2024
Simple versus radical cholecystectomy and survival for pathologic stage T1B gallbladder cancer
Rhodin K, Goins S, Kramer R, Eckhoff A, Herbert G, Shah K, Allen P, Nussbaum D, Blazer D, Zani S, Lidsky M. Simple versus radical cholecystectomy and survival for pathologic stage T1B gallbladder cancer. Hepato Pancreato Biliary 2024, 26: 594-602. PMID: 38336604, DOI: 10.1016/j.hpb.2024.01.012.Peer-Reviewed Original Research
2023
Contemporary management of acute pancreatitis: What you need to know
Palumbo R, Schuster K. Contemporary management of acute pancreatitis: What you need to know. Journal Of Trauma And Acute Care Surgery 2023, 96: 156-165. PMID: 37722072, DOI: 10.1097/ta.0000000000004143.Peer-Reviewed Original ResearchConceptsAcute care surgeonsSevere acute pancreatitisAcute pancreatitisPeripancreatic fluid collectionsFluid collectionEarly enteral nutritionTiming of cholecystectomyEndoscopic treatment modalitiesAcute care surgeryAcute Pancreatitis ScoreSpecific clinical scenariosCross-sectional imagingEnteral nutritionGallstone pancreatitisBiliary pancreatitisInitial managementOngoing symptomsSurgical debridementAtlanta criteriaBedside indexCare surgeryFluid resuscitationInvasive necrosectomyLandmark trialsTrauma gradeEvaluating Educational Outcomes Using Patient Outcomes of New Surgeons Performing Partial Colectomy Compared to Cholecystectomy
George B, Thelen A, Howard R, Kendrick D, Chen X, Clark M, Gupta T, Brown C, Bandeh-Ahmadi H, Luckoski J, Wnuk G, Fan Z, Krumm A, Ryan A, Buyske J, Mukherjee B, Dimick J. Evaluating Educational Outcomes Using Patient Outcomes of New Surgeons Performing Partial Colectomy Compared to Cholecystectomy. Academic Medicine 2023, 98: s143-s148. PMID: 37983406, DOI: 10.1097/acm.0000000000005368.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedCholecystectomyColectomyHumansMedicareRetrospective StudiesSurgeonsUnited StatesConceptsPartial colectomyPatient outcomesYears of practiceExperienced surgeonSurgeon yearsRisk-adjusted ratesCholecystectomyColectomyTraining of surgeonsInpatient cholecystectomyComplicationsImprove surgical educationPatientsEvaluate educational outcomesSurgeonsSurgical residentsBenefit patientsInpatient operationsResidency trainingStudy periodDeathOutcomesSurgical educationMixed modelsTrainingFrom mild to gangrenous cholecystitis, laparoscopic cholecystectomy is safe 24 hours a day
Taveras L, Scrushy M, Cripps M, Kuhlenschmidt K, Crandall M, Puri R, Schroeppel T, Schuster K, Dumas R. From mild to gangrenous cholecystitis, laparoscopic cholecystectomy is safe 24 hours a day. The American Journal Of Surgery 2023, 226: 83-86. PMID: 36746709, DOI: 10.1016/j.amjsurg.2023.01.029.Peer-Reviewed Original Research
2022
Index Admission Cholecystectomy and Recurrence of Pediatric Gallstone Pancreatitis: Multicenter Cohort Analysis.
