2025
Identification of genetic architecture shared between schizophrenia and Alzheimer’s disease
Liu H, Xie Y, Ji Y, Zhou Y, Xu J, Tang J, Liu N, Ding H, Qin W, Liu F, Yu C. Identification of genetic architecture shared between schizophrenia and Alzheimer’s disease. Translational Psychiatry 2025, 15: 150. PMID: 40240757, PMCID: PMC12003746, DOI: 10.1038/s41398-025-03348-w.Peer-Reviewed Original ResearchConceptsPolygenic overlapFalse discovery rateGenetic architectureAlzheimer's diseaseConditional/conjunctional false discovery rateConditional false discovery rateGenome-wide association studiesIndividuals of European ancestryConcordant effect directionsGenetic risk architectureMolecular genetic mechanismsHeritable brain disorderAssociation studiesGenetic mechanismsGenetic variantsEuropean ancestryGenetic associationObserved comorbiditySchizophreniaSNPsDiscovery rateCognitive declineRisk architectureBrain disordersGenetic correlationsI Got Rhythm and Executive Function, Memory, and More: The Automated Test of Embodied Cognition (ATEC)
Bell M, Gonzalez Y, Weinstein A, Ciosek D, Wang Y, Yoon G. I Got Rhythm and Executive Function, Memory, and More: The Automated Test of Embodied Cognition (ATEC). Brain Sciences 2025, 15: 299. PMID: 40149820, PMCID: PMC11940590, DOI: 10.3390/brainsci15030299.Peer-Reviewed Original ResearchPre-morbid IQStory memoryExecutive functionVisual memoryNeurocognitive measuresStandard measures of executive functioningMeasures of executive functionCognitive declineVerbal list learningAdministered standardized measuresCommunity control participantsRisk of cognitive declineYears of educationEF factorIQ estimatesList learningCognitive reserveEF measuresMeasure cognitionAt-risk participantsControl participantsVisual sequencesConcurrent validityCommunity controlsFactor analysisA biomarker framework for auditory system aging: the Aging Biomarker Consortium consensus statement
Consortium A, Fu X, Wang S, Wu Y, Sun Y, Liu W, Xi X, Li G, Liu K, Yuan W, Chen F, Wang H, Yang T, Liu Y, Zheng J, Shi H, Qu J, Chen X, Suo L, Huang Y, Xu X, Tang X, Li X, Xu L, Gao X, Yu L, Shu Y, Zhang W, Sun J, Yuan H, Gong S, Li W, Ma X, Zha D, Gao J, Li H, He Z, Liu G, Pei G, Kong W, Wang H, Chai R. A biomarker framework for auditory system aging: the Aging Biomarker Consortium consensus statement. Life Medicine 2025, lnaf011. DOI: 10.1093/lifemedi/lnaf011.Peer-Reviewed Original ResearchAuditory healthAuditory systemAssociated with cognitive declineQuality of lifeHearing lossOlder adultsPsychosocial disordersSensory impairmentElderly populationConsensus statementCognitive declineHearingHealthAging societyVerbal communicationAgeSensory functionAbstract HearingHumoral biomarkersBiomarkers ConsortiumBiomarkersInterventionAging biomarkersAdultsComprehensive evaluationBrain Signatures of Very Early Cognitive Decline in Asymptomatic Middle‐Aged Offspring of People With Alzheimer's Disease
