2025
Mitral Valve Repair Optimal Annual Case Volume for Surgery
Hameed I, Ahmed A, Waldron C, Algarate P, Kawczynski M, Fatima M, Alhazmi A, Colon S, Brackett A, Heuts S, Nia P, Gaudino M, Badhwar V, Geirsson A. Mitral Valve Repair Optimal Annual Case Volume for Surgery. JACC Advances 2025, 4: 101589. PMID: 39933365, PMCID: PMC11867518, DOI: 10.1016/j.jacadv.2025.101589.Peer-Reviewed Original ResearchRecurrent mitral regurgitationLong-term freedomLong-term survivalAnnual case volumeMitral regurgitationMitral valve diseaseCase volumeIsolated MVRValve diseaseContemporary long-term outcomesLong-term outcomes of patientsVolume outcome associationOutcomes of patientsDegenerative mitral diseaseOptimal long-term outcomesLow-volume centersLong-term outcomesDurability of repairDegenerative mitral valve diseaseIndividual patient dataVolume-outcome relationshipSystematic literature searchMitral diseaseVolume centersImproved freedom
2024
Immunotherapy Initiation at the End of Life in Patients With Metastatic Cancer in the US
Kerekes D, Frey A, Prsic E, Tran T, Clune J, Sznol M, Kluger H, Forman H, Becher R, Olino K, Khan S. Immunotherapy Initiation at the End of Life in Patients With Metastatic Cancer in the US. JAMA Oncology 2024, 10: 342-351. PMID: 38175659, PMCID: PMC10767643, DOI: 10.1001/jamaoncol.2023.6025.Peer-Reviewed Original ResearchNon-small cell lung cancerEnd of lifeMonth of deathImmunotherapy initiationCohort studyMAIN OUTCOMEStage IV non-small cell lung cancerCharlson-Deyo comorbidity indexHigh metastatic burdenInitiation of immunotherapyNational prescribing patternsRisk-adjusted patientsImmune checkpoint inhibitorsRetrospective cohort studyStage IV melanomaPercentage of patientsHigh-volume centersLocation of metastasesLow-volume centersOdds of deathCell lung cancerNational Clinical DatabaseLow-volume facilitiesDrug Administration approvalCheckpoint inhibitorsImmunotherapy utilization in stage IIIA melanoma: less may be more
Frey A, Kerekes D, Khan S, Tran T, Kluger H, Clune J, Ariyan S, Sznol M, Ishizuka J, Olino K. Immunotherapy utilization in stage IIIA melanoma: less may be more. Frontiers In Oncology 2024, 14: 1336441. PMID: 38380358, PMCID: PMC10876869, DOI: 10.3389/fonc.2024.1336441.Peer-Reviewed Original ResearchStage IIIA melanomaHigh-volume centersRisk-adjusted survivalLow-volume centersImmunotherapy utilizationAdjuvant immunotherapyStage IIIATreatment of stage III melanomaAcademic centersMultivariable Cox proportional hazards regressionStage III melanomaNational Cancer DatabaseStage III diseaseFactors associated with receiptCox proportional hazards regressionCompare patient outcomesProportional hazards regressionIII melanomaImmunotherapy receiptReceiving immunotherapyIII diseaseImmunotherapy agentsOverall survivalSurvival benefitAdjuvant treatment
2023
Pacemaker implantation following tricuspid valve annuloplasty
Ragnarsson S, Taha A, Nielsen S, Amabile A, Geirsson A, Krane M, Mörtsell D, Sjögren J, Jeppsson A, Martinsson A. Pacemaker implantation following tricuspid valve annuloplasty. JTCVS Open 2023, 16: 276-289. PMID: 38204629, PMCID: PMC10775064, DOI: 10.1016/j.xjon.2023.08.017.Peer-Reviewed Original ResearchPermanent pacemaker implantationPacemaker implantationPermanent pacemakerTricuspid annuloplastyRisk factorsLong-term survivalCumulative incidenceConcomitant mitral valve surgeryMajor adverse cardiovascular eventsWorse long-term survivalLong-term mortality riskMultivariable logistic regression modelMandatory national registryPermanent pacemaker rateAdverse cardiovascular eventsIndependent risk factorMultivariable Cox regressionMitral valve surgeryLow-volume centersTricuspid valve annuloplastyLogistic regression modelsCardiovascular eventsValve surgeryExact incidenceHeart failureDiscrepant Volume-cost Relationship Of Septal Reduction Therapies For The Treatment Of Obstructive Hypertrophic Cardiomyopathy
