2024
Cognition in patients with mild autonomous cortisol secretion at baseline and post-adrenalectomy
Saini J, Nathani R, Singh S, Ebbehoj A, Thangamuthu K, Suresh M, Zhang C, Nevin S, Fell V, Atkinson E, Achenbach S, Stricker N, Bancos I. Cognition in patients with mild autonomous cortisol secretion at baseline and post-adrenalectomy. European Journal Of Endocrinology 2024, 191: 636-645. PMID: 39671564, PMCID: PMC11662234, DOI: 10.1093/ejendo/lvae157.Peer-Reviewed Original ResearchConceptsMild autonomous cortisol secretionReference subjectsT-scorePost-adrenalectomyBeck Depression InventoryComposite T-scoreAutonomous cortisol secretionSF-36Urine steroid profileImpact of adrenalectomyFrailty indexCross-sectional studyShort Form-36Longitudinal cohort studyNational Institutes of Health Toolbox Cognition BatteryCohort studyMultivariate analysisSteroid profileLower cognitionCortisol secretionPatientsAssociated with lower cognitionStandardized T scoresAdrenalectomyCognitive batteryVentral hernia repair with permanent mesh for non-Hispanic black versus white patients: access and post-operative outcomes in the era of robotic surgery
Chao G, Ying L, Huang L, Ma J, Ghiassi S, Gibbs K, Nadzam G, Morton J, Duffy A, Zhou R. Ventral hernia repair with permanent mesh for non-Hispanic black versus white patients: access and post-operative outcomes in the era of robotic surgery. Surgical Endoscopy 2024, 39: 560-567. PMID: 39433584, DOI: 10.1007/s00464-024-11252-5.Peer-Reviewed Original ResearchRobotic surgeryVentral hernia repairBlack patientsHernia repairPermanent meshT-scoreEra of robotic surgeryAbdominal Core Health Quality CollaborativeRate of laparoscopyHigher pain scoresPatient outcomesPost-operative outcomesSurgical site infectionPropensity-score matchingVentral hernia surgeryRecurrence scoreChi-square testPain scoresSite infectionFisher's exactHernia recurrenceOpen approachHernia surgeryWhite patientsSurgeryLong-Term Patient-Reported Health-Related Quality of Life in the Randomized FORMULA-509 Trial of Salvage Radiotherapy and 6 Months of GnRH Agonist with Either Bicalutamide or Abiraterone Acetate Plus Prednisone and Apalutamide after Radical Prostatectomy
Hoffman K, Nguyen P, Rathkopf D, Zurita-Saavedra A, Spratt D, Dess R, Liauw S, Szmulewitz R, Einstein D, Bubley G, Yu J, An Y, Wong A, Feng F, Mckay R, Rose B, Lee K, Kibel A, Taplin M, Kollmeier M. Long-Term Patient-Reported Health-Related Quality of Life in the Randomized FORMULA-509 Trial of Salvage Radiotherapy and 6 Months of GnRH Agonist with Either Bicalutamide or Abiraterone Acetate Plus Prednisone and Apalutamide after Radical Prostatectomy. International Journal Of Radiation Oncology • Biology • Physics 2024, 120: s54. DOI: 10.1016/j.ijrobp.2024.07.088.Peer-Reviewed Original ResearchAbiraterone acetate plus prednisoneMonths of GnRH agonistAcetate plus prednisonePatient-reported health-related quality of lifeEPIC-26Hormonal functionHealth-related quality of lifeGnRH agonistTreatment armsTreatment to 1 yearQuality of lifeMental statusMetastasis-free survivalBaseline to endCompletion of treatmentSalvage radiationSalvage radiotherapyOncological outcomesRadical prostatectomyClinically meaningful differencesSaint Louis University Mental Status ExamNear baselineClinically meaningful declineT-scoreHormonal domainsBoneScore: A natural language processing algorithm to extract bone mineral density data from DXA scans
Fodeh S, Wang R, Murphy T, Kidwai-Khan F, Leo-Summers L, Tessier-Sherman B, Hsieh E, Womack J. BoneScore: A natural language processing algorithm to extract bone mineral density data from DXA scans. Health Informatics Journal 2024, 30: 14604582241295930. PMID: 39526751, PMCID: PMC11872221, DOI: 10.1177/14604582241295930.Peer-Reviewed Original ResearchConceptsT-score valuesT-scoreNLP algorithmsDXA scansFemoral neck T-scoreNatural language processing algorithmsBone mineral density dataLanguage processing algorithmsBone mineral densityExtract annotationsRegular expressionsTest dataProcessing algorithmsDXA reportsMineral densityAlgorithmMultivariate linear regressionClinical face validityRisk factorsPresence of informationDXANLPClinical validationClinical expertsAccuracyRace, Ethnicity, and Gender Differences in Patient Reported Well-Being and Cognitive Functioning Within 3 Months of Symptomatic Illness During COVID-19 Pandemic
