 510-515. PMID: 27612433, DOI: 10.1016/j.jep.2016.08.053.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnti-Inflammatory AgentsAntioxidantsAntitubercular AgentsBenzothiazolesBiphenyl CompoundsCarrageenanChemotaxis, LeukocyteDexamethasoneDisease Models, AnimalDose-Response Relationship, DrugEdemaFemaleGas Chromatography-Mass SpectrometryMaleMiceMycobacterium tuberculosisOils, VolatilePhytotherapyPicratesPlant ExtractsPlant LeavesPlant OilsPlants, MedicinalPleurisySapindaceaeSulfonic AcidsTerpenesTime FactorsConceptsNatural anti-inflammatory agentAnti-inflammatory agentsSubcutaneous injectionOral administrationAnti-Mycobacterium tuberculosis activityAnti-mycobacterial activityAntioxidant activityTotal leucocytesEOAETuberculosis activityMycobacterium tuberculosisGas chromatography-mass spectrometrySignificant inhibitionMiceTraditional medicineEdemaPleurisyPositive controlReference standardDexamethasoneCarrageenanAdministrationModerate antioxidant activityInjectionMajor constituentsEvaluation of the Antiplasmodial Activity and Lethality of the Leaf Extract of <I>Cassia alata</I> L. (Fabaceae)
Da O, Yerbanga R, Traore/Coulibaly M, Koama B, Kabre Z, Tamboura S, Dakuyo Z, Sekhoacha M, Matsabisa M, Nikiema J, Ouedraogo J, Ouedraogo G. Evaluation of the Antiplasmodial Activity and Lethality of the Leaf Extract of Cassia alata L. (Fabaceae). Pakistan Journal Of Biological Sciences 2016, 19: 171-178. PMID: 29022993, DOI: 10.3923/pjbs.2016.171.178.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntimalarialsCassiaDisease Models, AnimalFemaleL-Lactate DehydrogenaseLethal Dose 50Malaria, FalciparumMaleMaximum Tolerated DoseMethanolMethylene ChlorideMiceParasitic Sensitivity TestsPhytotherapyPlant ExtractsPlant LeavesPlants, MedicinalPlasmodium falciparumProtozoan ProteinsSolventsConceptsVivo antiplasmodial activityBody weightAntiplasmodial activityPlasmodium falciparumMean percent suppressionDay suppressive testChloroquine-sensitive strainNon-lethal doseParasite lactate dehydrogenase assayAnimal body weightMaximum non-lethal doseMethanol leaf extractSuppressive testSignificant changesLactate dehydrogenase assayOral routePercent suppressionHematological parametersHigh dosesHaematological parametersPlasmodium bergheiMiceAntimalarial potentialLeaf extractCassia alataAntibacterial Flavonoids from Medicinal Plants Covalently Inactivate Type III Protein Secretion Substrates
Tsou LK, Lara-Tejero M, RoseFigura J, Zhang ZJ, Wang YC, Yount JS, Lefebre M, Dossa PD, Kato J, Guan F, Lam W, Cheng YC, Galán J, Hang HC. Antibacterial Flavonoids from Medicinal Plants Covalently Inactivate Type III Protein Secretion Substrates. Journal Of The American Chemical Society 2016, 138: 2209-2218. PMID: 26847396, PMCID: PMC4831573, DOI: 10.1021/jacs.5b11575.Peer-Reviewed Original ResearchConceptsVirulence pathwaysType III protein secretionType III secretion system effectorsSpecific plant metabolitesSPI-1 T3SSSecretion system effectorsS. typhimurium invasionSalmonella enterica serovar TyphimuriumSecretion substratesEnterica serovar TyphimuriumTraditional Chinese medicineUnappreciated mechanismPlant metabolitesTyphimurium invasionProtein secretionSerovar TyphimuriumAntibacterial flavonoidsBacterial invasionEpithelial cellsSpecific flavonoidsBacterial growthMedicinal plantsPathwayPotential mechanismsInvasion
2007
In vitro and in vivo antiplasmodial activity of ‘Saye’, an herbal Remedy used in Burkina Faso traditional medicine
Traoré M, Diallo A, Nikièma J, Tinto H, Dakuyo Z, Ouédraogo J, Guissou I, Guiguemdé T. In vitro and in vivo antiplasmodial activity of ‘Saye’, an herbal Remedy used in Burkina Faso traditional medicine. Phytotherapy Research 2007, 22: 550-551. PMID: 17926335, DOI: 10.1002/ptr.2308.Peer-Reviewed Original ResearchCombined effect of total alkaloids from Feculae Bombycis and natural flavonoids on diabetes
Geng P, Yang Y, Gao Z, Yu Y, Shi Q, Bai G. Combined effect of total alkaloids from Feculae Bombycis and natural flavonoids on diabetes. Journal Of Pharmacy And Pharmacology 2007, 59: 1145-1150. PMID: 17725858, DOI: 10.1211/jpp.59.8.0013.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, OralAlkaloidsAnimalsBlood GlucoseBombyxCholesterolDiabetes Mellitus, ExperimentalDrug SynergismDrug Therapy, CombinationFemaleFlavonoidsGlycoside Hydrolase InhibitorsIntestinal MucosaMaleMedicine, Chinese TraditionalMicePlant ExtractsPlants, MedicinalPostprandial PeriodRatsRats, WistarStarchConceptsInhibiting alpha-glucosidase activityAlpha-glucosidase activityDiabetic mice in vivoMice in vivoBlood glucoseStarch hydrolysateFlavonoidsFasting blood total cholesterolGlucose levelsIn vivoIndividual ingredientsBlood total cholesterolFasting blood glucoseDepressed blood glucose levelsNatural flavonoidPostprandial elevationBlood glucose levelsModel in vitroTherapy of diabetesTAFBShort-term studiesTotal cholesterolOral administrationBombycisBlood
2006
