2025
The Association of Gender in the Management and Prognosis of Vertebral and Sacral Chordoma: A SEER Analysis
Elsamadicy A, Sayeed S, Sherman J, Serrato P, Ghanekar S, Lo S, Sciubba D. The Association of Gender in the Management and Prognosis of Vertebral and Sacral Chordoma: A SEER Analysis. Journal Of Clinical Medicine 2025, 14: 1737. PMID: 40095791, PMCID: PMC11901273, DOI: 10.3390/jcm14051737.Peer-Reviewed Original ResearchFive-year survivalICD-O-3 codesNeo-adjuvant radiotherapyPredictors of survivalCancer Registry databaseRetrospective cohort studyAssociated with survivalICD-O-3SEER analysisTumor characteristicsSacral chordomaTumor sizeTumor locationMale patientsPatient demographicsSkull baseOsseous tumorsTreatment utilizationEnd ResultsRegistry databaseChordomaCohort studyTreatment characteristicsTumorPatientsIncreasing Omission of Race and Ethnicity in a National Surgical Database.
Hu K, Ihnat J, Zhao K, Oh S, Goss J, Parikh N, Kammien A, Fereydooni S, Butler P, Alperovich M. Increasing Omission of Race and Ethnicity in a National Surgical Database. Journal Of The American College Of Surgeons 2025 PMID: 40035446, DOI: 10.1097/xcs.0000000000001372.Peer-Reviewed Original ResearchBM patientsNSQIP-PHospital lengths-of-stayNational surgical databaseLengths-of-stayNon-BM patientsEthnicity dataCochran-Armitage testOdds of readmissionSurgical databaseSurgical outcomesPatient demographicsSurgery typeNSQIP-P.Multivariate analysisIncreased omissionsPatientsSurgical disparitiesCochran-ArmitageMissing raceSurgical careLinear mixed-effects modelsAccurate data collectionComplicationsMixed-effects modelsEndovascular Embolization versus Observation of Congenital Renal Arteriovenous Malformations: A Retrospective Study
Hufnagle J, Fish A, Schlachter T. Endovascular Embolization versus Observation of Congenital Renal Arteriovenous Malformations: A Retrospective Study. Journal Of Vascular And Interventional Radiology 2025 PMID: 39938714, DOI: 10.1016/j.jvir.2025.02.001.Peer-Reviewed Original ResearchCongenital renal arteriovenous malformationRenal arteriovenous malformationType I AVMArteriovenous malformationsEndovascular embolizationAdverse eventsImaging review of patientsReview of patientsArteriovenous malformation ruptureFollow-up dataYakes classificationTransarterial embolizationEmbolization groupPresenting symptomsPatient demographicsRetrospective studyProcedural imagingImaging reviewEmbolizationPatientsObservation groupMalformationsComplicationsVessel sizeNephrectomyAlemtuzumab and thrombotic thrombocytopenic purpura: Analysis of an international surveillance database and systematic literature review
Jacobs J, Binns T, Schlafer D, Woo J, Booth G, Adkins B. Alemtuzumab and thrombotic thrombocytopenic purpura: Analysis of an international surveillance database and systematic literature review. Transfusion And Apheresis Science 2025, 64: 104081. PMID: 39883995, DOI: 10.1016/j.transci.2025.104081.Peer-Reviewed Original ResearchConceptsThrombotic thrombocytopenic purpuraSecondary thrombotic thrombocytopenic purpuraFood and Drug Administration Adverse Event Reporting SystemAssociated with alemtuzumabThrombocytopenic purpuraMultiple sclerosisReport of thrombotic thrombocytopenic purpuraImmune-mediated thrombotic thrombocytopenic purpuraCongenital thrombotic thrombocytopenic purpuraHematopoietic stem cell transplantationFAERS databaseAnd Drug Administration Adverse Event Reporting SystemStem cell transplantationUnited States Food and Drug Administration Adverse Event Reporting SystemAdverse Event Reporting SystemADAMTS13 deficiencyAlemtuzumab administrationCell transplantationADAMTS13 geneEvent Reporting SystemPatient demographicsAlemtuzumabCase reportTherapy indicationsCross-sectional analysisImpact of patient age on morbidity and mortality in adults with acute traumatic cervical spinal cord injury: An ACS trauma quality programs database study