Hill M, Huebinger R, Ebna Mannan I, Yu H, Wisk L, O’Laughlin K, Gentile N, Stephens K, Gottlieb M, Weinstein R, Koo K, Santangelo M, Saydah S, Spatz E, Lin Z, Schaeffer K, Kean E, Montoy J, Rodriguez R, Idris A, McDonald S, Elmore J, Venkatesh A. Race, Ethnicity, and Gender Differences in Patient Reported Well-Being and Cognitive Functioning Within 3 Months of Symptomatic Illness During COVID-19 Pandemic. Journal Of Racial And Ethnic Health Disparities 2024, 1-18. PMID: 39172356, DOI: 10.1007/s40615-024-02124-8.Peer-Reviewed Original ResearchPROMIS T-scoresPain interferenceBlack participantsWell-beingHealth-related quality of lifeNon-Hispanic white participantsCognitive functionMeasures of healthHealth-related qualityMethodsThis prospective cohort studyFollow-up surveyProspective cohort studyT-scoreQuality of lifeCOVID-19-related health outcomesLower well-beingPROMIS-29Physical functionHealth outcomesBaseline to 3Social participationWhite participantsCohort studyCOVID-19Sleep disturbanceCONNEX, a Phase III Randomized Trial Program Assessing Efficacy and Safety of Iclepertin in Schizophrenia: Recruitment and Baseline Characteristics
Blahova Z, Ikezawa S, Falkai P, Krystal J, Rangan T. CONNEX, a Phase III Randomized Trial Program Assessing Efficacy and Safety of Iclepertin in Schizophrenia: Recruitment and Baseline Characteristics. BJPsych Open 2024, 10: s72-s73. PMCID: PMC11738127, DOI: 10.1192/bjo.2024.230.Peer-Reviewed Original ResearchVirtual Reality Functional Capacity Assessment ToolComposite T-scoreSchizophrenia Cognition Rating ScaleSchizophrenia Consensus Cognitive BatteryCognitive impairmentGlycine transporter-1 inhibitorStable antipsychotic treatmentN-methyl-d-aspartate receptor signallingConsensus Cognitive BatteryCognitive remediation therapyIncrease synaptic levelsCognition Rating ScaleT-scoreDuration of illnessCo-agonist glycineAntipsychotic treatmentAntipsychotic medicationSchizophrenia treatmentCognitive batteryRemediation therapyCognitive symptomsTreatment researchSchizophreniaImprove cognitionPlacebo-controlled parallel-group trial
2023
Quality of Life in Emicizumab-Treated People with Hemophilia A in the ATHN 7 Hemophilia Natural History Study - an Assessment of Baseline PROMIS®-29 Scores
Buckner T, Daoud N, Lee L, Lim E, Schwartz J, Raimundo K, Recht M. Quality of Life in Emicizumab-Treated People with Hemophilia A in the ATHN 7 Hemophilia Natural History Study - an Assessment of Baseline PROMIS®-29 Scores. Blood 2023, 142: 3998. DOI: 10.1182/blood-2023-174092.Peer-Reviewed Original ResearchImpairment of physical functionPain interferencePhysical functionPROMIS-29Reference population meanQuality of lifePatient-Reported Outcomes Measurement Information SystemReference populationOutcomes Measurement Information SystemT-scoreHealth-related quality of lifeCohort studyPatient-reported outcome measuresStudy entrySocial health domainsMeasurement Information SystemPROMIS-29 profileT-score metricUS reference populationHealth-related qualityUS general populationSleep disturbanceSymptoms of anxietyProspective observational cohort studyPROMIS measuresTHU606 Cognitive Impairment In Patients With Mild Autonomous Cortisol Secretion: A Cross-sectional Study