Reassignment of the Configuration of Salvianolic Acid B and Establishment of Its Identity with Lithospermic Acid B
Watzke A, O'Malley SJ, Bergman RG, Ellman JA. Reassignment of the Configuration of Salvianolic Acid B and Establishment of Its Identity with Lithospermic Acid B. Journal Of Natural Products 2006, 69: 1231-1233. PMID: 16933885, DOI: 10.1021/np060136w.Peer-Reviewed Original Research
2001
The Natural History of Periodontal Disease in Man. Risk Factors for Progression of Attachment Loss in Individuals Receiving No Oral Health Care
Neely A, Holford T, Löe H, Ånerud Å, Boysen H. The Natural History of Periodontal Disease in Man. Risk Factors for Progression of Attachment Loss in Individuals Receiving No Oral Health Care. The Journal Of Periodontology 2001, 72: 1006-1015. PMID: 11525431, DOI: 10.1902/jop.2001.72.8.1006.Peer-Reviewed Original ResearchConceptsHistory of smokingAttachment lossPeriodontal attachment lossGingival indexCalculus indexPlaque indexRisk factorsPeriodontal diseaseNatural historyMean attachment lossOral health assessmentProfessional dental careOral health careFinal adjusted modelPotential risk factorsMesio-buccal surfaceThird molar teethBetel nut useAbsence of teethCaries indexDental careAttachment levelAdjusted modelNut useMolar teethThe anti-inflammatory natural product parthenolide from the medicinal herb Feverfew directly binds to and inhibits IκB kinase
Kwok B, Koh B, Ndubuisi M, Elofsson M, Crews C. The anti-inflammatory natural product parthenolide from the medicinal herb Feverfew directly binds to and inhibits IκB kinase. Cell Chemical Biology 2001, 8: 759-766. PMID: 11514225, DOI: 10.1016/s1074-5521(01)00049-7.Peer-Reviewed Original ResearchConceptsAnti-inflammatory activityHerb feverfewPro-inflammatory signaling pathwaysDirect molecular targetVivo anti-inflammatory activityAnti-inflammatory propertiesAnti-inflammatory agentsCytokine-mediated stimulationCytokine-mediated signalingIkappaB kinase betaSesquiterpene lactone parthenolidePharmaceutical interventionsIκB kinaseMolecular targetsNatural product parthenolideKinase betaParthenolideCysteine 179Signaling pathwaysPossible molecular basisIntracellular signaling processesAttractive targetIKK complexMolecular mechanismsAlpha-methylene gamma-lactone moiety
1998
Molecular Evolution of Genes Controlling Petal and Stamen Development: Duplication and Divergence Within the APETALA3 and PISTILLATA MADS-Box Gene Lineages
Kramer E, Dorit R, Irish V. Molecular Evolution of Genes Controlling Petal and Stamen Development: Duplication and Divergence Within the APETALA3 and PISTILLATA MADS-Box Gene Lineages. Genetics 1998, 149: 765-783. PMID: 9611190, PMCID: PMC1460198, DOI: 10.1093/genetics/149.2.765.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceArabidopsis ProteinsEvolution, MolecularGenes, PlantHomeodomain ProteinsMADS Domain ProteinsMolecular Sequence DataMultigene FamilyPapaverPhylogenyPlant ProteinsPlant StructuresPlants, MedicinalSequence AlignmentSequence Analysis, DNASequence Homology, Amino AcidSolanum lycopersicumTranscription FactorsConceptsDuplication eventsGene lineagesLower eudicotHigher eudicotsPI genesMADS-box gene familyMajor duplication eventsFloral organ identityMultiple duplication eventsAP3 lineageStamen identityOrgan identityEudicot lineagesHomeotic genesDicot speciesMolecular evolutionStamen developmentGene familyAPETALA3Such genesEudicotsPistillataLineagesGenesSimilar functions
1990
Thapsigargin, but not caffeine, blocks the ability of thyrotropin-releasing hormone to release Ca2+ from an intracellular store in GH4C1 pituitary cells
Law G, Pachter J, Thastrup O, Hanley M, Dannies P. Thapsigargin, but not caffeine, blocks the ability of thyrotropin-releasing hormone to release Ca2+ from an intracellular store in GH4C1 pituitary cells. Biochemical Journal 1990, 267: 359-364. PMID: 1692207, PMCID: PMC1131296, DOI: 10.1042/bj2670359.Peer-Reviewed Original ResearchMeSH Keywords3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl esterAnimalsCaffeineCalciumCell LineInositol PhosphatesKineticsNimodipinePituitary NeoplasmsPlants, MedicinalProlactinTerpenesThapsigarginThyrotropin-Releasing HormoneTumor Cells, CulturedConceptsThyrotropin-releasing hormoneGH4C1 pituitary cellsPituitary cellsIntracellular storesGH4C1 cellsAbility of TRHBay K 8644Cytosolic free Ca2Action of thapsigarginInsP3-sensitive storesSustained elevationChannel blockersReceptor levelsTRH stimulationExtracellular Ca2Intracellular Ca2Transient increaseFree Ca2ThapsigarginSubsequent spikesHormoneCell typesCa2CellsEfflux
1982
Organization and nucleotide sequence of nuclear 5S rRNA genes in yellow lupin ( Lupinus lutens )
Rafalski J, Wiewiorowski M, SÖll D. Organization and nucleotide sequence of nuclear 5S rRNA genes in yellow lupin ( Lupinus lutens ). Nucleic Acids Research 1982, 10: 7635-7642. PMID: 7155897, PMCID: PMC327035, DOI: 10.1093/nar/10.23.7635.Peer-Reviewed Original Research
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply