2024
Contemporary management of aneurysmal subarachnoid haemorrhage. An update for the intensivist
Robba C, Busl K, Claassen J, Diringer M, Helbok R, Park S, Rabinstein A, Treggiari M, Vergouwen M, Citerio G. Contemporary management of aneurysmal subarachnoid haemorrhage. An update for the intensivist. Intensive Care Medicine 2024, 50: 646-664. PMID: 38598130, PMCID: PMC11078858, DOI: 10.1007/s00134-024-07387-7.Peer-Reviewed Original ResearchConceptsIntensive care unitAneurysmal subarachnoid haemorrhageRuptured aneurysmsLong-term prognostic factorsRisk of rebleedingIntensive care unit managementRobust clinical evidenceDelayed cerebral ischaemiaExpert clinical experienceSecondary brain damageDeterminants of functional outcomePrognostic factorsASAH patientsPrompt diagnosisHaemodynamic monitoringClinical evidenceMorbidity rateSpecialized centersTreatment strategiesClinical trialsContemporary guidelinesPatient populationFunctional outcomesCare unitCerebral ischaemia
2023
Maternal and Pregnancy Outcomes Following Heart Transplantation in the United States
Craig A, Campbell A, Snow S, Spates T, Goldstein S, Denoble A, Meng M, Schroder J, Flores K, Agarwal R, Ward C, Federspiel J. Maternal and Pregnancy Outcomes Following Heart Transplantation in the United States. JACC Heart Failure 2023, 11: 1666-1674. PMID: 37804312, PMCID: PMC10841668, DOI: 10.1016/j.jchf.2023.08.018.Peer-Reviewed Original ResearchNontransfusion severe maternal morbiditySevere maternal morbidityHT recipientsHeart transplantationPreterm birthDelivery hospitalizationsGreater oddsPregnancy outcomesRate of SMMNationwide Readmissions DatabaseOutcome of pregnancyHigher readmission ratesProportional hazards regressionHigh morbidity rateMaternal morbidityReadmission ratesHospital readmissionAdjusted analysisComorbid conditionsClinical comorbiditiesHazards regressionMorbidity rateHigh riskHT historyDays postpartum
2022
Early Reexploration for Bleeding Is Associated With Improved Outcome in Cardiac Surgery
Shou BL, Aravind P, Ong CS, Alejo D, Canner JK, Etchill EW, DiNatale J, Prokupets R, Esfandiary T, Lawton JS, Schena S. Early Reexploration for Bleeding Is Associated With Improved Outcome in Cardiac Surgery. The Annals Of Thoracic Surgery 2022, 115: 232-239. PMID: 35952856, DOI: 10.1016/j.athoracsur.2022.07.037.Peer-Reviewed Original ResearchConceptsCardiac surgeryActive bleedingAdult cardiac surgery patientsSingle-institution retrospective reviewMultivariable logistic regression modelCardiac surgery patientsEarly surgical interventionRisk-adjusted analysisLogistic regression modelsEarly reexplorationEligible patientsPostoperative bleedingNonoperative managementSurgery patientsRetrospective reviewUnivariable analysisMorbidity rateSurgical interventionCommon siteMediastinal structuresReexplorationKruskal-Wallis testMortality rateBleedingPatient harm
2021
Thymomectomy plus total thymectomy versus simple thymomectomy for early-stage thymoma without myasthenia gravis: a European Society of Thoracic Surgeons Thymic Working Group Study
Guerrera F, Falcoz PE, Moser B, van Raemdonck D, Bille’ A, Toker A, Spaggiari L, Ampollini L, Filippini C, Thomas PA, Verdonck B, Mendogni P, Aigner C, Voltolini L, Novoa N, Patella M, Mantovani S, Bravio IG, Zisis C, Guirao A, Londero F, Congregado M, Rocco G, Du Pont B, Martucci N, Esch M, Brunelli A, Detterbeck FC, Venuta F, Weder W, Ruffini E, Centers T, Klepetko W, Olland A, Du Pont B, Nonaka D, Ozkan B, Iacono G, Braggio C, Filosso P, Brioude G, van Schil P, Nosotti M, Valdivia D, Bongiolatti S, Inci I, Dimitra R, Sànchez D, Grossi W, Moreno-Merino S, Teschner M. Thymomectomy plus total thymectomy versus simple thymomectomy for early-stage thymoma without myasthenia gravis: a European Society of Thoracic Surgeons Thymic Working Group Study. European Journal Of Cardio-Thoracic Surgery 2021, 60: 881-887. PMID: 34023891, PMCID: PMC10060729, DOI: 10.1093/ejcts/ezab224.Peer-Reviewed Original ResearchConceptsEarly-stage thymomaMyasthenia gravisTT groupST groupPropensity score-adjusted comparisonsNon-MG patientsPathological stage IPostoperative morbidity rateEuropean SocietyRate of complicationsCompleteness of resectionOverall survival rateLong-term outcomesProcedure of choiceMost relevant articlesOncological standpointCurative intentPostoperative complicationsPostoperative lengthTotal thymectomyOverall recurrenceThymic tumorsMorbidity rateSurgical approachThymus gland