Saini J, Nathani R, Singh S, Thangamuthu K, Suresh M, Zhang C, Ebbehøj A, Thomas M, Fell V, Atkinson E, Achenbach S, Stricker N, Bancos I. THU606 Cognitive Impairment In Patients With Mild Autonomous Cortisol Secretion: A Cross-sectional Study. Journal Of The Endocrine Society 2023, 7: bvad114.136. PMCID: PMC10553766, DOI: 10.1210/jendso/bvad114.136.Peer-Reviewed Original ResearchComposite T-scoreDexamethasone suppression testPost-DST cortisolFluid cognitionCrystallized cognitionCognitive performanceCognitive impairmentNIH Toolbox Cognition BatteryPattern of cognitive impairmentCrystallized composite scoresComposite scoreReference subjectsT-scoreCognitive batterySubgroup analysisCognitive agingComposite cognitionMild autonomous cortisol secretionCognitive domainsNIH ToolboxSubgroup analysis of patientsImpaired cognitionCognitive functionSingle-center cross-sectional studyCompared to reference subjectsFRI184 Impact Of Adrenalectomy On Cognition In Patients With Mild Autonomous Cortisol Secretion
Saini J, Nathani R, Zhang C, Suresh M, Thangamuthu K, Singh S, Fell V, Atkinson E, Achenbach S, Stricker N, Bancos I. FRI184 Impact Of Adrenalectomy On Cognition In Patients With Mild Autonomous Cortisol Secretion. Journal Of The Endocrine Society 2023, 7: bvad114.179. PMCID: PMC10555084, DOI: 10.1210/jendso/bvad114.179.Peer-Reviewed Original ResearchComposite T-scoreDexamethasone suppression testImpact of adrenalectomyCognitive functionNational Institutes of Health (NIH) Toolbox Cognition BatteryCognitive evaluationT-scoreCortisol secretionLongitudinal study of adultsPost-DST cortisolProspective longitudinal study of adultsAutonomous cortisol secretionFluid cognitionCognitive batteryCrystallized cognitionImpaired cognitionTotal cognitionAssociated with improvementsCognitionStudy of adultsSuppression testAdrenal adenomaFollow-upScore changesMild autonomous cortisol secretionThe Selective Social Attention task in children with autism spectrum disorder: Results from the Autism Biomarkers Consortium for Clinical Trials (ABC‐CT) feasibility study
Shic F, Barney E, Naples A, Dommer K, Chang S, Li B, McAllister T, Atyabi A, Wang Q, Bernier R, Dawson G, Dziura J, Faja S, Jeste S, Murias M, Johnson S, Sabatos‐DeVito M, Helleman G, Senturk D, Sugar C, Webb S, McPartland J, Chawarska K, Trials T. The Selective Social Attention task in children with autism spectrum disorder: Results from the Autism Biomarkers Consortium for Clinical Trials (ABC‐CT) feasibility study. Autism Research 2023, 16: 2150-2159. PMID: 37749934, PMCID: PMC11003770, DOI: 10.1002/aur.3026.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderSocial attention taskSchool-aged childrenAttention taskASD groupSpectrum disorderEye-tracking taskTotal T-scoreAttentional patternsAutism spectrumTD groupPresentation timeTrial feasibility studyGroup differencesPercent of timeOlder childrenTaskComparison groupToddlersT-scoreChildrenChildren 4Outcome variablesFaceCondition effectsGoal Attainment Scaling with a Dance-Based Intervention for Breast Cancer Survivors With CIPN: Pilot Study
Bland C, Worthen-Chaudhari L, Hackney M, Crasta J, Lustberg M. Goal Attainment Scaling with a Dance-Based Intervention for Breast Cancer Survivors With CIPN: Pilot Study. Archives Of Physical Medicine And Rehabilitation 2023, 104: e31-e32. DOI: 10.1016/j.apmr.2022.12.089.Peer-Reviewed Original ResearchChemotherapy-induced neuropathyBreast cancer survivorsGoal Attainment ScalingCancer survivorsIndividualized goalsClinical utilityT-scoreDance-based interventionPilot intervention studyLevel of functioningGAS T-scoresOverall T scoreOutpatient oncologyBreast cancerMAIN OUTCOMEPost interventionNeuropathyIntervention studiesLarger sample sizePaired-samples t-testPilot studyChange scoresSurvivorsInterventionFurther studies
2022
Long-term effects of eliglustat on skeletal manifestations in clinical trials of patients with Gaucher disease type 1