Muñoz Abraham AS, Osei H, Bajinting A, Cowles RA, Greenspon J, Hosfield BD, Keller MS, Landman MP, Owens H, Shaughnessy MP, St Peter SD, Sujka J, Vogel AM, Villalona GA. Index Admission Cholecystectomy and Recurrence of Pediatric Gallstone Pancreatitis: Multicenter Cohort Analysis. Journal Of The American College Of Surgeons 2022, 234: 352-358. PMID: 35213498, DOI: 10.1097/xcs.0000000000000062.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentChildCholecystectomyFemaleGallstonesHospitalizationHumansMalePancreatitisRecurrenceRetrospective StudiesConceptsGallstone pancreatitisEarly cholecystectomyIndex admissionRecurrent pancreatitisRecurrence rateMean body mass indexIndex admission cholecystectomyMean age 13.5Multicenter cohort analysisTiming of cholecystectomyBody mass indexBiliary complicationsInterval cholecystectomyIndex dischargeCholecystectomy ratesGroup patientsMost patientsLaboratory characteristicsMild pancreatitisPediatric patientsRetrospective reviewMass indexCholecystectomyCohort analysisPancreatitis
2021
Cholecystectomy Is Superior to Medical Management for Biliary Pain in Pediatric Patients
Shah P, Saluja S, Cowles R. Cholecystectomy Is Superior to Medical Management for Biliary Pain in Pediatric Patients. Journal Of Gastrointestinal Surgery 2021, 25: 2435-2436. PMID: 34255291, DOI: 10.1007/s11605-021-05083-1.Peer-Reviewed Original ResearchHealthcare Disparities in the Management of Acute Cholecystitis: Impact of Race, Gender, and Socioeconomic Factors on Cholecystectomy vs Percutaneous Cholecystostomy
McCarty TR, Chouairi F, Hathorn KE, Sharma P, Muniraj T, Thompson CC. Healthcare Disparities in the Management of Acute Cholecystitis: Impact of Race, Gender, and Socioeconomic Factors on Cholecystectomy vs Percutaneous Cholecystostomy. Journal Of Gastrointestinal Surgery 2021, 25: 880-886. PMID: 33629232, DOI: 10.1007/s11605-021-04959-6.Peer-Reviewed Original ResearchConceptsLength of stayCharlson Comorbidity IndexPercutaneous cholecystostomyAcute cholecystitisRace/ethnicityU.S. Nationwide Inpatient Sample (NIS) databaseNationwide Inpatient Sample databaseAsian race/ethnicityHealthcare-related factorsHigher CCI scoresMedicare payer statusGood surgical candidatesMajority of patientsMultivariable logistic regressionUrban hospital locationUrban teaching hospitalSocioeconomic factorsCCI scoreComorbidity indexSurgical candidatesPayer statusMale genderHospital costsTeaching hospitalTreatment strategiesEvaluation of socioeconomic and healthcare disparities on same admission cholecystectomy after endoscopic retrograde cholangiopancreatography among patients with acute gallstone pancreatitis
Chouairi F, McCarty TR, Hathorn KE, Sharma P, Aslanian HR, Jamidar PA, Thompson CC, Muniraj T. Evaluation of socioeconomic and healthcare disparities on same admission cholecystectomy after endoscopic retrograde cholangiopancreatography among patients with acute gallstone pancreatitis. Surgical Endoscopy 2021, 36: 274-281. PMID: 33481109, DOI: 10.1007/s00464-020-08272-2.Peer-Reviewed Original ResearchConceptsSame-admission cholecystectomyAcute gallstone pancreatitisEndoscopic retrograde cholangiopancreatographyCharlson Comorbidity IndexGallstone pancreatitisRetrograde cholangiopancreatographyU.S. Nationwide Inpatient Sample (NIS) databaseHigher Charlson comorbidity indexNationwide Inpatient Sample databaseMedicare payer statusUrban-teaching hospitalsMajority of patientsMultivariable logistic regressionRace/ethnicitySocio-demographic factorsHospital mortalityComorbidity indexHospital stayPayer statusSurgical managementHospitalization costsResultsA totalBlack raceTreatment strategiesFemale gender
2020
Multicenter validation of the American Association for the Surgery of Trauma grading scale for acute cholecystitis.
Schuster KM, O'Connor R, Cripps M, Kuhlenschmidt K, Taveras L, Kaafarani HM, El Hechi M, Puri R, Mull J, Schroeppel TJ, Rodriquez J, Cullinane DC, Cullinane LM, Enniss TM, Sensenig R, Zilberman B, Crandall M. Multicenter validation of the American Association for the Surgery of Trauma grading scale for acute cholecystitis. Journal Of Trauma And Acute Care Surgery 2020, 90: 87-96. PMID: 33332782, DOI: 10.1097/ta.0000000000002901.Peer-Reviewed Original ResearchConceptsAAST gradeTokyo GuidelinesAcute cholecystitisOperative timeEmergency general surgery (EGS) diseasesMedian AAST gradeTrauma grading scaleLonger operative timeSingle-institution studyModest discriminatory powerMulti-institutional fashionClinical decision makingAmerican AssociationPreoperative gradeUnderwent cholecystectomySurgical complicationsMean ageWorse outcomesPatient outcomesLevel IVCholecystitisOperative surgeonMulticenter validationGrading scaleGrading systemRole of Prophylactic Cholecystectomy After Endoscopic Sphincterotomy for Biliary Stone Disease: A Systematic Review and Meta-analysis.