Elsamadicy A, Serrato P, Belkasim S, Ghanekar S, Khalid S, Lo S, Sciubba D. Impact of patient age on morbidity and mortality in adults with acute traumatic cervical spinal cord injury: An ACS trauma quality programs database study. Clinical Neurology And Neurosurgery 2025, 249: 108740. PMID: 39813756, DOI: 10.1016/j.clineuro.2025.108740.Peer-Reviewed Original ResearchConceptsIn-hospital mortalityAcute CSCI patientsLength of stayCSCI patientsTreatment modalitiesCervical SCIAcute traumatic cervical spinal cord injuryTraumatic cervical spinal cord injuryAssociated with increased morbidityImpact of patient ageAcute cervical SCICervical spinal cord injuryRetrospective cohort studyMultivariate logistic regressionPredictors of AEYears of ageSpinal cord injuryCervicothoracic fusionAssociated with AECervical fusionPatient ageIndependent predictorsInjury typePatient demographicsProgram database
2024
Acute Promyelocytic Leukemia in the Real World: Understanding Outcome Differences and How We Can Improve Them
Bidikian A, Bewersdorf J, Kewan T, Stahl M, Zeidan A. Acute Promyelocytic Leukemia in the Real World: Understanding Outcome Differences and How We Can Improve Them. Cancers 2024, 16: 4092. PMID: 39682277, PMCID: PMC11640703, DOI: 10.3390/cancers16234092.Peer-Reviewed Original ResearchAcute promyelocytic leukemiaAdvent of all-trans retinoic acidEarly mortalityLong-term treatment toxicitiesArsenic trioxidePromyelocytic leukemiaClinical practiceIncidence of acute promyelocytic leukemiaRates of remissionLong-term outcomesTreatment of acute promyelocytic leukemiaLong-term survivalComprehensive patient evaluationResource-limited settingsTreatment toxicityAll-trans retinoic acidDelayed diagnosisPatient demographicsSignificant comorbiditiesTreatment initiationOlder patientsExpert centersClinical trialsTreatment outcomesReal-world settingsSystem-level Variability in Trauma Center Utilization for Seriously Injured Older Adults
Ordoobadi A, Castillo-Angeles M, Tabata-Kelly M, Jenkins P, Hwang U, Cooper Z, Jarman M. System-level Variability in Trauma Center Utilization for Seriously Injured Older Adults. Journal Of Surgical Research 2024, 305: 10-18. PMID: 39616785, PMCID: PMC11779583, DOI: 10.1016/j.jss.2024.10.047.Peer-Reviewed Original ResearchInjured older adultsTrauma service areasSystem-level factorsOlder adultsMultivariable hierarchical logistic regressionHierarchical logistic regressionTrauma centerLogistic regressionRate of undertriageLevel IRetrospective cross-sectional studyCross-sectional studyUnited States countiesHospital destinationInjury characteristicsTrauma center utilizationMedicare dataSystem-level variablesPatient demographicsRandom interceptStates countiesUndertriagePrimary outcomeRural regionsCenter utilizationFactors associated with elective surgical case cancellation at a tertiary hospital in Malawi
Serrato P, Msosa V, Kondwani J, Nkhumbwah M, Mowafi H, Smith J, Mulima G, Sion M. Factors associated with elective surgical case cancellation at a tertiary hospital in Malawi. World Journal Of Surgery 2024, 48: 2990-3000. PMID: 39558490, DOI: 10.1002/wjs.12404.Peer-Reviewed Original ResearchKamuzu Central HospitalFactors associated with lower oddsLower oddsFactors associated with cancellationTertiary hospitalProcess-related factorsAssociated with lower oddsPublic tertiary hospitalCase cancellationsElective surgical case cancellationCancellation of elective surgeriesCross-sectional studyMedian waiting timeReturn for surgerySurgery completion rateMultivariate regression modelHigher cancellation rateSurgical case cancellationCancellation of surgeryCompletion ratesPatient outcomesPatient demographicsOddsElective surgeryRegression modelsComparative analysis of negative pressure wound therapy (PICO) and standard dressing application after arterial vascular reconstructions.