Ramsingh N, Lin H, Ouyang Y, Ravona‐Springer R, Livny A, Soleimani L, Bendlin B, Matatov A, Niv T, Shamir T, Ganmore I, Heymann A, Sano M, Azuri J, Beeri M. Brain Signatures of Very Early Cognitive Decline in Asymptomatic Middle‐Aged Offspring of People With Alzheimer's Disease. International Journal Of Geriatric Psychiatry 2025, 40: e70060. PMID: 40050014, DOI: 10.1002/gps.70060.Peer-Reviewed Original ResearchConceptsSuperior longitudinal fasciculusCortical volumeCortical brain volumesWhite matterAlzheimer's Prevention studyEarly cognitive declineBrain signaturesBrain regionsCognitive changesWM microstructureMiddle-aged adultsBrain volumeLongitudinal fasciculusCognitive declinePreclinical cognitive changesOffspring of peopleBrain tractsPatient's offspringTarget individualsEarly interventionCorpus callosumParental historyBrainAlzheimer's diseaseLinear regression modelsBrain connectivity correlates of the impact of a digital intervention for individuals with subjective cognitive decline on depression and IL-18
Catalogna M, Somerville Y, Saporta N, Nathansohn-Levi B, Shelly S, Edry L, Zagoory-Sharon O, Feldman R, Amedi A. Brain connectivity correlates of the impact of a digital intervention for individuals with subjective cognitive decline on depression and IL-18. Scientific Reports 2025, 15: 6863. PMID: 40011544, PMCID: PMC11865443, DOI: 10.1038/s41598-025-91457-3.Peer-Reviewed Original ResearchConceptsBrain connectivityCognitive declineResting-state functional connectivityEffect sizeCognitive behavioral therapyLate-life depressionSelf-reported depressionMedium effect sizeDigital interventionsInterventions targeting mental healthMood regulationBehavioral therapyDepressive symptomsDecreased connectivityPost-intervention changesFunctional connectivityTwo-week interventionCognitive functionSpatial cognitionDepression scoresBrain healthBehavioral outcomesBrain functionPsychological techniquesPsychological healthEmbodied Cognition and Alcohol Use Disorder: Frequency of Impairments and Relationship to Neurocognitive Assessments
Bell M, Weinstein A, Ciosek D, Reilly S, Wang Y, Yoon G. Embodied Cognition and Alcohol Use Disorder: Frequency of Impairments and Relationship to Neurocognitive Assessments. Brain Sciences 2025, 15: 228. PMID: 40149750, PMCID: PMC11940586, DOI: 10.3390/brainsci15030228.Peer-Reviewed Original ResearchAlcohol use disorderEmbodied cognitionTotal scoreExecutive functionUse disorderNeurocognitive assessmentCognitive declineMeasure executive functionFrequency of impairmentPotential protective factorsPremorbid IQEF impairmentsMemory domainDelayed recallOverall impairmentEF domainsCognitive processesNeurocognitive testsConcurrent validityFrequent impairmentCognitionSelf-regulationCognitive scienceImpairmentProtective factorsAlpha rhythm and Alzheimer’s disease: Has Hans Berger’s dream come true?
Babiloni C, Arakaki X, Baez S, Barry R, Benussi A, Blinowska K, Bonanni L, Borroni B, Bayard J, Bruno G, Cacciotti A, Carducci F, Carino J, Carpi M, Conte A, Cruzat J, D'Antonio F, Della Penna S, Del Percio C, De Sanctis P, Escudero J, Fabbrini G, Farina F, Fraga F, Fuhr P, Gschwandtner U, Güntekin B, Guo Y, Hajos M, Hallett M, Hampel H, Hanoğlu L, Haraldsen I, Hassan M, Hatlestad-Hall C, Horváth A, Ibanez A, Infarinato F, Jaramillo-Jimenez A, Jeong J, Jiang Y, Kamiński M, Koch G, Kumar S, Leodori G, Li G, Lizio R, Lopez S, Ferri R, Maestú F, Marra C, Marzetti L, McGeown W, Miraglia F, Moguilner S, Moretti D, Mushtaq F, Noce G, Nucci L, Ochoa J, Onorati P, Padovani A, Pappalettera C, Parra M, Pardini M, Pascual-Marqui R, Paulus W, Pizzella V, Prado P, Rauchs G, Ritter P, Salvatore M, Santamaria-García H, Schirner M, Soricelli A, Taylor J, Tankisi