McCarty TR, Farrelly J, Njei B, Jamidar P, Muniraj T. Role of Prophylactic Cholecystectomy After Endoscopic Sphincterotomy for Biliary Stone Disease: A Systematic Review and Meta-analysis. Annals Of Surgery 2020, 273: 667-675. PMID: 32590541, DOI: 10.1097/sla.0000000000003977.Peer-Reviewed Original ResearchConceptsRecurrent biliary painProphylactic cholecystectomyBile duct stonesMeta-AnalysisSystematic reviewBiliary painDuct stonesCommon bile duct stonesBiliary stone diseaseSubset of patientsCochrane Library databasesRisk of mortalityConfidence intervalsRate of pancreatitisPooled effect sizeSearch of PubMedPreferred Reporting ItemsRandom-effects modelWeb of ScienceBiliary complicationsEventual cholecystectomyComplication rateEndoscopic cholangiopancreatographyEndoscopic sphincterotomyBiliary sphincterotomy
2019
International Normalized Ratio (INR) is Comparable to MELD in Predicting Mortality after Cholecystectomy
Rudasill S, DiPardo B, Sanaiha Y, Mardock A, Cale M, Antonios J, Khoury H, Benharash P. International Normalized Ratio (INR) is Comparable to MELD in Predicting Mortality after Cholecystectomy. The American Surgeon 2019, 85: 1184-1188. PMID: 31657321, DOI: 10.1177/000313481908501024.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAnalysis of VarianceCholecystectomyCholecystectomy, LaparoscopicDiabetes MellitusEnd Stage Liver DiseaseFemaleHumansHypertensionInternational Normalized RatioLogistic ModelsMaleMiddle AgedPostoperative HemorrhagePredictive Value of TestsRetrospective StudiesRisk AssessmentConceptsInternational Normalized RatioPostoperative mortalityLaparoscopic cholecystectomyPreoperative international normalization ratioPredicting mortalityIncreased risk of bleedingPredictor of postoperative mortalityDay postoperative mortalityRisk of bleedingAmerican College of Surgeons NSQIPMultivariate logistic regressionPreoperative correctionAdult patientsCholecystectomy patientsNormalized RatioIncreased riskPrimary outcomeCholecystectomyAmerican CollegePredictive valueBaseline differencesPatientsC-statisticMELDMortalitySymptomatic human immunodeficiency virus–infected patients have poorer outcomes following emergency general surgery
Sandler BJ, Davis KA, Schuster KM. Symptomatic human immunodeficiency virus–infected patients have poorer outcomes following emergency general surgery. Journal Of Trauma And Acute Care Surgery 2019, 86: 479-488. PMID: 30531208, DOI: 10.1097/ta.0000000000002161.Peer-Reviewed Original ResearchConceptsHIV/AIDS patientsHIV-negative patientsAsymptomatic HIV-positive patientsHIV-positive patientsActive antiretroviral therapyAIDS patientsAntiretroviral therapyHospital stayPostoperative complicationsHuman immunodeficiency virus-infected patientsEmergency general surgery proceduresHigher median total chargesImmune deficiency syndrome (AIDS) patientsHuman immunodeficiency virus (HIV) infectionEmergency general surgeryLonger hospital stayRetrospective cohort studyAcute renal failureHIV-negative controlsImmunodeficiency virus infectionVirus-infected patientsRecords of patientsUrinary tract infectionMedian total chargesNationwide Inpatient Sample
2018
Validation of a new American Association for the Surgery of Trauma (AAST) anatomic severity grading system for acute cholecystitis
Vera K, Pei KY, Schuster KM, Davis KA. Validation of a new American Association for the Surgery of Trauma (AAST) anatomic severity grading system for acute cholecystitis. Journal Of Trauma And Acute Care Surgery 2018, 84: 650-654. PMID: 29271871, DOI: 10.1097/ta.0000000000001762.Peer-Reviewed Original ResearchConceptsLength of stayAcute cholecystitisICU useGrade 2Anatomic gradingAdverse eventsGrade 1Longer LOSAnatomic grading systemGrade 1 diseaseEmergency general surgeryGrade 3 patientsRetrospective cohort studyIncidence of complicationsMajority of patientsTertiary medical centerLow-grade diseaseSurgery of TraumaRisk-adjusted outcomesGood inter-rater reliabilityAAST gradeAmerican AssociationCholecystitis severityCohort studyConsecutive patientsClinical spectrum of pyruvate kinase deficiency: data from the Pyruvate Kinase Deficiency Natural History Study