Kostiuk V, Fereydooni S, Setia O, Loh S, Strosberg D, Tonnessen B, Ochoa Chaar C, Aboian E. Comparative analysis of negative pressure wound therapy (PICO) and standard dressing application after arterial vascular reconstructions. Vascular 2024, 17085381241296606. PMID: 39460535, DOI: 10.1177/17085381241296606.Peer-Reviewed Original ResearchGroin wound complicationsWound complicationsNegative pressure wound therapyNegative pressure therapyVascular reconstructionGroin dissectionPressure therapyPICO dressingIncidence of groin wound complicationsProcedure indicationArterial reconstructionWound therapyIncidence of wound complicationsReduction of wound complicationsMultivariate logistic regression analysisAssociated with lower riskSurgical site infectionAntibiotics post-operativelyFemoral artery dissectionOpen vascular reconstructionLogistic regression analysisSzilagyi classificationGroin surgerySite infectionPatient demographicsDevelopment of a Uniform Apheresis Case Report Form for Standardized Collection of Apheresis Data
Johnson A, Szczepiorkowski Z, Balogun R, Karam O, Nellis M, Schneiderman J, Schwartz J, Winters J, Wu Y, Armendariz T, Burgstaler E, Collins L, Geile K, Pavenski K, Sanchez A, Witt V, Muthusamy A, Pederson T, Ramesh V, Thao M, Chlebeck T, Zantek N. Development of a Uniform Apheresis Case Report Form for Standardized Collection of Apheresis Data. Journal Of Clinical Apheresis 2024, 39: e22146. PMID: 39420527, PMCID: PMC11523286, DOI: 10.1002/jca.22146.Peer-Reviewed Original ResearchConceptsElectronic case report formsCase report formsReport formsData elementsConsensus panelImprove patient careRelevant data elementsOnline survey toolPatient careSurvey toolQuality InitiativeBlood cell collectionLaboratory parametersPatient demographicsDraft documentTool's abilityStandardized collectionApheresisCell collectionDatabase developmentVascular accessTherapeutic apheresisOnline conferencingUsabilitySubject eligibilityComplications and Radiographic Outcomes of Tibial Tubercle Osteotomy at Minimum 5-Year Follow-up
Yalcin S, Seals K, Joo P, Fulkerson J, Farrow L. Complications and Radiographic Outcomes of Tibial Tubercle Osteotomy at Minimum 5-Year Follow-up. Orthopaedic Journal Of Sports Medicine 2024, 12: 23259671241278722. PMID: 39430114, PMCID: PMC11489970, DOI: 10.1177/23259671241278722.Peer-Reviewed Original ResearchMidterm follow-upTibial tubercle osteotomyComplication rateFollow-upLogistic regression analysisRadiographic outcomesYears of clinical follow-up dataClinical follow-up dataRisk factorsUnivariate logistic regression analysisMultivariate logistic regression analysisGrades 3 to 4Tubercle osteotomyTreatment of patellofemoral instabilityHistory of smokingCase series studyFollow-up periodRate of patientsLong-term outcomesFollow-up dataLevel of evidenceRegression analysisPatient demographicsCase seriesPatellofemoral instabilityOutcomes Following In-Office Peroneal Needle Tendoscopy: A Retrospective Review
Butler J, Randall G, Wingo T, Gianakos A, Kennedy J. Outcomes Following In-Office Peroneal Needle Tendoscopy: A Retrospective Review. Foot & Ankle Orthopaedics 2024, 9: 2473011424s00398. PMCID: PMC11686665, DOI: 10.1177/2473011424s00398.Peer-Reviewed Original ResearchReturn to sportPre-operative MRIVisual analog scaleFollow-upIn-officeTendon dysfunctionRetrospective reviewAmerican Orthopaedic Foot and Ankle Society (AOFAS) ankle-hindfoot scoreAnkle-hindfoot scorePeroneal tendon disordersPeroneal tearsComplication rateRadiological outcomesPatient demographicsAnalog scaleRetrospective studyEffective modalityPathological characteristicsTreatment characteristicsTendon disordersTEN casesPatientsTendoscopyOperating suiteDysfunctionAnatomic and reverse total shoulder arthroplasty: variables affecting 90-day overall reimbursement