Altibi A, Ghanem F, Masri A. Discrepant Volume-cost Relationship Of Septal Reduction Therapies For The Treatment Of Obstructive Hypertrophic Cardiomyopathy. Journal Of Cardiac Failure 2023, 29: 639-640. DOI: 10.1016/j.cardfail.2022.10.228.Peer-Reviewed Original ResearchAlcohol septal ablationSeptal reduction therapyObstructive hypertrophic cardiomyopathyHigh-volume centersSeptal myectomyTertile of hospital volumeLow-volume centersNational Readmission DatabaseSeptal ablationHypertrophic cardiomyopathyTreatment of obstructive hypertrophic cardiomyopathyReduction therapyAlcohol septal ablation proceduresInverse volume-cost relationshipHospital volumeProcedure volumeHospital procedure volumeMedical therapyAnnual procedure volumeReadmissions DatabaseAverage annual chargesInflation-adjusted chargesVolume-cost relationshipHospital costsTherapyTrends in the likelihood of receiving percutaneous coronary intervention in a low-volume hospital and disparities by sociodemographic communities
Wang C, Lindquist K, Krumholz H, Hsia R. Trends in the likelihood of receiving percutaneous coronary intervention in a low-volume hospital and disparities by sociodemographic communities. PLOS ONE 2023, 18: e0279905. PMID: 36652416, PMCID: PMC9847957, DOI: 10.1371/journal.pone.0279905.Peer-Reviewed Original ResearchConceptsLow-volume hospitalsNon-Latinx WhitesRelative riskSociodemographic groupsLow-income zip codesHospital PCI volumeRetrospective cohort studyPercutaneous coronary interventionCoronary artery diseaseLow-volume centersFavorable patient outcomesLow-volume facilitiesZip code median incomeLow incomeRace/ethnicityCohort studyCoronary interventionLatinx patientsSecondary outcomesArtery diseasePCI centerPrimary outcomePCI volumeAsian patientsCertain socioeconomic factors
2022
Association of Lymph Node Sampling and Clinical Volume in Lobectomy for Non–Small Cell Lung Cancer
Udelsman BV, Chang DC, Boffa DJ, Gaissert HA. Association of Lymph Node Sampling and Clinical Volume in Lobectomy for Non–Small Cell Lung Cancer. The Annals Of Thoracic Surgery 2022, 115: 166-173. PMID: 35752354, DOI: 10.1016/j.athoracsur.2022.05.051.Peer-Reviewed Original ResearchConceptsNon-small cell lung cancerHigh-volume centersThoracic Surgeons General Thoracic Surgery DatabaseGeneral Thoracic Surgery DatabaseMedium-volume centersLow-volume centersCell lung cancerThoracic Surgery DatabaseNodal harvestParticipant centersLymph nodesLung cancerSurgery DatabaseLymph node samplingMultivariable logistic regressionHigher center volumeLong-term survivalPotential quality metricElective lobectomyAdjuvant therapyNodal yieldGuideline adherencePrimary outcomeUnivariable analysisMultivariable analysis
2021
The association between cardiac intensive care unit mechanical ventilation volumes and in-hospital mortality