Grace RF, Bianchi P, van Beers EJ, Eber SW, Glader B, Yaish HM, Despotovic JM, Rothman JA, Sharma M, McNaull MM, Fermo E, Lezon-Geyda K, Morton DH, Neufeld EJ, Chonat S, Kollmar N, Knoll CM, Kuo K, Kwiatkowski JL, Pospíšilová D, Pastore YD, Thompson AA, Newburger PE, Ravindranath Y, Wang WC, Wlodarski MW, Wang H, Holzhauer S, Breakey VR, Kunz J, Sheth S, Rose MJ, Bradeen HA, Neu N, Guo D, Al-Sayegh H, London WB, Gallagher PG, Zanella A, Barcellini W. Clinical spectrum of pyruvate kinase deficiency: data from the Pyruvate Kinase Deficiency Natural History Study. Blood 2018, 131: 2183-2192. PMID: 29549173, DOI: 10.1182/blood-2017-10-810796.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnemia, Hemolytic, Congenital NonspherocyticBlood TransfusionChildChild, PreschoolCholecystectomyCombined Modality TherapyEnzyme ActivationFemaleGenetic Association StudiesGenotypeHumansInfantInfant, NewbornMaleMiddle AgedMutationPhenotypePyruvate KinasePyruvate Metabolism, Inborn ErrorsSplenectomySymptom AssessmentTreatment OutcomeYoung AdultConceptsIron overloadHemolytic anemiaPyruvate kinase deficiencyChildren age 5 yearsProspective clinical dataPK deficiencySeverity of anemiaKinase deficiencyNatural history studiesAge 5 yearsCongenital nonspherocytic hemolytic anemiaCongenital hemolytic anemiaBaseline hemoglobinPostsplenectomy thrombosisMulticenter registryPostsplenectomy sepsisPulmonary hypertensionSimultaneous cholecystectomyFrequent complicationPerinatal complicationsTransfusion burdenAplastic crisisExchange transfusionLeg ulcersRadiologic dataHospitalization costs and resource allocation in cholecystectomy with use of intravenous versus oral acetaminophen
Hansen RN, Pham AT, Böing EA, Lovelace B, Wan GJ, Thomas DA, Fontes ML. Hospitalization costs and resource allocation in cholecystectomy with use of intravenous versus oral acetaminophen. Current Medical Research And Opinion 2018, 34: 1549-1555. PMID: 29192528, DOI: 10.1080/03007995.2017.1412301.Peer-Reviewed Original ResearchConceptsNausea/vomitingCholecystectomy patientsRespiratory depressionHospitalization costsOral APAPAPAP useOpioid useShorter LOSOpioid-related adverse eventsDaily morphine equivalent doseAssociated hospital lengthMorphine equivalent doseClinical risk factorsPerioperative pain managementMultivariable logistic regressionLower hospitalization costsYears of ageAdjunctive analgesicsOral acetaminophenBowel obstructionHospital lengthIntravenous acetaminophenAdverse eventsPatient demographicsPain management
2017
Intraoperative cholangiography during cholecystectomy among hospitalized medicare beneficiaries with non-neoplastic biliary disease
Lilley EJ, Scott JW, Jiang W, Krasnova A, Raol N, Changoor N, Salim A, Haider AH, Weissman JS, Schneider EB, Cooper Z. Intraoperative cholangiography during cholecystectomy among hospitalized medicare beneficiaries with non-neoplastic biliary disease. The American Journal Of Surgery 2017, 214: 682-686. PMID: 28669532, DOI: 10.1016/j.amjsurg.2017.06.021.Peer-Reviewed Original ResearchConceptsCBD injuryIntraoperative cholangiographyBiliary diseaseInpatient cholecystectomyMedicare beneficiariesCommon bile duct injuryBile duct injuryMultivariable logistic regressionHazard of deathHospitalized Medicare beneficiariesNon-neoplastic indicationsGallbladder obstructionDuct injuryCox regressionRetrospective studyCholecystectomyHigh riskPatientsInjuryLogistic regressionConfirmatory testDiseaseCholangiographySelective useSurvivalObesity and its implications for morbidity and mortality after cholecystectomy: A matched NSQIP analysis