2020
Intracellular Staphylococcus aureus in bone and joint infections: A mechanism of disease recurrence, inflammation, and bone and cartilage destruction
Alder KD, Lee I, Munger AM, Kwon HK, Morris MT, Cahill SV, Back J, Yu KE, Lee FY. Intracellular Staphylococcus aureus in bone and joint infections: A mechanism of disease recurrence, inflammation, and bone and cartilage destruction. Bone 2020, 141: 115568. PMID: 32745687, DOI: 10.1016/j.bone.2020.115568.Peer-Reviewed Original ResearchConceptsArticular cartilage lossJoint infectionCartilage lossStaphylococcus aureusIntracellular Staphylococcus aureusPotential combination therapyFurther studiesPotential treatment solutionAntibiotic therapyDisease recurrenceProinflammatory stateCartilage destructionMorbidity rateCombination therapyDismal outcomeMassive boneConsequence of boneHigh mortalityMedical interventionsInfectionIntracellular infectionMusculoskeletal systemDevastating afflictionFundamental cellular componentsBoneCoronary Disease in Pregnancy: Myocardial Infarction and Spontaneous Coronary Artery Dissection
Campbell KH, Tweet MS. Coronary Disease in Pregnancy: Myocardial Infarction and Spontaneous Coronary Artery Dissection. Clinical Obstetrics & Gynecology 2020, 63: 852-867. PMID: 32701519, PMCID: PMC10767871, DOI: 10.1097/grf.0000000000000558.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionSpontaneous coronary artery dissectionCoronary artery dissectionArtery dissectionMyocardial infarctionPregnancy-associated acute myocardial infarctionPregnancy-related maternal mortalityManagement of AMIMaternal cardiac deathsCoronary vasospasmNonatherosclerotic etiologyMaternal outcomesCardiac deathCoronary diseaseMultidisciplinary carePregnancy resultsMorbidity rateCoronary arteryMaternal mortalityGlobal improvementSubstantial proportionInfarctionPregnancyEtiologyPhysiological changes
2019
Severe maternal morbidity during delivery hospitalisation in a large international administrative database, 2008–2013: a retrospective cohort
Lipkind H, Zuckerwise L, Turner E, Collins J, Campbell K, Reddy U, Illuzi J, Merriam A. Severe maternal morbidity during delivery hospitalisation in a large international administrative database, 2008–2013: a retrospective cohort. BJOG An International Journal Of Obstetrics & Gynaecology 2019, 126: 1223-1230. PMID: 31100201, DOI: 10.1111/1471-0528.15818.Peer-Reviewed Original ResearchMeSH KeywordsAdultAustraliaCenters for Disease Control and Prevention, U.S.ComorbidityDatabases, FactualEnglandFemaleHospitalizationHumansMaternal AgeMaternal DeathMiddle AgedObstetric Labor ComplicationsPregnancyPregnancy ComplicationsPregnancy OutcomeRetrospective StudiesRisk FactorsUnited StatesYoung AdultConceptsSevere maternal morbidityMaternal morbidityDelivery hospitalisationRetrospective cohortRisk factorsSevere maternal morbidity ratesMaternal morbidity ratesAcute renal failureLife-threatening diagnosisAdvanced maternal ageLife-saving procedureLarge university hospitalChi-square testMorbidity variesPregnancy complicationsClinical characteristicsIntravascular coagulationRenal failureSevere morbidityMultivariable analysisMorbidity rateAdverse outcomesClinical differencesMaternal ageUniversity HospitalPediatric thymectomy: a study of national trends in demographics, short-term outcomes, and cost
Catalano MA, Mullan CW, Rich BS, Glick RD. Pediatric thymectomy: a study of national trends in demographics, short-term outcomes, and cost. Pediatric Surgery International 2019, 35: 749-757. PMID: 31119357, DOI: 10.1007/s00383-019-04486-1.Peer-Reviewed Original ResearchConceptsShort-term outcomesMyasthenia gravisRetrospective cross-sectional analysisOverall morbidity rateShorter hospital staySingle-institution cohortHospital discharge recordsLength of stayCross-sectional analysisMethodsThe KidsHospital deathHospital stayRespiratory complicationsPatient characteristicsCommon indicationLow morbidityPediatric patientsPediatric populationThymic neoplasmsHispanic raceInpatient DatabaseMorbidity rateMore complicationsSurgical approachRisk factors