Nandiwada S, Islam S, Jentzer JC, Miller PE, Fordyce CB, Lawler P, Alviar CL, Sun LY, Dover DC, Lopes RD, Kaul P, van Diepen S. The association between cardiac intensive care unit mechanical ventilation volumes and in-hospital mortality. European Heart Journal Acute Cardiovascular Care 2021, 10: 797-805. PMID: 34318875, PMCID: PMC9067446, DOI: 10.1093/ehjacc/zuab055.Peer-Reviewed Original ResearchConceptsCardiac intensive care unitMechanical ventilationHospital mortalityRespiratory failureCICU LOSNon-invasive mechanical ventilationNational population-based dataInvasive mechanical ventilationVolume-mortality relationshipProlonged mechanical ventilationProportion of patientsHigh-volume hospitalsPercutaneous coronary interventionLow-volume centersHigh-volume centersIntensive care unitPopulation-based dataOutcomes of interestCICU lengthCICU admissionCoronary interventionSurgical ICUCare unitVolume centersLower incidenceHigher CICU mechanical ventilation volumes are associated with lower in-hospital mortality
Nandiwada S, Islam S, Jentzer J, Miller P, Fordyce C, Lawler P, Alviar C, Sun L, Dover D, Kaul P, Van Diepen S. Higher CICU mechanical ventilation volumes are associated with lower in-hospital mortality. European Heart Journal Acute Cardiovascular Care 2021, 10: zuab020.161. DOI: 10.1093/ehjacc/zuab020.161.Peer-Reviewed Original ResearchCardiac intensive care unitCICU LOSIn-hospital mortalityAssociated with lower in-hospital mortalityProlonged MVLower in-hospital mortalityProportion of patientsMechanical ventilationRespiratory failureVolume centersCardiac intensive care unit lengthCardiac intensive care unit admissionIncidence of respiratory failureNon-invasive mechanical ventilationAssociated with reduced mortalityInvasive mechanical ventilationLow-volume centersIntensive care unitHigh-volume hospitalsCardiac intensive care unit populationPopulation-based dataSurgical ICUOdds ratioAcademic centersCare unitEffect of institutional transcatheter aortic valve replacement volume on mortality: A systematic review and meta‐analysis
Kir D, Shapero K, Chatterjee S, Grimshaw A, Oddleifson A, Spatz ES, Goldsweig AM, Desai NR. Effect of institutional transcatheter aortic valve replacement volume on mortality: A systematic review and meta‐analysis. Catheterization And Cardiovascular Interventions 2021, 98: e453-e461. PMID: 33565695, DOI: 10.1002/ccd.29502.Peer-Reviewed Original ResearchConceptsLow-volume centersVolume centersTitles/abstractsPatient outcomesTAVR centersTAVR volumeCause mortalitySystematic reviewHigh-volume centersIntermediate-volume centersReplacement volumeFull-text studiesCause mortality dataStrong referral networkFree-text termsSystematic literature searchPre-specified criteriaEligible studiesProcedural volumeExclusion criteriaMortality rateTAVRLiterature searchMortality dataRelevant articles
2020
Data-Driven Volume Thresholds Predictive of Improved Outcomes after Orthotopic Heart Transplantation
Frankel W, Godfrey E, Suarez E, Rana A, Shafii A, Loor G, Liao K. Data-Driven Volume Thresholds Predictive of Improved Outcomes after Orthotopic Heart Transplantation. The Journal Of Heart And Lung Transplantation 2020, 39: s363. DOI: 10.1016/j.healun.2020.01.441.Peer-Reviewed Original ResearchOrthotopic heart transplantationHigh-volume centersStratum-specific likelihood ratio (SSLR) analysisVolume centersHeart transplantationVolume strataImproved outcomesIntra-aortic balloon pumpImproved early outcomePost-transplant dialysisOrgan Sharing databaseLow-volume centersYears of ageLow-volume counterpartsComplex surgical careHalf of recipientsOHT casesPreoperative characteristicsPostoperative outcomesBalloon pumpFinal cohortPrimary outcomeSharing databaseMedication usageEarly mortalityRelationship Between Hospital Surgical Aortic Valve Replacement Volume and Transcatheter Aortic Valve Replacement Outcomes