Cox T, Charrow J, Lukina E, Mistry P, Foster M, Peterschmitt M. Long-term effects of eliglustat on skeletal manifestations in clinical trials of patients with Gaucher disease type 1. Genetics In Medicine 2022, 25: 100329. PMID: 36469032, DOI: 10.1016/j.gim.2022.10.011.Peer-Reviewed Original ResearchConceptsTreatment-naïve patientsHealthy reference rangeEnzyme replacement therapyReference rangeClinical trialsSkeletal manifestationsLong-term effectsEliglustat treatmentLumbar spine T-scoreGaucher disease type 1Bone marrow burden scoreLong-term efficacySpine T-scoreDisease type 1Bone painSkeletal complicationsTreatment-naïveMost patientsBone outcomesMIP-1βBurden scoreReplacement therapyPatientsTreatment durationT-scoreRole of time from transplantation to biopsy in histologic ABMR: A single center report
Chancay J, Liu C, Chauhan K, Andersen L, Harris C, Coca S, Delaney V, Tedla F, De Boccardo G, Sehgal V, Moledina D, Formica R, Reghuvaran A, Banu K, Florman S, Akalin E, Shapiro R, Salem F, Menon MC. Role of time from transplantation to biopsy in histologic ABMR: A single center report. Clinical Transplantation 2022, 36: e14802. PMID: 36069577, PMCID: PMC10211409, DOI: 10.1111/ctr.14802.Peer-Reviewed Original ResearchConceptsDeath-censored graft lossAntibody-Mediated RejectionDonor-specific antibodiesMicrovascular inflammationDQ-DSAAnti-human leukocyte antigen donor-specific antibodiesChronic allograft injurySingle-center reportsHigher inflammatory scoresCause biopsiesAllograft injuryGraft lossChronicity scoreInflammatory scoreHistologic factorsCT scoreFemale recipientsBiopsyMVI scoreT-scoreHeterogeneous etiologyCenter ReportTransplantationScoresSignificant correlationCan We Utilize PROMIS Neuropathic Pain Quality for Assessment of Neuropathic Heel Pain?
Joo P, Hoffman S, Baumhauer J, Oh I. Can We Utilize PROMIS Neuropathic Pain Quality for Assessment of Neuropathic Heel Pain? Foot & Ankle Orthopaedics 2022, 7: 2473011421s00713. PMCID: PMC9666847, DOI: 10.1177/2473011421s00713.Peer-Reviewed Original ResearchBody mass indexBack/neck painNeuropathic painSevere neuropathic painHeel painNeuropathic pain qualitiesPhysical functionPain interferenceT-scoreNeck painPain qualityOnly significant independent factorTertiary care academic institutionLow physical functionOutcomes Measurement Information SystemSignificant independent factorsMeasurement Information SystemNeuropathic mechanismsCurrent smokersMost etiologiesNociceptive painSecondary outcomesCommon presentationInitial visitPain managementComparison of Physical Function and Pain Levels of Hallux Rigidus Patients before and after Synthetic Cartilage Implant vs Arthrodesis Surgery
Oh I, Joo P, Baumhauer J, Houck J, Kohring J, Flemister A, Ketz J, DiGiovanni B. Comparison of Physical Function and Pain Levels of Hallux Rigidus Patients before and after Synthetic Cartilage Implant vs Arthrodesis Surgery. Foot & Ankle Orthopaedics 2022, 7: 2473011421s00381. PMCID: PMC8793603, DOI: 10.1177/2473011421s00381.Peer-Reviewed Original ResearchSynthetic cartilage implant hemiarthroplastyPostoperative physical functionPhysical functionSCI cohortT-scoreHallux rigidusAD cohortHallux rigidus patientsPain Interference LevelsPainful degenerative conditionsSynthetic cartilage implantPatients' physical functionTime pointsOutcomes Measurement Information SystemPROMIS T-scoresMeasurement Information SystemQuality of lifePhone surveyArthrodesis surgeryArthrodesis groupFinal followPain levelsComplication ratePROMIS scoresSCI groupClinical Outcomes of Nano Arthroscopy in the Office Setting for the Treatment of Posterior Ankle Impingement
Mercer N, Samsonov A, Dankert J, Delmonte R, Stornebrink T, Gianakos A, Kerkhoffs G, Kennedy J, Dahmen J. Clinical Outcomes of Nano Arthroscopy in the Office Setting for the Treatment of Posterior Ankle Impingement. Foot & Ankle Orthopaedics 2022, 7: 2473011421s00363. PMCID: PMC8793393, DOI: 10.1177/2473011421s00363.Peer-Reviewed Original ResearchBody mass indexPosterior ankleClinical outcomesOutcome scoresPatient satisfactionT-scoreOutcomes Measurement Information System (PROMIS) pain interferencePain interference T-scoresMean body mass indexExcellent patient-reported outcomesPain intensity domainsWork/sportRetrospective cohort studySignificant pain reductionPostoperative outcome scoresAnkle Outcome ScoreLow complication ratePosterior ankle impingementPatient-reported outcomesSports activitiesHigh patient satisfactionSport-specific activitiesStandard arthroscopic proceduresWilcoxon signed-rank testMean follow