2018
Optimal maternal and neonatal outcomes and associated hospital characteristics
Campbell KH, Illuzzi JL, Lee HC, Lin H, Lipkind HS, Lundsberg LS, Pettker CM, Xu X. Optimal maternal and neonatal outcomes and associated hospital characteristics. Birth 2018, 46: 289-299. PMID: 30251270, DOI: 10.1111/birt.12400.Peer-Reviewed Original ResearchMeSH KeywordsAdultBirth CertificatesCaliforniaCesarean SectionFemaleGestational AgeHospitalsHumansInfant, NewbornInfant, Newborn, DiseasesMorbidityObstetric Labor ComplicationsObstetricsPatient DischargePoisson DistributionPregnancyQuality Indicators, Health CareRegression AnalysisRisk FactorsYoung AdultConceptsRisk-standardized ratesMorbidity rateNeonatal outcomesObstetrical performancePatient clinical risk factorsFuture quality improvement effortsMaternal morbidity ratesNeonatal morbidity ratesProcedures/surgeriesSevere newborn morbiditySevere maternal morbidityClinical risk factorsShock/resuscitationHospital discharge recordsMaternal-newborn outcomesQuality improvement effortsPrevalent morbidityMaternal morbidityNeonatal morbidityRespiratory complicationsIntravascular coagulationNewborn morbidityHeart failureTerm birthsHospital variationMaternal Obstetric Complication Rates Remain High in Illinois: A Retrospective Study, 2010–2015
Roy A, Peaceman A, Son M, Feinglass J. Maternal Obstetric Complication Rates Remain High in Illinois: A Retrospective Study, 2010–2015. The Joint Commission Journal On Quality And Patient Safety 2018, 45: 24-30. PMID: 30121161, DOI: 10.1016/j.jcjq.2018.02.007.Peer-Reviewed Original ResearchConceptsSevere maternal morbidityMaternal morbidityMaternal complicationsCesarean deliveryDelivery complicationsComplication rateSevere maternal morbidity ratesStudy periodMaternal complication ratesMaternal morbidity ratesMaternal obstetric complicationsObstetric complication ratesObstetrics residency programsRetrospective cohort studyNinth Revision codesObstetric complicationsClinical characteristicsCohort studyPatient characteristicsChildbirth outcomesMorbidity ratePreventable complicationsRevision codesIllinois HospitalMorbidityCardiac Progenitor Cells in Basic Biology and Regenerative Medicine
Witman N, Sahara M. Cardiac Progenitor Cells in Basic Biology and Regenerative Medicine. Stem Cells International 2018, 2018: 8283648. PMID: 29535783, PMCID: PMC5832196, DOI: 10.1155/2018/8283648.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsStem cell therapyMyocardial infarctionCardiac progenitor cellsCell therapyMajor cardiovascular eventsProgenitor cellsPreclinical animal modelsCardiovascular stem cell therapyStem cell-based approachesCardiovascular eventsStem/progenitor cell biologyDevice therapyVentricular functionMorbidity rateClinical trialsHeart diseaseProgenitor cell biologyMortality ratePharmacological agentsAnimal modelsPatient careCell-based approachesPhase ITherapyCardiac tissueNovel and preclinical treatment strategies in pneumococcal meningitis
Bewersdorf J, Grandgirard D, Koedel U, Leib S. Novel and preclinical treatment strategies in pneumococcal meningitis. Current Opinion In Infectious Diseases 2018, 31: 85-92. PMID: 29095719, DOI: 10.1097/qco.0000000000000416.Peer-Reviewed Original ResearchConceptsAdjuvant therapyPneumococcal meningitisNew adjuvant therapiesSystematic clinical testingProtein-based pneumococcal vaccinesPreclinical treatment strategiesPneumococcal conjugate vaccineAnti-inflammatory therapyImprove disease outcomesToxic bacterial productsMatrix metalloproteinase inhibitorsNonbacteriolytic antibioticsAdjuvant dexamethasoneLife-threatening diseaseMeningeal inflammationBacterial meningitisSerotype replacementTreatment optionsConjugate vaccinePneumococcal vaccineMorbidity rateComplement inhibitorsTreatment strategiesSuppress inflammationMeningitis
2017
Effect of Longer-Interval vs Standard Dosing of Zoledronic Acid on Skeletal Events in Patients With Bone Metastases: A Randomized Clinical Trial