Halperin S, Dhodapkar M, Modrak M, Donohue K, Medvecky M, Grauer J. Anatomic and reverse total shoulder arthroplasty: variables affecting 90-day overall reimbursement. Seminars In Arthroplasty JSES 2024, 34: 564-570. DOI: 10.1053/j.sart.2024.02.007.Peer-Reviewed Original ResearchAnatomic total shoulder arthroplastyReverse total shoulder arthroplastyTotal shoulder arthroplastyTotal shoulder arthroplasty patientsPostoperative eventsShoulder arthroplastyPatient demographicsOverall reimbursementSurgery typeAdverse eventsMale sexAssociated with reimbursementMultivariate linear regressionOncological diagnosisEmergency department visitsPatientsOrthopedic proceduresEffective procedureAdministrative databasesHospital readmissionInsurance typeSurgeryReduce healthcare expendituresDepartment visitsIncreased frequencyLooking into the future: a machine learning powered prediction model for oocyte return rates after cryopreservation
Fouks Y, Bortoletto P, Chang J, Penzias A, Vaughan D, Sakkas D. Looking into the future: a machine learning powered prediction model for oocyte return rates after cryopreservation. Reproductive BioMedicine Online 2024, 50: 104432. PMID: 39642702, DOI: 10.1016/j.rbmo.2024.104432.Peer-Reviewed Original ResearchSociety for Assisted Reproductive TechnologyDiminished ovarian reserveStored oocytesUS fertility clinicsAge-related infertilityAssisted reproductive technologyFertility clinicsLikelihood of patientsOocyte cryopreservationUnexplained infertilityInfertility diagnosisOvarian reservePatient agePatient demographicsTreatment indicationsPatient counselingReproductive technologyFertility diagnosisPatientsOocytesGender-relatedInfertilitySelf-financingClinicDiagnosisIxekizumab Treatment Patterns and Health Care Resource Utilization Among Patients with Axial Spondyloarthritis: A Retrospective United States Claims Database Study
Danve A, Vadhariya A, Lisse J, Cholayil A, Bansal N, Bello N, Bakewell C. Ixekizumab Treatment Patterns and Health Care Resource Utilization Among Patients with Axial Spondyloarthritis: A Retrospective United States Claims Database Study. Rheumatology And Therapy 2024, 11: 1333-1345. PMID: 39162898, PMCID: PMC11422398, DOI: 10.1007/s40744-024-00710-0.Peer-Reviewed Original ResearchHealth care resource utilizationFollow-up periodTumor necrosis factor-alpha inhibitorsTreatment patternsAxial spondyloarthritisPre-indexMethodsThis retrospective cohort studyBiologic-experienced patientsCharlson Comorbidity Index scoreRetrospective cohort studyClaims database studyIntroductionReal-world dataAssessed patient demographicsComorbidity Index scoreHigher comorbidity burdenProportion of daysBiologic-experiencedPatient demographicsClinical characteristicsIxekizumabIndex dateCohort studyPharmacy enrollmentEmergency room visitsAxSpALamotrigine Emerging as a Driver of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: An 8-Year Retrospective Study
Glahn J, Almeida M, Kochen A, Noel O, Stogner V, Hsia H, Savetamal A. Lamotrigine Emerging as a Driver of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: An 8-Year Retrospective Study. Burns 2024, 50: 2114-2123. PMID: 39127578, DOI: 10.1016/j.burns.2024.07.006.Peer-Reviewed Original ResearchStevens-Johnson syndromeToxic epidermal necrolysisOff-label useEpidermal necrolysisCause of SJS/TENDiagnosis of SJS/TENBurn centerNon-bipolar mood disordersImpact clinical courseLength of stayBiopsy confirmationDesquamating rashRegional burn centerCausative drugsClinical coursePresenting symptomsClinical presentationSJS/TEN patientsPrescribed lamotriginePatient demographicsHospital courseRetrospective cohortStevens-JohnsonSevere manifestationsPatient populationPediatric cutaneous Crohn disease: A case series of 89 patients and review