H, Tecchio F, Teipel S, Kodamullil A, Triggiani A, Valdes-Sosa M, Valdes-Sosa P, Vecchio F, Vossel K, Yao D, Yener G, Ziemann U, Kamondi A. Alpha rhythm and Alzheimer’s disease: Has Hans Berger’s dream come true? Clinical Neurophysiology 2025, 172: 33-50. PMID: 39978053, DOI: 10.1016/j.clinph.2025.02.256.Peer-Reviewed Original ResearchConceptsPathological agingAlzheimer's diseaseExpert panelAlpha rhythmAD patient’s qualityQuality of lifeAging-Alzheimer's AssociationCognitive impairmentCognitive declineClinical workupNeuroscience SocietyCortical circuitsAD patientsUS National InstitutesOlder adultsRoutine useSenile dementiaDecades of researchPatients' qualityClinical guidelinesOscillatory synchronizationCause of dementiaClinical applicationNIA-AADementiaThe REpeated ASSEssment of SurvivorS in intracerebral haemorrhage: protocol for a multicentre, prospective observational study
Ziai W, Woo D, Sansing L, Hanley D, Ostapkovich N, Triene K, Gilkerson L, Thompson R, Walborn N, Lane K, McBee N, Langefeld C, Howard T, Vagal A, Flaherty M, Consortium F. The REpeated ASSEssment of SurvivorS in intracerebral haemorrhage: protocol for a multicentre, prospective observational study. BMJ Open 2025, 15: e094322. PMID: 39915023, PMCID: PMC11800296, DOI: 10.1136/bmjopen-2024-094322.Peer-Reviewed Original ResearchConceptsMinimally invasive surgeryIntracerebral haemorrhageInvasive surgeryNon-surgical standard of careProspective observational studySpontaneous intracerebral haemorrhageStandard of careRepeated assessmentsCognitive declineICH volumeInstitutional review boardHaematoma volumeMISTIE IIITreated patientsInflammatory stateTreatment strategiesEthnic/Racial VariationsRt-PAAssessment of survivorsObservational studyRate of cognitive declineUniversity Institutional Review BoardHaemorrhageReview boardPeer-reviewed journalsDynamic proportional loss of functional connectivity revealed change of left superior frontal gyrus in subjective cognitive decline: an explanatory study based on Chinese and Western cohorts
Wang L, Hu W, Dong F, Sheng C, Wu J, Han Y, Jiang J, Weiner M, Aisen P, Petersen R, Jack C, Jagust W, Trojanowski J, Toga A, Beckett L, Green R, Saykin A, Morris J, Shaw L, Khachaturian Z, Sorensen G, Kuller L, Raichle M, Paul S, Davies P, Fillit H, Hefti F, Holtzman D, Mesulam M, Potter W, Snyder P, Schwartz A, Montine T, Thomas R, Donohue M, Walter S, Gessert D, Sather T, Jiminez G, Harvey D, Bernstein M, Thompson P, Schuff N, Borowski B, Gunter J, Senjem M, Vemuri P, Jones D, Kantarci K, Ward C, Koeppe R, Foster N, Reiman E, Chen K, Mathis C, Landau S, Cairns N, Householder E, Taylor-Reinwald L, Lee V, Korecka M, Figurski M, Crawford K, Neu S, Foroud T, Potkin S, Shen L, Faber K, Kim S, Nho K, Thal L, Buckholtz N, Albert M, Frank R, Hsiao J, Kaye J, Quinn J, Lind B, Carter R, Dolen S, Schneider L, Pawluczyk S, Beccera M, Teodoro L, Spann B, Brewer J, Vanderswag H, Fleisher A, Heidebrink J, Lord J, Mason S, Albers C, Knopman D, Johnson K, Doody R, Villanueva-Meyer J, Chowdhury M, Rountree S, Dang M, Stern Y, Honig L, Bell K, Ances B, Carroll M, Leon S, Mintun M, Schneider S, Oliver A, Marson D, Griffith R, Clark D, Geldmacher D, Brockington J, Roberson E, Grossman H, Mitsis E, de Toledo-Morrell L, Shah R, Duara R, Varon D, Greig M, Roberts P, Onyike C, D’Agostino