Hirji S, McCarthy E, Kim D, McGurk S, Ejiofor J, Val F, Kolkailah A, Rosner B, Shook D, Nyman C, Berry N, Sobieszczyk P, Pelletier M, Shah P, O’Gara P, Kaneko T. Relationship Between Hospital Surgical Aortic Valve Replacement Volume and Transcatheter Aortic Valve Replacement Outcomes. JACC Cardiovascular Interventions 2020, 13: 335-343. PMID: 32029250, PMCID: PMC8858441, DOI: 10.1016/j.jcin.2019.09.048.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAortic ValveClinical CompetenceDatabases, FactualFemaleHeart Valve Prosthesis ImplantationHospitals, High-VolumeHospitals, Low-VolumeHumansMaleMedicareOutcome and Process Assessment, Health CareQuality Indicators, Health CareRisk AssessmentRisk FactorsTime FactorsTranscatheter Aortic Valve ReplacementTreatment OutcomeUnited StatesConceptsTranscatheter aortic valve replacementSurgical aortic valve replacementTranscatheter aortic valve replacement outcomesAortic valve replacementValve replacementConcomitant coronary artery bypass graft surgeryGroup 2Aortic valve replacement volumesGroup 1Group 3Group 4Surgical aortic valve replacement volumeCoronary artery bypass graft surgeryTranscatheter aortic valve replacement procedureArtery bypass graft surgeryAortic valve replacement proceduresYear post-procedureOpen-heart proceduresRisk-adjusted odds ratioMultivariate Cox regressionHeart valve proceduresLow-volume centersValve replacement proceduresTAVR admissionsBypass graft surgery
2019
Hepatocellular carcinoma: Impact of academic setting and hospital volume on patient survival
Uhlig J, Sellers CM, Khan SA, Cha C, Kim HS. Hepatocellular carcinoma: Impact of academic setting and hospital volume on patient survival. Surgical Oncology 2019, 31: 111-118. PMID: 31654956, DOI: 10.1016/j.suronc.2019.10.009.Peer-Reviewed Original ResearchMeSH KeywordsAcademic Medical CentersAntineoplastic Combined Chemotherapy ProtocolsCarcinoma, HepatocellularCombined Modality TherapyDatabases, FactualFemaleFollow-Up StudiesHepatectomyHospitals, High-VolumeHospitals, Low-VolumeHumansLiver NeoplasmsLiver TransplantationMaleMiddle AgedPractice Patterns, Physicians'PrognosisRetrospective StudiesSurvival RateConceptsOverall survivalHepatocellular carcinomaAcademic centersHospital volumePatient survivalInterventional oncologyYoung African American patientsHigh-volume academic centersMultivariable Cox regressionFirst-line treatmentLow-volume centersLonger patient survivalAfrican American patientsHCC treatment modalitiesNon-academic centersLiver transplantMultivariable adjustmentPatient demographicsSurgical resectionLine treatmentCox regressionPotential confoundersVolume centersTreatment modalitiesAmerican patients
2016
Hospital Volume and Outcomes of Robot-Assisted Lobectomies