Himelstein AL, Foster JC, Khatcheressian JL, Roberts JD, Seisler DK, Novotny PJ, Qin R, Go RS, Grubbs SS, O’Connor T, Velasco MR, Weckstein D, O’Mara A, Loprinzi CL, Shapiro CL. Effect of Longer-Interval vs Standard Dosing of Zoledronic Acid on Skeletal Events in Patients With Bone Metastases: A Randomized Clinical Trial. JAMA 2017, 317: 48-58. PMID: 28030702, PMCID: PMC5321662, DOI: 10.1001/jama.2016.19425.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBone and BonesBone Density Conservation AgentsBone NeoplasmsBreast NeoplasmsDiphosphonatesDrug Administration ScheduleFemaleHumansImidazolesMaleMiddle AgedMultiple MyelomaPain MeasurementProstatic NeoplasmsSample SizeSpinal Cord CompressionSpinal FracturesZoledronic AcidConceptsSkeletal morbidity rateProportion of patientsDosing groupZoledronic acidBone metastasesMultiple myelomaProstate cancerBreast cancerSkeletal eventsKidney dysfunctionBone turnoverMorbidity rateClinical trialsEastern Cooperative Oncology Group performance statusOpen-label clinical trialEnd pointIncidence of osteonecrosisYear of randomizationPerformance status scorePrimary end pointSecondary end pointsBrief Pain InventoryMetastatic breast cancerMetastatic prostate cancerAcceptable treatment option
2016
The Impact of Different Surgical Techniques on Outcomes in Laparoscopic Sleeve Gastrectomies
Berger ER, Clements RH, Morton JM, Huffman KM, Wolfe BM, Nguyen NT, Ko CY, Hutter MM. The Impact of Different Surgical Techniques on Outcomes in Laparoscopic Sleeve Gastrectomies. Annals Of Surgery 2016, 264: 464-473. PMID: 27433904, DOI: 10.1097/sla.0000000000001851.Peer-Reviewed Original ResearchConceptsLaparoscopic sleeve gastrectomyStaple line reinforcementBougie sizeSurgical techniqueSleeve gastrectomyWeight lossSurgeon levelMBSAQIP data registryLow morbidity rateGood surgical techniqueDifferent surgical techniquesPercent of surgeonsLeak rateLogistical regression modelLSG operationsMorbidity rateClinical effectivenessSafe procedurePatient levelStaple lineHigher leak rateData registryLine reinforcementSurgeonsGastrectomy
2013
Outcomes and Costs Associated With Robotic Colectomy in the Minimally Invasive Era
Tyler JA, Fox JP, Desai MM, Perry WB, Glasgow SC. Outcomes and Costs Associated With Robotic Colectomy in the Minimally Invasive Era. Diseases Of The Colon & Rectum 2013, 56: 458-466. PMID: 23478613, DOI: 10.1097/dcr.0b013e31827085ec.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAnastomosis, SurgicalColectomyCosts and Cost AnalysisEnterostomyFemaleHospital CostsHumansIleusIntestinal FistulaIntraoperative ComplicationsLaparoscopyLength of StayMaleMiddle AgedPneumoniaPostoperative ComplicationsRetrospective StudiesRoboticsVenous ThromboembolismYoung AdultConceptsRobotic-assisted colectomyLength of stayHospital outcomesLaparoscopic colectomyOverall postoperative morbidity ratePostoperative morbidity rateLow-volume centersNationwide Inpatient SampleCost of careRobotic-assisted surgeryPotential miscodingOverall morbidityPostoperative complicationsAdult patientsIndividual complicationsLaparoscopic approachPatient characteristicsColon surgeryRetrospective reviewMorbidity rateRobotic colectomyInvasive eraInpatient SampleLaparoscopic proceduresBaseline differences
2012
Hospital-Level Outcomes Associated with Laparoscopic Colectomy for Cancer in the Minimally Invasive Era
Fox JP, Desai MM, Krumholz HM, Gross CP. Hospital-Level Outcomes Associated with Laparoscopic Colectomy for Cancer in the Minimally Invasive Era. Journal Of Gastrointestinal Surgery 2012, 16: 2112-2119. PMID: 22948842, PMCID: PMC3670114, DOI: 10.1007/s11605-012-2018-z.Peer-Reviewed Original ResearchConceptsLaparoscopy rateLaparoscopic colectomyShorter hospitalizationColon resectionHospital mortalityPostoperative morbidityLow postoperative morbidity rateHigher laparoscopy ratePostoperative morbidity rateRisk-standardized outcomesLow postoperative morbidityShorter hospital stayNationwide Inpatient SampleShort-term outcomesHigher procedure volumeHospital stayComparable morbidityRandomized trialsMorbidity rateInvasive eraInpatient SampleOutcomes AssociatedColectomyMortality rateProcedure volumeMouse Transient Global Ischemia Two-Vessel Occlusion Model.