D, Kielb S, Galvin J, Cerbone B, Michel C, Rusinek H, de Leon M, Glodzik L, De Santi S, Doraiswamy P, Petrella J, Wong T, Arnold S, Karlawish J, Wolk D, Smith C, Jicha G, Hardy P, Sinha P, Oates E, Conrad G, Lopez O, Oakley M, Simpson D, Porsteinsson A, Goldstein B, Martin K, Makino K, Ismail M, Brand C, Mulnard R, Thai G, McAdams-Ortiz C, Womack K, Mathews D, Quiceno M, Diaz-Arrastia R, King R, Weiner M, Martin-Cook K, DeVous M, Levey A, Lah J, Cellar J, Burns J, Anderson H, Swerdlow R, Apostolova L, Tingus K, Woo E, Silverman D, Lu P, Bartzokis G, Graff-Radford N, Parfitt F, Kendall T, Johnson H, Farlow M, Hake A, Matthews B, Herring S, Hunt C, van Dyck C, Carson R, MacAvoy M, Chertkow H, Bergman H, Hosein C, Hsiung G, Feldman H, Mudge B, Assaly M, Bernick C, Munic D, Kertesz A, Rogers J, Trost D, Kerwin D, Lipowski K, Wu C, Johnson N, Sadowsky C, Martinez W, Villena T, Turner R, Johnson K, Reynolds B, Sperling R, Johnson K, Marshall G, Frey M, Lane B, Rosen A, Tinklenberg J, Sabbagh M, Belden C, Jacobson S, Sirrel S, Kowall N, Killiany R, Budson A, Norbash A, Johnson P, Allard J, Lerner A, Ogrocki P, Hudson L, Fletcher E, Carmichae O, Olichney J, DeCarli C, Kittur S, Borrie M, Lee T, Bartha R, Johnson S, Asthana S, Carlsson C, Preda A, Nguyen D, Tariot P, Reeder S, Bates V, Capote H, Rainka M, Scharre D, Kataki M, Adeli A, Zimmerman E, Celmins D, Brown A, Pearlson G, Blank K, Anderson K, Santulli R, Kitzmiller T, Schwartz E, Sink K, Williamson J, Garg P, Watkins F, Ott B, Querfurth H, Tremont G, Salloway S, Malloy P, Correia S, Rosen H, Miller B, Mintzer J, Spicer K, Bachman D, Pasternak S, Rachinsky I, Drost D, Pomara N, Hernando R, Sarrael A, Schultz S, Ponto L, Shim H, Smith K, Relkin N, Chaing G, Raudin L, Smith A, Fargher K, Raj B, Neylan T, Grafman J, Davis M, Morrison R, Hayes J, Finley S, Friedl K, Fleischman D, Arfanakis K, James O, Massoglia D, Fruehling J, Harding S, Peskind E, Petrie E, Li G, Yesavage J, Taylor J, Furst A. Dynamic proportional loss of functional connectivity revealed change of left superior frontal gyrus in subjective cognitive decline: an explanatory study based on Chinese and Western cohorts. GeroScience 2025, 1-16. PMID: 39888585, DOI: 10.1007/s11357-025-01528-6.Peer-Reviewed Original ResearchSuperior frontal gyrusSubjective cognitive declineLeft superior frontal gyrusCognitive declineFrontal gyrusResting-state functional magnetic resonance imaging dataFunctional magnetic resonance imaging dataSusceptible to individual differencesLongitudinal resting-state functional magnetic resonance imaging dataLoss of functional connectivityDiagnosis of subjective cognitive declineBrain network dynamicsMagnetic resonance imaging dataRisk of cognitive declineAlzheimer's diseaseIndividual differencesFunctional connectivityCognitively normal controlsNeuroimaging biomarkersDPLFCGyrusScale scoreNormal controlsAb depositionCognitionMultimorbidity patterns and cognitive change among Mexican older adults: findings from the Mexican Health and Aging Study