Augustin T, Moslim M, Brethauer S, Aminian A, Kroh M, Schneider E, Walsh R. Obesity and its implications for morbidity and mortality after cholecystectomy: A matched NSQIP analysis. The American Journal Of Surgery 2017, 213: 539-543. PMID: 28237044, DOI: 10.1016/j.amjsurg.2016.11.037.Peer-Reviewed Original ResearchConceptsAcute cholecystitisClavien 4 complicationsSO patientsNSQIP AnalysisSuper obesityOpen surgeryNon-obese patientsObese patientsSerious morbidityLaparoscopic surgeryCholecystectomyPatientsSurgeryMorbidityComplicationsObesityChronicMortalityAggressive recommendationsRiskCholecystitisComorbidities
2015
Effect of cholecystectomy on bile acid synthesis and circulating levels of fibroblast growth factor 19
Barrera F, Azocar L, Molina H, Schalper KA, Ocares M, Liberona J, Villarroel L, Pimentel F, Pérez-Ayuso RM, Nervi F, Groen AK, Miquel JF. Effect of cholecystectomy on bile acid synthesis and circulating levels of fibroblast growth factor 19. Annals Of Hepatology 2015, 14: 710-721. PMID: 26256900, DOI: 10.1016/s1665-2681(19)30766-5.Peer-Reviewed Original ResearchConceptsEffect of cholecystectomyBile acid synthesisBA synthesisFGF19 expressionFibroblast growth factor 19FGF19 mRNA levelsGallstone disease patientsGut-derived hormonesGrowth factor 19GB-d1 cellsDose-dependent expressionGallbladder refillingFGF19 levelsBA metabolismSerum levelsSerum cholesterolDisease patientsSerum changesSerum FGF19Metabolic dysregulationTerminal ileumCholecystectomyFGF19 mRNAFactor 19Distal ileum
2014
Transvaginal cholecystectomy learning curve
Wood SG, Dai F, Dabu-Bondoc S, Mikhael H, Vadivelu N, Duffy A, Roberts KE. Transvaginal cholecystectomy learning curve. Surgical Endoscopy 2014, 29: 1837-1841. PMID: 25294548, DOI: 10.1007/s00464-014-3873-3.Peer-Reviewed Original ResearchMeSH KeywordsAdultCholecystectomyCholecystectomy, LaparoscopicFemaleHumansLearning CurveOperative TimeConceptsOperative timeTransvaginal cholecystectomyTVC patientsAcademic centersAverage age 41Learning curveResultsSixty-one patientsLaparoscopic cholecystectomy patientsAverage operative timeFellowship-trained surgeonsCholecystectomy patientsFemale patientsLC patientsMean ageMethodsThis studyAge 41PatientsSecond quartileSurgical repertoireSame time periodThird quartileLack of exposureFellowship trainingQuartileInterested surgeonsEffect of Endoscopic Sphincterotomy for Suspected Sphincter of Oddi Dysfunction on Pain-Related Disability Following Cholecystectomy: The EPISOD Randomized Clinical Trial
Cotton PB, Durkalski V, Romagnuolo J, Pauls Q, Fogel E, Tarnasky P, Aliperti G, Freeman M, Kozarek R, Jamidar P, Wilcox M, Serrano J, Brawman-Mintzer O, Elta G, Mauldin P, Thornhill A, Hawes R, Wood-Williams A, Orrell K, Drossman D, Robuck P. Effect of Endoscopic Sphincterotomy for Suspected Sphincter of Oddi Dysfunction on Pain-Related Disability Following Cholecystectomy: The EPISOD Randomized Clinical Trial. JAMA 2014, 311: 2101-2109. PMID: 24867013, PMCID: PMC4428324, DOI: 10.1001/jama.2014.5220.Peer-Reviewed Original ResearchConceptsEndoscopic retrograde cholangiopancreatographySuccessful treatmentDual sphincterotomyAbdominal painOddi dysfunctionEndoscopic sphincterotomyBiliary sphincterotomyObservational study groupPancreatic sphincter hypertensionPancreatic sphincter pressuresReferral medical centerDays of disabilitySuccess of treatmentERCP interventionPancreatic sphincterotomyFinal followPain reliefManometry findingsSphincter pressureSphincterotomy groupManometry resultsNarcotic useRetrograde cholangiopancreatographySham groupClinical trials
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