Tchouta LN, Park HS, Boffa DJ, Blasberg JD, Detterbeck FC, Kim AW. Hospital Volume and Outcomes of Robot-Assisted Lobectomies. CHEST Journal 2016, 151: 329-339. PMID: 27687847, DOI: 10.1016/j.chest.2016.09.008.Peer-Reviewed Original ResearchMeSH KeywordsAgedCase-Control StudiesCohort StudiesDatabases, FactualFemaleHospital MortalityHospitals, High-VolumeHospitals, Low-VolumeHumansLength of StayLinear ModelsLogistic ModelsLungLung NeoplasmsMaleMiddle AgedMultivariate AnalysisPneumonectomyPostoperative ComplicationsRetrospective StudiesRobotic Surgical ProceduresThoracic Surgery, Video-AssistedTreatment OutcomeConceptsLength of stayLow-volume centersHospital volumeClinical impactHealth care system-related factorsShorter mean LOSUtilization Project National Inpatient Sample databaseVolume/outcome relationshipLong-term clinical impactMean LOSNational Inpatient Sample databaseShorter LOSVideo-assisted thoracoscopic surgeryHospital operative volumeHigh-volume hospitalsIncidence of complicationsHigher hospital volumeThoracoscopic surgery lobectomyAnnual case volumeSystem-related factorsOutcomes of interestLOS outcomesInfectious complicationsInpatient mortalityIndependent predictorsFactors Affecting Length of Postoperative Hospitalization for Pediatric Cardiac Operations in a Large North American Registry (1982–2007)
al-Haddad BJ, Menk JS, Kochilas L, Vinocur JM. Factors Affecting Length of Postoperative Hospitalization for Pediatric Cardiac Operations in a Large North American Registry (1982–2007). Pediatric Cardiology 2016, 37: 884-891. PMID: 26965705, PMCID: PMC5724563, DOI: 10.1007/s00246-016-1364-0.Peer-Reviewed Original ResearchConceptsPostoperative hospitalizationSurgical volumeAnnual surgical volumeHealthcare resource useLow-volume centersPediatric cardiac operationsFactors Affecting LengthCongenital heart diseaseNorth American RegistrySurgical treatmentEarly dischargeCardiac operationsPediatric hospitalizationsVolume centersHeart diseaseClinical significanceMerit further investigationSex-specific differencesHospitalizationEfficient careMajor causeRisk adjustmentOlder childrenTime interactionRandom effects
2014
Treatment Patterns and Outcomes for Patients with Adrenocortical Carcinoma Associated with Hospital Case Volume in the United States
Gratian L, Pura J, Dinan M, Reed S, Scheri R, Roman S, Sosa JA. Treatment Patterns and Outcomes for Patients with Adrenocortical Carcinoma Associated with Hospital Case Volume in the United States. Annals Of Surgical Oncology 2014, 21: 3509-3514. PMID: 25069860, PMCID: PMC4515350, DOI: 10.1245/s10434-014-3931-z.Peer-Reviewed Original ResearchMeSH KeywordsAdrenal Cortex NeoplasmsAdrenocortical CarcinomaAdultAgedDatabases, FactualElective Surgical ProceduresFemaleFollow-Up StudiesHospitals, High-VolumeHospitals, Low-VolumeHumansLength of StayMaleMiddle AgedNeoplasm StagingOutcome and Process Assessment, Health CarePractice Patterns, Physicians'RegistriesReoperationSurvival RateWorkloadConceptsHigh-volume centersLow-volume centersHospital case volumeOverall survivalTreatment patternsCase volumeRegional lymph node evaluationAggressive surgical resectionLymph node evaluationPrimary adrenal malignancyMedian overall survivalNational Cancer DatabasePostoperative mortality rateBackgroundAdrenocortical carcinomaChemotherapy useAggressive treatmentRadical resectionReadmission ratesSurgical resectionAdrenal malignancyCarcinoma AssociatedClinical outcomesTumor characteristicsACC patientsAggressive diseaseTransoral Robotic Surgery: A Population‐Level Analysis
Chen MM, Roman SA, Kraus DH, Sosa JA, Judson BL. Transoral Robotic Surgery: A Population‐Level Analysis. Otolaryngology 2014, 150: 968-975. PMID: 24618503, DOI: 10.1177/0194599814525747.Peer-Reviewed Original ResearchConceptsTransoral robotic surgeryNational Cancer DatabaseUnplanned readmissionPositive marginsNonrobotic surgeryOropharyngeal cancerTORS patientsMargin statusCancer DatabaseUse of TORSLower ratesCommunity cancer centerHigh-volume centersLow-volume centersHuman papilloma virusRetrospective database reviewOutcomes of interestAdjuvant chemoradiationAdjuvant therapyHPV positivityPathologic characteristicsPositive tumorsCancer CenterPapilloma virusDatabase review