Bishop N, Botoseneanu A, Newsom J, Allore H, Nagel C, Markwardt S, Samper-Ternent R, Quiñones A. Multimorbidity patterns and cognitive change among Mexican older adults: findings from the Mexican Health and Aging Study. Journal Of Global Ageing 2025, 1-33. DOI: 10.1332/29767202y2024d000000019.Peer-Reviewed Original ResearchMexican Health and Aging StudyHealth and Aging StudyMultimorbidity patternsMexican adultsChronic conditionsOlder adultsIncreasing burden of chronic conditionsDepressive symptomsBurden of chronic conditionsCo-occurring chronic conditionsCognitive declineCognitive functionAssociated with lower cognitive functionOlder Mexican adultsMexican older adultsRisk of cognitive declineAging StudyLower cognitive functionCognitive changesManagement of diabetesMultimorbidityIncreasing burdenCognitive trajectoriesLatent growth modelingOlder adulthoodIntegrated healthy lifestyle even in late-life mitigates cognitive decline risk across varied genetic susceptibility
Wang J, Chen C, Zhou J, Xu Z, Xu L, Li X, Zhong Z, Lv Y, Shi X. Integrated healthy lifestyle even in late-life mitigates cognitive decline risk across varied genetic susceptibility. Nature Communications 2025, 16: 539. PMID: 39789005, PMCID: PMC11718162, DOI: 10.1038/s41467-024-55763-0.Peer-Reviewed Original ResearchConceptsFavorable lifestyleRate of cognitive declineGenetic riskCognitive declineUnfavorable lifestyleHealthy lifestyleAssociations of combined lifestyle factorsChinese Longitudinal Healthy Longevity SurveyCombined lifestyle factorsHigh genetic riskDimensions of cognitionCognitive decline riskAccelerated cognitive declineLongevity SurveyLifestyle factorsCognitive domainsLate-lifeOlder adultsCognitive functionDeclining riskLifestyleGenetic susceptibilityGenetic factorsRiskCognition
2024
Robust, fully-automated assessment of cerebral perivascular spaces and white matter lesions: a multicentre MRI longitudinal study of their evolution and association with risk of dementia and accelerated brain atrophy
Barisano G, Iv M, Choupan J, Hayden-Gephart M, Weiner M, Aisen P, Petersen R, Jack C, Jagust W, Trojanowki J, Toga A, Beckett L, Green R, Saykin A, Morris J, Shaw L, Liu E, Montine T, Thomas R, Donohue M, Walter S, Gessert D, Sather T, Jiminez G, Harvey D, Donohue M, Bernstein M, Fox N, Thompson P, Schuff N, DeCarli C, Borowski B, Gunter J, Senjem M, Vemuri P, Jones D, Kantarci K, Ward C, Koeppe R, Foster N, Reiman E, Chen K, Mathis C, Landau S, Cairns N, Householder E, Reinwald L, Lee V, Korecka M, Figurski M, Crawford K, Neu S, Foroud T, Potkin S, Shen L, Kelley F, Kim S, Nho K, Kachaturian Z, Frank R, Snyder P, Molchan S, Kaye J, Quinn J, Lind B, Carter R, Dolen S, Schneider L, Pawluczyk S, Beccera M, Teodoro L, Spann B, Brewer J, Vanderswag H, Fleisher A, Heidebrink J, Lord J, Petersen R, Mason S, Albers C, Knopman D, Johnson K, Doody R, Meyer J, Chowdhury M, Rountree S, Dang M, Stern Y, Honig L, Bell K, Ances B, Morris J, Carroll M, Leon S, Householder E, Mintun M, Schneider S, Oliver A, Marson D, Griffith R, Clark D, Geld-macher D, Brockington J, Roberson E, Grossman H, Mitsis E, deToledo-Morrell L, Shah R, Duara R, Varon D, Greig M, Roberts P, Albert M, Onyike C, D’Agostino D, Kielb S, Galvin J, Pogorelec D, Cerbone B, Michel C, Rusinek H, de Leon M, Glodzik L, De Santi S, Doraiswamy P, Petrella J, Wong T, Arnold S, Karlawish J, Wolk D, Smith C, Jicha G, Hardy P, Sinha P, Oates E, Conrad G, Lopez O, Oakley M, Simpson D, Porsteinsson A, Goldstein B, Martin K, Makino K, Ismail M, Brand C, Mulnard R, Thai G, Mc Adams Ortiz C, Womack K, Mathews D, Quiceno M, Arrastia R, King R, Weiner