Pontarelli F, Ofengeim D, Zukin RS, Jonas EA. Mouse Transient Global Ischemia Two-Vessel Occlusion Model. Bio-protocol 2012, 2 PMID: 27446974, PMCID: PMC4950949, DOI: 10.21769/bioprotoc.262.Peer-Reviewed Original ResearchMitochondrial channel activityTransient global ischemiaTwo-vessel occlusion modelBcl-2 family proteinsGlobal ischemiaOcclusion modelChannel activityCaspase-resistant formFamily proteinsFour-vessel occlusion modelCaspase activationHuman cardiac arrestNeocortical layers IIHippocampal CA1 neuronsHigh morbidity rateTransgenic animalsBcl-xLRegional strokeHilar neuronsAspiny neuronsFocal ischemiaMorbidity ratePyramidal neuronsCA1 neuronsCardiac arrest
2008
In hospital outcomes after pancreatectomies: An analysis of a national database from 1996 to 2004
Turaga K, Kaushik M, Forse R, Sasson A. In hospital outcomes after pancreatectomies: An analysis of a national database from 1996 to 2004. Journal Of Surgical Oncology 2008, 98: 156-160. PMID: 18618606, DOI: 10.1002/jso.21099.Peer-Reviewed Original ResearchConceptsNational Hospital Discharge SurveyLarge hospitalsPulmonary edemaNational mortality ratesPost-operative pulmonary edemaRisk factors associated with mortalityAbsence of pulmonary edemaFactors associated with mortalityHospital Discharge SurveyNational complication ratesAssociated with high mortalityShorter hospital stayNational mortalityShorter hospital lengthLarger hospital sizeLength of stayHospital sizeDischarge SurveyHospital outcomesComplication rateHospital stayMorbidity rateNational databaseHospital lengthPancreatectomy
2004
Endoscopic balloon dilation compared with sphincterotomy for extraction of bile duct stones
DiSario JA, Freeman ML, Bjorkman DJ, MacMathuna P, Petersen BT, Jaffe PE, Morales TG, Hixson LJ, Sherman S, Lehman GA, Jamal MM, Al-Kawas FH, Khandelwal M, Moore JP, Derfus GA, Jamidar PA, Ramirez FC, Ryan ME, Woods KL, Carr-Locke DL, Alder SC. Endoscopic balloon dilation compared with sphincterotomy for extraction of bile duct stones. Gastroenterology 2004, 127: 1291-1299. PMID: 15520997, DOI: 10.1053/j.gastro.2004.07.017.Peer-Reviewed Original ResearchConceptsEndoscopic balloon dilationSphincter of OddiBile duct stonesBalloon dilationStone extractionDuct stonesShort-term morbidity rateFirst interim analysisShort-term outcomesEndoscopic retrograde cholangiopancreatographyBiliary stone extractionSphincterotomy patientsLonger hospitalOverall morbiditySevere morbidityMorbidity rateMulticenter studyRetrograde cholangiopancreatographyDuct fistulaSphincterotomyInterim analysisInvasive proceduresPatientsRoutine practiceNormal activity
2000
Gender does not impact infrainguinal vein bypass graft outcome
Frangos S, Karimi S, Kerstein M, Harpavat M, Sumpio B, Roberts A, Gahtan V. Gender does not impact infrainguinal vein bypass graft outcome. Surgery 2000, 127: 679-686. PMID: 10840364, DOI: 10.1067/msy.2000.105859.Peer-Reviewed Original ResearchConceptsGraft patencySurvival rateMultivariate analysisInfrainguinal vein bypass graftsCox proportional hazards modelInfrainguinal occlusive diseaseLimb salvage rateVein bypass graftsBypass graft operationsProportional hazards modelLife-table analysisInfrainguinal vein bypassPercentage of womenMajor amputationGraft outcomePostoperative complicationsIncisional complicationsOcclusive diseasePostoperative outcomesLimb salvageRenal diseaseBypass graftPatient selectionVein graftsMorbidity rate
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