McKay G, Liu L, Shaw K, Shakshouk H, Murphy M, Damsky W, Ortega‐Loayza A, Caplan A, Arkin L, Shields B. Pediatric cutaneous Crohn disease: A case series of 89 patients and review. Pediatric Dermatology 2024, 41: 807-813. PMID: 39011834, DOI: 10.1111/pde.15689.Peer-Reviewed Original ResearchBiologic therapyPediatric patientsCrohn's diseaseMetastatic Crohn's diseaseInterleukin-12/23 inhibitorsCutaneous granulomatous inflammationIntestinal Crohn's diseaseDiscordant therapyTNF blockadeOral corticosteroidsInterleukin-12/23Dual therapyRetrospective reviewPediatric casesCutaneous CDMechanism of actionPatient demographicsCase seriesChart reviewClinical characteristicsPartial clearanceGranulomatous inflammationCase of CCDSmall molecule inhibitorsCutaneous diseaseBlood pressure changes during ketamine infusion for the treatment of depression
Ansari M, Pittman B, Tylee D, Ostroff R, Wilkinson S, Nikayin S. Blood pressure changes during ketamine infusion for the treatment of depression. General Hospital Psychiatry 2024, 90: 62-67. PMID: 38991311, DOI: 10.1016/j.genhosppsych.2024.07.001.Peer-Reviewed Original ResearchKetamine infusionBlood pressure changesBlood pressureRetrospective chart review of patientsChart review of patientsMedical history of hypertensionRetrospective chart reviewHistory of hypertensionSignificant blood pressureDiastolic blood pressureTreatment of depressionSevere hypertensionPatient demographicsHypertensive patientsInfusion sessionsMedical historyHypertensive eventsInfusionPatientsKetamineBP surgeCardiovascular monitoringBloodHypertensionPressure changesIs yearly interferon gamma release assay latent tuberculosis infection screening warranted among patients with rheumatological diseases on disease-modifying drugs in non-endemic settings?
Palacios C, Chowdhary V, Hao R, Danve A, Malinis M. Is yearly interferon gamma release assay latent tuberculosis infection screening warranted among patients with rheumatological diseases on disease-modifying drugs in non-endemic settings? PLOS ONE 2024, 19: e0306337. PMID: 38959249, PMCID: PMC11221665, DOI: 10.1371/journal.pone.0306337.Peer-Reviewed Original ResearchConceptsInterferon-gamma release assayDisease-modifying antirheumatic drugsInterferon-gamma release assay testLatent tuberculosis infectionNon-endemic settingsRheumatologic diseasesRisk factorsPositive interferon-gamma release assayLatent tuberculosis infection screeningLatent tuberculosis infection diagnosisPositive IGRA testMonths of rifampinLow-risk patientsRetrospective chart reviewTNF-alpha inhibitorsTB risk factorsTargeted LTBI screeningOutpatient rheumatology clinicDisease-modifying drugsIGRA testPatient demographicsAdult patientsChart reviewAntirheumatic drugsNon-endemic areasRace- and Ethnicity-Related Differences in Heart Failure With Preserved Ejection Fraction Using Natural Language Processing
Brown S, Biswas D, Wu J, Ryan M, Bernstein B, Fairhurst N, Kaye G, Baral R, Cannata A, Searle T, Melikian N, Sado D, Lüscher T, Teo J, Dobson R, Bromage D, McDonagh T, Vazir A, Shah A, O’Gallagher K. Race- and Ethnicity-Related Differences in Heart Failure With Preserved Ejection Fraction Using Natural Language Processing. JACC Advances 2024, 3: 101064. PMID: 39050815, PMCID: PMC11268103, DOI: 10.1016/j.jacadv.2024.101064.Peer-Reviewed Original ResearchBlack patientsPro-B-type natriuretic peptide levelsN-terminal pro-B-type natriuretic peptide levelsEuropean Society of Cardiology criteriaDiagnosis of HFpEFNatriuretic peptide levelsHeterogeneous clinical syndromeEuropean SocietyCardiology criteriaHFpEF diagnosisClinical presentationFPEF scoreAsian patientsPatient demographicsEthnicity-related differencesMetabolic comorbiditiesAtrial fibrillationHeart failureHFpEFDiagnostic performancePeptide levelsWhite patientsClinical syndromePatientsQuantify health inequalities
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