M, Cook K, DeVous M, Levey A, Lah J, Cellar J, Burns J, Anderson H, Swerdlow R, Apostolova L, Tingus K, Woo E, Silverman D, Lu P, Bartzokis G, Radford N, Parfitt F, Kendall T, Johnson H, Farlow M, Hake A, Matthews B, Herring S, Hunt C, van Dyck C, Carson R, MacAvoy M, Chertkow H, Bergman H, Hosein C, Black S, Stefanovic B, Caldwell C, Hsiung G, Feldman H, Mudge B, Assaly M, Kertesz A, Rogers J, Trost D, Bernick C, Munic D, Kerwin D, Mesulam M, Lipowski K, Wu C, Johnson N, Sadowsky C, Martinez W, Villena T, Turner R, Johnson K, Reynolds B, Sperling R, Johnson K, Marshall G, Frey M, Yesavage J, Taylor J, Lane B, Rosen A, Tinklenberg J, Sabbagh M, Belden C, Jacobson S, Sirrel S, Kowall N, Killiany R, Budson A, Norbash A, Johnson P, Obisesan T, Wolday S, Allard J, Lerner A, Ogrocki P, Hudson L, Fletcher E, Carmichael O, Olichney J, DeCarli C, Kittur S, Borrie M, Lee T, Bartha R, Johnson S, Asthana S, Carlsson C, Potkin S, Preda A, Nguyen D, Tariot P, Fleisher A, Reeder S, Bates V, Capote H, Rainka M, Scharre D, Kataki M, Adeli A, Zimmerman E, Celmins D, Brown A, Pearlson G, Blank K, Anderson K, Santulli R, Kitzmiller T, Schwartz E, Sink K, Williamson J, Garg P, Watkins F, Ott B, Querfurth H, Tremont G, Salloway S, Malloy P, Correia S, Rosen H, Miller B, Mintzer J, Spicer K, Bachman D, Finger E, Pasternak S, Rachinsky I, Rogers J, Kertesz A, Drost D, Pomara N, Hernando R, Sarrael A, Schultz S, Ponto L, Shim H, Smith K, Relkin N, Chaing G, Raudin L, Smith A, Fargher K, Raj B. Robust, fully-automated assessment of cerebral perivascular spaces and white matter lesions: a multicentre MRI longitudinal study of their evolution and association with risk of dementia and accelerated brain atrophy. EBioMedicine 2024, 111: 105523. PMID: 39721217, PMCID: PMC11732520, DOI: 10.1016/j.ebiom.2024.105523.Peer-Reviewed Original ResearchConceptsRisk of dementiaDementia riskAccelerated brain atrophyLower risk of dementiaMeasures of cognitive functionLongitudinal studyUS National Institutes of HealthNational Institutes of HealthCombat dementiaInstitutes of HealthPerivascular spaces countAlzheimer's disease biomarkersUS National InstitutesClinical measures of cognitive functioningDementiaBrain healthMixed-effects modelsScreening toolClinical measuresConfounding factorsObservational studyCognitive declineLongitudinal trajectoriesParticipantsBrain atrophyPlasma Aβ42/Aβ40 is sensitive to early cerebral amyloid accumulation and predicts risk of cognitive decline across the Alzheimer's disease spectrum
Trelle A, Young C, Vossler H, Benitez J, Cody K, Mendiola J, Swarovski M, Le Guen Y, Feinstein I, Butler R, Channappa D, Romero A, Park J, Shahid‐Besanti M, Corso N, Chau K, Smith A, Skylar‐Scott I, Yutsis M, Fredericks C, Tian L, Younes K, Kerchner G, Deutsch G, Davidzon G, Sha S, Henderson V, Longo F, Greicius M, Wyss‐Coray T, Andreasson K, Poston K, Wagner A, Mormino E, Wilson E. Plasma Aβ42/Aβ40 is sensitive to early cerebral amyloid accumulation and predicts risk of cognitive decline across the Alzheimer's disease spectrum. Alzheimer's & Dementia 2024, 21: e14442. PMID: 39713875, PMCID: PMC11848181, DOI: 10.1002/alz.14442.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseCognitive declinePositron emission tomographyAmyloid-betaTau accumulationAmyloid positivityHippocampal-dependent memoryAlzheimer's disease spectrumAmyloidAmyloid accumulationTau burdenAb accumulationRisk of cognitive declineSensitive to memoryTau positron emission tomographyAlzheimer's Disease Research CenterPredicting cognitive declineAlzheimerTauScalable biomarkersAD continuumCerebral amyloid accumulationCross-sectional associationsCI individualsAccumulationRewiring of the glymphatic landscape in metabolic disorders