2013
Reliability adjustment
Hashmi Z, Dimick J, Efron D, Haut E, Schneider E, Zafar S, Schwartz D, Cornwell E, Haider A. Reliability adjustment. Journal Of Trauma And Acute Care Surgery 2013, 75: 166-172. PMID: 23940864, PMCID: PMC3989535, DOI: 10.1097/ta.0b013e318298494f.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedBenchmarkingCause of DeathDatabases, FactualFemaleHospital MortalityHumansInjury Severity ScoreMaleMiddle AgedOutcome Assessment, Health CareQuality ImprovementReproducibility of ResultsRisk AdjustmentSurvival AnalysisTrauma CentersUnited StatesWounds and InjuriesWounds, NonpenetratingWounds, PenetratingYoung AdultConceptsRisk-adjusted mortality ratesInjury Severity ScoreLow-volume centersMortality rateNational Trauma Data Bank 2010National Trauma Data BankReliability adjustmentHierarchical logistic regression modelingPatients 16 yearsRisk-adjusted mortalityTrauma Data BankNumber of patientsLogistic regression modelingHospital performance assessmentRisk adjustment methodsTrauma centerSeverity scoreVolume centersMortality ratioWorst quintileInterfacility variationOutcomes and Costs Associated With Robotic Colectomy in the Minimally Invasive Era
Tyler JA, Fox JP, Desai MM, Perry WB, Glasgow SC. Outcomes and Costs Associated With Robotic Colectomy in the Minimally Invasive Era. Diseases Of The Colon & Rectum 2013, 56: 458-466. PMID: 23478613, DOI: 10.1097/dcr.0b013e31827085ec.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAnastomosis, SurgicalColectomyCosts and Cost AnalysisEnterostomyFemaleHospital CostsHumansIleusIntestinal FistulaIntraoperative ComplicationsLaparoscopyLength of StayMaleMiddle AgedPneumoniaPostoperative ComplicationsRetrospective StudiesRoboticsVenous ThromboembolismYoung AdultConceptsRobotic-assisted colectomyLength of stayHospital outcomesLaparoscopic colectomyOverall postoperative morbidity ratePostoperative morbidity rateLow-volume centersNationwide Inpatient SampleCost of careRobotic-assisted surgeryPotential miscodingOverall morbidityPostoperative complicationsAdult patientsIndividual complicationsLaparoscopic approachPatient characteristicsColon surgeryRetrospective reviewMorbidity rateRobotic colectomyInvasive eraInpatient SampleLaparoscopic proceduresBaseline differences
2011
Morbidity and mortality after hepatic and pancreatic resections: results from one surgeon at a low-volume urban hospital over thirty years
Schwartz G, Swan R, Ruangvoravat L, Attiyeh F. Morbidity and mortality after hepatic and pancreatic resections: results from one surgeon at a low-volume urban hospital over thirty years. The American Journal Of Surgery 2011, 201: 438-444. PMID: 21421096, DOI: 10.1016/j.amjsurg.2010.10.005.Peer-Reviewed Original ResearchConceptsPancreatic resectionHepatic resectionSurgeon trainingLow-volume centersLow-volume institutionsAdequate surgeon trainingLow-volume hospitalsCentral pancreatectomyExtended lobectomyWedge resectionDistal pancreatectomyRetrospective reviewSurrogate markerResectionHospital volumeMorbidityUrban hospitalsEtiology of diseaseEtiologyMortalitySurgeonsLobectomyPancreatectomyNational databasePerioperative system
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