2020
Improvements in Health-Related Quality of Life for Patients Treated with LentiGlobin for Sickle Cell Disease (bb1111) Gene Therapy
Kanter J, Tisdale J, Mapara M, Kwiatkowski J, Krishnamurti L, Chen R, Gallagher M, Ding Y, Goyal S, Paramore C, Thompson A, Walters M. Improvements in Health-Related Quality of Life for Patients Treated with LentiGlobin for Sickle Cell Disease (bb1111) Gene Therapy. Blood 2020, 136: 10. DOI: 10.1182/blood-2020-136193.Peer-Reviewed Original ResearchSickle cell diseaseAcute chest syndromeNumeric rating scalePatient-reported outcomesMonth 12Pain intensitySleep disturbance domainsBaseline scoresPhysical functionBluebird BioPopulation normsMeaningful improvementsMonth 6Pain intensity numeric rating scalePROMIS-57T-scorePatient-reported HRQoL outcomesUS general population normsAdvisory CommitteePain interference scoresGene therapyGroup C patientsCohort of patientsHealth-related qualityHistory of strokePattern of recovery and outcomes of patient reported physical function and pain interference after ankle fusion: a retrospective cohort study
Kohring JM, Houck JR, Oh I, Flemister AS, Ketz JP, Baumhauer JF. Pattern of recovery and outcomes of patient reported physical function and pain interference after ankle fusion: a retrospective cohort study. Journal Of Patient-Reported Outcomes 2020, 4: 40. PMID: 32462241, PMCID: PMC7253567, DOI: 10.1186/s41687-020-00203-y.Peer-Reviewed Original ResearchPROMIS Physical FunctionPhysical functionAnkle fusionT-scoreCohort studyPain interferenceProspective single cohort studyPain interference measuresOutcomes of patientsPercentage of patientsProportion of patientsRetrospective cohort studyPostoperative time pointsAnkle arthrodesis proceduresSingle cohort studyAnkle fusion surgeryPattern of recoveryRetrospective reviewRoutine careArthrodesis proceduresAnkle arthrodesisFusion surgeryEvidenceLevel IIProvider communicationPatient recovery
2019
Immediate Improvement in Physical Function after Symptomatic Syndesmotic Screw Removal
Kohring J, Baumhauer J, Flemister S, Oh I, DiGiovanni B, Ketz J. Immediate Improvement in Physical Function after Symptomatic Syndesmotic Screw Removal. Foot & Ankle Orthopaedics 2019, 4: 2473011419s00042. PMCID: PMC8696822, DOI: 10.1177/2473011419s00042.Peer-Reviewed Original ResearchSyndesmotic screw removalScrew removalAnkle fracturesSyndesmotic fixationAnkle ROMSyndesmotic screwT-scoreEarly post-operative periodPost-operative periodPhysical function outcomesCohort comparison groupSame study periodT-score changePROMIS outcomesAsymptomatic patientsOpen reductionFunction outcomesInternal fixationPhysical functionAnkle rangeEarly improvementSymptomatic implantsFunctional limitationsSyndesmotic instabilityPatientsAre Sicker Patients Less Likely to Improve after Ankle Fusion?
Kohring J, Houck J, Flemister S, Ketz J, Oh I, Baumhauer J. Are Sicker Patients Less Likely to Improve after Ankle Fusion? Foot & Ankle Orthopaedics 2019, 4: 2473011419s00252. PMCID: PMC8696802, DOI: 10.1177/2473011419s00252.Peer-Reviewed Original ResearchCharlson Comorbidity IndexPROMIS Physical FunctionPROMIS T-scoresPain interferenceASA scorePhysical functionAnkle arthrodesisT-scoreSicker patientsAnkle fusionDemographic dataHigher Charlson comorbidity indexPre-existing medical conditionsPre-operative functionLow physical functionPost-operative patientsAnkle arthrodesis proceduresComorbidity indexMedical comorbiditiesChart reviewRetrospective reviewRisk stratificationRoutine careAnkle arthritisArthrodesis procedures
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