Chen B, Meseguer D, Lenck S, Thomas J, Schneeberger M. Rewiring of the glymphatic landscape in metabolic disorders. Trends In Endocrinology And Metabolism 2024 PMID: 39638721, DOI: 10.1016/j.tem.2024.11.005.Peer-Reviewed Original ResearchMetabolic dysfunctionNeurological disordersBlood-brain barrier leakageCerebral blood flow disruptionBlood flow disruptionGlymphatic systemTreatment strategiesCognitive declineRisk factorsMetabolic disordersNeurovascular uncouplingBarrier leakageGlymphatic clearance systemMetabolic diseasesDisordersObesityDysfunctionGEAR 2.0 ‐ Detection of Dementia and Cognitive Impairment
Hwang U. GEAR 2.0 ‐ Detection of Dementia and Cognitive Impairment. Alzheimer's & Dementia 2024, 20: e091835. PMCID: PMC11711980, DOI: 10.1002/alz.091835.Peer-Reviewed Original ResearchDetection of dementiaEmergency departmentOlder adultsED-based careImprove care coordinationUnder-recognitionAcute medical careIncreased health care costsRate of cognitive declineLower patient satisfactionCognitive declineHealth care costsAccelerated cognitive declineCare coordinationCare partnersEmergency carePatient safetyAvoidable visitsImplement interventionsInpatient servicesStaff's abilityCare costsMedical carePatient satisfactionCareLongitudinal associations of microstructural changes, amyloid, and cognition in preclinical Alzheimer's disease
Vannini P, Bertazzoli G, Rodriguez‐Vieitez E, Ramseyer M, Diez I, Sepulcre J, Hanseeuw B, Lois C, Gagliardi G, Westin C, Johnson K, Sperling R, Marshall G. Longitudinal associations of microstructural changes, amyloid, and cognition in preclinical Alzheimer's disease. Alzheimer's & Dementia 2024, 20: e089927. PMCID: PMC11714664, DOI: 10.1002/alz.089927.Peer-Reviewed Original ResearchCortical mean diffusivityCognitive declineLongitudinal associationsCortical thicknessHarvard Aging Brain StudyBaseline cortical thicknessCN older adultsAging Brain StudyCompound B PETLongitudinal cognitive declinePreclinical Alzheimer's diseaseDrug-induced changesCognitive covariatesIsthmus cingulateStructural MRIPost-hoc stratifying analysisCognitive AssessmentAt-risk individualsCognitionGeneralized linear modelBrain studiesMean diffusivityOlder adultsGray matterDiffusion-weighted imagingThe Cerebellum Plays a Protective Role in Cognitive Aging and Disease: Insights from a Multi‐Cohort Study
Uquillas F, Sefik E, Seidlitz J, Merriman J, Zhang V, Kislin M, Cohen J, Alexander‐Bloch A, Bethlehem R, Sepulcre J, Wang S, Vannini P, Gomez J, Initiative T. The Cerebellum Plays a Protective Role in Cognitive Aging and Disease: Insights from a Multi‐Cohort Study. Alzheimer's & Dementia 2024, 20: e085743. PMCID: PMC11716736, DOI: 10.1002/alz.085743.Peer-Reviewed Original ResearchMontreal Cognitive AssessmentEstimated intracranial volumeBrain reserveCognitive declineMontreal Cognitive Assessment scoreCerebellar volumePattern of cognitive declineUK BiobankAging-related cognitive declineCerebellar tissue volumesPosterior cerebellar cortexAmyloid burdenAPOE genotypeAlzheimer's diseaseCerebellar associationsMild cognitive impairmentExecutive functionCognitive agingAmyloid-beta burdenVentral attentionPosterior cerebellumCrus IAge-related changesDiagnostic groupsProcessing speedA multimodal Neuroimaging-Based risk score for mild cognitive impairment
Zendehrouh E, Sendi M, Abrol A, Batta I, Hassanzadeh R, Calhoun V. A multimodal Neuroimaging-Based risk score for mild cognitive impairment. NeuroImage Clinical 2024, 45: 103719. PMID: 39637673, PMCID: PMC11664180, DOI: 10.1016/j.nicl.2024.103719.Peer-Reviewed Original ResearchMild cognitive impairment riskMild cognitive impairmentMild cognitive impairment groupRisk of mild cognitive impairmentRisk scoreUK Biobank participantsFunctional network connectivityCognitive impairmentPrecursor to ADSignificant cognitive declineBiobank participantsUK BiobankMild cognitive impairment individualsGenetic risk factorsAlzheimer's diseaseFunctional MRIHigh-risk groupStructural MRIAD riskRisk factorsCognitive declineFeatures of CNGray matterDifferentiate CNParticipantsPost hoc analysis of ADAMANT, a phase 2 clinical trial of active tau immunotherapy with AADvac1 in patients with Alzheimer’s disease, positive for plasma p-tau217
Kovacech B, Cullen N, Novak P, Hanes J, Kontsekova E, Katina S, Parrak V, Fresser M, Vanbrabant J, Feldman H, Winblad B, Stoops E, Vanmechelen E, Zilka N. Post hoc analysis of ADAMANT, a phase 2 clinical trial of active tau immunotherapy with AADvac1 in patients with Alzheimer’s disease, positive for plasma p-tau217. Alzheimer's Research & Therapy 2024, 16: 254. PMID: 39580468, PMCID: PMC11585249, DOI: 10.1186/s13195-024-01620-7.Peer-Reviewed Original ResearchConceptsClinical Dementia Rating-Sum of BoxesPhase 2 clinical trialGlial fibrillary acidic proteinPost hoc analysisAlzheimer's diseaseAlzheimer's Disease Cooperative Study ActivitiesPlasma p-tau217Clinical Dementia Rating-SumClinical trialsWhole-brain volumeSpread of tau pathologyPlasma biomarkers of neurodegenerationPlasma P-tau217 levelsMicrotubule-binding regionSubgroup of participantsADAMS participantsTau pathologyAD-related neuropathological changesCognitive declineFibrillary acidic proteinActive immunotherapyDouble-blindPlacebo-controlledVolumetric MRITau immunotherapyAPOE 4‐related blood–brain barrier breakdown is associated with microstructural abnormalities
Reas E, Solders S, Tsiknia A, Triebswetter C, Shen Q, Rivera C, Andrews M, Alderson‐Myers A, Brewer J. APOE 4‐related blood–brain barrier breakdown is associated with microstructural abnormalities. Alzheimer's & Dementia 2024, 20: 8615-8624. PMID: 39411970, PMCID: PMC11667544, DOI: 10.1002/alz.14302.Peer-Reviewed Original ResearchAPOE4 carriersAlzheimer's diseaseAmyloid-negative individualsAmyloid-betaAmyloid-positive individualsApoE4AD cascadeAmyloidBlood-brain barrierAPOE 4Magnetic resonance imagingBrain microstructureAbsence of cognitive declinePreclinical ADLinear regression assessed associationsAmyloid positivityNeurodegenerative changesCortical gray matterCognitive declineMicrostructural abnormalitiesAssociated with microstructural abnormalitiesCognitive statusApoNeurodegenerationOlder adults
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